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FEDER\/COMPETE","doi-asserted-by":"publisher","award":["SFRH\/BD\/147938\/2019"],"award-info":[{"award-number":["SFRH\/BD\/147938\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Chronic skin exposure to external hostile agents (e.g., UV radiation, microorganisms, and oxidizing chemicals) may increase oxidative stress, causing skin damage and aging. Because of their well-known skincare and protective benefits, quercetin (Q) and omega-3 fatty acids (\u03c93) have attracted the attention of the dermocosmetic and pharmaceutical sectors. However, both bioactives have inherent properties that limit their efficient skin delivery. Therefore, nanostructured lipid carriers (NLCs) and enriched PFC\u00ae hydrogels (HGs) have been developed as a dual-approach vehicle for Q and\/or \u03c93 skin topical administration to improve bioactives\u2019 stability and skin permeation. Two NLC formulations were prepared with the same lipid composition but differing in surfactant composition (NLC1\u2014soy lecithin and poloxamer 407; NLC2\u2014Tween\u00ae 80 and dioctyl sodium sulfosuccinate (DOSS)), which have an impact on physicochemical properties and pharmaceutical and therapeutic performance. Despite both NLCs presenting high Q loading capacity, NLC2\u2032s physicochemical properties make them more suitable for topical skin administration and ensure longer colloidal stability. Additionally, NLC2 demonstrated a more sustained Q release, indicating higher bioactive storage while improving permeability. The occlusive effect of NLCs-enriched HGs also has a positive impact on skin permeability. Q-loaded NLC2, with or without \u03c93, -enriched HGs demonstrated efficacy as antioxidant and photoprotective formulations as well as effective reduction in S. aureus growth, indicating that they constitute a promising approach for topical skin administration to prevent skin aging and other damaging cutaneous processes.<\/jats:p>","DOI":"10.3390\/pharmaceutics15082078","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T11:13:06Z","timestamp":1691061186000},"page":"2078","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Nanostructured Lipid Carriers Enriched Hydrogels for Skin Topical Administration of Quercetin and Omega-3 Fatty Acid"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2593-1672","authenticated-orcid":false,"given":"Marlene","family":"L\u00facio","sequence":"first","affiliation":[{"name":"CF-UM-UP, Centro de F\u00edsica das Universidades do Minho e Porto, Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal"},{"name":"CBMA, Centro de Biologia Molecular e Ambiental, Departamento de Biologia, Universidade do Minho, 4710-057 Braga, Portugal"}]},{"given":"Nicole","family":"Giannino","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento (FP-I3ID), Biomedical and Health Sciences Research Unit (FP-BHS), Faculdade Ci\u00eancias da Sa\u00fade, Universidade Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Dipartimento di Farmacia, Universit\u00e0 degli Studi di Napoli Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-7501","authenticated-orcid":false,"given":"S\u00e9rgio","family":"Barreira","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento (FP-I3ID), Biomedical and Health Sciences Research Unit (FP-BHS), Faculdade Ci\u00eancias da Sa\u00fade, Universidade Fernando Pessoa, 4200-150 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7270-5702","authenticated-orcid":false,"given":"Jos\u00e9","family":"Catita","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento (FP-I3ID), Biomedical and Health Sciences Research Unit (FP-BHS), Faculdade Ci\u00eancias da Sa\u00fade, Universidade Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Paralab, SA, 4420-392 Valbom, Portugal"}]},{"given":"Hugo","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Paralab, SA, 4420-392 Valbom, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3298-5564","authenticated-orcid":false,"given":"Artur","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"CEB, Centro de Engenharia Biol\u00f3gica, Universidade do Minho, 4710-057 Braga, Portugal"},{"name":"LABBELS, Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0870-039X","authenticated-orcid":false,"given":"Eduarda","family":"Fernandes","sequence":"additional","affiliation":[{"name":"CF-UM-UP, Centro de F\u00edsica das Universidades do Minho e Porto, Departamento de F\u00edsica, Universidade do Minho, 4710-057 Braga, Portugal"}]},{"given":"Isabel","family":"Carvalho","sequence":"additional","affiliation":[{"name":"CEB, Centro de Engenharia Biol\u00f3gica, Universidade do Minho, 4710-057 Braga, Portugal"},{"name":"LABBELS, Associate Laboratory, Braga\/Guimar\u00e3es, Portugal"},{"name":"LIBRO\u2014Laborat\u00f3rio de Investiga\u00e7\u00e3o em Biofilmes Ros\u00e1rio Oliveira, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal"}]},{"given":"Hugo","family":"Pinho","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento (FP-I3ID), Biomedical and Health Sciences Research Unit (FP-BHS), Faculdade Ci\u00eancias da Sa\u00fade, Universidade Fernando Pessoa, 4200-150 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-4654","authenticated-orcid":false,"given":"F\u00e1tima","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento (FP-I3ID), Biomedical and Health Sciences Research Unit (FP-BHS), Faculdade Ci\u00eancias da Sa\u00fade, Universidade Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Molecular Oncology and Viral Pathology Group, Research Center of IPO Porto (CI-IPOP)\/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)\/Porto Comprehensive Cancer Center (Porto.CCC), 4200-072 Porto, Portugal"}]},{"given":"Marco","family":"Biondi","sequence":"additional","affiliation":[{"name":"Dipartimento di Farmacia, Universit\u00e0 degli Studi di Napoli Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-032X","authenticated-orcid":false,"given":"Carla M.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento (FP-I3ID), Biomedical and Health Sciences Research Unit (FP-BHS), Faculdade Ci\u00eancias da Sa\u00fade, Universidade Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Associate Laboratory i4HB\u2014Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"},{"name":"UCIBIO\u2014Applied Molecular Biosciences Unit, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier 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