{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:13:17Z","timestamp":1770462797211,"version":"3.49.0"},"reference-count":70,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Council for Scientific and Technological (CNPq)"},{"name":"Research and Technological Innovation Support Foundation of the State of Sergipe (FAPITEC)"},{"name":"Coordination for the Improvement of Higher Education Personnel (CAPES)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The present work aimed to evaluate the healing effect of hydrophilic polymeric resorbable biomembrane scaffolds containing plant extracts obtained from two different species, both popularly known as Stryphnodendron adstringens or Barbatim\u00e3o. The hydrogel-based scaffolds were characterized and submitted to biological tests using Wistar rats to evaluate their healing capacity. The wound retraction index and the evaluation of the inflammatory process and tissue collagenization were recorded. The extracts showed antioxidant activity with IC50 between 10 and 20 \u00b5g\/mL (DPPH assay) and 4\u20136 mmol Trolox\/g (FRAP assay). The extract of Stryphnodendron adstringens (SA) presented gallocatechin, epigallocatechin, and O-methylpigalocatechin, while the extract of Abarema cochliacarpa (AC) presented catechin, dimers of procyanidins, di-O-hydroxide, O-deoxyhexosi-hexoside, and epicatechin. The membranes containing SA extract (GELSA) were more rigid, with a more intense color, but less thick, with a more compact structure and few pores. The membranes containing AC extract (GELAC) presented a mechanical profile like the gelatin membrane (GEL), with greater permeability to water vapor. The GELAC and GELSA membranes showed similar thermal degradation profiles. The wounds treated with the membranes containing the extracts obtained high levels of retraction of the wounds with values around 60% and 80% in three and seven days, respectively. These data indicate that the compounds of both species have promising biological activities in the repair process, showing that the extracts accelerated the healing process due to the lower intensity of the inflammatory reaction and the presence of compounds such as catechin and epigallocatechin.<\/jats:p>","DOI":"10.3390\/pharmaceutics14102150","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:50:01Z","timestamp":1665449401000},"page":"2150","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hydrophilic Scaffolds Containing Extracts of Stryphnodendron adstringens and Abarema cochliacarpa for Wound Healing: In Vivo Proofs of Concept"],"prefix":"10.3390","volume":"14","author":[{"given":"Maria C. M. A.","family":"Alves","sequence":"first","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"}]},{"given":"Marismar F.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"},{"name":"Department of Nursing, Campus Petrolina, University of Pernambuco, Recife 50100-010, Brazil"}]},{"given":"Bernadeth M.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"},{"name":"Federal Institute of Sergipe, Aracaju 49055-260, Brazil"}]},{"given":"Matheus M. A.","family":"Alves","sequence":"additional","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"}]},{"given":"Isabel B.","family":"Lima-Verde","sequence":"additional","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"}]},{"given":"Daniela S.","family":"Costa","sequence":"additional","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"}]},{"given":"Daniela C. Medeiros","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Ing\u00e1 University Centre, Maring\u00e1 87035-510, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0088-8252","authenticated-orcid":false,"given":"Mariana N.","family":"de Paula","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biology, Palafito, Department of Pharmacy, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-3395","authenticated-orcid":false,"given":"Jo\u00e3o C. P. de","family":"Mello","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biology, Palafito, Department of Pharmacy, State University of Maring\u00e1, Maring\u00e1 87020-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9567-4283","authenticated-orcid":false,"given":"Amanda","family":"Cano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08007 Barcelona, Spain"},{"name":"Institute of Nanoscience and Nanotechnology (IN2UB), 08028 Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patricia","family":"Severino","sequence":"additional","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"},{"name":"Institute of Technology and Research, University of Tiradentes, Aracaju 49032-490, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4444-7632","authenticated-orcid":false,"given":"Ricardo L. C. de","family":"Albuquerque-J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Pathology, Federal University of Santa Catarina, Florian\u00f3polis 88040-370, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"},{"name":"REQUIMTE\/UCIBIO, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-4144","authenticated-orcid":false,"given":"Juliana C.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Post-Graduating Program in Health and Environment, University of Tiradentes, Av. Murilo Dantas, 300, Aracaju 49010-390, Brazil"},{"name":"Institute of Technology and Research, University of Tiradentes, Aracaju 49032-490, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/wound.2019.0946","article-title":"Human Wounds and Its Burden: An Updated Compendium of Estimates","volume":"8","author":"Sen","year":"2019","journal-title":"Adv. Wound Care"},{"key":"ref_2","first-page":"182","article-title":"Wound dressing products: A translational investigation from the bench to the market","volume":"3","author":"Laurano","year":"2022","journal-title":"Eng. Regen."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"47738","DOI":"10.1002\/app.47738","article-title":"Wound dressings: Current advances and future directions","volume":"136","author":"Khalili","year":"2019","journal-title":"J. Appl. Polym. 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