{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:05:31Z","timestamp":1773162331692,"version":"3.50.1"},"reference-count":118,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT","award":["UIDB\/04326\/2020"],"award-info":[{"award-number":["UIDB\/04326\/2020"]}]},{"name":"FCT","award":["UIDP\/04326\/2020"],"award-info":[{"award-number":["UIDP\/04326\/2020"]}]},{"name":"FCT","award":["LA\/P\/0101\/2020"],"award-info":[{"award-number":["LA\/P\/0101\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceuticals"],"abstract":"<jats:p>Repurposing drugs by uncovering new indications for approved drugs accelerates the process of establishing new treatments and reduces the high costs of drug discovery and development. Metal complexes with clinically approved drugs allow further opportunities in cancer therapy\u2014many vanadium compounds have previously shown antitumor effects, which makes vanadium a suitable metal to complex with therapeutic drugs, potentially improving their efficacy in cancer treatment. In this review, covering the last 25 years of research in the field, we identified non-oncology-approved drugs suitable as ligands to obtain different vanadium complexes. Metformin-decavanadate, vanadium-bisphosphonates, vanadyl(IV) complexes with non-steroidal anti-inflammatory drugs, and cetirizine and imidazole-based oxidovanadium(IV) complexes, each has a parent drug known to have different medicinal properties and therapeutic indications, and all showed potential as novel anticancer treatments. Nevertheless, the precise mechanisms of action for these vanadium compounds against cancer are still not fully understood.<\/jats:p>","DOI":"10.3390\/ph17010012","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T03:36:17Z","timestamp":1703129777000},"page":"12","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Repurposing Therapeutic Drugs Complexed to Vanadium in Cancer"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8451-4302","authenticated-orcid":false,"given":"Ana Lu\u00edsa","family":"De Sousa-Coelho","sequence":"first","affiliation":[{"name":"Algarve Biomedical Center Research Institute (ABC-RI), Universidade do Algarve, 8005-139 Faro, Portugal"},{"name":"Algarve Biomedical Center (ABC), Universidade do Algarve, 8005-139 Faro, Portugal"},{"name":"Escola Superior de Sa\u00fade, Universidade do Algarve (ESSUAlg), 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-9292","authenticated-orcid":false,"given":"Gil","family":"Fraqueza","sequence":"additional","affiliation":[{"name":"Instituto Superior de Engenharia (ISE), Universidade do Algarve, 8005-139 Faro, Portugal"},{"name":"Centro de Ci\u00eancias do Mar (CCMar), Universidade do Algarve, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-3201","authenticated-orcid":false,"given":"Manuel","family":"Aureliano","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias do Mar (CCMar), Universidade do Algarve, 8005-139 Faro, Portugal"},{"name":"Faculdade de Ci\u00eancias e Tecnologia (FCT), Universidade do Algarve, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sales, T.A., Prandi, I.G., de Castro, A.A., Leal, D.H.S., da Cunha, E.F.F., Kuca, K., and Ramalho, T.C. 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