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However, the poor water solubility and low bioavailability of Cur limit its therapeutic effects for clinical applications. A variety of nanocarriers have been successfully developed to improve the water solubility, in vivo distribution, and pharmacokinetics of Cur, as well as to enhance the ability of Cur to polarize macrophages and relieve macrophage oxidative stress or anti-apoptosis, thus accelerating the therapeutic effects of Cur on inflammatory diseases. Herein, we review the design and development of diverse Cur nanoformulations in recent years and introduce the biomedical applications and potential therapeutic mechanisms of Cur nanoformulations in common inflammatory diseases, such as arthritis, neurodegenerative diseases, respiratory diseases, and ulcerative colitis, by regulating macrophage behaviors. Finally, the perspectives of the design and preparation of future nanocarriers aimed at efficiently exerting the biological activity of Cur are briefly discussed.<\/jats:p>","DOI":"10.3390\/pharmaceutics14102239","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:34:30Z","timestamp":1666312470000},"page":"2239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Modulation of Macrophages Using Nanoformulations with Curcumin to Treat Inflammatory Diseases: A Concise Review"],"prefix":"10.3390","volume":"14","author":[{"given":"Huxiao","family":"Sun","sequence":"first","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China"}]},{"given":"Mengsi","family":"Zhan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China"}]},{"given":"Serge","family":"Mignani","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, MMRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"},{"name":"Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique, Universit\u00e9 Paris Descartes, PRES Sorbonne Paris Cit\u00e9, CNRS UMR 860, 45, rue des Saints Peres, 75006 Paris, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1414-4465","authenticated-orcid":false,"given":"Dzmitry","family":"Shcharbin","sequence":"additional","affiliation":[{"name":"Institute of Biophysics and Cell Engineering of NASB, Akademicheskaya 27, 220072 Minsk, Belarus"}]},{"given":"Jean-Pierre","family":"Majoral","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie de Coordination du CNRS, 205 Route de Narbonne, CEDEX 4, 31077 Toulouse, France"},{"name":"Laboratoire de Chimie de Coordination du CNRS, Universit\u00e9 Toulouse, 31077 Toulouse, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4552-1953","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, MMRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-6645","authenticated-orcid":false,"given":"Xiangyang","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China"},{"name":"CQM\u2014Centro de Qu\u00edmica da Madeira, MMRG, Universidade da Madeira, Campus Universit\u00e1rio da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-0854","authenticated-orcid":false,"given":"Mingwu","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41578-022-00426-z","article-title":"Design of therapeutic biomaterials to control inflammation","volume":"7","author":"Tu","year":"2022","journal-title":"Nat. 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