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The vicious cycle of enteric infections and malnutrition is closely related to environmental-driven enteric dysfunction early in life, and such chronic inflammatory conditions may blunt the developmental trajectories of children with worrisome and often irreversible physical and cognitive faltering. This window of time for microbiota maturation and brain plasticity is key to protecting cognitive domains, brain health, and achieving optimal\/full developmental potential. This review summarizes the potential role of promising apoE mimetic peptides to improve the function of the gut-brain axis, including targeting the blood-brain barrier in children afflicted with malnutrition and enteric infections.<\/jats:p>","DOI":"10.3390\/pharmaceutics15041086","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T06:15:15Z","timestamp":1679984115000},"page":"1086","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers"],"prefix":"10.3390","volume":"15","author":[{"given":"Reinaldo B.","family":"Ori\u00e1","sequence":"first","affiliation":[{"name":"Laboratory of Tissue Healing, Ontogeny and Nutrition, Department of Morphology, School of Medicine, Institute of Biomedicine, Federal University of Ceara, Fortaleza 60430-270, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-3362","authenticated-orcid":false,"given":"Raul S.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Healing, Ontogeny and Nutrition, Department of Morphology, School of Medicine, Institute of Biomedicine, Federal University of Ceara, Fortaleza 60430-270, Brazil"}]},{"given":"C\u00e1ssia R.","family":"Roque","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Healing, Ontogeny and Nutrition, Department of Morphology, School of Medicine, Institute of Biomedicine, Federal University of Ceara, Fortaleza 60430-270, Brazil"}]},{"given":"Jos\u00e9 Carlos R.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Laboratory of Tissue Healing, Ontogeny and Nutrition, Department of Morphology, School of Medicine, Institute of Biomedicine, Federal University of Ceara, Fortaleza 60430-270, Brazil"},{"name":"Institute of Health Sciences, Medicine, University of International Integration of Afro-Brazilian Lusofonia, Reden\u00e7\u00e3o 62790-970, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7802-8690","authenticated-orcid":false,"given":"Ana Paula","family":"Silva","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Experimental Therapeutics and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-4447","authenticated-orcid":false,"given":"Jo\u00e3o O.","family":"Malva","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology and Experimental Therapeutics and Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine and Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Richard L.","family":"Guerrant","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and International Health, Department of Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8140-8048","authenticated-orcid":false,"given":"Michael P.","family":"Vitek","sequence":"additional","affiliation":[{"name":"Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ebiom.2019.05.043","article-title":"Childhood growth and neurocognition are associated with distinct sets of metabolites","volume":"44","author":"Moreau","year":"2019","journal-title":"EBioMedicine"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Rogawski McQuade, E.T., Scharf, R.J., Svensen, E., Huggins, A., Maphula, A., Bayo, E., Blacy, L., de Souza, P.P.E., Costa, H., and Houpt, E.R. 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