{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T12:43:25Z","timestamp":1763988205256,"version":"build-2065373602"},"reference-count":66,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T00:00:00Z","timestamp":1624838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation programme - Marie Sk\u0142odowska-Curie Actions (ORBITAL\u2014Ocular Research by Integrated Training And Learning)","award":["813440"],"award-info":[{"award-number":["813440"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["UID\/QUI\/00100\/2019","UIDB\/00100\/2020","UID\/BIM\/04585\/2020"],"award-info":[{"award-number":["UID\/QUI\/00100\/2019","UIDB\/00100\/2020","UID\/BIM\/04585\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Pseudophakic cystoid macular edema (PCME), caused by chronic inflammation, is the most common cause of visual impairment in the medium-term after cataract surgery. Therefore, the prophylactic topical administration of combined steroidal and non-steroidal anti-inflammatory drugs is commonly done. Drug-eluting intraocular lenses (IOLs) gained interest as an efficient way to overcome the compliance issues related to the use of ocular drops without the need for additional surgical steps. The incorporation of functional monomers and molecular imprinting were herein applied to design hydrogels suitable as IOLs and able to co-deliver steroidal (dexamethasone sodium phosphate) and non-steroidal (bromfenac sodium) drugs. The incorporation of N-(2-aminopropyl) methacrylamide (APMA) increased the drug uptake and improved the in vitro release kinetics. Imprinting with bromfenac resulted in a decreased drug release due to permanent drug bonding, while imprinting with dexamethasone increased the amount of dexamethasone released after dual-drug loading. The application of a mathematical model to predict the in vivo drug release behavior suggests the feasibility of achieving therapeutic drug concentrations of bromfenac and dexamethasone in the aqueous humor for about 2 and 8 weeks, respectively, which is compatible with the current topical prophylaxis after cataract surgery.<\/jats:p>","DOI":"10.3390\/pharmaceutics13070976","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T13:39:22Z","timestamp":1624887562000},"page":"976","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2321-906X","authenticated-orcid":false,"given":"Nadia","family":"Toffoletto","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, University of Lisbon, Avenue Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5668-6705","authenticated-orcid":false,"given":"Madalena","family":"Salema-Oom","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal"}]},{"given":"Soledad","family":"Anguiano Igea","sequence":"additional","affiliation":[{"name":"HGBeyond Materials Science S.L., Edificio EMPRENDIA, 15782 Santiago de Compostela, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8546-7085","authenticated-orcid":false,"given":"Carmen","family":"Alvarez-Lorenzo","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Farmacia y Tecnolog\u00eda Farmac\u00e9utica, I + D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8968-4781","authenticated-orcid":false,"given":"Benilde","family":"Saramago","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, University of Lisbon, Avenue Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-9296","authenticated-orcid":false,"given":"Ana Paula","family":"Serro","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, University of Lisbon, Avenue Rovisco Pais, 1049-001 Lisbon, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz, Instituto Universit\u00e1rio Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1444-0938.2002.tb03014.x","article-title":"Cataract in the 21st Century: Lessons from previous epidemiologic research","volume":"85","author":"McCarty","year":"2002","journal-title":"Clin. 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