{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:08:02Z","timestamp":1768734482448,"version":"3.49.0"},"reference-count":52,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq","award":["305799\/2019-3"],"award-info":[{"award-number":["305799\/2019-3"]}]},{"name":"CNPq","award":["2018\/2019"],"award-info":[{"award-number":["2018\/2019"]}]},{"name":"CNPq","award":["2018\/019"],"award-info":[{"award-number":["2018\/019"]}]},{"name":"PPG-BQA\/PNPD","award":["305799\/2019-3"],"award-info":[{"award-number":["305799\/2019-3"]}]},{"name":"PPG-BQA\/PNPD","award":["2018\/2019"],"award-info":[{"award-number":["2018\/2019"]}]},{"name":"PPG-BQA\/PNPD","award":["2018\/019"],"award-info":[{"award-number":["2018\/019"]}]},{"name":"MJSF, and CAPES\/PPG-Biochemistry","award":["305799\/2019-3"],"award-info":[{"award-number":["305799\/2019-3"]}]},{"name":"MJSF, and CAPES\/PPG-Biochemistry","award":["2018\/2019"],"award-info":[{"award-number":["2018\/2019"]}]},{"name":"MJSF, and CAPES\/PPG-Biochemistry","award":["2018\/019"],"award-info":[{"award-number":["2018\/019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>This pre-clinical study investigated the transient receptor potential ankyrin-1 (TRPA1) channels on modulating targets for glucose homeostasis using agonists: the electrophilic agonists, cinnamaldehyde (CIN) and allyl isothiocyanate (AITC), and the non-electrophilic agonist, carvacrol (CRV). A glucose tolerance test was performed on rats. CIN and AITC (5, 10 and 20 mg\/kg) or CRV (25, 100, 300, and 600 mg\/kg) were administered intraperitoneally (i.p.), and glycemia was measured. In the intestine, Glucagon-like peptide-1 (GLP-1) and disaccharidase activity were evaluated (in vivo and in vitro, respectively). Furthermore, in vivo and in vitro insulin secretion was determined. Islets were used to measure insulin secretion and calcium influx. CIN and AITC improved glucose tolerance and increased insulin secretion in vivo and in vitro. CRV was unable to reduce glycemia. Electrophilic agonists, CIN and AITC, inhibited disaccharidases and acted as secretagogues in the intestine by inducing GLP-1 release in vivo and in vitro and contributed to insulin secretion and glycemia. The effect of CIN on calcium influx in pancreatic islets (insulin secretion) involves voltage-dependent calcium channels and calcium from stores. TRPA1 triggers calcium influx and potentiates intracellular calcium release to induce insulin secretion, suggesting that electrophilic agonists mediate this signaling transduction for the control of glycemia.<\/jats:p>","DOI":"10.3390\/ph16081167","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T09:57:02Z","timestamp":1692179822000},"page":"1167","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Electrophilic Agonists Modulate the Transient Receptor Potential Ankyrin-1 Channels Mediated by Insulin and Glucagon-like Peptide-1 Secretion for Glucose Homeostasis"],"prefix":"10.3390","volume":"16","author":[{"given":"Marisa Jadna Silva","family":"Frederico","sequence":"first","affiliation":[{"name":"Laboratory of Hormones & Signal Transduction, Departament of Biochemistry, Center of Biological Sciences, Campus Trindade, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, SC, Brazil"},{"name":"Laboratory of Biochemistry and Pharmacology, Departament of Pharmacology and Physiology, Drug Research and Development Center (DRDC), Medical School, Federal University of Cear\u00e1, Rua Coronel Nunes de Melo, Fortaleza 60430-275, CE, Brazil"}]},{"given":"Andreza","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Laboratory of Hormones & Signal Transduction, Departament of Biochemistry, Center of Biological Sciences, Campus Trindade, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, SC, Brazil"}]},{"given":"Jocelyn Brice Alexandre","family":"Heim","sequence":"additional","affiliation":[{"name":"Laboratory of Hormones & Signal Transduction, Departament of Biochemistry, Center of Biological Sciences, Campus Trindade, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, SC, Brazil"}]},{"given":"Ana Karla Bittencourt","family":"Mendes","sequence":"additional","affiliation":[{"name":"Laboratory of Hormones & Signal Transduction, Departament of Biochemistry, Center of Biological Sciences, Campus Trindade, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, SC, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-3771","authenticated-orcid":false,"given":"Marcela","family":"Arag\u00f3n","sequence":"additional","affiliation":[{"name":"Departament of Pharmacy, Science School, National University of Colombia, Bogot\u00e1 11011, Colombia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-4234","authenticated-orcid":false,"given":"Joana Margarida","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Laboratory of Hormones & Signal Transduction, Departament of Biochemistry, Center of Biological Sciences, Campus Trindade, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, SC, Brazil"}]},{"given":"Nylane Maria Nunes","family":"De Alencar","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Pharmacology, Departament of Pharmacology and Physiology, Drug Research and Development Center (DRDC), Medical School, Federal University of Cear\u00e1, Rua Coronel Nunes de Melo, Fortaleza 60430-275, CE, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-2354","authenticated-orcid":false,"given":"F\u00e1tima Regina Mena Barreto","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Hormones & Signal Transduction, Departament of Biochemistry, Center of Biological Sciences, Campus Trindade, Federal University of Santa Catarina, Florian\u00f3polis 88040-900, SC, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3389\/fped.2020.00407","article-title":"Special Attention to Diet and Physical Activity in Children and Adolescents with Obesity During the Coronavirus Disease-2019 Pandemic","volume":"8","author":"Calcaterra","year":"2020","journal-title":"Front. 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