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Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.2147\/CIA.S65448","article-title":"N-palmitoylethanolamine and N-acetylethanolamine are effective in asteatotic eczema: Results of a randomized, double-blind, controlled study in 60 patients","volume":"9","author":"Yuan","year":"2014","journal-title":"Clin. Interv. Aging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1468-3083.2007.02351.x","article-title":"Adjuvant treatment of atopic eczema: Assessment of an emollient containing N-palmitoylethanolamine (ATOPA study)","volume":"22","author":"Eberlein","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00011-003-1162-z","article-title":"Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin","volume":"52","author":"Dvorak","year":"2003","journal-title":"Inflamm. Res."},{"key":"ref_18","unstructured":"Changoer, L., and Anastassov, G. (2019). Method to Treat Psoriasis. (Patent 20190060250), Available online: https:\/\/www.freepatentsonline.com\/y2019\/0060250.html."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Aguzzi, C., Perinelli, D.R., Cespi, M., Zeppa, L., Mazzara, E., Maggi, F., Petrelli, R., Bonacucina, G., and Nabissi, M. (2023). Encapsulation of Hemp (Cannabis sativa L.) Essential Oils into Nanoemulsions for Potential Therapeutic Applications: Assessment of Cytotoxicological Profiles. 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