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The magnetic\/plasmonic nanoparticles were characterized using XRD, UV\/Visible absorption, HR-TEM, and SQUID, exhibiting superparamagnetic behavior at room temperature. The average size of the gold-decorated nanoparticles was 26.7 nm for MnFe2O4 with 5\u20137 nm gold nanospheres. The average size of the core\/shell nanoparticles was 28.8 nm for the magnetic core and around 4 nm for the gold shell. Two new potential antitumor fluorescent drugs, tricyclic lactones derivatives of thienopyridine, were loaded in these nanosystems with very high encapsulation efficiencies (higher than 98%). Assays in human tumor cell lines demonstrate that the nanocarriers do not release the antitumor compounds in the absence of irradiation. Moreover, the nanosystems do not cause any effect on the growth of primary (non-tumor) cells (with or without irradiation). The drug-loaded systems containing the core\/shell magnetic\/plasmonic nanoparticles efficiently inhibit the growth of tumor cells when irradiated with red light, making them suitable for a triggered release promoted by irradiation.<\/jats:p>","DOI":"10.3390\/pharmaceutics13111905","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T23:04:46Z","timestamp":1636671886000},"page":"1905","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Magnetoliposomes Based on Magnetic\/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy"],"prefix":"10.3390","volume":"13","author":[{"given":"Irina","family":"Rio","sequence":"first","affiliation":[{"name":"Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-1713","authenticated-orcid":false,"given":"Ana","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-1101","authenticated-orcid":false,"given":"Juliana","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Centre of Chemistry (CQUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4322-8035","authenticated-orcid":false,"given":"Maria-Jo\u00e3o","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Centre of Chemistry (CQUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-4578","authenticated-orcid":false,"given":"R.","family":"Calhelha","sequence":"additional","affiliation":[{"name":"Mountain Research Centre, Polytechnic Institute of Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":false,"given":"Isabel","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Mountain Research Centre, Polytechnic Institute of Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"given":"Bernardo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Centre of Physics of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Ana","family":"Pires","sequence":"additional","affiliation":[{"name":"IFIMUP\u2014Instituto de F\u00edsica dos Materiais, Universidade do Porto, R. 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