{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T01:32:04Z","timestamp":1768267924804,"version":"3.49.0"},"reference-count":89,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT-Portugal) and COMPETE (FEDER)","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT-Portugal) and COMPETE (FEDER)","award":["UIDP\/00100\/2020"],"award-info":[{"award-number":["UIDP\/00100\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>To investigate the impact of the surface functionalization of mesoporous silica nanoparticle (MSN) carriers in the physical state, molecular mobility and the release of Fenofibrate (FNB) MSNs with ordered cylindrical pores were prepared. The surface of the MSNs was modified with either (3-aminopropyl) triethoxysilane (APTES) or trimethoxy(phenyl)silane (TMPS), and the density of the grafted functional groups was quantified via 1H-NMR. The incorporation in the ~3 nm pores of the MSNs promoted FNB amorphization, as evidenced via FTIR, DSC and dielectric analysis, showing no tendency to undergo recrystallization in opposition to the neat drug. Moreover, the onset of the glass transition was slightly shifted to lower temperatures when the drug was loaded in unmodified MSNs, and MSNs modified with APTES composite, while it increased in the case of TMPS-modified MSNs. Dielectric studies have confirmed these changes and allowed researchers to disclose the broad glass transition in multiple relaxations associated with different FNB populations. Moreover, DRS showed relaxation processes in dehydrated composites associated with surface-anchored FNB molecules whose mobility showed a correlation with the observed drug release profiles.<\/jats:p>","DOI":"10.3390\/pharmaceutics15061624","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T02:01:15Z","timestamp":1685498475000},"page":"1624","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Understanding Fenofibrate Release from Bare and Modified Mesoporous Silica Nanoparticles"],"prefix":"10.3390","volume":"15","author":[{"given":"Giorgia","family":"Figari","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Complexo I, Instituto Superior T\u00e9cnico, University of Lisbon, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0256-6078","authenticated-orcid":false,"given":"Jos\u00e9 L. M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Complexo I, Instituto Superior T\u00e9cnico, University of Lisbon, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0808-1306","authenticated-orcid":false,"given":"Herm\u00ednio P.","family":"Diogo","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Complexo I, Instituto Superior T\u00e9cnico, University of Lisbon, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1487-0889","authenticated-orcid":false,"given":"Madalena","family":"Dion\u00edsio","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6394-5031","authenticated-orcid":false,"given":"Jos\u00e9 Paulo","family":"Farinha","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Complexo I, Instituto Superior T\u00e9cnico, University of Lisbon, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8574-7351","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Viciosa","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Complexo I, Instituto Superior T\u00e9cnico, University of Lisbon, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1517\/17425247.2014.911728","article-title":"Refining stability and dissolution rate of amorphous drug","volume":"11","author":"Grohganz","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1021\/nl0705081","article-title":"Manipulating the crystalline state of pharmaceuticals by nanoconfinement","volume":"7","author":"Beiner","year":"2007","journal-title":"Nano Lett."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"13857","DOI":"10.1021\/jp500630m","article-title":"Influence of nanoscale confinement on the molecular mobility of ibuprofen","volume":"118","author":"Fonseca","year":"2014","journal-title":"J. Phys. Chem. C"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"14390","DOI":"10.1021\/acs.jpcc.6b04078","article-title":"Accessing the physical state and molecular mobility of naproxen confined to nanoporous silica matrixes","volume":"120","author":"Cordeiro","year":"2016","journal-title":"J. Phys. Chem. C"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1021\/cg401170m","article-title":"Morphology of porous host directs preferred polymorph formation and influences kinetics of solid\/solid transition of confined pharmaceuticals","volume":"14","author":"Graubner","year":"2014","journal-title":"Cryst. Growth Des."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.micromeso.2013.02.007","article-title":"Mesoporous silica-based macromolecules for dissolution enhancement of irbesartan drug using pre-adjusted pH method","volume":"173","author":"Khanfar","year":"2013","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1002\/jps.10169","article-title":"Physical stability of amorphous pharmaceuticals: Importance of configurational thermodynamic quantities and molecular mobility","volume":"91","author":"Zhou","year":"2002","journal-title":"J. Pharm. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/archinternmed.2012.187","article-title":"How Abbott\u2019s fenofibrate franchise avoided generic competition","volume":"172","author":"Downing","year":"2012","journal-title":"Arch. Intern. Med."},{"key":"ref_9","first-page":"47","article-title":"A Review of Currently Available Fenofibrate and Fenofibric Acid Formulations","volume":"4","author":"Ling","year":"2013","journal-title":"Cardiol. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13153","DOI":"10.1039\/C8RA01182F","article-title":"Towards controlling the crystallisation behaviour of fenofibrate melt: Triggers of crystallisation and polymorphic transformation","volume":"8","author":"Tipduangta","year":"2018","journal-title":"RSC Adv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1021\/acs.molpharmaceut.8b00548","article-title":"Polyurethane nanoparticle-loaded fenofibrate exerts inhibitory effects on nonalcoholic fatty liver disease in mice","volume":"15","author":"Cao","year":"2018","journal-title":"Mol. Pharm."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1021\/acs.chemmater.9b04241","article-title":"High loading capacity nanoencapsulation and release of hydrophobic drug nanocrystals from microgel particles","volume":"32","author":"Domenech","year":"2020","journal-title":"Chem. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.colsurfb.2016.02.013","article-title":"Enhancing in vitro dissolution and in vivo bioavailability of fenofibrate by solid self-emulsifying matrix combined with SBA-15","volume":"141","author":"Quan","year":"2017","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejpb.2011.05.009","article-title":"A novel nanomatrix system consisted of colloidal silica and pH-sensitive polymethylacrylate improves the oral bioavailability of fenofibrate","volume":"79","author":"Jia","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jnoncrysol.2014.10.020","article-title":"Optimization of MCM-41 type silica nanoparticles for biological applications: Control of size and absence of aggregation and cell cytotoxicity","volume":"408","author":"Varache","year":"2015","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Skwira, A., Szewczyk, A., Konopacka, A., G\u00f3rska, M., Majda, D., S\u0105dej, R., and Prokopowicz, M. (2020). Silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12010028"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Alharthi, S., Ziora, Z.M., Janjua, T., Popat, A., and Moyle, P.M. (2022). Formulation and biological evaluation of mesoporous silica nanoparticles loaded with combinations of sortase A inhibitors and antimicrobial peptides. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14050986"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijpharm.2008.04.041","article-title":"Dissolution-rate enhancement of fenofibrate by adsorption onto silica using supercritical carbon dioxide","volume":"360","author":"Sanganwar","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1021\/acs.jpcc.7b10946","article-title":"Confinement-induced changes in the glassy dynamics and crystallization behavior of supercooled fenofibrate","volume":"122","author":"Szklarz","year":"2018","journal-title":"J. Phys. Chem. C"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ejpb.2016.08.020","article-title":"Ordered mesoporous silica to enhance the bioavailability of poorly water-soluble drugs: Proof of concept in man","volume":"108","author":"Bukara","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.xphs.2016.05.019","article-title":"In vivo performance of fenofibrate formulated with ordered mesoporous silica versus 2-marketed formulations: A comparative bioavailability study in beagle dogs","volume":"105","author":"Bukara","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpha.2014.09.003","article-title":"Molecular dynamics of amorphous pharmaceutical fenofibrate studied by broadband dielectric spectroscopy","volume":"6","author":"Sailaja","year":"2016","journal-title":"J. Pharm. Anal."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tca.2015.11.012","article-title":"Differential scanning calorimetry and thermally stimulated depolarization currents study on the molecular dynamics in amorphous fenofibrate","volume":"623","author":"Diogo","year":"2016","journal-title":"Thermochim. Acta"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.1073\/pnas.1722263115","article-title":"Surface chemical heterogeneity modulates silica surface hydration","volume":"115","author":"Schrader","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0032-3861(67)90021-3","article-title":"A complex plane representation of dielectric and mechanical relaxation processes in some polymers","volume":"8","author":"Havriliak","year":"1967","journal-title":"Polymer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/polc.5070140111","article-title":"A complex plane analysis of \u03b1-dispersions in some polymer systems","volume":"14","author":"Havriliak","year":"1966","journal-title":"J. Polym. Sci. Part C."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Kremer, F., and Sch\u00f6nhals, A. (2003). Broadband Dielectric Spectroscopy, Springer.","DOI":"10.1007\/978-3-642-56120-7"},{"key":"ref_28","first-page":"645","article-title":"Das Temperaturabhaengigkeitsgesetz der Viskositaet von Fluessigkeiten","volume":"22","author":"Vogel","year":"1921","journal-title":"Phys. Z."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1151-2916.1925.tb16731.x","article-title":"Analysis of recent measurements of the viscosity of glasses","volume":"8","author":"Fulcher","year":"1925","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/zaac.19261560121","article-title":"Die Abh\u00e4ngigkeit der Viscosit\u00e4t von der Temperatur bie unterk\u00fchlten Fl\u00fcssigkeiten","volume":"156","author":"Tammann","year":"1926","journal-title":"Anorg. Allg. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1802180","DOI":"10.1002\/smll.201802180","article-title":"On the structure of amorphous mesoporous silica nanoparticles by aberration-corrected STEM","volume":"14","author":"Ribeiro","year":"2018","journal-title":"Small"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jcis.2019.11.036","article-title":"Silica nanocarriers with user-defined precise diameters by controlled template self-assembly","volume":"561","author":"Ribeiro","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijpharm.2007.05.010","article-title":"Surface chemistry and pore size affect carrier properties of mesoporous silicon microparticles","volume":"343","author":"Limnell","year":"2007","journal-title":"Int. J. Pharm."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3109\/10717544.2014.913323","article-title":"High drug load, stable, manufacturable and bioavailable fenofibrate formulations in mesoporous silica: A comparison of spray drying versus solvent impregnation methods","volume":"23","author":"Hong","year":"2016","journal-title":"Drug Deliv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"110541","DOI":"10.1016\/j.micromeso.2020.110541","article-title":"Ibuprofen incorporated into unmodified and modified mesoporous silica: From matrix synthesis to drug release","volume":"310","author":"Cordeiro","year":"2021","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"13485","DOI":"10.1039\/C7NR03395H","article-title":"Hybrid mesoporous silica nanocarriers with thermovalve-regulated controlled release","volume":"9","author":"Ribeiro","year":"2017","journal-title":"Nanoscale"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.fluid.2014.01.029","article-title":"Thermodynamics of fenofibrate and solubility in pure organic solvents","volume":"367","author":"Watterson","year":"2014","journal-title":"Fluid Phase Equilibria"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/acs.analchem.6b03117","article-title":"Functional group coverage and conversion quantification in nanostructured silica by 1H-NMR","volume":"89","author":"Crucho","year":"2017","journal-title":"Anal. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1134\/S0036024406070211","article-title":"Density of silanol groups on the surface of silica precipitated from a hydrothermal solution","volume":"80","author":"Zhuravlev","year":"2006","journal-title":"Russ. J. Phys. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"154551","DOI":"10.1016\/j.apsusc.2022.154551","article-title":"A tag-and-count approach for quantifying surface silanol densities on fused silica based on atomic layer deposition and high-sensitivity low-energy ion scattering","volume":"607","author":"Avval","year":"2023","journal-title":"Appl. Surf. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"9226","DOI":"10.1063\/1.1614206","article-title":"Grand canonical Monte Carlo simulation study of water structure on hydrophilic mesoporous and plane silica substrates","volume":"119","author":"Puibasset","year":"2003","journal-title":"J. Chem. Phys."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1021\/jp212056s","article-title":"Molecular structure of 3-Aminopropyltriethoxysilane layers formed on silanol-terminated silicon surfaces","volume":"116","author":"Acres","year":"2012","journal-title":"Phys. Chem. C"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10876-011-0427-x","article-title":"Preparation of porous hollow SiO2 spheres by a modified St\u00f6ber process using MF microspheres as templates","volume":"23","author":"Liu","year":"2012","journal-title":"J. Clust. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1151-2916.1983.tb10531.x","article-title":"Preparation of High-Silica Glasses from Colloidal Gels: III, Infrared Spectrophotometric Studies","volume":"66","author":"DWood","year":"1983","journal-title":"J. Am. Ceram. Soc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0376-7388(95)00089-U","article-title":"An ATR-FTIR study of water in cellulose acetate membranes prepared by phase inversion","volume":"106","author":"Murphy","year":"1995","journal-title":"J. Membr. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3109\/10717544.2013.838715","article-title":"Synthesis and surface modification of mesoporous silica nanoparticles and its application as carriers for sustained drug delivery","volume":"21","author":"Ahmadi","year":"2014","journal-title":"Drug Deliv."},{"key":"ref_47","first-page":"108","article-title":"Functionalization of hollow mesoporous silica nanoparticles for improved 5-FU loading","volume":"16","author":"She","year":"2015","journal-title":"J. Nanomater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/j.saa.2008.04.027","article-title":"Vibrational spectra of phenyltriethoxysilane, phenyltrimethoxysilane and their sol\u2013gels","volume":"71","author":"Li","year":"2009","journal-title":"Spectrochem. Acta Part A"},{"key":"ref_49","first-page":"4249","article-title":"Qualitative and quantitative analysis on fibrates\u2014A spectroscopic study","volume":"20","author":"Gunasekaran","year":"2008","journal-title":"Asian J. Chem."},{"key":"ref_50","unstructured":"Meyers, R.A., and McKelvy, M.L. (2006). Encyclopedia of Analytical Chemistry, John Wiley & Sons Ltd."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jcrysgro.2018.05.030","article-title":"A New Polymorph of fenofibrate prepared by polymer- mediated crystallization","volume":"498","author":"Shi","year":"2018","journal-title":"J. Cryst. Growth"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejpb.2008.05.030","article-title":"Understanding the solid state forms of fenofibrate\u2014A spectroscopic and computational study","volume":"71","author":"Heinz","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1021\/acs.cgd.5b00956","article-title":"A new low melting-point polymorph of fenofibrate prepared via talc induced heterogeneous nucleation","volume":"15","author":"Tipduangta","year":"2015","journal-title":"Cryst. Growth Des."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41529-019-0105-2","article-title":"Hydrogen bonding interactions of H2O and SiOH on a boroaluminosilicate glass corroded in aqueous solution","volume":"4","author":"Ngo","year":"2020","journal-title":"npj Mater. Degrad."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"085214","DOI":"10.1063\/5.0011700","article-title":"The deconvolution of FTIR-ATR spectra to five Gaussians for detection of small changes in plant\u2013water clusters","volume":"10","author":"Laurson","year":"2020","journal-title":"AIP Adv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"332","DOI":"10.4236\/ajac.2011.23041","article-title":"Determination of fenofibrate and the degradation product using simultaneous UV-derivative spectrometric method and HPLC","volume":"2","author":"Salama","year":"2011","journal-title":"Am. J. Anal. Chem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/acs.molpharmaceut.6b01172","article-title":"Spectroscopic investigation of the formation and disruption of hydrogen bonds in pharmaceutical semicrystalline dispersions","volume":"14","author":"Duong","year":"2017","journal-title":"Mol. Pharm."},{"key":"ref_58","first-page":"625","article-title":"Evidence of a metastable form of fenofibrate","volume":"55","author":"Palmieri","year":"2000","journal-title":"Pharmazie"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1023\/A:1026199604374","article-title":"Determination of glass transition temperature and in situ study of the plasticizing effect of water by inverse gas chromatography","volume":"20","author":"Surana","year":"2003","journal-title":"Pharm. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1021\/mp400118v","article-title":"A molecular dynamics approach for predicting the glass transition temperature and plasticization effect in amorphous pharmaceuticals","volume":"10","author":"Gupta","year":"2013","journal-title":"Mol. Pharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jnoncrysol.2014.04.009","article-title":"Statistical mechanics of glass","volume":"396","author":"Mauro","year":"2014","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_62","first-page":"100026","article-title":"Impact of drug loading in mesoporous silica-amorphous formulations on thephysical stability of drugs with high recrystallization tendency","volume":"1","author":"Antonino","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1063\/1.442139","article-title":"The dielectric properties of ice Ih in the range 272\u2013133 K","volume":"75","author":"Johari","year":"1981","journal-title":"J. Chem. Phys."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1021\/jp0033061","article-title":"Dielectric relaxation of water adsorbed in porous glass","volume":"105","author":"Ryabov","year":"2001","journal-title":"J. Phys. Chem. B"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"24340","DOI":"10.1021\/jp307826s","article-title":"Dielectric study of hydration water in silica nanoparticles","volume":"116","author":"Cerveny","year":"2012","journal-title":"J. Phys. Chem. C"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1039\/b005867j","article-title":"On the cooperativity of the \u03b2-relaxation: A discussion based on dielectric relaxation and thermally stimulated depolarization currents data","volume":"2","author":"Correia","year":"2000","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1387-1811(02)00651-0","article-title":"Dielectric relaxation in porous glasses","volume":"58","author":"Gutina","year":"2003","journal-title":"Microporous Mesoporous Mater."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1140\/epje\/i2007-10340-y","article-title":"Relaxation processes of water confined to AlMCM-41 molecular sieves. Influence of the hydroxyl groups of the pore surface","volume":"26","author":"Frunza","year":"2008","journal-title":"Eur. Phys. J. E"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1346\/CCMN.2014.0620106","article-title":"Dielectric relaxation of water in clay minerals","volume":"62","author":"Vasilyeva","year":"2014","journal-title":"Clays Clay Miner."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"120407","DOI":"10.1016\/j.jnoncrysol.2020.120407","article-title":"Molecular dynamics in the supercooled liquid and glassy states of bezafibrate and binary mixture of fenofibrate","volume":"550","author":"Afzal","year":"2020","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1021\/acs.jpcb.6b08511","article-title":"Dielectric relaxation study at ambient and elevated pressure of the modeled lipophilic drug fenofibrate","volume":"120","author":"Szklarz","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.tranon.2019.04.006","article-title":"Chemically modified variants of Fenofibrate with antiglioblastoma potential","volume":"12","author":"Stalinska","year":"2019","journal-title":"Transl. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"27347","DOI":"10.1039\/D1TA06908J","article-title":"Complex H-bonded silanol network in zeolites revealed by IR and NMR spectroscopy combined with DFT calculations","volume":"9","author":"Dib","year":"2021","journal-title":"J. Mater. Chem. A"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8227","DOI":"10.1021\/jp802133e","article-title":"Confinement and surface effects on the molecular dynamics of a nematic mixture investigated by dielectric relaxation spectroscopy","volume":"112","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"244111","DOI":"10.1088\/0953-8984\/20\/24\/244111","article-title":"Confinement effects on strongly polar alkylcyanobiphenyl liquid crystals probed by dielectric spectroscopy","volume":"20","author":"Leys","year":"2008","journal-title":"J. Phys. Condens. Matter"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Kremer, F. (2014). Dynamics in Geometrical Confinement, Springer.","DOI":"10.1007\/978-3-319-06100-9"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1063\/1.1696442","article-title":"On the temperature dependence of cooperative relaxation properties in glass-forming liquids","volume":"43","author":"Adam","year":"1965","journal-title":"J. Chem. Phys."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"024504","DOI":"10.1063\/1.5080334","article-title":"Glycerol confined in zeolitic imidazolate frameworks: The temperature-dependent cooperativity length scale of glassy freezing","volume":"150","author":"Uhl","year":"2019","journal-title":"J. Chem. Phys."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1063\/1.466117","article-title":"Nonexponential relaxations in strong and fragile glass formers","volume":"99","author":"Ngai","year":"1993","journal-title":"J. Chem. Phys."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Cordeiro, T., Matos, I., Dan\u00e8de, F., Sotomayor, J.C., Fonseca, I.M., Corvo, M.C., Dion\u00edsio, M., Viciosa, M.T., Affouard, F., and Correia, N.T. (2023). Evidence of Strong Guest-Host Interactions in Simvastatin Loaded in Mesoporous Silica MCM-4. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15051320"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"194703","DOI":"10.1063\/1.4919877","article-title":"Electrode polarization vs. Maxwell-Wagner-Sillars interfacial polarization in dielectric spectra of materials: Characteristic frequencies and scaling laws","volume":"142","author":"Samet","year":"2015","journal-title":"J. Chem. Phys."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jallcom.2006.04.048","article-title":"Study of the interfacial MWS relaxation by dielectric spectroscopy in unidirectional PZT fibres\/epoxy resin composites","volume":"430","author":"Hammami","year":"2007","journal-title":"J. Alloy. Compd."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/267673a0","article-title":"The \u201cuniversal\u201d dielectric response","volume":"267","author":"Jonscher","year":"1977","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/00986445.2013.782290","article-title":"Modeling of drug dissolution kinetics with sigmoidal behavior from ordered mesoporous silica","volume":"201","author":"Murzin","year":"2014","journal-title":"Chem. Eng. Commun."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1063\/1.1674335","article-title":"Viscous liquids and the glass transition. II. Secondary relaxations in glasses of rigid molecules","volume":"53","author":"Johari","year":"1970","journal-title":"J. Chem. Phys."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"204507","DOI":"10.1063\/1.2121667","article-title":"Primary and secondary relaxations in bis-5-hydroxypentylphthalate revisited","volume":"123","author":"Ngai","year":"2005","journal-title":"J. Chem. Phys."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"S1107","DOI":"10.1088\/0953-8984\/15\/11\/332","article-title":"An extended coupling model description of the evolution of dynamics with time in supercooled liquids and ionic conductors","volume":"15","author":"Ngai","year":"2003","journal-title":"J. Phys. Condens. Matter"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1063\/1.1630295","article-title":"Classification of secondary relaxation in glass-formers based on dynamic properties","volume":"120","author":"Ngai","year":"2004","journal-title":"J. Chem. Phys."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1103\/PhysRevB.44.7306","article-title":"Relationship between the time-domain Kohlrausch-Williams-Watts and frequency-domain Havriliak-Negami relaxation functions","volume":"44","author":"Alvarez","year":"1991","journal-title":"Phys. Rev. B"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/6\/1624\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:45:30Z","timestamp":1760125530000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/6\/1624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":89,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["pharmaceutics15061624"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics15061624","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,30]]}}}