{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T11:11:34Z","timestamp":1778411494693,"version":"3.51.4"},"reference-count":235,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia \u2013 Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior (FCT-MCTES, Portugal)","award":["UID\/BIM\/50005\/2019"],"award-info":[{"award-number":["UID\/BIM\/50005\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Antimicrobial peptides (AMPs) have been described as excellent candidates to overcome antibiotic resistance. Frequently, AMPs exhibit a wide therapeutic window, with low cytotoxicity and broad-spectrum antimicrobial activity against a variety of pathogens. In addition, some AMPs are also able to modulate the immune response, decreasing potential harmful effects such as sepsis. Despite these benefits, only a few formulations have successfully reached clinics. A common flaw in the druggability of AMPs is their poor pharmacokinetics, common to several peptide drugs, as they may be degraded by a myriad of proteases inside the organism. The combination of AMPs with carrier nanoparticles to improve delivery may enhance their half-life, decreasing the dosage and thus, reducing production costs and eventual toxicity. Here, we present the most recent advances in lipid and metal nanodevices for AMP delivery, with a special focus on metal nanoparticles and liposome formulations.<\/jats:p>","DOI":"10.3390\/pharmaceutics11110588","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T11:30:19Z","timestamp":1573212619000},"page":"588","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["Advances in Lipid and Metal Nanoparticles for Antimicrobial Peptide Delivery"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6929-6143","authenticated-orcid":false,"given":"Marcin","family":"Makowski","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-2757","authenticated-orcid":false,"given":"\u00cdtala C.","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-9494","authenticated-orcid":false,"given":"Constan\u00e7a","family":"Pais do Amaral","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"S\u00f3nia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0580-0475","authenticated-orcid":false,"given":"Nuno C.","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1517\/14656566.2015.983077","article-title":"Clinical, economic and societal impact of antibiotic resistance","volume":"16","author":"Barriere","year":"2015","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_2","unstructured":"(2019, August 07). Tackling Drug-Resistant Infections Globally: Final Report and Recommendations. Available online: http:\/\/amr-review.org\/sites\/default\/files\/160525_Final paper_with cover.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5971","DOI":"10.3390\/ijms12095971","article-title":"The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation","volume":"12","author":"Park","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/nbt1267","article-title":"Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies","volume":"24","author":"Hancock","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.3390\/v7102883","article-title":"Perspective of Use of Antiviral Peptides against Influenza Virus","volume":"7","author":"Skalickova","year":"2015","journal-title":"Viruses"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3389\/fimmu.2018.00722","article-title":"Cathelicidin-Derived Antimicrobial Peptides Inhibit Zika Virus Through Direct Inactivation and Interferon Pathway","volume":"9","author":"He","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_7","first-page":"5","article-title":"Peptides with dual antimicrobial and anticancer activities","volume":"5","author":"Silva","year":"2017","journal-title":"Front. Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s10096-008-0553-z","article-title":"Human antimicrobial peptides\u2019 antifungal activity against Aspergillus fumigatus","volume":"27","author":"Lupetti","year":"2008","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Ko\u010dendov\u00e1, J., Va\u0148kov\u00e1, E., Volejn\u00edkov\u00e1, A., Ne\u0161uta, O., Bud\u011b\u0161\u00ednsk\u00fd, M., Socha, O., H\u00e1jek, M., Hadravov\u00e1, R., and \u010ce\u0159ovsk\u00fd, V. (2019). Antifungal activity of analogues of antimicrobial peptides isolated from bee venoms against vulvovaginal Candida spp.. FEMS Yeast Res., 19.","DOI":"10.1093\/femsyr\/foz013"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fphar.2014.00275","article-title":"Antimicrobial peptides: a new class of antimalarial drugs?","volume":"5","author":"Vale","year":"2014","journal-title":"Front. Pharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrmicro1098","article-title":"Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?","volume":"3","author":"Brogden","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"AB Naafs, M. (2018). The Antimicrobial Peptides: Ready for Clinical Trials?. Biomed. J. Sci. Tech. Res., 7.","DOI":"10.26717\/BJSTR.2018.07.001536"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1172\/JCI17545","article-title":"An angiogenic role for the human peptide antibiotic LL-37\/hCAP-18","volume":"111","author":"Koczulla","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/exd.12929","article-title":"Antimicrobial peptides and wound healing: biological and therapeutic considerations","volume":"25","author":"Mangoni","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.4049\/jimmunol.169.7.3883","article-title":"The Human Antimicrobial Peptide LL-37 Is a Multifunctional Modulator of Innate Immune Responses","volume":"169","author":"Scott","year":"2002","journal-title":"J. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1099\/jmm.0.000032","article-title":"Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control","volume":"64","author":"Percival","year":"2015","journal-title":"J. Med. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nrmicro.2017.99","article-title":"Targeting microbial biofilms: current and prospective therapeutic strategies","volume":"15","author":"Koo","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.drudis.2014.10.003","article-title":"Peptide therapeutics: Current status and future directions","volume":"20","author":"Fosgerau","year":"2015","journal-title":"Drug Discov. Today"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fchem.2017.00040","article-title":"D-BMAP18 Antimicrobial Peptide Is Active In vitro, Resists to Pulmonary Proteases but Loses Its Activity in a Murine Model of Pseudomonas aeruginosa Lung Infection","volume":"5","author":"Mardirossian","year":"2017","journal-title":"Front. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0378-5173(03)00376-4","article-title":"Shifting paradigms: biopharmaceuticals versus low molecular weight drugs","volume":"266","author":"Crommelin","year":"2003","journal-title":"Int. J. Pharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/wnan.1325","article-title":"Advances in the synthesis and application of nanoparticles for drug delivery","volume":"7","author":"Park","year":"2015","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.2147\/IJN.S146315","article-title":"Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors","volume":"12","author":"Din","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.nano.2016.06.002","article-title":"Antimicrobial molecular nanocarrier\u2013drug conjugates","volume":"12","author":"Skwarecki","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Gallego, S., Franci, G., Falanga, A., G\u00f3mez, R., Folliero, V., Galdiero, S., De La Mata, F.J., and Galdiero, M. (2017). Function oriented molecular design: Dendrimers as novel antimicrobials. Molecules, 22.","DOI":"10.3390\/molecules22101581"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Henr\u00edquez, C.M., Sarabia-Vallejos, M.A., and Rodriguez-Hernandez, J. (2017). Advances in the fabrication of antimicrobial hydrogels for biomedical applications. Materials (Basel), 10.","DOI":"10.3390\/ma10030232"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.carbpol.2017.09.053","article-title":"Development of chitosan-sodium phytate nanoparticles as a potent antibacterial agent","volume":"178","author":"Yang","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_27","first-page":"133","article-title":"Drug delivery and nanoparticles: Applications and hazards","volume":"3","author":"Borm","year":"2008","journal-title":"Int. J. Nanomed."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.2147\/IJN.S133832","article-title":"Physicochemical characterization of drug nanocarriers","volume":"12","author":"Manaia","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/psc.1007","article-title":"What can light scattering spectroscopy do for membrane-active peptide studies?","volume":"14","author":"Domingues","year":"2008","journal-title":"J. Pept. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fchem.2018.00237","article-title":"Application of Light Scattering Techniques to Nanoparticle Characterization and Development","volume":"6","author":"Carvalho","year":"2018","journal-title":"Front. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/08982109209039901","article-title":"Size homogeneity of a liposome preparation is crucial for liposome biodistribution in vivo","volume":"2","author":"Liu","year":"1992","journal-title":"J. Liposome Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbamem.2015.11.012","article-title":"The protein corona of circulating PEGylated liposomes","volume":"1858","author":"Palchetti","year":"2016","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"ref_33","first-page":"283","article-title":"Long-Circulating and Target-Specific Nanoparticles: Theory to Practice","volume":"53","author":"Moghimi","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1517\/14712598.1.6.923","article-title":"Developments in liposomal drug delivery systems","volume":"1","author":"Maurer","year":"2005","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1002\/smll.200900126","article-title":"Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes","volume":"5","author":"Yen","year":"2009","journal-title":"Small"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s11095-008-9562-y","article-title":"Role of particle size in phagocytosis of polymeric microspheres","volume":"25","author":"Champion","year":"2008","journal-title":"Pharm. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1002\/anie.201403036","article-title":"Engineered nanoparticles for drug delivery in cancer therapy","volume":"53","author":"Sun","year":"2014","journal-title":"Angew. Chemie Int. Ed."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.taap.2015.12.022","article-title":"Current understanding of interactions between nanoparticles and the immune system","volume":"299","author":"Dobrovolskaia","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1080\/21691401.2017.1282496","article-title":"Recent advances on liposomal nanoparticles: Synthesis, characterization and biomedical applications","volume":"45","author":"Panahi","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1021\/acs.jpca.7b02186","article-title":"Role of Capping Agent in Wet Synthesis of Nanoparticles","volume":"121","author":"Phan","year":"2017","journal-title":"J. Phys. Chem. A"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.carbpol.2018.07.077","article-title":"Topical delivery of chitosan-capped silver nanoparticles speeds up healing in burn wounds: A preclinical study","volume":"200","author":"Oryan","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.fct.2017.11.051","article-title":"Stable PEG-coated silver nanoparticles \u2013 A comprehensive toxicological profile","volume":"111","author":"Pinzaru","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/1040841X.2017.1313813","article-title":"Factors pivotal for designing of nanoantimicrobials: an exposition","volume":"44","author":"Jamil","year":"2018","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcimb.2016.00194","article-title":"Antimicrobial Peptides: An Emerging Category of Therapeutic Agents","volume":"6","author":"Mahlapuu","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3389\/fcimb.2019.00128","article-title":"Application of Antimicrobial Peptides of the Innate Immune System in Combination With Conventional Antibiotics\u2014A Novel Way to Combat Antibiotic Resistance?","volume":"9","author":"Zharkova","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/1386207053764558","article-title":"Design of Host Defence Peptides for Antimicrobial and Immunity Enhancing Activities","volume":"8","author":"McPhee","year":"2005","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"ref_48","first-page":"1","article-title":"Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications","volume":"2015","author":"Luo","year":"2015","journal-title":"Biomed Res. Int."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1039\/c2ib20117h","article-title":"Common pitfalls in nanotechnology: lessons learned from NCI\u2019s Nanotechnology Characterization Laboratory","volume":"5","author":"Crist","year":"2013","journal-title":"Integr. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.smim.2017.08.013","article-title":"Nanoparticles and innate immunity: new perspectives on host defence","volume":"34","author":"Boraschi","year":"2017","journal-title":"Semin. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","article-title":"Recent advances with liposomes as pharmaceutical carriers","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1468-3083.2009.03100.x","article-title":"Liposomes in dermatology today","volume":"23","author":"Bjerring","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2017.10.046","article-title":"Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications","volume":"535","author":"Sala","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s12035-017-0728-7","article-title":"Intranasal Administration of TAT-Conjugated Lipid Nanocarriers Loading GDNF for Parkinson\u2019s Disease","volume":"55","author":"Hernando","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3233\/JAD-160355","article-title":"Development of Nasal Lipid Nanocarriers Containing Curcumin for Brain Targeting","volume":"59","author":"Vaz","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/btm2.10003","article-title":"Nanoparticles in the clinic","volume":"1","author":"Anselmo","year":"2016","journal-title":"Bioeng. Transl. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2012.03.020","article-title":"(Chezy) Doxil\u00ae \u2014 The first FDA-approved nano-drug: Lessons learned","volume":"160","author":"Barenholz","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/735349","article-title":"Nonviral Gene Delivery to Mesenchymal Stem Cells Using Cationic Liposomes for Gene and Cell Therapy","volume":"2010","author":"Madeira","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1056\/NEJM197609302951406","article-title":"The Carrier Potential of Liposomes in Biology and Medicine","volume":"295","author":"Gregoriadis","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref_60","first-page":"416","article-title":"Nanoparticle interactions with the immune system: Clinical implications for liposome-based cancer chemotherapy","volume":"8","author":"Gabizon","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2174\/187221050902150819151721","article-title":"Recent Progress in Liposome Production, Relevance to Drug Delivery and Nanomedicine","volume":"9","author":"Koynova","year":"2015","journal-title":"Recent Pat. Nanotechnol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ijpharm.2007.11.035","article-title":"Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains","volume":"355","author":"Alipour","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s13346-015-0220-8","article-title":"Influence of cholesterol on liposome stability and on in vitro drug release","volume":"5","author":"Briuglia","year":"2015","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"8073","DOI":"10.1021\/jf0348368","article-title":"Size, Stability, and Entrapment Efficiency of Phospholipid Nanocapsules Containing Polypeptide Antimicrobials","volume":"51","author":"Were","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1073\/pnas.81.6.1715","article-title":"pH-sensitive liposomes: Acid-induced liposome fusion","volume":"81","author":"Connor","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ajps.2014.09.004","article-title":"A review on phospholipids and their main applications in drug delivery systems","volume":"10","author":"Li","year":"2015","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_67","first-page":"149","article-title":"Dysregulated pH in tumor microenvironment checkmates cancer therapy","volume":"3","author":"Barar","year":"2013","journal-title":"BioImpacts"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"922","DOI":"10.4315\/0362-028X-67.5.922","article-title":"Encapsulation of nisin and lysozyme in liposomes enhances efficacy against Listeria monocytogenes","volume":"67","author":"Were","year":"2004","journal-title":"J. Food Prot."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1074\/jbc.M006770200","article-title":"Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity","volume":"276","author":"Wiedemann","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2015.00286","article-title":"Advances and challenges of liposome assisted drug delivery","volume":"6","author":"Sercombe","year":"2015","journal-title":"Front. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Alipour, M., Suntres, Z.E., Halwani, M., Azghani, A.O., and Omri, A. (2009). Activity and Interactions of Liposomal Antibiotics in Presence of Polyanions and Sputum of Patients with Cystic Fibrosis. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005724"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ijantimicag.2013.07.009","article-title":"Pharmacokinetics and efficacy of liposomal polymyxin B in a murine pneumonia model","volume":"42","author":"He","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2147\/IJN.S41695","article-title":"Preparation and characterization of flexible nanoliposomes loaded with daptomycin, a novel antibiotic, for topical skin therapy","volume":"8","author":"Li","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.molimm.2014.06.038","article-title":"Complement activation-related pseudoallergy: A stress reaction in blood triggered by nanomedicines and biologicals","volume":"61","author":"Szebeni","year":"2014","journal-title":"Mol. Immunol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.immuni.2014.10.015","article-title":"The Macrophage Paradox","volume":"41","author":"Price","year":"2014","journal-title":"Immunity"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Mitchell, G., Chen, C., and Portnoy, D.A. (2016). Strategies used by bacteria to grow in macrophages. Microbiol. Spectr., 4.","DOI":"10.1128\/microbiolspec.MCHD-0012-2015"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jconrel.2014.05.034","article-title":"Biodegradable nanoparticles for intracellular delivery of antimicrobial agents","volume":"187","author":"Xie","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1128\/AAC.24.5.742","article-title":"Enhanced activity of streptomycin and chloramphenicol against intracellular Escherichia coli in the J774 macrophage cell line mediated by liposome delivery","volume":"24","author":"Stevenson","year":"1983","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1042\/BCJ20161039","article-title":"Scolopendin, an antimicrobial peptide from centipede, attenuates mitochondrial functions and triggers apoptosis in Candida albicans","volume":"474","author":"Lee","year":"2017","journal-title":"Biochem. J."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Bulbake, U., Doppalapudi, S., Kommineni, N., and Khan, W. (2017). Liposomal Formulations in Clinical Use: An Updated Review. Pharmaceutics, 9.","DOI":"10.3390\/pharmaceutics9020012"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1021\/acs.bioconjchem.6b00437","article-title":"Nanodrug Delivery: Is the Enhanced Permeability and Retention Effect Sufficient for Curing Cancer?","volume":"27","author":"Nakamura","year":"2016","journal-title":"Bioconjug. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Raza, K., Kumar, P., Kumar, N., and Malik, R. (2017). Pharmacokinetics and biodistribution of the nanoparticles. Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids, Elsevier.","DOI":"10.1016\/B978-0-08-100557-6.00009-2"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/bmj.4.5734.525","article-title":"Effects of Large Doses of Colistin Sulphomethate Sodium on Renal Function","volume":"4","author":"Price","year":"1970","journal-title":"BMJ"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e02319-16","DOI":"10.1128\/AAC.02319-16","article-title":"Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B?","volume":"61","author":"Zavascki","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/10611869308996088","article-title":"Liposomal (MLV) polymyxin b: Physicochemical characterization and effect of surface charge on drug association","volume":"1","author":"Lawrence","year":"1993","journal-title":"J. Drug Target."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/jac\/43.2.203","article-title":"Antimicrobial properties of liposomal polymyxin B","volume":"43","author":"McAllister","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0168-1605(93)90217-5","article-title":"Antilisterial activity of pediocin AcH in model food systems in the presence of an emulsifier or encapsulated within liposomes","volume":"18","author":"Degnan","year":"1993","journal-title":"Int. J. Food Microbiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1128\/AEM.68.8.3683-3690.2002","article-title":"Inhibition of Listeria innocua in cheddar cheese by addition of nisin Z in liposomes or by in situ production in mixed culture","volume":"68","author":"Benech","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1752-4571.2008.00059.x","article-title":"Evolutionary ecology of microbial wars: Within-host competition and (incidental) virulence","volume":"2","author":"Brown","year":"2009","journal-title":"Evol. Appl."},{"key":"ref_90","first-page":"241","article-title":"Antibacterial activities of bacteriocins: application in foods and pharmaceuticals","volume":"5","author":"Yang","year":"2014","journal-title":"Front. Microbiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ifset.2016.07.017","article-title":"Antimicrobial activity of nanoliposomes co-encapsulating nisin and garlic extract against Gram-positive and Gram-negative bacteria in milk","volume":"36","author":"Pinilla","year":"2016","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/1462-2920.12534","article-title":"A single exposure to a sublethal pediocin concentration initiates a resistance-associated temporal cell envelope and general stress response in Listeria monocytogenes","volume":"17","author":"Laursen","year":"2015","journal-title":"Environ. Microbiol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.foodcont.2015.11.037","article-title":"Inhibition of Listeria monocytogenes in vitro and in goat milk by liposomal nanovesicles containing bacteriocins produced by Lactobacillus sakei subsp. sakei 2a","volume":"63","author":"Malheiros","year":"2016","journal-title":"Food Control"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1086\/511642","article-title":"Mutant Selection Window Hypothesis Updated","volume":"44","author":"Drlica","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/jac\/dkm053","article-title":"Antimycobacterial activity of bacteriocins and their complexes with liposomes","volume":"59","author":"Sosunov","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/10717544.2014.880756","article-title":"Liposomal co-delivery of daptomycin and clarithromycin at an optimized ratio for treatment of methicillin-resistant Staphylococcus aureus infection","volume":"22","author":"Li","year":"2015","journal-title":"Drug Deliv."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.2147\/IJN.S107107","article-title":"Novel antimicrobial peptide\u2014modified azithromycin-loaded liposomes against methicillin-resistant Staphylococcus aureus","volume":"11","author":"Liu","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3201\/eid0809.020063","article-title":"Biofilms: Microbial life on surfaces","volume":"8","author":"Donlan","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2174\/1874285801711010053","article-title":"Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents","volume":"11","author":"Singh","year":"2017","journal-title":"Open Microbiol. J."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1039\/C6MD00124F","article-title":"Nanoparticles vs. biofilms: a battle against another paradigm of antibiotic resistance","volume":"7","author":"Qayyum","year":"2016","journal-title":"Med. Chem. Commun."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/13880209.2012.717227","article-title":"Sustainable inhibition efficacy of liposome-encapsulated nisin on insoluble glucan-biofilm synthesis by Streptococcus mutans","volume":"51","author":"Yamakami","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_102","unstructured":"(2019, August 14). Search of: Liposome Infection\u2014List Results\u2014ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/results?cond=&term=liposome+infection&cntry=&state=&city=&dist=."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cbi.2015.08.023","article-title":"Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells","volume":"242","author":"Lo","year":"2015","journal-title":"Chem. Biol. Interact."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.2147\/IJN.S117618","article-title":"Cationic PEGylated liposomes incorporating an antimicrobial peptide tilapia hepcidin 2\u20133: An adjuvant of epirubicin to overcome multidrug resistance in cervical cancer cells","volume":"11","author":"Juang","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0006-3495(82)84681-X","article-title":"Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue","volume":"37","author":"DeGrado","year":"1982","journal-title":"Biophys. J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13045-017-0442-y","article-title":"A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety","volume":"10","author":"Mao","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3322\/caac.20114","article-title":"Photodynamic therapy of cancer: An update. CA","volume":"61","author":"Agostinis","year":"2011","journal-title":"Cancer J. Clin."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1039\/c1pp05100h","article-title":"Antimicrobial peptide-modified liposomes for bacteria targeted delivery of temoporfin in photodynamic antimicrobial chemotherapy","volume":"10","author":"Yang","year":"2011","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"19800","DOI":"10.1038\/srep19800","article-title":"Dual-functionalized liposomal delivery system for solid tumors based on RGD and a pH-responsive antimicrobial peptide","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.trecan.2015.11.003","article-title":"Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine","volume":"2","author":"Lipinski","year":"2016","journal-title":"Trends Cancer"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ajps.2013.07.011","article-title":"Liposomes as sterile preparations and limitations of sterilisation techniques in liposomal manufacturing","volume":"8","author":"Toh","year":"2013","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"10938","DOI":"10.1021\/acs.chemrev.5b00046","article-title":"New Developments in Liposomal Drug Delivery","volume":"115","author":"Pattni","year":"2015","journal-title":"Chem. Rev."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"6978","DOI":"10.1039\/C7RA12008G","article-title":"Factors affecting the structure of lyotropic liquid crystals and the correlation between structure and drug diffusion","volume":"8","author":"Huang","year":"2018","journal-title":"RSC Adv."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Dierking, I., and Al-Zangana, S. (2017). Lyotropic Liquid Crystal Phases from Anisotropic Nanomaterials. Nanomaterials, 7.","DOI":"10.3390\/nano7100305"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.drudis.2019.05.004","article-title":"Current potential and challenges in the advances of liquid crystalline nanoparticles as drug delivery systems","volume":"24","author":"Madheswaran","year":"2019","journal-title":"Drug Discov. Today"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1021\/la062851b","article-title":"Hexosome and hexagonal phases mediated by hydration and polymeric stabilizer","volume":"23","author":"Wachtel","year":"2007","journal-title":"Langmuir"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1021\/acs.langmuir.6b00338","article-title":"Lipid-Based Liquid Crystals As Carriers for Antimicrobial Peptides: Phase Behavior and Antimicrobial Effect","volume":"32","author":"Boge","year":"2016","journal-title":"Langmuir"},{"key":"ref_118","unstructured":"Delekta, S.S. (2015). Hexosomes as Drug Delivery Vehicles for Antimicrobial Peptides, KTH Royal Institute of Nanotechnology."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1021\/acs.jpclett.6b01622","article-title":"Antimicrobial peptide-driven colloidal transformations in liquid-crystalline nanocarriers","volume":"7","author":"Gontsarik","year":"2016","journal-title":"J. Phys. Chem. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1039\/C7BM00929A","article-title":"pH-triggered nanostructural transformations in antimicrobial peptide\/oleic acid self- assemblies","volume":"6","author":"Gontsarik","year":"2018","journal-title":"Biomater. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Bernegossi, J., Calixto, G.M.F., Da Silva Sanches, P.R., Fontana, C.R., Cilli, E.M., Garrido, S.S., and Chorilli, M. (2016). Peptide KSL-W-loaded mucoadhesive liquid crystalline vehicle as an alternative treatment for multispecies oral biofilm. Molecules, 21.","DOI":"10.3390\/molecules21010037"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4103\/0250-474X.57282","article-title":"Solid lipid nanoparticles: A modern formulation approach in drug delivery system","volume":"71","author":"Mukherjee","year":"2009","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.nano.2015.09.004","article-title":"Nanostructured lipid carriers: Promising drug delivery systems for future clinics","volume":"12","author":"Beloqui","year":"2016","journal-title":"Nanomedicine (NBM)"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1124\/pr.115.012070","article-title":"Lipid-based drug delivery systems in cancer therapy: what is available and what is yet to come","volume":"68","author":"Yingchoncharoen","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/2834941","article-title":"Lipid nano- and microparticles: An overview of patent-related research","volume":"2019","author":"Battaglia","year":"2019","journal-title":"J. Nanomater."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1080\/02652048.2016.1242665","article-title":"Stability study of sodium colistimethate-loaded lipid nanoparticles","volume":"33","author":"Pastor","year":"2016","journal-title":"J. Microencapsul."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijpharm.2017.04.071","article-title":"Interactions of the antimicrobial peptide nisin Z with conventional antibiotics and the use of nanostructured lipid carriers to enhance antimicrobial activity","volume":"526","author":"Lewies","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.jcf.2015.12.005","article-title":"Killing effect of nanoencapsulated colistin sulfate on Pseudomonas aeruginosa from cystic fibrosis patients","volume":"15","author":"Merlos","year":"2016","journal-title":"J. Cyst. Fibros."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.colsurfb.2015.12.033","article-title":"Solid lipid nanoparticles for encapsulation of hydrophilic drugs by an organic solvent free double emulsion technique","volume":"140","author":"Sayer","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3109\/10837450.2010.542163","article-title":"The use of hot and cold high pressure homogenization to enhance the loading capacity and encapsulation efficiency of nanostructured lipid carriers for the hydrophilic antiretroviral drug, didanosine for potential administration to paediatric patients","volume":"17","author":"Kasongo","year":"2012","journal-title":"Pharm. Dev. Technol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1021\/acs.bioconjchem.7b00368","article-title":"Recent Developments in Antimicrobial-Peptide-Conjugated Gold Nanoparticles","volume":"28","author":"Rajchakit","year":"2017","journal-title":"Bioconjug. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biotechadv.2008.09.002","article-title":"Silver nanoparticles as a new generation of antimicrobials","volume":"27","author":"Rai","year":"2009","journal-title":"Biotechnol. Adv."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1166\/jnn.2014.9526","article-title":"Recent Advances in Gold and Silver Nanoparticles: Synthesis and Applications","volume":"14","author":"Majdalawieh","year":"2014","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1021\/ar960016n","article-title":"Some interesting properties of metals confined in time and nanometer space of different shapes","volume":"34","year":"2001","journal-title":"Acc. Chem. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrd2591","article-title":"Strategies in the design of nanoparticles for therapeutic applications","volume":"9","author":"Petros","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Alaqad, K., and Saleh, T.A. (2016). Gold and Silver Nanoparticles: Synthesis Methods, Characterization Routes and Applications towards Drugs. J. Environ. Anal. Toxicol., 6.","DOI":"10.4172\/2161-0525.1000384"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40580-018-0170-1","article-title":"Peptide\u2013nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?","volume":"5","author":"Jeong","year":"2018","journal-title":"Nano Converg."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.nano.2016.08.016","article-title":"Role of metal and metal oxide nanoparticles as diagnostic and therapeutic tools for highly prevalent viral infections","volume":"13","author":"Yadavalli","year":"2017","journal-title":"Nanomedicine (NBM)"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s12951-015-0109-1","article-title":"One nanoprobe, two pathogens: gold nanoprobes multiplexing for point-of-care","volume":"13","author":"Veigas","year":"2015","journal-title":"J. Nanobiotechnol."},{"key":"ref_140","first-page":"1","article-title":"Gold Nanoparticles: Promising Nanomaterials for the Diagnosis of Cancer and HIV\/AIDS","volume":"2011","author":"Kumar","year":"2011","journal-title":"J. Nanomater."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ab.2011.12.024","article-title":"Signal-enhanced electrochemiluminescence immunosensor based on synergistic catalysis of nicotinamide adenine dinucleotide hydride and silver nanoparticles","volume":"422","author":"Wang","year":"2012","journal-title":"Anal. Biochem."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.colsurfb.2017.07.009","article-title":"Stabilized cationic dipeptide capped gold\/silver nanohybrids: Towards enhanced antibacterial and antifungal efficacy","volume":"158","author":"Bajaj","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"10376","DOI":"10.1021\/la2004535","article-title":"Rotello Nano meets biology: Structure and function at the nanoparticle interface","volume":"27","author":"Moyano","year":"2011","journal-title":"Langmuir"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1517\/17425247.2014.891582","article-title":"Gold nanoparticle conjugates: Recent advances toward clinical applications","volume":"11","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s12013-015-0529-4","article-title":"Gold Nanoparticles: Recent Advances in the Biomedical Applications","volume":"72","author":"Zhang","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1039\/C3CS60218D","article-title":"Nanosilver-based antibacterial drugs and devices: Mechanisms, methodological drawbacks, and guidelines","volume":"43","author":"Rizzello","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/j.bpj.2018.03.007","article-title":"Multivalent Binding of a Ligand-Coated Particle: Role of Shape, Size, and Ligand Heterogeneity","volume":"114","author":"McKenzie","year":"2018","journal-title":"Biophys. J."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-med-040210-162544","article-title":"Nanoparticle Delivery of Cancer Drugs","volume":"63","author":"Wang","year":"2012","journal-title":"Annu. Rev. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1021\/acsnano.7b00497","article-title":"Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles","volume":"11","author":"Talamini","year":"2017","journal-title":"ACS Nano"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"282","DOI":"10.4103\/0975-7406.72127","article-title":"Introduction to metallic nanoparticles","volume":"2","author":"Mody","year":"2010","journal-title":"J. Pharm. Bioallied Sci."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Slavin, Y.N., Asnis, J., H\u00e4feli, U.O., and Bach, H. (2017). Metal nanoparticles: Understanding the mechanisms behind antibacterial activity. J. Nanobiotechnol., 15.","DOI":"10.1186\/s12951-017-0308-z"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.1021\/nn3057005","article-title":"Gold Nanoparticles as a Vaccine Platform: Influence of Size and Shape on Immunological Responses in Vitro and in Vivo","volume":"7","author":"Niikura","year":"2013","journal-title":"ACS Nano"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Kl\u0119bowski, B., Depciuch, J., Parli\u0144ska-Wojtan, M., and Baran, J. (2018). Applications of Noble Metal-Based Nanoparticles in Medicine. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19124031"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cis.2015.01.007","article-title":"Understanding nanoparticle cellular entry: A physicochemical perspective","volume":"218","author":"Beddoes","year":"2015","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bbagen.2012.02.015","article-title":"Characterization of dual effects induced by antimicrobial peptides: Regulated cell death or membrane disruption","volume":"1820","author":"Martins","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/415389a","article-title":"Antimicrobial peptides of multicellular organisms","volume":"415","author":"Zasloff","year":"2002","journal-title":"Nature"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1080\/10717544.2018.1501119","article-title":"The challenges of oral drug delivery via nanocarriers","volume":"25","author":"Reinholz","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1038\/s41598-017-04229-z","article-title":"The Effect of shape on Cellular Uptake of Gold Nanoparticles in the forms of Stars, Rods, and Triangles","volume":"7","author":"Xie","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_159","first-page":"1043","article-title":"A review of stabilized silver nanoparticles \u2013 Synthesis, biological properties, characterization, and potential areas of applications","volume":"4","author":"Zewde","year":"2016","journal-title":"JSM Nanotechnol. Nanomed."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Venkatesh, N. (2018). Metallic Nanoparticle: A Review. Biomed. J. Sci. Tech. Res., 4.","DOI":"10.26717\/BJSTR.2018.04.0001011"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Richards, R., and B\u00f6nnemann, H. (2005). Synthetic Approaches to Metallic Nanomaterials. Nanofabrication towards Biomedical Applications: Techniques, Tools, Applications, and Impact, Wiley-VCH Verlag GmbH & Co. KGaA.","DOI":"10.1002\/3527603476.ch1"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1039\/df9511100055","article-title":"A study of the nucleation and growth processes in the synthesis of colloidal gold","volume":"11","author":"Turkevich","year":"1951","journal-title":"Discuss. Faraday Soc."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/physci241020a0","article-title":"Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions","volume":"241","author":"FRENS","year":"1973","journal-title":"Nat. Phys. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1007\/s00253-015-6622-1","article-title":"Bacteriagenic silver nanoparticles: synthesis, mechanism, and applications","volume":"99","author":"Singh","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1039\/c3nr34254a","article-title":"The potent antimicrobial properties of cell penetrating peptide-conjugated silver nanoparticles with excellent selectivity for Gram-positive bacteria over erythrocytes","volume":"5","author":"Liu","year":"2013","journal-title":"Nanoscale"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1021\/cm500316k","article-title":"Synthesis of Highly Monodisperse Citrate-Stabilized Silver Nanoparticles of up to 200 nm: Kinetic Control and Catalytic Properties","volume":"26","author":"Piella","year":"2014","journal-title":"Chem. Mater."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1166\/asem.2017.2027","article-title":"Synthesis and Applications of Noble Metal Nanoparticles: A Review","volume":"9","author":"Pareek","year":"2017","journal-title":"Adv. Sci. Eng. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12951-018-0334-5","article-title":"A review on biosynthesis of silver nanoparticles and their biocidal properties","volume":"16","author":"Siddiqi","year":"2018","journal-title":"J. Nanobiotechnol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.smim.2017.09.011","article-title":"Effects of engineered nanoparticles on the innate immune system","volume":"34","author":"Liu","year":"2017","journal-title":"Semin. Immunol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Sarkar, S., Leo, B.F., Carranza, C., Chen, S., Rivas-Santiago, C., Porter, A.E., Ryan, M.P., Gow, A., Chung, K.F., and Tetley, T.D. (2015). Modulation of human macrophage responses to mycobacterium tuberculosis by silver nanoparticles of different size and surface modification. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143077"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/toxsci\/kfw011","article-title":"Silver nanoparticle-induced autophagic-Lysosomal disruption and NLRP3-inflammasome activation in HepG2 cells is size-dependent","volume":"150","author":"Mishra","year":"2016","journal-title":"Toxicol. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.intimp.2007.08.025","article-title":"The effects of nano-silver on the proliferation and cytokine expression by peripheral blood mononuclear cells","volume":"7","author":"Shin","year":"2007","journal-title":"Int. Immunopharmacol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.4238\/2015.April.17.15","article-title":"Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-\u03b1 production via MAPK pathway in leukemic cell lines","volume":"14","author":"Parnsamut","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.nano.2011.06.014","article-title":"Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles","volume":"8","author":"Thi","year":"2012","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Taratummarat, S., Sangphech, N., Vu, C.T.B., Palaga, T., Ondee, T., Surawut, S., Sereemaspun, A., Ritprajak, P., and Leelahavanichkul, A. (2018). Gold nanoparticles attenuates bacterial sepsis in cecal ligation and puncture mouse model through the induction of M2 macrophage polarization. BMC Microbiol., 18.","DOI":"10.1186\/s12866-018-1227-3"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00253-018-9476-5","article-title":"Prospects for the use of spherical gold nanoparticles in immunization","volume":"103","author":"Staroverov","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijpharm.2019.03.041","article-title":"Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy","volume":"562","author":"Dul","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1111\/j.1365-2672.2012.05253.x","article-title":"Silver nanoparticles: The powerful nanoweapon against multidrug-resistant bacteria","volume":"112","author":"Rai","year":"2012","journal-title":"J. Appl. Microbiol."},{"key":"ref_179","unstructured":"(2019, August 14). Search of: Silver Nanoparticles\u2014List Results\u2014ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/results?cond=&term=silver+nanoparticles&cntry=&state=&city=&dist=."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1128\/AAC.01106-08","article-title":"Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides","volume":"53","author":"Ruden","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"10328","DOI":"10.1016\/j.biomaterials.2013.09.045","article-title":"Bioconjugated nanoparticles for attachment and penetration into pathogenic bacteria","volume":"34","author":"Mei","year":"2013","journal-title":"Biomaterials"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1128\/AAC.02475-12","article-title":"Cationic antimicrobial peptides and biogenic silver nanoparticles kill mycobacteria without eliciting dna damage and cytotoxicity in mouse macrophages","volume":"57","author":"Mohanty","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jcis.2016.08.043","article-title":"Enhanced stability and activity of an antimicrobial peptide in conjugation with silver nanoparticle","volume":"483","author":"Pal","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.1038\/s41598-019-41005-7","article-title":"A Peptide-Nanoparticle System with Improved Efficacy against Multidrug Resistant Bacteria","volume":"9","author":"Pal","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_185","first-page":"696","article-title":"Dos Strategic role of selected noble metal nanoparticles in medicine","volume":"42","author":"Rai","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3762\/bjoc.10.136","article-title":"Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs","volume":"10","author":"Chiodo","year":"2014","journal-title":"Beilstein J. Org. Chem."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"8216","DOI":"10.3390\/ijms15058216","article-title":"Efficient pH Dependent Drug Delivery to Target Cancer Cells by Gold Nanoparticles Capped with Carboxymethyl Chitosan","volume":"15","author":"Madhusudhan","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1039\/c2an35170f","article-title":"Label-free Raman spectroscopy for accessing intracellular anticancer drug release on gold nanoparticles","volume":"137","author":"Ock","year":"2012","journal-title":"Analyst"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"13572","DOI":"10.1038\/s41598-017-14127-z","article-title":"Antimicrobial peptide-loaded gold nanoparticle-DNA aptamer conjugates as highly effective antibacterial therapeutics against Vibrio vulnificus","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biomaterials.2016.01.051","article-title":"One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model","volume":"85","author":"Rai","year":"2016","journal-title":"Biomaterials"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.actbio.2016.09.041","article-title":"Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a(1-21)NH2 as a reliable strategy for antipseudomonal drugs","volume":"47","author":"Casciaro","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bej.2017.04.013","article-title":"A simple nanostructured biosensor based on clavanin A antimicrobial peptide for gram-negative bacteria detection","volume":"124","author":"Oliveira","year":"2017","journal-title":"Biochem. Eng. J."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.2147\/IJN.S72923","article-title":"Facile biofunctionalization of silver nanoparticles for enhanced antibacterial properties, endotoxin removal, and biofilm control","volume":"10","author":"Navani","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"915","DOI":"10.2147\/IDR.S164262","article-title":"Efficiency of gold nanoparticles coated with the antimicrobial peptide indolicidin against biofilm formation and development of Candida spp. clinical isolates","volume":"11","author":"Maselli","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.2147\/IJN.S165125","article-title":"Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies","volume":"13","author":"Qing","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.bpj.2015.07.033","article-title":"PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties","volume":"109","author":"Leite","year":"2015","journal-title":"Biophys. J."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"46635","DOI":"10.18632\/oncotarget.16743","article-title":"Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications","volume":"8","author":"Deslouches","year":"2017","journal-title":"Oncotarget"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.bmc.2017.10.038","article-title":"Exploiting the human peptidome for novel antimicrobial and anticancer agents","volume":"26","author":"Bosso","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s40204-019-0106-9","article-title":"Effect of peptide-conjugated nanoparticles on cell lines","volume":"8","author":"Banerjee","year":"2019","journal-title":"Prog. Biomater."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.toxlet.2008.04.009","article-title":"Cellular responses induced by silver nanoparticles: In vitro studies","volume":"179","author":"Arora","year":"2008","journal-title":"Toxicol. Lett."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.peptides.2014.04.015","article-title":"Cell penetrating peptides: Efficient vectors for delivery of nanoparticles, nanocarriers, therapeutic and diagnostic molecules","volume":"57","author":"Farkhani","year":"2014","journal-title":"Peptides"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.nano.2017.01.013","article-title":"Smuggling gold nanoparticles across cell types \u2013 A new role for exosomes in gene silencing","volume":"13","author":"Pereira","year":"2017","journal-title":"Nanomedicine (NBM)"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"11429","DOI":"10.1038\/s41598-018-29870-0","article-title":"Combination of chemotherapy and Au-nanoparticle photothermy in the visible light to tackle doxorubicin resistance in cancer cells","volume":"8","author":"Pedrosa","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4155\/fmc-2014-0032","article-title":"Ask the experts: how to curb antibiotic resistance and plug the antibiotics gap?","volume":"8","author":"Piddock","year":"2016","journal-title":"Future Med. Chem."},{"key":"ref_205","first-page":"742","article-title":"Progress in Nanomedicine: Approved and Investigational Nanodrugs","volume":"42","author":"Ventola","year":"2017","journal-title":"P T"},{"key":"ref_206","unstructured":"(2019, May 27). Search of: nano | Recruiting, Not yet recruiting, Active, not recruiting Studies\u2014List Results\u2014ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/results?term=nano&Search=Apply&recrs=b&recrs=a&recrs=d&age_v=&gndr=&type=&rslt=."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s11095-016-1958-5","article-title":"Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date","volume":"33","author":"Bobo","year":"2016","journal-title":"Pharm. Res."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"185101","DOI":"10.1088\/0957-4484\/22\/18\/185101","article-title":"Antimicrobial activity and cellular toxicity of nanoparticle\u2013polymyxin B conjugates","volume":"22","author":"Park","year":"2011","journal-title":"Nanotechnology"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"8928","DOI":"10.1039\/c2cc34653b","article-title":"Retention of nisin activity at elevated pH in an organic acid complex and gold nanoparticle composite","volume":"48","author":"Adhikari","year":"2012","journal-title":"Chem. Commun."},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"5725","DOI":"10.1039\/C4NR01284D","article-title":"LL37 peptide@silver nanoparticles: combining the best of the two worlds for skin infection control","volume":"6","author":"Vignoni","year":"2014","journal-title":"Nanoscale"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s00284-015-0813-y","article-title":"Co-spinning of Silver Nanoparticles with Nisin Increases the Antimicrobial Spectrum of PDLLA: PEO Nanofibers","volume":"71","author":"Ahire","year":"2015","journal-title":"Curr. Microbiol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s12275-015-4686-3","article-title":"Antibacterial potential of a small peptide from Bacillus sp. RPT-0001 and its capping for green synthesis of silver nanoparticles","volume":"53","author":"Patil","year":"2015","journal-title":"J. Microbiol."},{"key":"ref_213","doi-asserted-by":"crossref","unstructured":"Sur, A., Pradhan, B., Banerjee, A., and Aich, P. (2015). Immune Activation Efficacy of Indolicidin Is Enhanced upon Conjugation with Carbon Nanotubes and Gold Nanoparticles. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0123905"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2016.06.057","article-title":"Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity","volume":"103","author":"Peng","year":"2016","journal-title":"Biomaterials"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.freeradbiomed.2016.11.016","article-title":"Interfacial assembly at silver nanoparticle enhances the antibacterial efficacy of nisin","volume":"101","author":"Arakha","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"19200","DOI":"10.1039\/C6NR07976H","article-title":"Sprayable peptide-modified silver nanoparticles as a barrier against bacterial colonization","volume":"8","author":"McLaughlin","year":"2016","journal-title":"Nanoscale"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biomaterials.2016.07.009","article-title":"Gold nanoparticle-DNA aptamer conjugate-assisted delivery of antimicrobial peptide effectively eliminates intracellular Salmonella enterica serovar Typhimurium","volume":"104","author":"Yeom","year":"2016","journal-title":"Biomaterials"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"31030","DOI":"10.1038\/srep31030","article-title":"Tuning the anticancer activity of a novel pro-apoptotic peptide using gold nanoparticle platforms","volume":"6","author":"Akrami","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"11366","DOI":"10.1021\/acsami.6b03355","article-title":"High Antimicrobial Activity and Low Human Cell Cytotoxicity of Core\u2013Shell Magnetic Nanoparticles Functionalized with an Antimicrobial Peptide","volume":"8","author":"Maleki","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.actbio.2016.01.035","article-title":"High-density antimicrobial peptide coating with broad activity and low cytotoxicity against human cells","volume":"33","author":"Rai","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00249-016-1160-z","article-title":"Findings on the interaction of the antimicrobial peptide cecropin-melittin with a gold surface from molecular dynamics studies","volume":"46","author":"Ferreira","year":"2017","journal-title":"Eur. Biophys. J."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1021\/acsami.6b15200","article-title":"TAT-Modified Gold Nanoparticle Carrier with Enhanced Anticancer Activity and Size Effect on Overcoming Multidrug Resistance","volume":"9","author":"Wang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_223","first-page":"1","article-title":"Antibacterial Efficacy of Gold and Silver Nanoparticles Functionalized with the Ubiquicidin (29-41) Antimicrobial Peptide","volume":"2017","year":"2017","journal-title":"J. Nanomater."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jconrel.2017.07.007","article-title":"Antimicrobial peptide-gold nanoscale therapeutic formulation with high skin regenerative potential","volume":"262","author":"Comune","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1166\/jbn.2017.2355","article-title":"A fresh shine on cystic fibrosis inhalation therapy: Antimicrobial synergy of polymyxin B in combination with silver nanoparticles","volume":"13","author":"Jasim","year":"2017","journal-title":"J. Biomed. Nanotechnol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1039\/C7BM00069C","article-title":"Antibiotic gold: Tethering of antimicrobial peptides to gold nanoparticles maintains conformational flexibility of peptides and improves trypsin susceptibility","volume":"5","author":"Wadhwani","year":"2017","journal-title":"Biomater. Sci."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.7150\/thno.19780","article-title":"Spider toxin peptide lycosin-I functionalized gold nanoparticles for in vivo tumor targeting and therapy","volume":"7","author":"Tan","year":"2017","journal-title":"Theranostics"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1039\/C7NR04062H","article-title":"Multivalent gold nanoparticle-peptide conjugates for targeting intracellular bacterial infections","volume":"9","author":"Chowdhury","year":"2017","journal-title":"Nanoscale"},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"8359","DOI":"10.1021\/acs.jpcb.8b05717","article-title":"Atomistic-Level Investigation of a LL37-Conjugated Gold Nanoparticle by Well-Tempered Metadynamics","volume":"122","author":"Ferreira","year":"2018","journal-title":"J. Phys. Chem. B"},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2147\/IJN.S150897","article-title":"Human \u03b2-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments","volume":"13","author":"Zhou","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.micpath.2017.12.034","article-title":"Determining the effects of green chemistry synthesized Ag-nisin nanoparticle on macrophage cells","volume":"114","author":"Moein","year":"2018","journal-title":"Microb. Pathog."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1039\/C8BM00807H","article-title":"Antimicrobial peptide modification enhances the gene delivery and bactericidal efficiency of gold nanoparticles for accelerating diabetic wound healing","volume":"6","author":"Wang","year":"2018","journal-title":"Biomater. Sci."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1021\/acs.bioconjchem.8b00706","article-title":"Small Synthetic Peptides Bioconjugated to Hybrid Gold Nanoparticles Destroy Potentially Deadly Bacteria at Submicromolar Concentrations","volume":"29","author":"Palmieri","year":"2018","journal-title":"Bioconjug. Chem."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcis.2019.03.052","article-title":"Conjugating gold nanoclusters and antimicrobial peptides: From aggregation-induced emission to antibacterial synergy","volume":"546","author":"Zheng","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1038\/s41598-019-44256-6","article-title":"Exploiting chitosan and gold nanoparticles for antimycobacterial activity of in silico identified antimicrobial motif of human neutrophil peptide-1","volume":"9","author":"Sharma","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/11\/11\/588\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:32:55Z","timestamp":1760189575000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/11\/11\/588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,8]]},"references-count":235,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["pharmaceutics11110588"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics11110588","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,8]]}}}