{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:02:45Z","timestamp":1777518165364,"version":"3.51.4"},"reference-count":58,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Banco do Nordeste (grant FUNDECI\/2016.0015), Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq), Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa e \u00e0 Inova\u00e7\u00e3o Tecnol\u00f3gica do Estado de Sergipe (Fapitec) and Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel","award":["grant FUNDECI\/2016.0015"],"award-info":[{"award-number":["grant FUNDECI\/2016.0015"]}]},{"name":"Portuguese Science and Technology Foundation (FCT\/MCT) and from European Funds (PRODER\/COMPETE) for the project UIDB\/04469\/2020 (strategic fund), co-financed by FEDER, under the Partnership Agreement PT2020","award":["UIDB\/04469\/2020 (strategic fund)"],"award-info":[{"award-number":["UIDB\/04469\/2020 (strategic fund)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The low solubility and high volatility of perillyl alcohol (POH) compromise its bioavailability and potential use as chemotherapeutic drug. In this work, we have evaluated the anticancer activity of POH complexed with \u03b2-cyclodextrin (\u03b2-CD) using three complexation approaches. Molecular docking suggests the hydrogen-bond between POH and \u03b2-cyclodextrin in molar proportion was 1:1. Thermal analysis and Fourier-transform infrared spectroscopy (FTIR) confirmed that the POH was enclosed in the \u03b2-CD cavity. Also, there was a significant reduction of particle size thereof, indicating a modification of the \u03b2-cyclodextrin crystals. The complexes were tested against human L929 fibroblasts after 24 h of incubation showing no signs of cytotoxicity. Concerning the histopathological results, the treatment with POH\/\u03b2-CD at a dose of 50 mg\/kg promoted approximately 60% inhibition of tumor growth in a sarcoma S180-induced mice model and the reduction of nuclear immunoexpression of the Ki67 antigen compared to the control group. Obtained data suggest a significant reduction of cycling cells and tumor proliferation. Our results confirm that complexation of POH\/\u03b2-CD not only solves the problem related to the volatility of the monoterpene but also increases its efficiency as an antitumor agent.<\/jats:p>","DOI":"10.3390\/pharmaceutics13020245","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T16:12:10Z","timestamp":1613146330000},"page":"245","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Anti-Tumor Efficiency of Perillylalcohol\/\u03b2-Cyclodextrin Inclusion Complexes in a Sarcoma S180-Induced Mice Model"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-9608","authenticated-orcid":false,"given":"Allan A.","family":"Rezende","sequence":"first","affiliation":[{"name":"University of Tiradentes (Unit), Postgraduate Program Industrial Biotechnology, and Health and Enviroment. Av. Murilo Dantas, 300, 49010-390 Aracaju, Brazil"},{"name":"Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, 49010-390 Aracaju, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6458-4661","authenticated-orcid":false,"given":"Rafael S.","family":"Santos","sequence":"additional","affiliation":[{"name":"University of Tiradentes (Unit), Postgraduate Program Industrial Biotechnology, and Health and Enviroment. Av. Murilo Dantas, 300, 49010-390 Aracaju, Brazil"},{"name":"Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, 49010-390 Aracaju, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-4355","authenticated-orcid":false,"given":"Luciana N.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Physiology, Federal University of Sergipe, S\u00e3o Cristov\u00e3o, 49100-000 Sergipe, Brazil"}]},{"given":"Ricardo G.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Department of Physiology, Federal University of Sergipe, S\u00e3o Cristov\u00e3o, 49100-000 Sergipe, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-6900","authenticated-orcid":false,"given":"Matheus M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"CICECO, Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"given":"Cristiane","family":"Bani","sequence":"additional","affiliation":[{"name":"Department of Physiology, Federal University of Sergipe, S\u00e3o Cristov\u00e3o, 49100-000 Sergipe, Brazil"}]},{"given":"Mo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics &amp; Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4586-0405","authenticated-orcid":false,"given":"Ronny","family":"Priefer","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences, 179 Longwood Avenue, Boston, MA 02115, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-5598","authenticated-orcid":false,"given":"Classius F.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of S\u00e3o Paulo, 09972-270 Diadema, S\u00e3o Paulo, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-7632","authenticated-orcid":false,"given":"Ricardo L. C.","family":"de Albuquerque J\u00fanior","sequence":"additional","affiliation":[{"name":"University of Tiradentes (Unit), Postgraduate Program Industrial Biotechnology, and Health and Enviroment. Av. Murilo Dantas, 300, 49010-390 Aracaju, Brazil"},{"name":"Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, 49010-390 Aracaju, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"},{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[{"name":"University of Tiradentes (Unit), Postgraduate Program Industrial Biotechnology, and Health and Enviroment. Av. Murilo Dantas, 300, 49010-390 Aracaju, Brazil"},{"name":"Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, 49010-390 Aracaju, Brazil"},{"name":"Tiradentes Institute, 150 Mt Vernon St, Dorchester, MA 02125, USA"},{"name":"Center for Biomedical Engineering, Department of Medicine, Brigham and Women&amp; Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cardoso-Teixeira, A.C., Ferreira-da-Silva, F.B., Peixoto-Neves, D., Oliveira-Abreu, K., Pereira-Gon\u00e7alves, \u00c1., Coelho-de-Souza, A.N., and Leal-Cardoso, J.N. (2018). Hydroxyl Group and Vasorelaxant Effects of Perillyl Alcohol, Carveol, Limonene on Aorta Smooth Muscle of Rats. Molecules, 23.","DOI":"10.3390\/molecules23061430"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Cavendish, M., Nalone, L., Barbosa, T., Barbosa, R., Costa, S., Nunes, R., da Silva, C.F., Chaud, M.V., Souto, E.B., and Hollanda, L. (2019). 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