{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:55:49Z","timestamp":1777895749578,"version":"3.51.4"},"reference-count":163,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Curcumin (CUR) is a polyphenol extracted from the rhizome of Curcuma longa that possesses potent anti-inflammatory and antioxidant potential. Despite CUR\u2019s numerous beneficial effects on human health, it has limitations, such as poor absorption. Nano-based drug delivery systems have recently been applied to improve CUR\u2019s solubility and bioavailability and potentialize its health effects. This review investigated the effects of different CUR-based nanomedicines on inflammatory and immunomodulated diseases. PUBMED, EMBASE, COCHRANE, and GOOGLE SCHOLAR databases were searched, and the Scale for Assessment of Narrative Review Articles (SANRA) was used for quality assessment and PRISMA guidelines. Overall, 66 studies were included comprising atherosclerosis, rheumatoid arthritis (RA), Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), multiple sclerosis (MS), Huntington\u2019s disease (HD), inflammatory bowel diseases (IBD), psoriasis, liver fibrosis, epilepsy, and COVID-19. The available scientific studies show that there are many known nanoformulations with curcumin. They can be found in nanosuspensions, nanoparticles, nanoemulsions, solid lipid particles, nanocapsules, nanospheres, and liposomes. These formulations can improve CUR bioavailability and can effectively be used as adjuvants in several inflammatory and immune-mediated diseases such as atheroma plaque formation, RA, dementia, AD, PD, MS, IBD, psoriasis, epilepsy, COVID-19, and can be used as potent anti-fibrotic adjuvants in fibrotic liver disease.<\/jats:p>","DOI":"10.3390\/pharmaceutics15010229","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T01:30:47Z","timestamp":1673314247000},"page":"229","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["Curcumin-Based Nanomedicines in the Treatment of Inflammatory and Immunomodulated Diseases: An Evidence-Based Comprehensive Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3159-0982","authenticated-orcid":false,"given":"Lucas Fornari","family":"Laurindo","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Mar\u00edlia, S\u00e3o Paulo 17525-902, Brazil"}]},{"given":"Gabriel Magno","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Mar\u00edlia, S\u00e3o Paulo 17525-902, Brazil"}]},{"given":"B\u00e1rbara","family":"de Oliveira Zanuso","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Mar\u00edlia, S\u00e3o Paulo 17525-902, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1561-6858","authenticated-orcid":false,"given":"Maria Eduardo","family":"Figueira","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Integration Pharmacology, Clinical & Regulatory Science, Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"},{"name":"Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4143-4302","authenticated-orcid":false,"given":"Rosa","family":"Direito","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Integration Pharmacology, Clinical & Regulatory Science, Research Institute for Medicines (iMed.ULisboa), Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"},{"name":"Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"given":"Ricardo","family":"de Alvares Goulart","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Mar\u00edlia, S\u00e3o Paulo 17525-902, Brazil"},{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Mar\u00edlia, S\u00e3o Paulo 17525-902, Brazil"}]},{"given":"Daiene Santos","family":"Buglio","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Mar\u00edlia, S\u00e3o Paulo 17525-902, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-876X","authenticated-orcid":false,"given":"Sandra Maria","family":"Barbalho","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, School of Medicine, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Mar\u00edlia, S\u00e3o Paulo 17525-902, Brazil"},{"name":"Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Mar\u00edlia (UNIMAR), Avenida Hygino Muzzy Filho, 1001, Mar\u00edlia, S\u00e3o Paulo 17525-902, Brazil"},{"name":"Department of Biochemistry and Nutrition, School of Food and Technology of Mar\u00edlia (FATEC), Avenida Castro Alves, 62, Mar\u00edlia, S\u00e3o Paulo 17500-000, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3149223","DOI":"10.1155\/2021\/3149223","article-title":"Nano-Derived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases","volume":"2021","author":"Quispe","year":"2021","journal-title":"Oxid. 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