{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T10:16:35Z","timestamp":1772878595237,"version":"3.50.1"},"reference-count":54,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T00:00:00Z","timestamp":1607644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPITEC\/SE (Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa e Inova\u00e7\u00e3o Tecnol\u00f3gica do Estado de Sergipe) and from the Brazilian Bureau of Research","award":["FAPITEC\/SE"],"award-info":[{"award-number":["FAPITEC\/SE"]}]},{"name":"FRC Kazan Scientific Center of Russian Academy of Sciences","award":["FRC"],"award-info":[{"award-number":["FRC"]}]},{"name":"Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT\/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020","award":["M-ERA-NET-0004\/2015-PAIRED and UIDB\/04469\/2020"],"award-info":[{"award-number":["M-ERA-NET-0004\/2015-PAIRED and UIDB\/04469\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Punica granatum Linn (pomegranate) extracts have been proposed for wound healing due to their antimicrobial, antioxidant, and anti-inflammatory properties. In this work, we designed biointeractive membranes that contain standard extracts of P. granatum for the purpose of wound healing. The used standard extract contained 32.24 mg\/g of gallic acid and 41.67 mg\/g of ellagic acid, and it showed high antioxidant activity (the concentration of the extract that produces 50% scavenging (IC50) 1.715 \u00b5g\/mL). Compared to the gelatin-based membranes (GEL), membranes containing P. granatum extracts (GELPG) presented a higher maximal tension (p = 0.021) and swelling index (p = 0.033) and lower water vapor permeability (p = 0.003). However, no difference was observed in the elongation and elastic modulus of the two types of membranes (p &gt; 0.05). Our wound-healing assay showed that a GELPG-treated group experienced a significant increase compared to that of the control group in their wound contraction rates on days 3 (p &lt; 0.01), 7 (p &lt; 0.001), and on day 14 (p &lt; 0.001). The GELPG membranes promoted major histological changes in the dynamics of wound healing, such as improvements in the formation of granular tissue, better collagen deposition and arrangement, and earlier development of cutaneous appendages. Our results suggest that a biointeractive gelatin-based membrane containing P. granatum extracts has a promising potential application for dressings that are used to treat wounds.<\/jats:p>","DOI":"10.3390\/pharmaceutics12121204","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:45:36Z","timestamp":1607906736000},"page":"1204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Development and Characterization of Biointeractive Gelatin Wound Dressing Based on Extract of Punica granatum Linn"],"prefix":"10.3390","volume":"12","author":[{"given":"Marismar F.","family":"do Nascimento","sequence":"first","affiliation":[{"name":"Health and Environment Post-Graduating Program, University Tiradentes (UNIT), Aracaju 49032-490, Sergipe, Brazil"},{"name":"School of Nursing, University of Pernambuco, Brazil BR 203, Km 2, s\/n, Petrolina 56328-903, Pernambuco, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-4144","authenticated-orcid":false,"given":"Juliana C.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Health and Environment Post-Graduating Program, University Tiradentes (UNIT), Aracaju 49032-490, Sergipe, Brazil"},{"name":"Institute of Research and Technology (ITR), Av. Murilo Dantas 300, Aracaju 49032-490, Sergipe, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9041-5135","authenticated-orcid":false,"given":"Tarsizio S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Health and Environment Post-Graduating Program, University Tiradentes (UNIT), Aracaju 49032-490, Sergipe, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-9369","authenticated-orcid":false,"given":"L\u00edvia A.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Health and Environment Post-Graduating Program, University Tiradentes (UNIT), Aracaju 49032-490, Sergipe, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2001-1570","authenticated-orcid":false,"given":"Tatiana N.","family":"Pashirova","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy (FFUC), University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov St., 8, 420088 Kazan, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patricia","family":"Severino","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Industrial Biotechnology Post-Graduating Program, University Tiradentes, Aracaju 49032-490, Sergipe, Brazil"},{"name":"Tiradentes Institute, 150 Mt Vernon St, Dorchester, MA 02125, USA"},{"name":"Center for Biomedical Engineering, Department of Medicine, Brigham and Women &amp; Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy (FFUC), University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Ricardo L. C. de","family":"Albuquerque-Junior","sequence":"additional","affiliation":[{"name":"Health and Environment Post-Graduating Program, University Tiradentes (UNIT), Aracaju 49032-490, Sergipe, Brazil"},{"name":"Institute of Research and Technology (ITR), Av. Murilo Dantas 300, Aracaju 49032-490, Sergipe, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,11]]},"reference":[{"key":"ref_1","first-page":"976","article-title":"Hydroalcoholic extract based-ointment from Punica granatum L. peels with enhanced in vivo healing potential on dermal wounds","volume":"18","author":"Hayouni","year":"2011","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.ijnurstu.2013.10.013","article-title":"Current practice in the management of wound odour: An international survey","volume":"51","author":"Gethin","year":"2014","journal-title":"Int. J. Nurs. Stud."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Diniz, F.R., Maia, R.C.A.P., Rannier, L., Andrade, L.N., Chaud, M.V., da Silva, C.F., Corr\u00eaa, C.B., de Albuquerque Junior, R.L.C., da Costa, L.P., and Souto, E.B. (2020). Silver nanoparticles-composing alginate\/gelatin hydrogel improves wound healing in vivo. Nanomaterials, 10.","DOI":"10.3390\/nano10020390"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hissae Yassue-Cordeiro, P., Zandonai, C.H., Pereira Genesi, B., Santos Lopes, P., Sanchez-Lopez, E., Garcia, M.L., Camargo Fernandes-Machado, N.R., Severino, P., and Ferreira da Silva, C. (2019). Development of Chitosan\/Silver Sulfadiazine\/Zeolite Composite Films for Wound Dressing. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11100535"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijpharm.2012.09.043","article-title":"Development of ethyl alcohol-precipitated silk sericin\/polyvinyl alcohol scaffolds for accelerated healing of full-thickness wounds","volume":"439","author":"Siritienthong","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_6","first-page":"761593","article-title":"Collagen-Based Films Containing Liposome-Loaded Usnic Acid as Dressing for Dermal Burn Healing","volume":"2011","author":"Nunes","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.msec.2015.11.034","article-title":"Design and characterization of chitosan\/zeolite composite films\u2014Effect of zeolite type and zeolite dose on the film properties","volume":"60","author":"Barbosa","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijpharm.2014.04.062","article-title":"Active wound dressings based on bacterial nanocellulose as drug delivery system for octenidine","volume":"471","author":"Moritz","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jep.2013.03.031","article-title":"The incorporation of Brazilian propolis into collagen-based dressing films improves dermal burn healing","volume":"147","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ijpharm.2012.05.044","article-title":"Alginate based bilayer hydrocolloid films as potential slow-release modern wound dressing","volume":"434","author":"Thu","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"120001","DOI":"10.1016\/j.ijpharm.2020.120001","article-title":"Double membrane based on lidocaine-coated polymyxin-alginate nanoparticles for wound healing: In vitro characterization and in vivo tissue repair","volume":"591","author":"Oliveira","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jep.2012.07.028","article-title":"Anti-inflammatory and cicatrizing activities of thymol, a monoterpene of the essential oil from Lippia gracilis, in rodents","volume":"143","author":"Riella","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jep.2005.07.027","article-title":"Pomegranate as a cosmeceutical source: Pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells","volume":"103","author":"Aslam","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","first-page":"3059745","article-title":"The Effects of Punica granatum Flower Extract on Skin Injuries Induced by Burn in Rats","volume":"2017","author":"Nasiri","year":"2017","journal-title":"Adv. Pharmacol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1089\/1096620041224111","article-title":"Study on wound healing activity of Punica granatum peel","volume":"7","author":"Murthy","year":"2004","journal-title":"J. Med. Food"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1541-4337.2010.00131.x","article-title":"Pomegranate and its Many Functional Components as Related to Human Health: A Review","volume":"9","author":"Viudamartos","year":"2010","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_17","first-page":"128","article-title":"Therapeutic applications of pomegranate (Punica granatum L.): A review","volume":"13","author":"Jurenka","year":"2008","journal-title":"Altern. Med. Rev. J. Clin. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1600-0625.2008.00829.x","article-title":"Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin","volume":"18","author":"Afaq","year":"2009","journal-title":"Exp. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1751-1097.2007.00157.x","article-title":"Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx","volume":"83","author":"Zaid","year":"2007","journal-title":"Photochem. Photobiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1365-4632.2009.04269.x","article-title":"Extract of Punica granatum inhibits skin photoaging induced by UVB irradiation","volume":"49","author":"Park","year":"2010","journal-title":"Int. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4103\/2347-9264.158862","article-title":"Assessment of the histological state of the healing wound","volume":"2","author":"Gupta","year":"2015","journal-title":"Plast. Aesthetic Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3329\/bjpath.v24i1.2874","article-title":"Histological differences in wound healing in Maxillofacial region in patients with or without risk factors","volume":"24","author":"Sultana","year":"2009","journal-title":"Bangladesh J. Pathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.foodchem.2011.07.009","article-title":"HPLC\/DAD\/ESI-MS analyses and anti-radical activity of hydrolyzable tannins from different vegetal species","volume":"130","author":"Romani","year":"2012","journal-title":"Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.fitote.2005.03.025","article-title":"Twenty years\u2019 experience in the botanical health food market","volume":"76","author":"Bombardelli","year":"2005","journal-title":"Fitoterapia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.foodres.2012.07.059","article-title":"Anti-proliferative activity and protection against oxidative DNA damage by punicalagin isolated from pomegranate husk","volume":"49","author":"Aqil","year":"2012","journal-title":"Food Res. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.indcrop.2012.06.031","article-title":"Optimization of extraction and enrichment of phenolics from pomegranate (Punica granatum L.) leaves","volume":"42","author":"Wang","year":"2013","journal-title":"Ind. Crop. Prod."},{"key":"ref_27","first-page":"303","article-title":"Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing","volume":"3","author":"Peh","year":"2000","journal-title":"J. Pharm. Pharm. Sci. Publ. Can. Soc. Pharm. Sci. Soc. Can. Sci. Pharm."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1016\/j.biomaterials.2004.01.033","article-title":"Relationship between triple-helix content and mechanical properties of gelatin films","volume":"25","author":"Bigi","year":"2004","journal-title":"Biomaterials"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijbiomac.2013.03.002","article-title":"Evaluation of chitosan nano dressing for wound healing: Characterization, in vitro and in vivo studies","volume":"57","author":"Archana","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.foodhyd.2012.08.011","article-title":"Mechanical properties and water vapour permeability of hydrolysed collagen\u2013cocoa butter edible films plasticised with sucrose","volume":"30","author":"Fadini","year":"2013","journal-title":"Food Hydrocoll."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.memsci.2006.01.002","article-title":"Alginate\/gelatin blend films and their properties for drug controlled release","volume":"280","author":"Dong","year":"2006","journal-title":"J. Membr. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Dzia\u0142o, M., Mierziak, J., Korzun, U., Preisner, M., Szopa, J., and Kulma, A. (2016). The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17020160"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Piazza, S., Fumagalli, M., Khalilpour, S., Martinelli, G., Magnavacca, A., Dell\u2019Agli, M., and Sangiovanni, E. (2020). A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders. Antioxidants, 9.","DOI":"10.3390\/antiox9060542"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/iep.12346","article-title":"Experimental models and methods for cutaneous wound healing assessment","volume":"101","author":"Andrade","year":"2020","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/s10620-008-0423-7","article-title":"Ellagic Acid Inhibits Pancreatic Fibrosis in Male Wistar Bonn\/Kobori Rats","volume":"54","author":"Suzuki","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yang, D.J., Moh, S.H., Son, D.H., You, S., Kinyua, A.W., Ko, C.M., Song, M., Yeo, J., Choi, Y.H., and Kim, K.W. (2016). Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions. Molecules, 21.","DOI":"10.3390\/molecules21070899"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000487400","article-title":"Punicalagin and (-)-Epigallocatechin-3-Gallate Rescue Cell Viability and Attenuate Inflammatory Responses of Human Epidermal Keratinocytes Exposed to Airborne Particulate Matter PM10","volume":"31","author":"Seok","year":"2018","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/joa.12840","article-title":"Thepanniculus carnosusmuscle: An evolutionary enigma at the intersection of distinct research fields","volume":"233","author":"Bahri","year":"2018","journal-title":"J. Anat."},{"key":"ref_39","first-page":"3706315","article-title":"Skin Acute Wound Healing: A Comprehensive Review","volume":"2019","year":"2019","journal-title":"Int. J. Inflamm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1089\/wound.2012.0383","article-title":"Neutrophils and Wound Repair: Positive Actions and Negative Reactions","volume":"2","author":"Wilgus","year":"2013","journal-title":"Adv. Wound Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00441-017-2785-7","article-title":"Neutrophils in tissue injury and repair","volume":"371","author":"Wang","year":"2018","journal-title":"Cell Tissue Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1365-2133.2000.03591.x","article-title":"The role of lymphocytes in human dermal wound healing","volume":"143","author":"Boyce","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bjorl.2015.09.011","article-title":"The influence of growth factors on skin wound healing in rats","volume":"82","author":"Masi","year":"2016","journal-title":"J. Braz. J. Otorhinolaryngol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1002\/ptr.3131","article-title":"Inhibitory effect of Thuja orientalis on TNF-\u03b1-induced vascular inflammation","volume":"24","author":"Lee","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jopan.2010.05.011","article-title":"Evaluation of the Anti-inflammatory Effects of Ellagic Acid","volume":"25","author":"Corbett","year":"2010","journal-title":"J. PeriAnesthesia Nurs."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000337184","article-title":"Anti-inflammatory gallic Acid and wedelolactone are G protein-coupled receptor-35 agonists","volume":"89","author":"Deng","year":"2012","journal-title":"Pharmacology"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1142\/S0192415X99000422","article-title":"Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats","volume":"27","author":"Lin","year":"1999","journal-title":"Am. J. Chin. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.phrs.2008.06.004","article-title":"Oxidative stress in normal and impaired wound repair","volume":"58","author":"Werner","year":"2008","journal-title":"Pharmacol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1016\/0006-2952(87)90660-5","article-title":"The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leukocytes stimulated by zymosan or formyl-methionyl-leucyl-phenylalanine","volume":"36","author":"Gryglewski","year":"1987","journal-title":"Biochem. Pharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.fct.2012.02.020","article-title":"Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes","volume":"50","author":"Hseu","year":"2012","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2011.02.037","article-title":"Ellagic acid ameliorates isoproterenol induced oxidative stress: Evidence from electrocardiological, biochemical and histological study","volume":"659","author":"Kannan","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_52","first-page":"107","article-title":"The wound healing activity of flower extracts of Punica granatum and Achillea kellalensis in Wistar rats","volume":"67","author":"Pirbalouti","year":"2010","journal-title":"Acta Pol. Pharm."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/039463200702000209","article-title":"Tannic acid induces in vitro acantholysis of keratinocytes via IL-1alpha and TNF-alpha","volume":"20","author":"Feliciani","year":"2007","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/bbrc.1997.7742","article-title":"Involvement of the Heme Oxygenase\u2013Carbon Monoxide Pathway in Keratinocyte Proliferation","volume":"241","author":"Clark","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/12\/12\/1204\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:43:55Z","timestamp":1760179435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/12\/12\/1204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,11]]},"references-count":54,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["pharmaceutics12121204"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics12121204","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,11]]}}}