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Furthermore, MNs can also be used as a stand-alone tool to be combined with microfluidic devices. For that purpose, lab- or organ-on-a-chip are being developed. This systematic review aims to summarize the most recent progress in these emerging systems, to identify their advantages and limitations, and discuss promising potential applications of MNs in microfluidics. Therefore, three databases were used to search papers of interest, and their selection was made following the guidelines for systematic reviews proposed by PRISMA. In the selected studies, the MNs type, fabrication strategy, materials, and function\/application were evaluated. The literature reviewed showed that although the use of MNs for lab-on-a-chip has been more explored than for organ-on-a-chip, some recent studies have explored this applicability with great potential for the monitoring of organ models. 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Bioelectron."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.protcy.2015.07.010","article-title":"Lab-on-a-chip or Chip-in-a-lab: Challenges of Commercialization Lost in Translation","volume":"20","author":"Mohammed","year":"2015","journal-title":"Procedia Technol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.mee.2014.09.024","article-title":"Point-of-care testing (POCT) diagnostic systems using microfluidic lab-on-a-chip technologies","volume":"132","author":"Jung","year":"2015","journal-title":"Microelectron. Eng."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"14631","DOI":"10.1021\/acs.analchem.9b03774","article-title":"Portable Microfluidic Biosensing System for Real-Time Analysis of Microdialysate in Transplant Kidneys","volume":"91","author":"Samper","year":"2019","journal-title":"Anal. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1021\/acsnano.9b08349","article-title":"A Cell-Phone-Based Acoustofluidic Platform for Quantitative Point-of-Care Testing","volume":"14","author":"Zhang","year":"2020","journal-title":"ACS Nano"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"114626","DOI":"10.1016\/j.bios.2022.114626","article-title":"Organ-on-a-chip: A new tool for in vitro research","volume":"216","author":"Yan","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"ref_8","first-page":"10","article-title":"Microphysiological systems: Analysis of the current status, challenges and commercial future","volume":"2","author":"Ribas","year":"2018","journal-title":"Microphysiol. Syst."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bios.2014.07.029","article-title":"Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices","volume":"63","author":"Halldorsson","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.tifs.2021.02.049","article-title":"Microfluidic based human-on-a-chip: A revolutionary technology in scientific research","volume":"110","author":"Syama","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"123262","DOI":"10.1016\/j.talanta.2022.123262","article-title":"Design and fabrication of an integrated 3D dynamic multicellular liver-on-a-chip and its application in hepatotoxicity screening","volume":"241","author":"Zheng","year":"2022","journal-title":"Talanta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"113080","DOI":"10.1016\/j.bios.2021.113080","article-title":"Design and fabrication of an integrated heart-on-a-chip platform for construction of cardiac tissue from human iPSC-derived cardiomyocytes and in situ evaluation of physiological function","volume":"179","author":"Zhang","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12015-017-9738-0","article-title":"Microphysiological Human Brain and Neural Systems-on-a-Chip: Potential Alternatives to Small Animal Models and Emerging Platforms for Drug Discovery and Personalized Medicine","volume":"13","author":"Haring","year":"2017","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/S0378-4274(21)00384-2","article-title":"Development of a kidney-on-a-chip model that replicates an antisense oligonucleotide-induced kidney injury biomarker response","volume":"350","author":"Nieskens","year":"2021","journal-title":"Toxicol. Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.xphs.2021.07.014","article-title":"Comprehensive Development in Organ-On-A-Chip Technology","volume":"111","author":"Joseph","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2003517","DOI":"10.1002\/smll.202003517","article-title":"Organ-on-a-Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine","volume":"16","author":"Rodrigues","year":"2020","journal-title":"Small"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.pnsc.2020.09.016","article-title":"Micro\/nano needles for advanced drug delivery","volume":"30","author":"Meng","year":"2020","journal-title":"Prog. Nat. Sci. Mater. Int."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12478","DOI":"10.1021\/acsami.9b22425","article-title":"A Novel Transdermal Protein Delivery Strategy via Electrohydrodynamic Coating of PLGA Microparticles onto Microneedles","volume":"12","author":"Angkawinitwong","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nmat4249","article-title":"Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization","volume":"14","author":"Chiappini","year":"2015","journal-title":"Nat. Mater"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejpb.2020.10.002","article-title":"Study on the fabrication and characterization of tip-loaded dissolving microneedles for transdermal drug delivery","volume":"157","author":"Zhuang","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jconrel.2014.05.004","article-title":"Organ-on-a-chip platforms for studying drug delivery systems","volume":"190","author":"Bhise","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.biopha.2018.10.078","article-title":"Microneedles: A smart approach and increasing potential for transdermal drug delivery system","volume":"109","author":"Waghule","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jmapro.2020.02.024","article-title":"Optimal design and fabrication of a microneedle arrays patch","volume":"54","author":"Chang","year":"2020","journal-title":"J. Manuf. Process."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"103119","DOI":"10.1016\/j.jddst.2022.103119","article-title":"Step-wise micro-fabrication techniques of microneedle arrays with applications in transdermal drug delivery\u2014A review","volume":"68","author":"Sonetha","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"15325","DOI":"10.1038\/srep15325","article-title":"Oscillating high-aspect-ratio monolithic silicon nanoneedle array enables efficient delivery of functional bio-macromolecules into living cells","volume":"5","author":"Matsumoto","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kaur, R., Arora, S., and Goswami, M. (2022). Advancement in microneedles as minimally invasive delivery system for pharmaceutical and biomedical application: A review. Mater. TodayProc.","DOI":"10.1016\/j.matpr.2022.11.182"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ajps.2021.07.002","article-title":"Polymeric microneedle-mediated sustained release systems: Design strategies and promising applications for drug delivery","volume":"17","author":"Yang","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_28","unstructured":"Li, X. (James), and Zhou, Y. (2021). Microfluidic Devices for Biomedical Applications, Woodhead Publishing. [2nd ed.]. Woodhead Publishing Series in Biomaterials."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.addr.2013.05.008","article-title":"Design, fabrication and characterization of drug delivery systems based on lab-on-a-chip technology","volume":"65","author":"Nguyen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.09.013","article-title":"Recent advances of controlled drug delivery using microfluidic platforms","volume":"128","author":"Sanjay","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"102477","DOI":"10.1016\/j.jddst.2021.102477","article-title":"Design and optimization of a microneedle with skin insertion analysis for transdermal drug delivery applications","volume":"63","author":"Sawon","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1109\/TMECH.2015.2476362","article-title":"A High-Throughput Automated Microinjection System for Human Cells With Small Size","volume":"21","author":"Chow","year":"2016","journal-title":"IEEE\/ASME Trans. Mechatron."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.matpr.2022.08.337","article-title":"Prospection of fabrication techniques and material selection of microneedles for transdermal drug delivery: An update on clinical trials","volume":"69","author":"Naveen","year":"2022","journal-title":"Mater. Today Proc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s10856-021-06559-x","article-title":"A systematic review of carbohydrate-based microneedles: Current status and future prospects","volume":"32","author":"Bhadale","year":"2021","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jare.2020.07.017","article-title":"Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems","volume":"26","author":"Meng","year":"2020","journal-title":"J. Adv. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11706-018-0409-0","article-title":"Graphene: From synthesis to engineering to biosensor applications","volume":"12","author":"Singh","year":"2018","journal-title":"Front. Mater. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"101923","DOI":"10.1016\/j.jddst.2020.101923","article-title":"A review of recent advances in microneedle technology for transdermal drug delivery","volume":"59","author":"Nagarkar","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.3390\/polym13162815","article-title":"A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications","volume":"13","author":"Aldawood","year":"2021","journal-title":"Polymers"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1007\/s13346-017-0466-4","article-title":"An update on coating\/manufacturing techniques of microneedles","volume":"8","author":"Tarbox","year":"2018","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"16049","DOI":"10.1038\/micronano.2016.49","article-title":"Scalable fabrication of microneedle arrays via spatially controlled UV exposure","volume":"2","author":"Takahashi","year":"2016","journal-title":"Microsyst. Nanoeng."},{"key":"ref_41","first-page":"45","article-title":"Nickel Microneedles Fabricated by Sequential Copper and Nickel Electroless Plating and Copper Chemical Wet Etching","volume":"20","author":"Jung","year":"2008","journal-title":"Sens. Mater."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"38755","DOI":"10.1038\/srep38755","article-title":"Microneedles with Controlled Bubble Sizes and Drug Distributions for Efficient Transdermal Drug Delivery","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.sna.2006.11.022","article-title":"Laser fabrication of high aspect ratio thin holes on biodegradable polymer and its application to a microneedle","volume":"139","author":"Aoyagi","year":"2007","journal-title":"Sens. Actuators A Phys."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jconrel.2013.05.026","article-title":"Droplet-born air blowing: Novel dissolving microneedle fabrication","volume":"170","author":"Kim","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mfglet.2021.10.007","article-title":"Rapid prototyping and customizable microneedle design: Ultra-sharp microneedle fabrication using two-photon polymerization and low-cost micromolding techniques","volume":"30","author":"Prewett","year":"2021","journal-title":"Manuf. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ijpharm.2018.03.031","article-title":"3D printed microneedles for insulin skin delivery","volume":"544","author":"Pere","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s10544-009-9311-y","article-title":"In vivo evaluation of a microneedle-based miniature syringe for intradermal drug delivery","volume":"11","author":"Mokhtari","year":"2009","journal-title":"Biomed. Microdevices"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.snb.2011.11.085","article-title":"Multiplexed and switchable release of distinct fluids from microneedle platforms via conducting polymer nanoactuators for potential drug delivery","volume":"161","author":"Windmiller","year":"2012","journal-title":"Sens. Actuators B Chem."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Liberati, A., Altman, D.G., Tetzlaff, J., Mulrow, C., G\u00f8tzsche, P.C., Ioannidis, J.P.A., Clarke, M., Devereaux, P.J., Kleijnen, J., and Moher, D. (2009). The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000100"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"b2535","DOI":"10.1136\/bmj.b2535","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"339","author":"Moher","year":"2009","journal-title":"BMJ"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/adhm.201500450","article-title":"Microneedles for Transdermal Biosensing: Current Picture and Future Direction","volume":"4","author":"Ventrelli","year":"2015","journal-title":"Adv. Healthc. Mater."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10544-012-9683-2","article-title":"An optimized hollow microneedle for minimally invasive blood extraction","volume":"15","author":"Li","year":"2013","journal-title":"Biomed. Microdevices"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41551-020-00672-y","article-title":"Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid","volume":"5","author":"Wang","year":"2021","journal-title":"Nat. Biomed. Eng."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40580-018-0161-2","article-title":"Functionalized microneedles for continuous glucose monitoring","volume":"5","author":"Takeuchi","year":"2018","journal-title":"Nano Converg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.coelec.2019.05.012","article-title":"Microneedles-based electrochemical sensors: New tools for advanced biosensing","volume":"17","author":"Dardano","year":"2019","journal-title":"Curr. Opin. Electrochem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/s41467-021-20948-4","article-title":"Transdermal electroosmotic flow generated by a porous microneedle array patch","volume":"12","author":"Kusama","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1039\/D1LC00067E","article-title":"High-throughput organ-on-chip platform with integrated programmable fluid flow and real-time sensing for complex tissue models in drug development workflows","volume":"21","author":"Azizgolshani","year":"2021","journal-title":"Lab Chip"},{"key":"ref_58","unstructured":"Zimmermann, S., Fienbork, D., Stoeber, B., Flounders, A.W., and Liepmann, D. (2003, January 8\u201312). A microneedle-based glucose monitor: Fabricated on a wafer-level using in-device enzyme immobilization. Proceedings of the TRANSDUCERS \u201903, 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers (Cat. No.03TH8664), Boston, MA, USA."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"129569","DOI":"10.1016\/j.snb.2021.129569","article-title":"Fabrication of a microdialysis-based nonenzymatic microfluidic sensor for regular glucose measurement","volume":"333","author":"Najmi","year":"2021","journal-title":"Sens. Actuators B Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e00723","DOI":"10.1016\/j.btre.2022.e00723","article-title":"Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement","volume":"34","author":"Najmi","year":"2022","journal-title":"Biotechnol. Rep."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s10544-019-0370-4","article-title":"Microfluidic chip to interface porous microneedles for ISF collection","volume":"21","author":"Takeuchi","year":"2019","journal-title":"Biomed. Microdevices"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s13346-021-01050-0","article-title":"Microfluidic chip connected to porous microneedle array for continuous ISF sampling","volume":"12","author":"Takeuchi","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/adhm.201300541","article-title":"Microneedle-Based Transdermal Sensor for On-Chip Potentiometric Determination of K +","volume":"3","author":"Miller","year":"2014","journal-title":"Adv. Healthc. Mater."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"113404","DOI":"10.1016\/j.bios.2021.113404","article-title":"Aptamer-decorated porous microneedles arrays for extraction and detection of skin interstitial fluid biomarkers","volume":"190","author":"Yi","year":"2021","journal-title":"Biosens. Bioelectron."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.snb.2012.11.064","article-title":"Microneedle biosensor: A method for direct label-free real time protein detection","volume":"177","author":"Esfandyarpour","year":"2013","journal-title":"Sens. Actuators B Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1039\/C5LC00669D","article-title":"One-touch-activated blood multidiagnostic system using a minimally invasive hollow microneedle integrated with a paper-based sensor","volume":"15","author":"Li","year":"2015","journal-title":"Lab Chip"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1039\/C1LC20885C","article-title":"Microfluidic device to investigate factors affecting performance in biosensors designed for transdermal applications","volume":"12","author":"Trzebinski","year":"2012","journal-title":"Lab Chip"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00542-006-0221-0","article-title":"High aspect ratio tapered hollow metallic microneedle arrays with microfluidic interconnector","volume":"13","author":"Kim","year":"2006","journal-title":"Microsyst. Technol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/17425247.2016.1218460","article-title":"Minimally invasive microneedles for ocular drug delivery","volume":"14","author":"Singh","year":"2017","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1023\/B:BMMD.0000042047.83433.96","article-title":"Continuous On-Chip Micropumping for Microneedle Enhanced Drug Delivery","volume":"6","author":"Zahn","year":"2004","journal-title":"Biomed. Microdevices"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41378-021-00295-6","article-title":"A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery","volume":"7","author":"Kang","year":"2021","journal-title":"Microsyst. Nanoeng."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.snb.2014.11.132","article-title":"A new thin silicon microneedle with an embedded microchannel for deep brain drug infusion","volume":"209","author":"Lee","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1109\/JMEMS.2015.2429675","article-title":"Development of a Flexible and Disposable Microneedle-Fluidic-System With Finger-Driven Drug Loading and Delivery Functions for Inflammation Treatment","volume":"24","author":"Xiang","year":"2015","journal-title":"J. Microelectromech. Syst."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1039\/b803212b","article-title":"Microfluidic based single cell microinjection","volume":"8","author":"Adamo","year":"2008","journal-title":"Lab Chip"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1039\/C9LC00963A","article-title":"Localized microinjection of intact Drosophila melanogaster larva to investigate the effect of serotonin on heart rate","volume":"20","author":"Zabihihesari","year":"2020","journal-title":"Lab Chip"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.sna.2019.04.008","article-title":"In-plane silicon microneedles with open capillary microfluidic networks by deep reactive ion etching and sacrificial layer based sharpening","volume":"292","author":"Li","year":"2019","journal-title":"Sens. Actuators A Phys."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1007\/s00542-015-2596-2","article-title":"Fabrication of a 2-D in-plane micro needle array integrated with microfluidic components using crystalline wet etching of (110) silicon","volume":"22","author":"Jung","year":"2016","journal-title":"Microsyst. Technol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1109\/JMEMS.2007.892909","article-title":"Bulk Micromachined Titanium Microneedles","volume":"16","author":"Parker","year":"2007","journal-title":"J. Microelectromech. Syst."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1109\/JMEMS.2003.809959","article-title":"Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer","volume":"12","author":"Griss","year":"2003","journal-title":"J. Microelectromech. Syst."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"033019","DOI":"10.1117\/1.JMM.12.3.033019","article-title":"Fabricating process of hollow out-of-plane Ni microneedle arrays and properties of the integrated microfluidic device","volume":"12","author":"Zhu","year":"2013","journal-title":"J. Micro\/Nanolith. MEMS MOEMS"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.sna.2003.11.008","article-title":"Microneedle array for transdermal biological fluid extraction and in situ analysis","volume":"114","author":"Mukerjee","year":"2004","journal-title":"Sens. Actuators A Phys."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1016\/j.apsb.2021.02.010","article-title":"Microneedle-based devices for point-of-care infectious disease diagnostics","volume":"11","author":"Dixon","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3648","DOI":"10.3390\/ijms12063648","article-title":"Micro Electromechanical Systems (MEMS) Based Microfluidic Devices for Biomedical Applications","volume":"12","author":"Ashraf","year":"2011","journal-title":"IJMS"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2006839","DOI":"10.1002\/adfm.202006839","article-title":"Intelligent Silk Fibroin Based Microneedle Dressing (i-SMD)","volume":"31","author":"Gao","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Mansor, M., Takeuchi, M., Nakajima, M., Hasegawa, Y., and Ahmad, M. (2017). Electrical Impedance Spectroscopy for Detection of Cells in Suspensions Using Microfluidic Device with Integrated Microneedles. Appl. Sci., 7.","DOI":"10.3390\/app7020170"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41378-019-0046-5","article-title":"Towards a versatile point-of-care system combining femtosecond laser generated microfluidic channels and direct laser written microneedle arrays","volume":"5","author":"Trautmann","year":"2019","journal-title":"Microsyst. Nanoeng."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"054109","DOI":"10.1063\/1.4931045","article-title":"Microfluidic sampling system for tissue analytics","volume":"9","author":"Hokkanen","year":"2015","journal-title":"Biomicrofluidics"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"102012","DOI":"10.1016\/j.isci.2020.102012","article-title":"3D-printed microneedles in biomedical applications","volume":"24","author":"Dabbagh","year":"2021","journal-title":"iScience"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10544-006-9004-8","article-title":"Three dimensional MEMS microfluidic perfusion system for thick brain slice cultures","volume":"9","author":"Choi","year":"2007","journal-title":"Biomed. Microdevices"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.1002\/adma.201201109","article-title":"A Minimally Invasive Blood-Extraction System: Elastic Self-Recovery Actuator Integrated with an Ultrahigh- Aspect-Ratio Microneedle","volume":"24","author":"Li","year":"2012","journal-title":"Adv. Mater."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Ju, J., Li, L., Regmi, S., Zhang, X., and Tang, S. (2022). Microneedle-Based Glucose Sensor Platform: From Vitro to Wearable Point-of-Care Testing Systems. Biosensors, 12.","DOI":"10.3390\/bios12080606"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Sarabi, M.R., Ahmadpour, A., Yetisen, A.K., and Tasoglu, S. (2021). Finger-Actuated Microneedle Array for Sampling Body Fluids. Appl. Sci., 11.","DOI":"10.3390\/app11125329"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/1567201815666181017095044","article-title":"Continuous Vector-free Gene Transfer with a Novel Microfluidic Chip and Nanoneedle Array","volume":"16","author":"Huang","year":"2018","journal-title":"CDD"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1007\/s10439-012-0562-z","article-title":"Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels","volume":"40","author":"Wang","year":"2012","journal-title":"Ann. Biomed. Eng."},{"key":"ref_95","unstructured":"Minas, H., Maria, G., Rodrigues, R.O., de Sousa, T., Jorge, P., De Lima, M.M., Alberto, R., De Sousa, S., Catarina, P., and Cabanas, C. (2023, January 10). WO2022180595\u2014Multiorgan-on-Chip Device with Integrated Microbiosensors, Methods and Uses Thereof. WO\/2022\/180595. Available online: https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2022180595&_cid=P20-L7J87M-45311-1."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/3\/792\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:43:51Z","timestamp":1760121831000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/3\/792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,28]]},"references-count":95,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["pharmaceutics15030792"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics15030792","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,28]]}}}