{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:48:58Z","timestamp":1777636138639,"version":"3.51.4"},"reference-count":113,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This research was funded by the Portuguese Science and Technology Foundation (FCT\/MCT) and European Funds (PRODER\/COMPETE),  co-financed by FEDER, under the Partnership Agreement PT2020.","award":["UIDB\/04469\/2020"],"award-info":[{"award-number":["UIDB\/04469\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The use of lipids in the composition of polymeric-based films for topical administration of bioactive ingredients is a recent research topic; while few products are commercially available, films containing lipids represent a strategic area for the development of new products. Some lipids are usually used in polymeric-based film formulations due to their plasticizing action, with a view to improving the mechanical properties of these films. On the other hand, many lipids have healing, antimicrobial, anti-inflammatory, anti-aging properties, among others, that make them even more interesting for application in the medical-pharmaceutical field. This manuscript discusses the production methods of these films both on a laboratory and at industrial scales, the properties of the developed biopolymers, and their advantages for the development of dermatologic and cosmetic products.<\/jats:p>","DOI":"10.3390\/pharmaceutics13081199","type":"journal-article","created":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T08:47:52Z","timestamp":1628066872000},"page":"1199","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Lipid-Polymeric Films: Composition, Production and Applications in Wound Healing and Skin Repair"],"prefix":"10.3390","volume":"13","author":[{"given":"Eliana B.","family":"Souto","sequence":"first","affiliation":[{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Cristiana M. P.","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Federal University of S\u00e3o Paulo, Rua S\u00e3o Nicolau, 210, Diadema, S\u00e3o Paulo 09913-030, Brazil"}]},{"given":"Gislaine R.","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, State University of Campinas, Rua C\u00e2ndido Portinari, 200\u2014Cidade Universit\u00e1ria, Campinas 13083-871, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-4283","authenticated-orcid":false,"given":"Amanda","family":"Cano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-108X","authenticated-orcid":false,"given":"Elena","family":"Sanchez-Lopez","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain"},{"name":"Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2603-1377","authenticated-orcid":false,"given":"Aleksandra","family":"Zielinska","sequence":"additional","affiliation":[{"name":"CEB\u2014Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"},{"name":"Institute of Human Genetics, Polish Academy of Sciences, Strzeszy\u0144ska 32, 60-479 Pozna\u0144, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-3566","authenticated-orcid":false,"given":"C\u00e9sar","family":"Viseras","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja s\/n, 18071 Granada, Spain"},{"name":"Andalusian Institute of Earth Sciences, CSIC-University of Granada, Av. de Las Palmeras 4, 18100 Armilla, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patricia","family":"Severino","sequence":"additional","affiliation":[{"name":"Institute of Technology and Research (ITP), Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"},{"name":"Industrial Biotechnology Program, University of Tiradentes (UNIT), Av. Murilo Dantas 300, Aracaju 49032-490, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-5598","authenticated-orcid":false,"given":"Classius F. da","family":"Silva","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Federal University of S\u00e3o Paulo, Rua S\u00e3o Nicolau, 210, Diadema, S\u00e3o Paulo 09913-030, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3798-5512","authenticated-orcid":false,"given":"Raquel de M.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Development, Department of Pharmacy, School of Pharmacy, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jid.2016.11.045","article-title":"Human Skin Is the Largest Epithelial Surface for Interaction with Microbes","volume":"137","author":"Gallo","year":"2017","journal-title":"J. Investig. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.1038\/s41598-021-85553-3","article-title":"Utilization of patterned bioprinting for heterogeneous and physiologically representative reconstructed epidermal skin models","volume":"11","author":"Desbouis","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jaad.2021.03.022","article-title":"May 2021: Heterogeneity in reported skin manifestations of COVID-19 and vaccines","volume":"84","author":"Kantor","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1364\/BOE.9.006425","article-title":"Characterizing stratum corneum structure, barrier function, and chemical content of human skin with coherent Raman scattering imaging","volume":"9","author":"Osseiran","year":"2018","journal-title":"Biomed. Opt. Express"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/17425247.2020.1772750","article-title":"Analytical tools and evaluation strategies for nanostructured lipid carrier-based topical delivery systems","volume":"17","author":"Mahant","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/17425247.2020.1727883","article-title":"SLN and NLC for topical, dermal, and transdermal drug delivery","volume":"17","author":"Souto","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_7","first-page":"59","article-title":"Approach to the process knowledge of skin aging among different ethnics","volume":"88","author":"Batistela","year":"2007","journal-title":"Rev. Bras. Farm."},{"key":"ref_8","unstructured":"Freeman, S.C., and Sonthalia, S. (2021). Histology, Keratohyalin Granules. StatPearls, StatPearls Publishing LLC."},{"key":"ref_9","unstructured":"Treuting, P.M., and Dintzis, S.M. (2012). 23\u2014Skin and Adnexa. Comparative Anatomy and Histology, Academic Press."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wertz, P.W. (2021). Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22105229"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/0963689717725755","article-title":"Fighting against Skin Aging: The Way from Bench to Bedside","volume":"27","author":"Zhang","year":"2018","journal-title":"Cell Transplant."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"De Luca, M., Pappalardo, I., Limongi, A.R., Viviano, E., Radice, R.P., Todisco, S., Martelli, G., Infantino, V., and Vassallo, A. (2021). Lipids from Microalgae for Cosmetic Applications. Cosmetics, 8.","DOI":"10.3390\/cosmetics8020052"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/1523-1747.ep12474562","article-title":"Stratum corneum lipids serve as a bound-water modulator","volume":"96","author":"Imokawa","year":"1991","journal-title":"J. Investig. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1461-5347(00)00295-9","article-title":"Transdermal drug delivery: Overcoming the skin\u2019s barrier function","volume":"3","author":"Naik","year":"2000","journal-title":"Pharm. Sci. Technol. Today."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3121\/cmr.2017.1363","article-title":"The Role of Moisturizers in Addressing Various Kinds of Dermatitis: A Review","volume":"15","author":"Purnamawati","year":"2017","journal-title":"Clin. Med. Res."},{"key":"ref_16","first-page":"S2","article-title":"Understanding the Epidermal Barrier in Healthy and Compromised Skin: Clinically Relevant Information for the Dermatology Practitioner: Proceedings of an Expert Panel Roundtable Meeting","volume":"9","author":"Rosso","year":"2016","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chandan, N., Rajkumar, J.R., Shi, V.Y., and Lio, P.A. (2021). A new era of moisturizers. J. Cosmet. Dermatol.","DOI":"10.1111\/jocd.14217"},{"key":"ref_18","first-page":"85","article-title":"Skin constituents as cosmetic ingredients","volume":"107","author":"Rieger","year":"1992","journal-title":"Cosmet. Toilet."},{"key":"ref_19","first-page":"36","article-title":"Skin lipids and their importance to cosmetic science","volume":"102","author":"Rieger","year":"1987","journal-title":"Cosmet. Toilet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4161\/derm.1.2.7811","article-title":"Epidermal surface lipids","volume":"1","author":"Pappas","year":"2009","journal-title":"Dermatoendocrinol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1590\/S0365-05962002000500006","article-title":"Study of pH variation on the skin using cosmetic formulation s with and without vitamins A, E or ceramide: By a non-invasive method","volume":"77","author":"Leonardi","year":"2002","journal-title":"Bras. Dermatol."},{"key":"ref_22","unstructured":"Leonardi, G.R. (2008). Cosmetologia Aplicada, MedFarma."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s13197-019-04128-3","article-title":"Characterization of physico-chemical and bioactive properties of oils of some important almond cultivars by cold press and soxhlet extraction","volume":"57","author":"Ghafoor","year":"2020","journal-title":"J. Food Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s11746-997-0044-x","article-title":"Lipids and biopackaging","volume":"74","author":"Callegarin","year":"1997","journal-title":"J. Am. Oil. Chem. Soc."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ibrahim, N.I., Fairus, S., Zulfarina, M.S., and Naina Mohamed, I. (2020). The Efficacy of Squalene in Cardiovascular Disease Risk-A Systematic Review. Nutrients, 12.","DOI":"10.3390\/nu12020414"},{"key":"ref_26","unstructured":"Ebnesajjad, S. (2013). 14\u2014Biopolymers in Controlled-Release Delivery Systems. Handbook of Biopolymers and Biodegradable Plastics, William Andrew Publishing."},{"key":"ref_27","first-page":"403","article-title":"Collagen Powder in Wound Healing","volume":"17","author":"Kallis","year":"2018","journal-title":"J. Drugs Dermatol. JDD"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e2221","DOI":"10.1097\/GOX.0000000000002221","article-title":"Hyaluronic Acid Accelerates Re-epithelialization and Alters Protein Expression in a Human Wound Model","volume":"7","author":"Nyman","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob Open"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Matica, M.A., Aachmann, F.L., T\u00f8ndervik, A., Sletta, H., and Ostafe, V. (2019). Chitosan as a Wound Dressing Starting Material: Antimicrobial Properties and Mode of Action. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20235889"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Yoshida, C.M.P., Pacheco, M.S., de Moraes, M.A., Lopes, P.S., Severino, P., Souto, E.B., and da Silva, C.F. (2021). Effect of Chitosan and Aloe Vera Extract Concentrations on the Physicochemical Properties of Chitosan Biofilms. Polymers, 13.","DOI":"10.3390\/polym13081187"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Negut, I., Dorcioman, G., and Grumezescu, V. (2020). Scaffolds for Wound Healing Applications. Polymers, 12.","DOI":"10.3390\/polym12092010"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11249-009-9411-0","article-title":"Fabrication, Characterisation and Tribological Investigation of Artificial Skin Surface Lipid Films","volume":"34","author":"Gerhardt","year":"2009","journal-title":"Tribol. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/jemt.20484","article-title":"Novel sample preparation method of polymer emulsion for SEM observation","volume":"70","author":"Xu","year":"2007","journal-title":"Microsc. Res. Tech."},{"key":"ref_34","first-page":"153","article-title":"Principles of emulsion stabilization with special reference to polymeric surfactants","volume":"57","author":"Tadros","year":"2006","journal-title":"J. Cosmet. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Gall, V., Runde, M., and Schuchmann, H.P. (2016). Extending Applications of High-Pressure Homogenization by Using Simultaneous Emulsification and Mixing (SEM)\u2014An Overview. Processes, 4.","DOI":"10.3390\/pr4040046"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14859","DOI":"10.1021\/acs.iecr.9b00634","article-title":"Production of Oil-in-Water Emulsions with Varying Dispersed-Phase Content using Confined Impinging Jet Mixers","volume":"58","author":"Tripodi","year":"2019","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/10837450.2019.1647235","article-title":"Key production parameters for the development of solid lipid nanoparticles by high shear homogenization","volume":"24","author":"Souto","year":"2019","journal-title":"Pharm. Dev. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0168-3659(95)00123-9","article-title":"Liquid-liquid emulsification by rotor\/stator homogenization","volume":"38","author":"Maa","year":"1996","journal-title":"J. Control Release"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/ceat.200500304","article-title":"Rotor-Stator and Disc Systems for Emulsification Processes","volume":"29","author":"Urban","year":"2006","journal-title":"Chem. Eng. Technol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.matsci.29.1.295","article-title":"Applications of Ultrasound to Materials Chemistry","volume":"29","author":"Suslick","year":"1999","journal-title":"Ann. Rev. Mater. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijpharm.2010.10.045","article-title":"Effect of process parameters on nanoemulsion droplet size and distribution in SPG membrane emulsification","volume":"404","author":"Oh","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/ceat.200406111","article-title":"High-Pressure Homogenization as a Process for Emulsion Formation","volume":"27","author":"Schultz","year":"2004","journal-title":"Chem. Eng. Technol."},{"key":"ref_43","first-page":"1","article-title":"Solvent cast technology\u2014A versatile tool for thin film production","volume":"130","author":"Siemann","year":"2005","journal-title":"Progr. Colloid. Polym. Sci."},{"key":"ref_44","first-page":"9","article-title":"A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products","volume":"2012","author":"Maniruzzaman","year":"2012","journal-title":"ISRN Pharm."},{"key":"ref_45","first-page":"3","article-title":"Hot-Melt Extrusion Technique: A Review","volume":"3","author":"Chokshi","year":"2004","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"110994","DOI":"10.1016\/j.msec.2020.110994","article-title":"Electrospinning of natural polymers for the production of nanofibres for wound healing applications","volume":"114","author":"Dunne","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Tottoli, E.M., Dorati, R., Genta, I., Chiesa, E., Pisani, S., and Conti, B. (2020). Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12080735"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.msec.2018.09.058","article-title":"Preparation and characterization of Aloe vera acetate and electrospinning fibers as promising antibacterial properties materials","volume":"94","author":"Aghamohamadi","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"112245","DOI":"10.1016\/j.msec.2021.112245","article-title":"Curcumin-loaded sandwich-like nanofibrous membrane prepared by electrospinning technology as wound dressing for accelerate wound healing","volume":"127","author":"Chen","year":"2021","journal-title":"Mater. Sci. Eng."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Yang, Q., Yuan, F., Xu, L., Yan, Q., Yang, Y., Wu, D., Guo, F., and Yang, G. (2019). An Update of Moisture Barrier Coating for Drug Delivery. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11090436"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ramos, M., Mellinas, C., Solaberrieta, I., Garrig\u00f3s, M.C., and Jim\u00e9nez, A. (2021). Emulsions Incorporated in Polysaccharide-Based Active Coatings for Fresh and Minimally Processed Vegetables. Foods, 10.","DOI":"10.3390\/foods10030665"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10408699891274219","article-title":"Edible Films and Coatings: Tomorrow\u2019s Packagings: A Review","volume":"38","author":"Debeaufort","year":"1998","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_53","unstructured":"Embuscado, M.E., and Huber, K.C. (2009). Edible Films and Coatings for Food Applications. Lipid-Based Edible Films and Coatings, Springer Nature."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/jphp.12984","article-title":"Lipophilicity and hydrophobicity considerations in bio-enabling oral formulations approaches\u2014A PEARRL review","volume":"71","author":"Ditzinger","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kocira, A., Koz\u0142owicz, K., Panasiewicz, K., Staniak, M., Szpunar-Krok, E., and Horty\u0144ska, P. (2021). Polysaccharides as Edible Films and Coatings: Characteristics and Influence on Fruit and Vegetable Quality\u2014A Review. Agronomy, 11.","DOI":"10.3390\/agronomy11050813"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"101395","DOI":"10.1016\/j.progpolymsci.2021.101395","article-title":"Challenges and new opportunities on barrier performance of biodegradable polymers for sustainable packaging","volume":"117","author":"Wu","year":"2021","journal-title":"Prog. Polym. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1365-2621.1985.tb13408.x","article-title":"Use of an Edible Film to Maintain Water Vapor Gradients in Foods","volume":"50","author":"Kamper","year":"1985","journal-title":"J. Food. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1021\/jf00016a002","article-title":"Chitosan-lipid films: Microstructure and surface energy","volume":"40","author":"Wong","year":"1992","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","unstructured":"Ficai, A., and Grumezescu, A. (2017). Chapter 8\u2014Delivery of Antimicrobials by Chitosan-Composed Therapeutic Nanostructures. Nanostructures for Antimicrobial Therapy, Elsevier. Chapter 8."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Ataide, J.A., Gerios, E.F., Cefali, L.C., Fernandes, A.R., Teixeira, M.D.C., Ferreira, N.R., Tambourgi, E.B., Jozala, A.F., Chaud, M.V., and Oliveira-Nascimento, L. (2019). Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain-Chitosan Nanoparticles. Polymers, 11.","DOI":"10.3390\/polym11101681"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/j.1365-2621.1995.tb04593.x","article-title":"Edible Packaging Films Based on Fish Myofibrillar Proteins: Formulation and Functional Properties","volume":"60","author":"Cuq","year":"1995","journal-title":"J. Food Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1007\/s10924-020-01829-1","article-title":"Characterization of Pectin Films Integrated with Cocoa Butter by Continuous Casting: Physical, Thermal and Barrier Properties","volume":"28","author":"Mendes","year":"2020","journal-title":"J. Polym. Environ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10800-014-0697-8","article-title":"The effects of curing temperature on bilayer and monolayer hybrid films: Mechanical and electrochemical properties","volume":"44","author":"Kunst","year":"2014","journal-title":"J. Appl. Electrochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4534","DOI":"10.1021\/jf9802981","article-title":"Effect of Fatty Acid Type on Dispersed Phase Particle Size Distributions in Emulsion Edible Films","volume":"46","author":"Sherwin","year":"1998","journal-title":"J Agric. Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Yousuf, B., Sun, Y., and Wu, S. (2021). Lipid and Lipid-containing Composite Edible Coatings and Films. Food Rev. Int.","DOI":"10.1080\/87559129.2021.1876084"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0268-005X(97)80053-7","article-title":"Interfacial interactions in edible emulsion films from whey protein isolate","volume":"11","author":"Fairley","year":"1997","journal-title":"Food Hydrocoll."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1365-2621.1994.tb02045.x","article-title":"Edible composite films of wheat gluten and lipids: Water vapour permeability and other physical properties","volume":"29","author":"Gontard","year":"1994","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/BF02638058","article-title":"Water vapor permeability properties of edible whey protein-lipid emulsion films","volume":"71","author":"McHugh","year":"1994","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_69","first-page":"404","article-title":"Functional, physical and morphological properties of methyl cellulose and fatty acid-based edible barriers","volume":"25","author":"Koelsch","year":"1992","journal-title":"Lebensm. Wiss. Und Technol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/pts.839","article-title":"Chitosan Films: Additives effects on barrier and mechanical properties","volume":"22","author":"Yoshida","year":"2009","journal-title":"Packag. Sci. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1365-2621.1993.tb09388.x","article-title":"Water Vapor Permeability of Caseinate-Based Edible Films as Affected by pH, Calcium Crosslinking and Lipid Content","volume":"58","author":"Krochta","year":"1993","journal-title":"J. Food Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1745-4549.1994.tb00259.x","article-title":"Dispersed phase concentration effect on water vapor permeability in composite methyl cellulose-stearic acid edible films","volume":"18","author":"Sapru","year":"1994","journal-title":"J. Food Process. Preserv."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/pts.2770080607","article-title":"Technology and applications of edible protective films","volume":"8","author":"Guilbert","year":"1995","journal-title":"Packag. Technol. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11483-020-09626-y","article-title":"Application of Cellulose Nanofibrils Isolated from an Agroindustrial Residue of Peach Palm in Cassava Starch Films","volume":"15","author":"Martins","year":"2020","journal-title":"Food Biophys."},{"key":"ref_75","unstructured":"Robertson, G.L. (1993). Food Packaging: Principles and Practice, Marcell Dekker Inc."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Krywko-Cendrowska, A., di Leone, S., Bina, M., Yorulmaz-Avsar, S., Palivan, C.G., and Meier, W. (2020). Recent Advances in Hybrid Biomimetic Polymer-Based Films: From Assembly to Applications. Polymers, 12.","DOI":"10.3390\/polym12051003"},{"key":"ref_77","first-page":"48","article-title":"Water vapour permeability of whey protein emulsion films","volume":"59","author":"Yoshida","year":"2004","journal-title":"Milchwissenchaft"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S0104-66322004000200014","article-title":"Characterization of whey protein emulsion films","volume":"21","author":"Yoshida","year":"2004","journal-title":"Braz. J. Chem. Eng."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.lwt.2009.10.005","article-title":"Modeling of potassium sorbate diffusion through chitosan films","volume":"43","author":"Yoshida","year":"2010","journal-title":"Lebensm. Wiss. Technol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"120001","DOI":"10.1016\/j.ijpharm.2020.120001","article-title":"Double membrane based on lidocaine-coated polymyxin-alginate nanoparticles for wound healing: In vitro characterization and in vivo tissue repair","volume":"591","author":"Oliveira","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Grabska-Zieli\u0144ska, S., Sionkowska, A., Olewnik-Kruszkowska, E., Reczy\u0144ska, K., and Pamu\u0142a, E. (2021). Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073391"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Wardhono, E.Y., Pinem, M.P., Kustiningsih, I., Agustina, S., Oudet, F., Lefebvre, C., Clausse, D., Saleh, K., and Gu\u00e9nin, E. (2019). Cellulose Nanocrystals to Improve Stability and Functional Properties of Emulsified Film Based on Chitosan Nanoparticles and Beeswax. Nanomaterials, 9.","DOI":"10.3390\/nano9121707"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Leiva, J.M., and Geffroy, E. (2018). Evolution of the Size Distribution of an Emulsion under a Simple Shear Flow. Fluids, 3.","DOI":"10.3390\/fluids3030046"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11947-016-1800-4","article-title":"Design and Characterization of Corn Starch Edible Films Including Beeswax and Natural Antimicrobials","volume":"10","author":"Ochoa","year":"2017","journal-title":"Food Bioprocess Technol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"D\u00edaz-Montes, E., and Castro-Mu\u00f1oz, R. (2021). Trends in Chitosan as a Primary Biopolymer for Functional Films and Coatings Manufacture for Food and Natural Products. Polymers, 13.","DOI":"10.3390\/polym13050767"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"112330","DOI":"10.1016\/j.indcrop.2020.112330","article-title":"Buriti (Mauritia Flexuosa L.) pulp oil as an immunomodulator against enteropathogenic Escherichia coli","volume":"149","author":"Cruz","year":"2020","journal-title":"Ind. Crop. Prod."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1590\/S0103-84782011005000155","article-title":"Atividade antibacteriana e cicatrizante do \u00f3leo de buriti Mauritia flexuosa L","volume":"42","author":"Batista","year":"2012","journal-title":"Ci\u00eancia Rural."},{"key":"ref_88","unstructured":"Maia Campos, P.M.B.G. (1993). Estudos da Estabilidade Qu\u00edmica e da Absor\u00e7\u00e3o In Vivo da Vitamina A em Prepara\u00e7\u00f5es Cosm\u00e9ticas Para a Pele, S\u00e3o Paulo University."},{"key":"ref_89","unstructured":"de Moraes, M.A., da Silva, C.F., and Vieira, R.S. (2020). Chapter \u2014Skin rejuvenation: Biopolymers applied to UV sunscreens and sheet masks. Biopolymer Membranes and Films, Elsevier."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Alves, T.F.R., Morsink, M., Batain, F., Chaud, M.V., Almeida, T., Fernandes, D.A., da Silva, C.F., Souto, E.B., and Severino, P. (2020). Applications of Natural, Semi-Synthetic, and Synthetic Polymers in Cosmetic Formulations. Cosmetics, 7.","DOI":"10.3390\/cosmetics7040075"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"102437","DOI":"10.1016\/j.cis.2021.102437","article-title":"The emerging role of nanotechnology in skincare","volume":"293","author":"Salvioni","year":"2021","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Gubitosa, J., Rizzi, V., Fini, P., and Cosma, P. (2019). Hair Care Cosmetics: From Traditional Shampoo to Solid Clay and Herbal Shampoo, A Review. Cosmetics, 6.","DOI":"10.3390\/cosmetics6010013"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Souto, E.B., Zielinska, A., Souto, S.B., Durazzo, A., Lucarini, M., Santini, A., Silva, A.M., Atanasov, A.G., Marques, C., and Andrade, L.N. (2020). (+)-Limonene 1,2-Epoxide-Loaded SLNs: Evaluation of Drug Release, Antioxidant Activity, and Cytotoxicity in an HaCaT Cell Line. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21041449"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/09546634.2018.1479726","article-title":"Innovative nanocompounds for cutaneous administration of classical antifungal drugs: A systematic review","volume":"30","author":"Santos","year":"2019","journal-title":"J. Dermatolog. Treat."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Carbone, C., Teixeira, M.D.C., Sousa, M.D.C., Martins-Gomes, C., Silva, A.M., Souto, E.M.B., and Musumeci, T. (2019). Clotrimazole-Loaded Mediterranean Essential Oils NLC: A Synergic Treatment of Candida Skin Infections. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11050231"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.colsurfb.2018.07.065","article-title":"Solid lipid nanoparticles optimized by 2(2) factorial design for skin administration: Cytotoxicity in NIH3T3 fibroblasts","volume":"171","author":"Rigon","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ejps.2017.05.063","article-title":"Antimicrobial activity of polymyxin-loaded solid lipid nanoparticles (PLX-SLN): Characterization of physicochemical properties and in vitro efficacy","volume":"106","author":"Severino","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejpb.2016.08.001","article-title":"Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation","volume":"108","author":"Doktorovova","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_99","unstructured":"Lulla, A., and Malhotra, G. (2005). (Inventor); Cipla Pvt. Ltd., Assignee. Transdermal Pharmaceutical Spray Formulations Comprising a vp\/va Copolymer and a Non-Aqueous Vehicle. (2005041943A1), U.S. Patent."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s41702-020-00062-9","article-title":"Lipid-based formulations in cosmeceuticals and biopharmaceuticals","volume":"4","author":"Ahmad","year":"2020","journal-title":"Biomed. Dermatol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1007\/s10856-007-3275-3","article-title":"Chitosan composite films. Biomedical applications","volume":"19","author":"Anaya","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_102","first-page":"2227","article-title":"Physical, antibacterial and antioxidant properties of chitosan films incorporated with thyme oil for potential wound healing applications","volume":"21","author":"Altiok","year":"2010","journal-title":"J. Mater. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.msec.2015.11.034","article-title":"Design and characterization of chitosan\/zeolite composite films\u2014Effect of zeolite type and zeolite dose on the film properties","volume":"60","author":"Barbosa","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Hissae Yassue-Cordeiro, P., Zandonai, C.H., Pereira Genesi, B., Santos Lopes, P., Sanchez-Lopez, E., Garcia, M.L., Camargo Fernandes-Machado, N.R., Severino, P., Souto, E.B., and da Silva, C.F. (2019). Development of Chitosan\/Silver Sulfadiazine\/Zeolite Composite Films for Wound Dressing. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11100535"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Khater, D., Nsairat, H., Odeh, F., Saleh, M., Jaber, A., Alshaer, W., Al Bawab, A., and Mubarak, M.S. (2021). Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review. Cosmetics, 8.","DOI":"10.3390\/cosmetics8020039"},{"key":"ref_106","unstructured":"Nosari, A.B.F.L. (2012). Development of Microparticles Containing Green Coffee Oil by Spray Congealing, Universidade de S\u00e3o Paulo."},{"key":"ref_107","first-page":"1","article-title":"Solid Lipid nanoparticles: Colloidal carrier systems for drug delivery","volume":"1","author":"Swathi","year":"2010","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Favaro-Trindade, C.S., de Matos Junior, F.E., Okuro, P.K., Dias-Ferreira, J., Cano, A., Severino, P., Zielinska, A., and Souto, E.B. (2021). Encapsulation of active pharmaceutical ingredients in lipid nanoparticles by spray-cooling. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13081186"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1211\/jpp.61.05.0003","article-title":"Evaluation of solid lipid microparticles produced by spray congealing for topical application of econazole nitrate","volume":"61","author":"Passerini","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijpharm.2012.06.004","article-title":"Novel multifunctional platforms for potential treatment of cutaneous wounds: Development and in vitro characterization","volume":"440","author":"Albertini","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1002\/jps.21636","article-title":"Evaluation of spray congealing as technique for the preparation of highly loaded solid lipid microparticles containing the sunscreen agent, avobenzona","volume":"98","author":"Albertini","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ejps.2008.12.009","article-title":"Polymer-lipid based mucoadhesive microspheres prepared by spray-congealing for the vaginal delivery of econazole nitrate","volume":"36","author":"Albertini","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1211\/jpp.61.09.0001","article-title":"Aminolevulinic acid-loaded Witepsol microparticles manufactured using a spray congealing procedure: Implications for topical photodynamic therapy","volume":"61","author":"Donnelly","year":"2009","journal-title":"J. Pharm. Pharmacol."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/13\/8\/1199\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:40:20Z","timestamp":1760164820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/13\/8\/1199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,4]]},"references-count":113,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["pharmaceutics13081199"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics13081199","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,4]]}}}