{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:09:43Z","timestamp":1776193783783,"version":"3.50.1"},"reference-count":88,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/QUI-QIN\/0586\/2020"],"award-info":[{"award-number":["PTDC\/QUI-QIN\/0586\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/MED-QUI\/31721\/2017"],"award-info":[{"award-number":["PTDC\/MED-QUI\/31721\/2017"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/135797\/2018"],"award-info":[{"award-number":["SFRH\/BD\/135797\/2018"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["2018-2.1.15-T\u00c9T-PT-2018-00002"],"award-info":[{"award-number":["2018-2.1.15-T\u00c9T-PT-2018-00002"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/QUI-QIN\/0586\/2020"],"award-info":[{"award-number":["PTDC\/QUI-QIN\/0586\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PTDC\/MED-QUI\/31721\/2017"],"award-info":[{"award-number":["PTDC\/MED-QUI\/31721\/2017"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/135797\/2018"],"award-info":[{"award-number":["SFRH\/BD\/135797\/2018"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["2018-2.1.15-T\u00c9T-PT-2018-00002"],"award-info":[{"award-number":["2018-2.1.15-T\u00c9T-PT-2018-00002"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["PTDC\/QUI-QIN\/0586\/2020"],"award-info":[{"award-number":["PTDC\/QUI-QIN\/0586\/2020"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["PTDC\/MED-QUI\/31721\/2017"],"award-info":[{"award-number":["PTDC\/MED-QUI\/31721\/2017"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["SFRH\/BD\/135797\/2018"],"award-info":[{"award-number":["SFRH\/BD\/135797\/2018"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["2018-2.1.15-T\u00c9T-PT-2018-00002"],"award-info":[{"award-number":["2018-2.1.15-T\u00c9T-PT-2018-00002"]}]},{"name":"National Research, Development and Innovation Office-NKFIA of Hungary","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["PTDC\/QUI-QIN\/0586\/2020"],"award-info":[{"award-number":["PTDC\/QUI-QIN\/0586\/2020"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["PTDC\/MED-QUI\/31721\/2017"],"award-info":[{"award-number":["PTDC\/MED-QUI\/31721\/2017"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["SFRH\/BD\/135797\/2018"],"award-info":[{"award-number":["SFRH\/BD\/135797\/2018"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["2018-2.1.15-T\u00c9T-PT-2018-00002"],"award-info":[{"award-number":["2018-2.1.15-T\u00c9T-PT-2018-00002"]}]},{"name":"Portuguese-Hungarian Scientific &amp; Technological Cooperation","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]},{"name":"Lend\u00fclet","award":["UIDB\/04138\/2020"],"award-info":[{"award-number":["UIDB\/04138\/2020"]}]},{"name":"Lend\u00fclet","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]},{"name":"Lend\u00fclet","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Lend\u00fclet","award":["UIDP\/04138\/2020"],"award-info":[{"award-number":["UIDP\/04138\/2020"]}]},{"name":"Lend\u00fclet","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]},{"name":"Lend\u00fclet","award":["PTDC\/QUI-QIN\/0586\/2020"],"award-info":[{"award-number":["PTDC\/QUI-QIN\/0586\/2020"]}]},{"name":"Lend\u00fclet","award":["PTDC\/MED-QUI\/31721\/2017"],"award-info":[{"award-number":["PTDC\/MED-QUI\/31721\/2017"]}]},{"name":"Lend\u00fclet","award":["SFRH\/BD\/135797\/2018"],"award-info":[{"award-number":["SFRH\/BD\/135797\/2018"]}]},{"name":"Lend\u00fclet","award":["TKP-2021-EGA-32"],"award-info":[{"award-number":["TKP-2021-EGA-32"]}]},{"name":"Lend\u00fclet","award":["2018-2.1.15-T\u00c9T-PT-2018-00002"],"award-info":[{"award-number":["2018-2.1.15-T\u00c9T-PT-2018-00002"]}]},{"name":"Lend\u00fclet","award":["LP2019-6\/2019"],"award-info":[{"award-number":["LP2019-6\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Designing new metallodrugs for anticancer therapy is a driving force in the scientific community. Aiming to contribute to this field, we hereby report the development of a Schiff base (H2L) derived from the condensation of 2-carbaldehyde-8-hydroxyquinoline with 2-hydrazinobenzothiazole and its complexation with transition metal ions. All compounds were characterised by analytical and spectroscopic techniques, which disclosed their structure: [Cu(HL)Cl], [Cu(HL)2], [Ni(HL)(acetate)], [Ni(HL)2], [Ru(HL)Cl(DMSO)], [VO(HL)2] and [Fe(HL)2Cl(H2O)]. Different binding modes were proposed, showing the ligand\u2019s coordination versatility. The ligand proton dissociation constants were determined, and the tested compounds showed high lipophilicity and light sensitivity. The stability of all complexes in aqueous media and their ability to bind to albumin were screened. Based on an antiproliferative in vitro screening, [Ni(HL)(acetate)] and [Ru(HL)Cl(DMSO)] were selected for further studies aiming to investigate their mechanisms of action and therapeutic potential towards colon cancer. The complexes displayed IC50 &lt; 21 \u03bcM towards murine (CT-26) and human (HCT-116) colon cancer cell lines. Importantly, both complexes exhibited superior antiproliferative properties compared to the clinically approved 5-fluorouracil. [Ni(HL)(acetate)] induced cell cycle arrest in S phase in CT-26 cells. For [Ru(HL)Cl(DMSO)] this effect was observed in both colon cancer cell lines. Additionally, both compounds significantly inhibited cell migration particularly in the human colon cancer cell line, HCT-116. Overall, the therapeutic potential of both metal complexes was demonstrated.<\/jats:p>","DOI":"10.3390\/pharmaceutics14122583","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T03:58:16Z","timestamp":1669262296000},"page":"2583","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Metal Coordination and Biological Screening of a Schiff Base Derived from 8-Hydroxyquinoline and Benzothiazole"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2725-7781","authenticated-orcid":false,"given":"N\u00e1dia","family":"Ribeiro","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences and Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3833-4105","authenticated-orcid":false,"given":"Pedro F.","family":"Farinha","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-4701","authenticated-orcid":false,"given":"Jacinta O.","family":"Pinho","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-2352","authenticated-orcid":false,"given":"Hugo","family":"Luiz","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6301-5259","authenticated-orcid":false,"given":"J\u00e1nos P.","family":"M\u00e9sz\u00e1ros","sequence":"additional","affiliation":[{"name":"MTA-SZTE Lend\u00fclet Functional Metal Complexes Research Group, Department of Inorganic and Analytical Chemistry, University of Szeged, D\u00f3m t\u00e9r 7, H-6720 Szeged, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4740-0613","authenticated-orcid":false,"given":"Adelino M.","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences and Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3978-9964","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Costa Pessoa","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences and Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8058-8128","authenticated-orcid":false,"given":"\u00c9va A.","family":"Enyedy","sequence":"additional","affiliation":[{"name":"MTA-SZTE Lend\u00fclet Functional Metal Complexes Research Group, Department of Inorganic and Analytical Chemistry, University of Szeged, D\u00f3m t\u00e9r 7, H-6720 Szeged, Hungary"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1046-4031","authenticated-orcid":false,"given":"Catarina Pinto","family":"Reis","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7096-4284","authenticated-orcid":false,"given":"Isabel","family":"Correia","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences and Departamento de Engenharia Qu\u00edmica, Instituto Superior T\u00e9cnico, Universidade de Lisboa, Av. Rovisco Pais, 1, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6814-7226","authenticated-orcid":false,"given":"Maria Manuela","family":"Gaspar","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines, iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"ref_2","unstructured":"(2022, August 21). European Commission: Eurostat. Available online: https:\/\/ec.europa.eu\/eurostat\/en\/web\/products-eurostat-news\/-\/edn-20200204-1."},{"key":"ref_3","unstructured":"(2022, August 21). International Agency for Research on Cancer. Available online: https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/620-portugal-fact-sheets.pdf."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s13346-021-00916-7","article-title":"Nanomedicines in the treatment of colon cancer: A focus on metallodrugs","volume":"12","author":"Farinha","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.soc.2017.11.001","article-title":"Systemic Therapy for Colon Cancer","volume":"27","author":"Wu","year":"2018","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.bioorg.2019.102925","article-title":"Cisplatin: The first metal based anticancer drug","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/med.10038","article-title":"Platinum-based anticancer agents: Inovative design strategies and biological perspectives","volume":"23","author":"Ho","year":"2003","journal-title":"Med. Res. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2174\/138161210791209009","article-title":"Novel Metals and Metal Complexes as Platforms for Cancer Therapy","volume":"16","author":"Frezza","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2174\/18715206113139990312","article-title":"Benzothiazoles: How Relevant in Cancer Drug Design Strategy?","volume":"14","author":"Singh","year":"2014","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1039\/C4MD00284A","article-title":"8-Hydroxyquinoline: A privileged structure with a broad-ranging pharmacological potential","volume":"6","author":"Song","year":"2015","journal-title":"Medchemcomm"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejmech.2014.08.039","article-title":"Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones","volume":"86","author":"Lindgren","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1021\/mp400592n","article-title":"Oxidative Stress Induced by Copper and Iron Complexes with 8-Hydroxyquinoline Derivatives Causes Paraptotic Death of HeLa Cancer Cells","volume":"11","author":"Barilli","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/ml300238z","article-title":"Synthesis of 8-Hydroxyquinoline Derivatives as Novel Antitumor Agents","volume":"4","author":"Chan","year":"2013","journal-title":"Acs Med. Chem. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.biopha.2016.03.014","article-title":"Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride","volume":"80","author":"Lam","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cbi.2018.08.006","article-title":"Small benzothiazole molecule induces apoptosis and prevents metastasis through DNA interaction and c-MYC gene supression in diffuse-type gastric adenocarcinoma cell line","volume":"294","author":"Mesquita","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1038\/s41598-017-02489-3","article-title":"A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2\/M Arrest In Cancer Cells","volume":"7","author":"Hegde","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bmcl.2013.10.072","article-title":"Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus","volume":"24","author":"Lam","year":"2014","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molstruc.2018.10.070","article-title":"Synthesis, structural investigations, DFT, molecular docking and antifungal studies of transition metal complexes with benzothiazole based Schiff base ligands","volume":"1179","author":"Mohapatra","year":"2019","journal-title":"J. Mol. Struct."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1021\/acs.jmedchem.6b01393","article-title":"Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays","volume":"60","author":"Bremer","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6178","DOI":"10.1021\/ic9005136","article-title":"Benzothiazole- and Benzoxazole-Substituted Pyridine-2-Carboxylates as Efficient Sensitizers of Europium Luminescence","volume":"48","author":"Shavaleev","year":"2009","journal-title":"Inorg. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"20139","DOI":"10.1039\/C5DT03719K","article-title":"A 2-(2\u2032-hydroxyphenyl)benzothiazole (HBT)-quinoline conjugate: A highly specific fluorescent probe for Hg2+ based on ESIPT and its application in bioimaging","volume":"44","author":"Sahana","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jinorgbio.2014.04.002","article-title":"Synthesis, characterization, crystal structures and biological activity of set of Cu(II) benzothiazole complexes: Artificial nucleases with cytotoxic activities","volume":"137","author":"Steiner","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ribeiro, N., Albino, M., Ferreira, A., Escrevente, C., Barral, D.C., Pessoa, J.C., Reis, C.P., Gaspar, M.M., and Correia, I. (2022). Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23126728"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/ic00004a005","article-title":"Synthesis, molecular structure, and chemical behavior of hydrogen trans-bis(dimethyl sulfoxide)tetrachlororuthenate(III) and mer-trichlorotris(dimethyl sulfoxide)ruthenium(III): The first fully characterized chloride-dimethyl sulfoxide-ruthenium(III) comp","volume":"30","author":"Alessio","year":"1991","journal-title":"Inorg. Chem."},{"key":"ref_25","unstructured":"Menges, F. (2022, October 28). Spectragryph\u2014Optical Spectroscopy Software Version 1.2.16.1. Available online: http:\/\/www.effemm2.de\/spectragryph\/."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jinorgbio.2012.08.005","article-title":"Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands","volume":"117","author":"Enyedy","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"16887","DOI":"10.1039\/D0DT03465G","article-title":"Complex formation and cytotoxicity of Triapine derivatives: A comparative solution study on the effect of the chalcogen atom and NH-methylation","volume":"49","author":"Enyedy","year":"2020","journal-title":"Dalton Trans."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zekany, L., and Nagypal, I. (1985). PSEQUAD. Computational Methods for the Determination of Formation Constants, Springer.","DOI":"10.1007\/978-1-4684-4934-1_8"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1021\/ed070p425","article-title":"Ribonuclease-T(1) and Alcohol-Dehydrogenase fluorescence quenching by acrylamide\u2014A laboratory experiment for undergraduate students","volume":"70","author":"Coutinho","year":"1993","journal-title":"J. Chem. Educ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1021\/ed300599d","article-title":"Application of Ratiometric Measurements and Microplate Fluorimetry to Protein Denaturation: An Experiment for Analytical and Biochemistry Students","volume":"90","year":"2013","journal-title":"J. Chem. Educ."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lakowicz, J.R. (2007). Principles of Fluorescence Spectroscopy, Springer. [3rd ed.].","DOI":"10.1007\/978-0-387-46312-4"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Santos-Rebelo, A., Garcia, C., Eleut\u00e9rio, C., Bastos, A., Coelho, S.C., Coelho, M.A.N., Molpeceres, J., Viana, A.S., Ascens\u00e3o, L., and Pinto, J.F. (2018). Development of Parvifloron D-Loaded Smart Nanoparticles to Target Pancreatic Cancer. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10040216"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2217\/nnm-2016-0086","article-title":"Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells","volume":"11","author":"Nave","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Brito, H., Martins, A.C., Lavrado, J., Mendes, E., Francisco, A.P., Santos, S.A., Ohnmacht, S.A., Kim, N.S., Rodrigues, C.M.P., and Moreira, R. (2015). Targeting KRAS oncogene in colon cancer cells with 7-carboxylate Indolo[3,2-b] quinoline tri-alkylamine derivatives. PLOS ONE, 10.","DOI":"10.1371\/journal.pone.0126891"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.24218\/jnat.2016.16","article-title":"Nanoformulations of a Triazene Analogue with Specific Affinity to Human Melanoma","volume":"1","author":"Calado","year":"2016","journal-title":"J. Nanosci. Adv. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"120463","DOI":"10.1016\/j.ijpharm.2021.120463","article-title":"Therapeutic Potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management","volume":"599","author":"Pinho","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Pimp\u00e3o, C., da Silva, I.V., M\u00f3sca, A.F., Pinho, J.O., Gaspar, M.M., Gumerova, N.I., Rompel, A., Aureliano, M., and Soveral, G. (2020). The aquaporin-3-inhibiting potential of polyoxotungstates. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21072467"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jcc.540141112","article-title":"General atomic and molecular electronic structure system","volume":"14","author":"Schmidt","year":"1993","journal-title":"J. Comput. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/j.1751-1097.1968.tb08038.x","article-title":"Correlation of orbital classification of molecular electronic transitions with transition mechanism: The aromatic amines*","volume":"7","author":"Kasha","year":"1968","journal-title":"Photochem. Photobiol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Tisovsk\u00fd, P., Horv\u00e1th, M., Csicsai, K., Donovalov\u00e1, J., Filo, J., Cig\u00e1\u0148, M., Sokol\u00edk, R., Addov\u00e1, G., and G\u00e1plovsk\u00fd, A. (2019). Isatin-1,8-naphthalimide hydrazones: A study of their sensor and on\/off functionality. Molecules, 24.","DOI":"10.3390\/molecules24030397"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1021\/ic00242a006","article-title":"Phosphorescent 8-quinolinol metal chelates. Excited-state properties and redox behavior","volume":"25","author":"Ballardini","year":"1986","journal-title":"Inorg. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0013-4686(76)85034-7","article-title":"Empirical parameters for donor and acceptor properties of solvents","volume":"21","author":"Gutmann","year":"1976","journal-title":"Electrochim. Acta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"6401","DOI":"10.1021\/ic970868z","article-title":"Structural and Electron Paramagnetic Resonance Studies of the Square Pyramidal to Trigonal Bipyramidal Distortion of Vanadyl Complexes Containing Sterically Crowded Schiff Base Ligands","volume":"36","author":"Cornman","year":"1997","journal-title":"Inorg. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1021\/acs.accounts.5b00068","article-title":"Amine functionalization via oxidative photoredox catalysis: Methodology development and complex molecule synthesis","volume":"48","author":"Beatty","year":"2015","journal-title":"Acc. Chem. Res."},{"key":"ref_45","first-page":"781","article-title":"Formation of acetone thiosemicarbazone complex of ruthenium via usual chelation and unexpected fragmentation: Characterization and catalytic application","volume":"93","author":"Dhibar","year":"2016","journal-title":"J. Indian Chem. Soc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF03163097","article-title":"Automatic computer simulations of ESR spectra","volume":"10","author":"Rockenbauer","year":"1996","journal-title":"Appl. Magn. Reson."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1021\/ed083p1229","article-title":"The Determination of the Geometry of Cu(II) Complexes: An EPR Spectroscopy Experiment","volume":"83","author":"Garribba","year":"2006","journal-title":"J. Chem. Educ."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0003-9861(74)90298-7","article-title":"Structural implications derived from analysis of electron-paramagnetic resonance-spectra of natural and artificial copper proteins","volume":"165","author":"Peisach","year":"1974","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"8347","DOI":"10.1039\/c3dt32992e","article-title":"Copper(ii) complexes with 2NO and 3N donor ligands: Synthesis, structures and chemical nuclease and anticancer activities","volume":"42","author":"Rajarajeswari","year":"2013","journal-title":"Dalton Trans."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Chasteen, N.D. (1981). Vanadyl(IV) EPR Spin Probes Inorganic and Biochemical Aspects. Biological Magnetic Resonance, Springer.","DOI":"10.1007\/978-1-4613-3201-5_2"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"17756","DOI":"10.1039\/C9NJ02589H","article-title":"Exploring oxidovanadium(iv) homoleptic complexes with 8-hydroxyquinoline derivatives as prospective antitrypanosomal agents","volume":"43","author":"Scalese","year":"2019","journal-title":"New J. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Collison, D., Gahan, B., and Mabbs, F.E. (1987). The single-crystal electron spin resonance spectrum of oxobis(2-methylquinolin-8-olato)vanadium(IV) as a pure compound and diluted in chlorobis(2-methylquinolin-8-olato)gallium(III). J. Chem. Soc. Dalton Trans., 111\u2013117.","DOI":"10.1039\/dt9870000111"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"12743","DOI":"10.1002\/slct.201903678","article-title":"Vanadium(V) and Molybdenum(VI) Complexes Containing ONO Tridentate Schiff Bases and Their Application as Catalysts for Oxidative Bromination of Phenols","volume":"4","author":"Maurya","year":"2019","journal-title":"ChemistrySelect"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/chem.201002308","article-title":"Configurational and Constitutional Information Storage: Multiple Dynamics in Systems Based on Pyridyl and Acyl Hydrazones","volume":"17","author":"Chaur","year":"2011","journal-title":"Chem.-A Eur. J."},{"key":"ref_55","unstructured":"(2018). Marvin, ChemAxon. version 18.23.0."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"111097","DOI":"10.1016\/j.jinorgbio.2020.111097","article-title":"Nickel and zinc complexes of testosterone N4-substituted thiosemicarbazone: Selective cytotoxicity towards human colorectal carcinoma cell line HCT 116 and their cell death mechanisms","volume":"208","author":"Heng","year":"2020","journal-title":"J. Inorg. Biochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.saa.2011.05.062","article-title":"Synthesis, spectral characterization, solution equilibria, in vitro antibacterial and cytotoxic activities of Cu(II), Ni(II), Mn(II), Co(II) and Zn(II) complexes with Schiff base derived from 5-bromosalicylaldehyde and 2-aminomethylthiophene","volume":"79","author":"Eldebss","year":"2011","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ddr.21559","article-title":"Schiff base-nickel, palladium, and platinum complexes derived from N -cyclohexyl hydrazine carbothioamide and 3-hydroxy-4-methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma","volume":"80","author":"Arafath","year":"2019","journal-title":"Drug Dev. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"111549","DOI":"10.1016\/j.jinorgbio.2021.111549","article-title":"Synthesis, characterization of ruthenium(II), nickel(II), palladium(II), and platinum(II) triphenylphosphine-based complexes bearing an ONS-donor chelating agent: Interaction with biomolecules, antioxidant, in vitro cytotoxic, apoptotic activity and cell","volume":"223","author":"Elsayed","year":"2021","journal-title":"J. Inorg. Biochem."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Savic, M., Arsenijevic, A., Milovanovic, J., Stojanovic, B., Stankovic, V., Rilak Simovic, A., Lazic, D., Arsenijevic, N., and Milovanovic, M. (2020). Antitumor Activity of Ruthenium(II) Terpyridine Complexes towards Colon Cancer Cells In Vitro and In Vivo. Molecules, 25.","DOI":"10.3390\/molecules25204699"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1021\/acs.organomet.5b00868","article-title":"Impact of the Halogen Substitution Pattern on the Biological Activity of Organoruthenium 8-Hydroxyquinoline Anticancer Agents","volume":"34","author":"Kubanik","year":"2015","journal-title":"Organometallics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"112763","DOI":"10.1016\/j.ejmech.2020.112763","article-title":"Potent half-sandwich Ru(\u2161) N^N (aryl-BIAN) complexes: Lysosome-mediated apoptosis, in vitro and in vivo anticancer activities","volume":"207","author":"Xu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"110768","DOI":"10.1016\/j.jinorgbio.2019.110768","article-title":"Hydroxyquinoline-derived anticancer organometallics: Introduction of amphiphilic PTA as an ancillary ligand increases their aqueous solubility","volume":"199","author":"Tremlett","year":"2019","journal-title":"J. Inorg. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41598-017-18639-6","article-title":"A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells","volume":"8","author":"Silva","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10637-014-0179-1","article-title":"Phase I\/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy","volume":"33","author":"Leijen","year":"2015","journal-title":"Investig. New Drugs"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1158\/1078-0432.CCR-03-0746","article-title":"A phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent","volume":"10","author":"Pluim","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jinorgbio.2016.02.025","article-title":"Inhibition of adhesion, migration and of \u03b15\u03b21 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A","volume":"160","author":"Pelillo","year":"2016","journal-title":"J. Inorg. Biochem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1039\/D1DT00185J","article-title":"A new bis-pyrazolylpyridine ruthenium(III) complex as a potential anticancer drug: In vitro and in vivo activity in murine colon cancer","volume":"50","author":"Lazic","year":"2021","journal-title":"Dalton Trans."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.2174\/1568026043387421","article-title":"Gianni Sava Ruthenium Antimetastatic Agents","volume":"4","author":"Alessio","year":"2004","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4939-0888-2_2","article-title":"Cell cycle regulation by Checkpoints","volume":"1170","author":"Barnum","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Fahmy, U.A., Aldawsari, H.M., Badr-Eldin, S.M., Ahmed, O.A.A., Alhakamy, N.A., Alsulimani, H.H., Caraci, F., and Caruso, G. (2020). The encapsulation of febuxostat into emulsomes strongly enhances the cytotoxic potential of the drug on HCT 116 colon cancer cells. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12100956"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Juan-Garc\u00eda, A., Tolosa, J., Juan, C., and Ruiz, M.J. (2019). Cytotoxicity, genotoxicity and disturbance of cell cycle in hepg2 cells exposed to OTA and BEA: Single and combined actions. Toxins, 11.","DOI":"10.3390\/toxins11060341"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2015.11.005","article-title":"Preparation of 4-([2,2\u2032:6\u2032,2g\u20ac3-terpyridin]-4\u2032-yl)-N,N-diethylaniline NiII and PtII complexes and exploration of their in vitro cytotoxic activities","volume":"108","author":"Zou","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_74","first-page":"100","article-title":"A \u03b2-carboline derivative-based nickel(II) complex as a potential antitumor agent: Synthesis, characterization, and cytotoxicity","volume":"9","author":"Yang","year":"2018","journal-title":"R. Soc. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/mc.22792","article-title":"Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer","volume":"57","author":"Roy","year":"2018","journal-title":"Mol. Carcinog."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"7690845","DOI":"10.1155\/2020\/7690845","article-title":"Decrypting the Molecular Mechanistic Pathways Delineating the Chemotherapeutic Potential of Ruthenium-Phloretin Complex in Colon Carcinoma Correlated with the Oxidative Status and Increased Apoptotic Events","volume":"2020","author":"Jin","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Arafat, M., Fouladian, P., Wignall, A., Song, Y., Parikh, A., Albreacht, H., Prestidge, C.A., Garg, S., and Blencowe, A. (2020). Development and in vitro evaluation of 5-fluorouracil-eluting stents for the treatment of colorectal cancer and cancer-related obstruction. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13010017"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1476-4598-5-20","article-title":"Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery","volume":"5","author":"Svendsrud","year":"2006","journal-title":"Mol. Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"112484","DOI":"10.1016\/j.fct.2021.112484","article-title":"Strawberry tree honey in combination with 5-fluorouracil enhances chemosensitivity in human colon adenocarcinoma cells","volume":"156","author":"Afrin","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"102144","DOI":"10.1016\/j.redox.2021.102144","article-title":"Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells","volume":"47","author":"Yang","year":"2021","journal-title":"Redox Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ejmech.2014.05.075","article-title":"Biological evaluation of new nickel(II) metallates: Synthesis, DNA\/protein binding and mitochondrial mediated apoptosis in human lung cancer cells (A549) via ROS hypergeneration and depletion of cellular antioxidant pool","volume":"82","author":"Kalaivani","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Yang, Q.-Y., Cao, Q.-Q., Qin, Q.-P., Deng, C.-X., Liang, H., and Chen, Z.-F. (2018). Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19071874"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"112605","DOI":"10.1016\/j.ejmech.2020.112605","article-title":"Novel NHC-coordinated ruthenium(II) arene complexes achieve synergistic efficacy as safe and effective anticancer therapeutics","volume":"203","author":"Chen","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fcell.2019.00107","article-title":"In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis","volume":"7","author":"Pijuan","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S1470-2045(04)01431-7","article-title":"Tumour-cell migration, invasion, and metastasis: Navigation by neurotransmitters","volume":"5","author":"Entschladen","year":"2004","journal-title":"Lancet Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9064","DOI":"10.1039\/D0NJ00921K","article-title":"Antitumor effects of novel nickel-hydrazone complexes in lung cancer cells","volume":"44","author":"Ay","year":"2020","journal-title":"New J. Chem."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"132458","DOI":"10.1016\/j.molstruc.2022.132458","article-title":"Synthesis, structure and anticancer studies of Cu(\u2161) and Ni(\u2161) complexes based on 2-hydroxy-1-naphthaldehyde-4-aminoantipyrine Schiff-base","volume":"1255","author":"Qi","year":"2022","journal-title":"J. Mol. Struct."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7733","DOI":"10.1021\/jm050758z","article-title":"Novel Lavendamycin Analogues as Antitumor Agents: Synthesis, in Vitro Cytotoxicity, Structure\u2212Metabolism, and Computational Molecular Modeling Studies with NAD(P)H:Quinone Oxidoreductase 1","volume":"48","author":"Hassani","year":"2005","journal-title":"J. Med. Chem."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/12\/2583\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:49Z","timestamp":1760145949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/14\/12\/2583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":88,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["pharmaceutics14122583"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics14122583","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]}}}