{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:08:03Z","timestamp":1778047683893,"version":"3.51.4"},"reference-count":144,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T00:00:00Z","timestamp":1605312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FCT-Compete-Feder","award":["This research was funded by the European Regional Development Fund (FEDER), through Programa Operacional Factores de Competitividade COMPETE2020 (CENTRO-01-0145-FEDER-000012-HealthyAging2020) and by National funds via Portuguese Science and Technology Fou"],"award-info":[{"award-number":["This research was funded by the European Regional Development Fund (FEDER), through Programa Operacional Factores de Competitividade COMPETE2020 (CENTRO-01-0145-FEDER-000012-HealthyAging2020) and by National funds via Portuguese Science and Technology Fou"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>An emergent trend of blueberries\u2019 (BB) \u201cprophylactic\u201d consumption, due to their phytochemicals\u2019 richness and well-known health-promoting claims, is widely scaled-up. However, the benefits arising from BB indiscriminate intake remains puzzling based on incongruent preclinical and human data. To provide a more in-depth elucidation and support towards a healthier and safer consumption, we conducted a translation-minded experimental study in healthy Wistar rats that consumed BB in a juice form (25 g\/kg body weight (BW)\/day; 14 weeks\u2019 protocol). Particular attention was paid to the physiological adaptations succeeding in the gut and liver tissues regarding the acknowledged BB-induced metabolic benefits. Systemically, BB boosted serum antioxidant activity and repressed the circulating levels of 3-hydroxybutyrate (3-HB) ketone bodies and 3-HB\/acetoacetate ratio. Moreover, BB elicited increased fecal succinic acid levels without major changes on gut microbiota (GM) composition and gut ultra-structural organization. Remarkably, an accentuated hepatic mitochondrial bioenergetic challenge, ensuing metabolic transcriptomic reprogramming along with a concerted anti-inflammatory pre-conditioning, was clearly detected upon long-term consumption of BB phytochemicals. Altogether, the results disclosed herein portray a quiescent mitochondrial-related metabolomics and hint for a unified adaptive response to this nutritional challenge. The beneficial or noxious consequences arising from this dietary trend should be carefully interpreted and necessarily claims future research.<\/jats:p>","DOI":"10.3390\/pharmaceutics12111094","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T21:48:52Z","timestamp":1605563332000},"page":"1094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Blueberry Consumption Challenges Hepatic Mitochondrial Bioenergetics and Elicits Transcriptomics Reprogramming in Healthy Wistar Rats"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-9059","authenticated-orcid":false,"given":"Sara","family":"Nunes","sequence":"first","affiliation":[{"name":"Institute of Pharmacology &amp; Experimental Therapeutics &amp; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-504 Coimbra, Portugal"}]},{"given":"Sofia D.","family":"Viana","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; Experimental Therapeutics &amp; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-504 Coimbra, Portugal"},{"name":"Polytechnic Institute of Coimbra, ESTESC-Coimbra Health School, Pharmacy\/Biomedical Laboratory Sciences, 3046-854 Coimbra, Portugal"}]},{"given":"In\u00eas","family":"Pregui\u00e7a","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; Experimental Therapeutics &amp; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-5239","authenticated-orcid":false,"given":"Andr\u00e9","family":"Alves","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; Experimental Therapeutics &amp; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7828-2296","authenticated-orcid":false,"given":"Rosa","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; Experimental Therapeutics &amp; Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-275X","authenticated-orcid":false,"given":"Jo\u00e3o S.","family":"Teodoro","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Science and Technology (FCTUC), University of Coimbra, 3000-456 Coimbra, Portugal"},{"name":"Center for Neurosciences and Cell Biology of Coimbra (CNC), University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-5718","authenticated-orcid":false,"given":"Artur","family":"Figueirinha","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"LAQV, REQUIMTE, Faculty of Pharmacy, University of Coimbra, 3000-456 Coimbra, Portugal"}]},{"given":"L\u00edgia","family":"Salgueiro","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"CIEPQPF, Chemical Process Engineering and Forest Products Research Centre, University of Coimbra, 3000-456 Coimbra, Portugal"}]},{"given":"Sara","family":"Silva","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Universidade Cat\u00f3lica Portuguesa, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"given":"Ivana","family":"Jarak","sequence":"additional","affiliation":[{"name":"Department of Microscopy, Laboratory of Cell Biology and Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Rui A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Science and Technology (FCTUC), University of Coimbra, 3000-456 Coimbra, Portugal"},{"name":"Associated Laboratory for Green Chemistry-Clean Technologies and Processes, REQUIMTE, Faculty of Sciences and Technology, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Cl\u00e1udia","family":"Cavadas","sequence":"additional","affiliation":[{"name":"Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Clinical Academic Center of Coimbra (CACC), 3004-504 Coimbra, Portugal"},{"name":"Center for Neurosciences and Cell Biology of Coimbra (CNC), University of Coimbra, 3004-504 Coimbra, Portugal"},{"name":"Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Anabela P.","family":"Rolo","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Science and Technology (FCTUC), University of Coimbra, 3000-456 Coimbra, Portugal"},{"name":"Center for Neurosciences and Cell Biology of Coimbra (CNC), University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"given":"Carlos M.","family":"Palmeira","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Science and Technology (FCTUC), University of Coimbra, 3000-456 Coimbra, Portugal"},{"name":"Center for Neurosciences and Cell Biology of Coimbra (CNC), University of Coimbra, 3004-504 Coimbra, Portugal"}]},{"given":"Maria M.","family":"Pintado","sequence":"additional","affiliation":[{"name":"CBQF\u2014Centro de Biotecnologia e Qu\u00edmica Fina\u2014Laborat\u00f3rio Associado, Universidade Cat\u00f3lica Portuguesa, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-9554","authenticated-orcid":false,"given":"Fl\u00e1vio","family":"Reis","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; 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Metab. Immune Disord. Drug Targets"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/ejcn.2016.234","article-title":"The effects of policy actions to improve population dietary patterns and prevent diet-related non-communicable diseases: Scoping review","volume":"71","author":"Hyseni","year":"2016","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/6986143","article-title":"Antioxidant Phytochemicals at the Pharma-Nutrition Interface","volume":"2017","author":"Azzini","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ma, L., Sun, Z., Zeng, Y., Luo, M., and Yang, J. (2018). Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092785"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1159\/000341101","article-title":"Blueberries and Neuronal Aging","volume":"58","year":"2012","journal-title":"Gerontology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"18642","DOI":"10.3390\/ijms160818642","article-title":"Bioactive Compounds of Blueberries: Post-Harvest Factors Influencing the Nutritional Value of Products","volume":"16","author":"Michalska","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Miller, K., Feucht, W., and Schmid, M. (2019). Bioactive Compounds of Strawberry and Blueberry and Their Potential Health Effects Based on Human Intervention Studies: A Brief Overview. Nutrients, 11.","DOI":"10.3390\/nu11071510"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3390\/nu5093367","article-title":"Flavonoid Bioavailability and Attempts for Bioavailability Enhancement","volume":"5","author":"Thilakarathna","year":"2013","journal-title":"Nutrients"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1002\/jps.22568","article-title":"First-Pass Metabolism via UDP-Glucuronosyltransferase: A Barrier to Oral Bioavailability of Phenolics","volume":"100","author":"Wu","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1080\/10408398.2017.1422111","article-title":"Superfruits: Phytochemicals, antioxidant efficacies, and health effects\u2013A comprehensive review","volume":"59","author":"Chang","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.1021\/jf0511300","article-title":"Antioxidant Properties of Prepared Blueberry (Vaccinium myrtillus) Extracts","volume":"53","author":"Faria","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/advances\/nmz065","article-title":"Recent Research on the Health Benefits of Blueberries and Their Anthocyanins","volume":"11","author":"Kalt","year":"2019","journal-title":"Adv. Nutr."},{"key":"ref_14","first-page":"134","article-title":"Edible berries: Bioactive components and their effect on human health","volume":"30","author":"Han","year":"2014","journal-title":"Nutrients"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jnutbio.2015.09.014","article-title":"Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells","volume":"33","author":"Kim","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"153209","DOI":"10.1016\/j.phymed.2020.153209","article-title":"Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense","volume":"69","author":"Li","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1089\/ars.2015.6393","article-title":"Antioxidants in Translational Medicine","volume":"23","author":"Schmidt","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Van Breda, S.G., Bried\u00e9, J.J., and De Kok, T.M. (2018). Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals. Nutrients, 11.","DOI":"10.3390\/nu11010061"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1039\/C7FO00996H","article-title":"Freeze-dried strawberry and blueberry attenuates diet-induced obesity and insulin resistance in rats by inhibiting adipogenesis and lipogenesis","volume":"8","author":"Aranaz","year":"2017","journal-title":"Food Funct."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.phymed.2018.10.009","article-title":"Mechanistic insights to the cardioprotective effect of blueberry nutraceutical extract in isoprenaline-induced cardiac hypertrophy","volume":"51","author":"Eladwy","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jnutbio.2018.07.008","article-title":"Blueberry polyphenols extract as a potential prebiotic with anti-obesity effects on C57BL\/6 J mice by modulating the gut microbiota","volume":"64","author":"Jiao","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1039\/C8FO02298D","article-title":"Protection of hepatocyte mitochondrial function by blueberry juice and probiotics via SIRT1 regulation in non-alcoholic fatty liver disease","volume":"10","author":"Ren","year":"2019","journal-title":"Food Funct."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1089\/jmf.2010.0292","article-title":"Blueberry Intake Alters Skeletal Muscle and Adipose Tissue Peroxisome Proliferator-Activated Receptor Activity and Reduces Insulin Resistance in Obese Rats","volume":"14","author":"Seymour","year":"2011","journal-title":"J. Med. Food"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1017\/S0007114513002390","article-title":"Wild blueberry (Vaccinium angustifolium)-enriched diet improves dyslipidaemia and modulates the expression of genes related to lipid metabolism in obese Zucker rats","volume":"111","author":"Vendrame","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1021\/acs.jafc.6b04603","article-title":"Blueberry Anthocyanin-Enriched Extracts Attenuate Fine Particulate Matter (PM2.5)-Induced Cardiovascular Dysfunction","volume":"65","author":"Wang","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/ajcn\/nqy380","article-title":"Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome\u2014Results from a 6-month, double-blind, randomized controlled trial","volume":"109","author":"Curtis","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.jdiacomp.2015.08.023","article-title":"Gastrointestinal microbiome modulator improves glucose tolerance in overweight and obese subjects: A randomized controlled pilot trial","volume":"29","author":"Rebello","year":"2015","journal-title":"J. Diabetes Complicat."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00394-012-0402-9","article-title":"Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors","volume":"52","author":"Riso","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40795-017-0164-0","article-title":"The effects of 100% wild blueberry (Vaccinium angustifolium) juice consumption on cardiometablic biomarkers: A randomized, placebo-controlled, crossover trial in adults with increased risk for type 2 diabetes","volume":"3","author":"Stote","year":"2017","journal-title":"BMC Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.3390\/nu7064107","article-title":"Blueberries Improve Endothelial Function, but Not Blood Pressure, in Adults with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","volume":"7","author":"Stull","year":"2015","journal-title":"Nutrients"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"8134","DOI":"10.1021\/jf402495k","article-title":"Differential Modulation of Human Intestinal Bifidobacterium Populations after Consumption of a Wild Blueberry (Vaccinium angustifolium) Drink","volume":"61","author":"Guglielmetti","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jff.2017.09.039","article-title":"Investigation of the impact of blueberries on metabolic factors influencing health","volume":"38","author":"Istek","year":"2017","journal-title":"J. Funct. Foods"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1079\/BJN2002665","article-title":"The effect of wild blueberry (Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects","volume":"88","author":"Kay","year":"2002","journal-title":"Br. J. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3945\/ajcn.113.066639","article-title":"Intake and time dependence of blueberry flavonoid\u2013induced improvements in vascular function: A randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity","volume":"98","author":"Mateos","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Stote, K.S., Corkum, A., Sweeney-Nixon, M., Shakerley, N., Kean, T., and Gottschall-Pass, K. (2019). Postprandial Effects of Blueberry (Vaccinium angustifolium) Consumption on Glucose Metabolism, Gastrointestinal Hormone Response, and Perceived Appetite in Healthy Adults: A Randomized, Placebo-Controlled Crossover Trial. Nutrients, 11.","DOI":"10.3390\/nu11010202"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.nutres.2012.12.009","article-title":"A single portion of blueberry (Vaccinium corymbosum L.) improves protection against DNA damage but not vascular function in healthy male volunteers","volume":"33","author":"Riso","year":"2013","journal-title":"Nutr. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/03009734.2013.825348","article-title":"Effects of exercise with or without blueberries in the diet on cardio-metabolic risk factors: An exploratory pilot study in healthy subjects","volume":"118","author":"Nyberg","year":"2013","journal-title":"Upsala J. Med. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3945\/jn.115.217943","article-title":"Common Phenolic Metabolites of Flavonoids, but Not Their Unmetabolized Precursors, Reduce the Secretion of Vascular Cellular Adhesion Molecules by Human Endothelial Cells","volume":"146","author":"Warner","year":"2016","journal-title":"J. Nutr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1002\/mnfr.201400231","article-title":"Impact of processing on the bioavailability and vascular effects of blueberry (poly)phenols","volume":"58","author":"George","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00394-018-1843-6","article-title":"The effects of acute wild blueberry supplementation on the cognition of 7\u201310-year-old schoolchildren","volume":"58","author":"Barfoot","year":"2019","journal-title":"Eur. J. Nutr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.nutres.2014.07.002","article-title":"Six weeks daily ingestion of whole blueberry powder increases natural killer cell counts and reduces arterial stiffness in sedentary males and females","volume":"34","author":"McAnulty","year":"2014","journal-title":"Nutr. Res."},{"key":"ref_42","first-page":"624","article-title":"The Laboratory Rat: Relating Its Age With Human\u2019s","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1158\/0008-5472.CAN-09-3565","article-title":"Blueberry Phytochemicals Inhibit Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3-Kinase Pathway","volume":"70","author":"Adams","year":"2010","journal-title":"Cancer Res."},{"key":"ref_44","first-page":"659","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Nihal","year":"2007","journal-title":"FASEB J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jfca.2013.11.007","article-title":"Cold storage of blueberry (Vaccinium spp.) fruits and juice: Anthocyanin stability and antioxidant activity","volume":"33","author":"Reque","year":"2014","journal-title":"J. Food Compos. Anal."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/j.1476-5381.2010.00872.x","article-title":"Animal research: Reporting in vivo experiments: The ARRIVE guidelines","volume":"160","author":"Kilkenny","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Nunes, S., Alves, A., Pregui\u00e7a, I., Barbosa, A., Vieira, P., Mendes, F., Martins, D., Viana, S.D., and Reis, F. (2020). Crescent-Like Lesions as an Early Signature of Nephropathy in a Rat Model of Prediabetes Induced by a Hypercaloric Diet. Nutrients, 12.","DOI":"10.3390\/nu12040881"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1017\/S0007114511002406","article-title":"Chronic caffeine intake decreases circulating catecholamines and prevents diet-induced insulin resistance and hypertension in rats","volume":"107","author":"Conde","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1758-5996-4-16","article-title":"Metabolic syndrome markers in wistar rats of different ages","volume":"4","author":"Ghezzi","year":"2012","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Burgeiro, A., Cerqueira, M.G., Varela-Rodriguez, B., Nunes, S., Neto, P., Pereira, F.C., Reis, F., and Carvalho, R.A. (2017). Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet. Nutrients, 9.","DOI":"10.20944\/preprints201704.0185.v1"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1475-2840-12-44","article-title":"Early cardiac changes in a rat model of prediabetes: Brain natriuretic peptide overexpression seems to be the best marker","volume":"12","author":"Nunes","year":"2013","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: The FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1002\/jsfa.3023","article-title":"Infusions of Portuguese medicinal plants: Dependence of final antioxidant capacity and phenol content on extraction features","volume":"87","author":"Malcata","year":"2007","journal-title":"J. Sci. Food Agric."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"D521","DOI":"10.1093\/nar\/gkl923","article-title":"HMDB: The Human Metabolome Database","volume":"35","author":"Wishart","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/ac048630x","article-title":"Statistical Total Correlation Spectroscopy: An Exploratory Approach for Latent Biomarker Identification from Metabolic1H NMR Data Sets","volume":"77","author":"Cloarec","year":"2005","journal-title":"Anal. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11306-007-0082-2","article-title":"Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI)","volume":"3","author":"Sumner","year":"2007","journal-title":"Metabolomics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jmr.2009.11.012","article-title":"icoshift: A versatile tool for the rapid alignment of 1D NMR spectra","volume":"202","author":"Savorani","year":"2010","journal-title":"J. Magn. Reson."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1039\/C4MB00414K","article-title":"PLS\/OPLS models in metabolomics: The impact of permutation of dataset rows on the K-fold cross-validation quality parameters","volume":"11","author":"Triba","year":"2015","journal-title":"Mol. BioSyst."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.2147\/IJN.S104623","article-title":"Safety profile of solid lipid nanoparticles loaded with rosmarinic acid for oral use: In vitro and animal approaches","volume":"11","author":"Reis","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.2337\/db09-1061","article-title":"Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism","volume":"59","author":"Kumar","year":"2010","journal-title":"Diabetes"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/toxsci\/57.1.177","article-title":"Bile acids affect liver mitochondrial bioenergetics: Possible relevance for cholestasis therapy","volume":"57","author":"Rolo","year":"2000","journal-title":"Toxicol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.mito.2010.04.006","article-title":"Indirubin-3\u2032-oxime prevents hepatic I\/R damage by inhibiting GSK-3\u03b2 and mitochondrial permeability transition","volume":"10","author":"Varela","year":"2010","journal-title":"Mitochondrion"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","article-title":"Determination of serum proteins by means of the biuret reaction","volume":"177","author":"Gornall","year":"1949","journal-title":"J. Biol. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.mito.2013.09.002","article-title":"Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation","volume":"13","author":"Teodoro","year":"2013","journal-title":"Mitochondrion"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3945\/jn.109.105155","article-title":"Dietary Blueberry Attenuates Whole-Body Insulin Resistance in High Fat-Fed Mice by Reducing Adipocyte Death and Its Inflammatory Sequelae","volume":"139","author":"DeFuria","year":"2009","journal-title":"J. Nutr."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ebenezer, P.J., Wilson, C.B., Wilson, L.D., Nair, A.R., and Francis, J. (2016). The Anti-Inflammatory Effects of Blueberries in an Animal Model of Post-Traumatic Stress Disorder (PTSD). PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160923"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.earlhumdev.2019.05.009","article-title":"To start or not: Factors to consider when implementing routine probiotic use in the NICU","volume":"135","author":"Barbian","year":"2019","journal-title":"Early Hum. Dev."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tox.2006.01.014","article-title":"Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products","volume":"221","author":"Gulati","year":"2006","journal-title":"Toxicology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/j.jand.2018.07.022","article-title":"Position of the Academy of Nutrition and Dietetics: Micronutrient Supplementation","volume":"118","author":"Marra","year":"2018","journal-title":"J. Acad. Nutr. Diet."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"11700","DOI":"10.1021\/jf802405y","article-title":"Effects of Blueberry (Vaccinium ashei) on DNA Damage, Lipid Peroxidation, and Phase II Enzyme Activities in Rats","volume":"56","author":"Dulebohn","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00213-012-2719-8","article-title":"Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats","volume":"223","author":"Rendeiro","year":"2012","journal-title":"Psychopharmacology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.phymed.2009.02.018","article-title":"Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton","volume":"16","author":"Grace","year":"2009","journal-title":"Phytomedicine"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1089\/jmf.2011.0212","article-title":"Effect of Dietary Blueberry Pomace on Selected Metabolic Factors Associated with High Fructose Feeding in Growing Sprague\u2013Dawley Rats","volume":"15","author":"Khanal","year":"2012","journal-title":"J. Med. Food"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.phymed.2006.08.005","article-title":"Anti-diabetic properties of the Canadian lowbush blueberry Vaccinium angustifolium Ait","volume":"13","author":"Martineau","year":"2006","journal-title":"Phytomedicine"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.3945\/jn.110.125336","article-title":"Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women","volume":"140","author":"Stull","year":"2010","journal-title":"J. Nutr."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ijo.2009.149","article-title":"Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKAy mice","volume":"33","author":"Vuong","year":"2009","journal-title":"Int. J. Obes."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1139\/Y07-090","article-title":"Fermented Canadian lowbush blueberry juice stimulates glucose uptake and AMP-activated protein kinase in insulin-sensitive cultured muscle cells and adipocytes","volume":"85","author":"Vuong","year":"2007","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.isci.2019.08.020","article-title":"Blueberry Extract Improves Obesity through Regulation of the Gut Microbiota and Bile Acids via Pathways Involving FXR and TGR5","volume":"19","author":"Guo","year":"2019","journal-title":"iScience"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1021\/jf902852d","article-title":"Purified Blueberry Anthocyanins and Blueberry Juice Alter Development of Obesity in Mice Fed an Obesogenic High-Fat Diet\u2020","volume":"58","author":"Prior","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Wankhade, U.D., Zhong, Y., Lazarenko, O.P., Chintapalli, S.V., Piccolo, B.D., Chen, J., and Shankar, K. (2019). Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL\/6J Mice. Nutrients, 11.","DOI":"10.3390\/nu11020313"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Lacombe, A., Li, R.W., Klimis-Zacas, D., Kristo, A.S., Tadepalli, S., Krauss, E., Young, R., and Wu, V.C.H. (2013). Lowbush Wild Blueberries have the Potential to Modify Gut Microbiota and Xenobiotic Metabolism in the Rat Colon. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0067497"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/jn\/nxx027","article-title":"Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet\u2013Fed Rats","volume":"148","author":"Lee","year":"2018","journal-title":"J. Nutr."},{"key":"ref_83","first-page":"324","article-title":"Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a\u2212\/\u2212 mice, a model of inflammatory bowel diseases","volume":"28","author":"Paturi","year":"2012","journal-title":"Nutrients"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cmet.2016.06.013","article-title":"Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis","volume":"24","author":"Zitoun","year":"2016","journal-title":"Cell Metab."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.1530\/JOE-17-0542","article-title":"Gut-brain signaling in energy homeostasis: The unexpected role of microbiota-derived succinate","volume":"236","author":"Mithieux","year":"2018","journal-title":"J. Endocrinol."},{"key":"ref_86","first-page":"102","article-title":"Accumulation of succinate controls activation of adipose tissue thermogenesis","volume":"560","author":"Mills","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1021\/jf501142k","article-title":"Cecal Succinate Elevated by Some Dietary Polyphenols May Inhibit Colon Cancer Cell Proliferation and Angiogenesis","volume":"62","author":"Haraguchi","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-13036-1","article-title":"Evaluation of 16S rRNA gene sequencing for species and strain-level microbiome analysis","volume":"10","author":"Johnson","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Adam, C.L., Gratz, S.W., Peinado, D.I., Thomson, L.M., Garden, K.E., Williams, P.A., Richardson, A.J., and Ross, A.W. (2016). Effects of Dietary Fibre (Pectin) and\/or Increased Protein (Casein or Pea) on Satiety, Body Weight, Adiposity and Caecal Fermentation in High Fat Diet-Induced Obese Rats. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0155871"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11154-019-09513-z","article-title":"Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?","volume":"20","author":"Vendrell","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2016","journal-title":"Environ. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"174","DOI":"10.15430\/JCP.2017.22.3.174","article-title":"Comparison of Blueberry (Vaccinium spp.) and Vitamin C via Antioxidative and Epigenetic Effects in Human","volume":"22","author":"Kim","year":"2017","journal-title":"J. Cancer Prev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/10408398.2018.1518895","article-title":"Health promoting properties of blueberries: A review","volume":"60","author":"Silva","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1021\/acs.jafc.7b02550","article-title":"Identification of Anthocyanins from Four Kinds of Berries and Their Inhibition Activity to \u03b1-Glycosidase and Protein Tyrosine Phosphatase 1B by HPLC\u2013FT-ICR MS\/MS","volume":"65","author":"Xiao","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3945\/jn.110.124701","article-title":"Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome","volume":"140","author":"Basu","year":"2010","journal-title":"J. Nutr."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3233\/BR-2011-016","article-title":"Short-term blueberry intake enhances biological antioxidant potential and modulates inflammation markers in overweight and obese children","volume":"1","author":"Giongo","year":"2011","journal-title":"J. Berry Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4103\/0974-8490.178642","article-title":"Anti-inflammatory activity of berry fruits in mice model of inflammation is based on oxidative stress modulation","volume":"8","author":"Locatelli","year":"2016","journal-title":"Pharmacogn. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10545-014-9704-9","article-title":"Ketone body metabolism and its defects","volume":"37","author":"Fukao","year":"2014","journal-title":"J. Inherit. Metab. Dis."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.tem.2013.09.002","article-title":"Ketone bodies as signaling metabolites","volume":"25","author":"Newman","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_100","unstructured":"Bhagavan, N., and Ha, C.-E. (2015). Essentials of Medical Biochemistry: With Clinical Cases, Elsevier Science Publishing Co Inc.\/Academic Press. [2nd ed.]."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.bbagen.2016.01.017","article-title":"Resveratrol and the mitochondria: From triggering the intrinsic apoptotic pathway to inducing mitochondrial biogenesis, a mechanistic view","volume":"1860","author":"Nabavi","year":"2016","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3390\/ph7090913","article-title":"Phytochemical Modulators of Mitochondria: The Search for Chemopreventive Agents and Supportive Therapeutics","volume":"7","author":"Grabacka","year":"2014","journal-title":"Pharmaceuticals"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1039\/C5FO00408J","article-title":"The chemoprotection of a blueberry anthocyanin extract against the acrylamide-induced oxidative stress in mitochondria: Unequivocal evidence in mice liver","volume":"6","author":"Chen","year":"2015","journal-title":"Food Funct."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1503\/cmaj.1040752","article-title":"Liver enzyme alteration: A guide for clinicians","volume":"172","author":"Giannini","year":"2005","journal-title":"Can. Med. Assoc. J."},{"key":"ref_105","first-page":"30","article-title":"What is the Real Function of the Liver \u2018Function\u2019 Tests?","volume":"81","author":"Hall","year":"2012","journal-title":"Ulst. Med. J."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bbabio.2009.06.009","article-title":"Mitochondrial calcium and the permeability transition in cell death","volume":"1787","author":"Lemasters","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.freeradbiomed.2004.10.016","article-title":"Mitochondrial H+ leak and ROS generation: An odd couple","volume":"38","author":"Brookes","year":"2005","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0005-2728(89)80063-5","article-title":"Slip and leak in mitochondrial oxidative phosphorylation","volume":"977","author":"Murphy","year":"1989","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem. J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.bbabio.2009.06.002","article-title":"Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols","volume":"1787","author":"Biasutto","year":"2009","journal-title":"Biochim. Biophys. Acta (BBA)-Bioenerg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.freeradbiomed.2003.12.018","article-title":"Effects of curcumin and curcumin derivatives on mitochondrial permeability transition pore","volume":"36","author":"Ligeret","year":"2004","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0703397","article-title":"Inhibition of mitochondrial proton F0F1-ATPase\/ATP synthase by polyphenolic phytochemicals","volume":"130","author":"Zheng","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"ref_113","first-page":"499","article-title":"Direct Effects of Vaccinium myrtillus L. Fruit Extracts on Rat Heart Mitochondrial Functions","volume":"27","author":"Burdulis","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/187152209788009850","article-title":"Targeting the Fatty Acid Transport Proteins (FATP) to Understand the Mechanisms Linking Fatty Acid Transport to Metabolism","volume":"9","author":"Black","year":"2009","journal-title":"Immunol. Endocr. Metab. Agents Med. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Grabacka, M., Pierzchalska, M., Dean, M., and Reiss, K. (2016). Regulation of Ketone Body Metabolism and the Role of PPAR\u03b1. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17122093"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","article-title":"Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Ren, T., Zhu, J., Zhu, L., and Cheng, M. (2017). The Combination of Blueberry Juice and Probiotics Ameliorate Non-Alcoholic Steatohepatitis (NASH) by Affecting SREBP-1c\/PNPLA-3 Pathway via PPAR-\u03b1. Nutrients, 9.","DOI":"10.3390\/nu9030198"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1007\/s00018-013-1505-z","article-title":"Hepatic glucose sensing and integrative pathways in the liver","volume":"71","author":"Oosterveer","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1210\/en.2018-00887","article-title":"Hepatic HKDC1 Expression Contributes to Liver Metabolism","volume":"160","author":"Pusec","year":"2018","journal-title":"Endocrinology"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/572405","article-title":"Role of PPAR\u03b1 in Hepatic Carbohydrate Metabolism","volume":"2010","author":"Peeters","year":"2010","journal-title":"PPAR Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0006-2952(99)00111-2","article-title":"Acetone catabolism by cytochrome P450 2E1: Studies with CYP2E1-null mice","volume":"58","author":"Bondoc","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1074\/jbc.271.20.12063","article-title":"Role of CYP2E1 in the Hepatotoxicity of Acetaminophen","volume":"271","author":"Lee","year":"1996","journal-title":"J. Biol. Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"13624","DOI":"10.1021\/acs.jafc.9b06155","article-title":"Identification of Cyanidin-3-arabinoside Extracted from Blueberry as a Selective Protein Tyrosine Phosphatase 1B Inhibitor","volume":"67","author":"Tian","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/1750-3841.13706","article-title":"Quercetin, Hyperin, and Chlorogenic Acid Improve Endothelial Function by Antioxidant, Antiinflammatory, and ACE Inhibitory Effects","volume":"82","author":"Huang","year":"2017","journal-title":"J. Food Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1039\/C9FO01913H","article-title":"The effects of blueberry and strawberry serum metabolites on age-related oxidative and inflammatory signaling in vitro","volume":"10","author":"Rutledge","year":"2019","journal-title":"Food Funct."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1021\/bk-2008-0993.ch027","article-title":"DNA Intercalation, Topoisomerase I Inhibition, and Oxidative Reactions of Polyphenols","volume":"Volume 993","author":"Webb","year":"2008","journal-title":"Functional Food and Health"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1080\/10408398.2015.1062353","article-title":"Dietary polyphenols and chromatin remodeling","volume":"57","author":"Russo","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_128","unstructured":"Fumiaki Uchiumi, I. (2018). Stress Response of Dietary Phytochemicals in a Hormetic Manner for Health and Longevity. Gene Expression and Regulation in Mammalian Cells\u2014Transcription Toward the Establishment of Novel Therapeutics, IntechOpen."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41514-017-0013-z","article-title":"How does hormesis impact biology, toxicology, and medicine?","volume":"3","author":"Calabrese","year":"2017","journal-title":"Npj Aging Mech. Dis."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s12017-008-8037-y","article-title":"Hormetic Dietary Phytochemicals","volume":"10","author":"Son","year":"2008","journal-title":"Neuromol. Med."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Musci, R.V., Hamilton, K.L., and Linden, M.A. (2019). Exercise-Induced Mitohormesis for the Maintenance of Skeletal Muscle and Healthspan Extension. Sports, 7.","DOI":"10.3390\/sports7070170"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.freeradbiomed.2019.07.017","article-title":"Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins","volume":"141","author":"Palmeira","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"R91","DOI":"10.1530\/JME-18-0005","article-title":"The mitochondrial unfolded protein response and mitohormesis: A perspective on metabolic diseases","volume":"61","author":"Yi","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.cmet.2014.01.011","article-title":"Mitohormesis","volume":"19","author":"Yun","year":"2014","journal-title":"Cell Metab."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1007\/s00018-017-2462-8","article-title":"Regulation of the H+-ATP synthase by IF1: A role in mitohormesis","volume":"74","author":"Cuezva","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1113\/JP276539","article-title":"Hepatic mitochondrial adaptations to physical activity: Impact of sexual dimorphism, PGC1\u03b1 and BNIP3-mediated mitophagy","volume":"596","author":"McCoin","year":"2018","journal-title":"J. Physiol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2013.03.002","article-title":"Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure","volume":"17","author":"Liesa","year":"2013","journal-title":"Cell Metab."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5157645","article-title":"Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health","volume":"2018","author":"Miller","year":"2018","journal-title":"J. Nutr. Metab."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2203\/dose-response.13-051.Lushchak","article-title":"Dissection of the Hormetic Curve: Analysis of Components and Mechanisms","volume":"12","author":"Lushchak","year":"2014","journal-title":"Dose-Response"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3945\/an.110.000026","article-title":"Which Sources of Flavonoids: Complex Diets or Dietary Supplements?","volume":"2","author":"Egert","year":"2011","journal-title":"Adv. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/acer.13361","article-title":"Global Transcriptional Response of Human Liver Cells to Ethanol Stress of Different Strength Reveals Hormetic Behavior","volume":"41","author":"Hiller","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3109\/03602532.2012.700715","article-title":"Drug interaction potential of resveratrol","volume":"44","author":"Detampel","year":"2012","journal-title":"Drug Metab. Rev."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/acs.chemrestox.5b00121","article-title":"Effect of Natural Polyphenols on CYP Metabolism: Implications for Diseases","volume":"28","author":"Korobkova","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"917","DOI":"10.18388\/abp.2002_3751","article-title":"Effect of natural phenols on the catalytic activity of cytochrome P450 2E","volume":"49","author":"Mikstacka","year":"2002","journal-title":"Acta Biochim. Pol."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/12\/11\/1094\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:33:29Z","timestamp":1760178809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/12\/11\/1094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,14]]},"references-count":144,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["pharmaceutics12111094"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics12111094","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,14]]}}}