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In this publication, the preparation of a set of three nanomaterials based on the modification of a MSN surface with cholinium ([MSN-Chol][Cip]), 1-methylimidazolium ([MSN-1-MiM][Cip]) and 3-picolinium ([MSN-3-Pic][Cip]) ionic liquids coupled with anionic ciprofloxacin have been reported. All ionic liquids and functionalized nanomaterials were prepared through sustainable protocols, using microwave-assisted heating as an alternative to conventional methods. All materials were characterized through FTIR, solution 1H NMR, elemental analysis, XRD and N2 adsorption at 77 K. The prepared materials showed no in vitro cytotoxicity in fibroblasts viability assays. The minimum inhibitory concentration (MIC) for all materials was tested against Gram-negative K. pneumoniae and Gram-positive Enterococcus spp., both with resistant and sensitive strains. All sets of nanomaterials containing the anionic antibiotic outperformed free ciprofloxacin against resistant and sensitive forms of K. pneumoniae, with the prominent case of [MSN-Chol][Cip] suggesting a tenfold decrease in the MIC against sensitive strains. Against resistant K. pneumoniae, a five-fold decrease in the MIC was observed for all sets of nanomaterials compared with neutral ciprofloxacin. Against Enterococcus spp., only [MSN-1-MiM][Cip] was able to demonstrate a slight improvement over the free antibiotic.<\/jats:p>","DOI":"10.3390\/pharmaceutics15071934","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T01:52:25Z","timestamp":1689213145000},"page":"1934","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In Vitro Antimicrobial Studies of Mesoporous Silica Nanoparticles Comprising Anionic Ciprofloxacin Ionic Liquids and Organic Salts"],"prefix":"10.3390","volume":"15","author":[{"given":"Lu\u00eds","family":"Filipe","sequence":"first","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), NOVA School of Science and Technology (FCT NOVA), Campus da Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-6226","authenticated-orcid":false,"given":"Telma","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), NOVA School of Science and Technology (FCT NOVA), Campus da Caparica, 2829-516 Caparica, Portugal"},{"name":"Department of Genetics and Biotechnology, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"Microbiology and Antibiotic Resistance Team (MicroART), Departamento de Ci\u00eancias Veterin\u00e1rias, Universidade de Tr\u00e1s-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal"},{"name":"Functional Genomics and Proteomics Unit, University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-089X","authenticated-orcid":false,"given":"D\u00e1rio","family":"Silva","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), NOVA School of Science and Technology (FCT NOVA), Campus da Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8973-1595","authenticated-orcid":false,"given":"Miguel M.","family":"Santos","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), NOVA School of Science and Technology (FCT NOVA), Campus da Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-5150","authenticated-orcid":false,"given":"Manuela","family":"Ribeiro Carrott","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Institute for Research and Advanced Studies, Department of Chemistry and Biochemistry, School of Sciences and Technology, University of \u00c9vora, 7000-671 \u00c9vora, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0925-689X","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Poeta","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), NOVA School of Science and Technology (FCT NOVA), Campus da Caparica, 2829-516 Caparica, Portugal"},{"name":"Microbiology and Antibiotic Resistance Team (MicroART), Departamento de Ci\u00eancias Veterin\u00e1rias, Universidade de Tr\u00e1s-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal"},{"name":"Veterinary and Animal Research Centre (CECAV), University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal"},{"name":"Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-1151","authenticated-orcid":false,"given":"Lu\u00eds C.","family":"Branco","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), NOVA School of Science and Technology (FCT NOVA), Campus da Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0221-8508","authenticated-orcid":false,"given":"Sandra","family":"Gago","sequence":"additional","affiliation":[{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), NOVA School of Science and Technology (FCT NOVA), Campus da Caparica, 2829-516 Caparica, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,12]]},"reference":[{"key":"ref_1","unstructured":"CDC (2019). 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