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The yet unclear etiology of AD and the high impenetrability of the blood\u2013brain barrier (BBB) limit most therapeutic compounds from reaching the brain. Although many efforts have been made to effectively deliver drugs to the CNS, both invasive and noninvasive strategies employed often come with associated side effects. Nanotechnology-based approaches such as nanoparticles (NPs), which can act as multifunctional platforms in a single system, emerged as a potential solution for current AD theranostics. Among these, magnetic nanoparticles (MNPs) are an appealing strategy since they can act as contrast agents for magnetic resonance imaging (MRI) and as drug delivery systems. The nanocarrier functionalization with specific moieties, such as peptides, proteins, and antibodies, influences the particles\u2019 interaction with brain endothelial cell constituents, facilitating transport across the BBB and possibly increasing brain penetration. In this review, we introduce MNP-based systems, combining surface modifications with the particles\u2019 physical properties for molecular imaging, as a novel neuro-targeted strategy for AD theranostics. The main goal is to highlight the potential of multifunctional MNPs and their advances as a dual nanotechnological diagnosis and treatment platform for neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/pharmaceutics15092316","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T10:00:23Z","timestamp":1694685623000},"page":"2316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["A Promising Approach: Magnetic Nanosystems for Alzheimer\u2019s Disease Theranostics"],"prefix":"10.3390","volume":"15","author":[{"given":"Catarina I. P.","family":"Chaparro","sequence":"first","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal"},{"name":"i3N\/CENIMAT, Department of Materials Science, NOVA School of Science and Technology, NOVA University of Lisbon, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"given":"Beatriz T.","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-6545","authenticated-orcid":false,"given":"Jo\u00e3o P.","family":"Borges","sequence":"additional","affiliation":[{"name":"i3N\/CENIMAT, Department of Materials Science, NOVA School of Science and Technology, NOVA University of Lisbon, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7891-7562","authenticated-orcid":false,"given":"Miguel A. R. B.","family":"Castanho","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4975-7480","authenticated-orcid":false,"given":"Paula I. P.","family":"Soares","sequence":"additional","affiliation":[{"name":"i3N\/CENIMAT, Department of Materials Science, NOVA School of Science and Technology, NOVA University of Lisbon, Campus de Caparica, 2829-516 Caparica, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2989-7208","authenticated-orcid":false,"given":"Vera","family":"Neves","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"952161","DOI":"10.3389\/fpubh.2022.952161","article-title":"Global, regional, and national burden and attributable risk factors of neurological disorders: The Global Burden of Disease study 1990-2019","volume":"10","author":"Ding","year":"2022","journal-title":"Front Public Health"},{"key":"ref_2","unstructured":"(2006). Global Burden of Neurological Disorders: Estimates and Projections, World Health Organization. [1st ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S1474-4422(17)30338-1","article-title":"Global analysis of neurological disease: Burden and benefit","volume":"16","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e1801362","DOI":"10.1002\/adma.201801362","article-title":"Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases","volume":"30","author":"Furtado","year":"2018","journal-title":"Adv. Mater."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1148\/radiol.12120010","article-title":"Predicting Cognitive Decline in Subjects at Risk for Alzheimer Disease by Using Combined Cerebrospinal Fluid, MR Imaging, and PET Biomarkers","volume":"266","author":"Shaffer","year":"2013","journal-title":"Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1021\/cn4001582","article-title":"Alzheimer\u2019s Disease: Pathophysiology and Applications of Magnetic Nanoparticles as MRI Theranostic Agents","volume":"4","author":"Amiri","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1750-1326-6-27","article-title":"Biology and pathophysiology of the amyloid precursor protein","volume":"6","author":"Zheng","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/alzrt258","article-title":"Truncated and modified amyloid-beta species","volume":"6","author":"Kummer","year":"2014","journal-title":"Alzheimers Res. Ther."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nature23094","article-title":"Neurodegeneration: Taming tangled tau","volume":"547","author":"Eisenberg","year":"2017","journal-title":"Nature"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3233\/JAD-2006-9S323","article-title":"Tau protein, the paired helical filament and Alzheimer\u2019s disease","volume":"9","author":"Goedert","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"595","DOI":"10.15252\/emmm.201606210","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease at 25 years","volume":"8","author":"Selkoe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cell.2005.02.008","article-title":"Twenty years of the Alzheimer\u2019s disease amyloid hypothesis: A genetic perspective","volume":"120","author":"Tanzi","year":"2005","journal-title":"Cell"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.3233\/JAD-131883","article-title":"Central and peripheral administration of antisense oligonucleotide targeting amyloid-beta protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (AbetaPPswe) mice","volume":"40","author":"Farr","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2174\/1567205014666170508121031","article-title":"Nanotechnology Based Theranostic Approaches in Alzheimer\u2019s Disease Management: Current Status and Future Perspective","volume":"14","author":"Ahmad","year":"2017","journal-title":"Curr. Alzheimer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8876","DOI":"10.1523\/JNEUROSCI.19-20-08876.1999","article-title":"Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons","volume":"19","author":"Hartley","year":"1999","journal-title":"J. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0166-2236(00)01749-5","article-title":"Targeting small A\u03b2 oligomers: The solution to an Alzheimer\u2019s disease conundrum?","volume":"24","author":"Klein","year":"2001","journal-title":"Trends Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in alzheimer\u2019s disease: Synapse loss is the major correlate of cognitive impairment","volume":"30","author":"Terry","year":"1991","journal-title":"Ann. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0197-4580(95)00013-5","article-title":"Correlations of synaptic and pathological markers with cognition of the elderly","volume":"16","author":"Dickson","year":"1995","journal-title":"Neurobiol. Aging"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/jcbfm.2013.135","article-title":"Blood-brain barrier dysfunction as a cause and consequence of Alzheimer\u2019s disease","volume":"33","author":"Erickson","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00294173","article-title":"Pathological alterations of the cerebral microvasculature in Alzheimer\u2019s disease and related dementing disorders","volume":"87","author":"Buee","year":"1994","journal-title":"Acta Neuropathol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1212\/WNL.0b013e3181b59bf3","article-title":"Treatment of vascular risk factors is associated with slower decline in Alzheimer disease","volume":"73","author":"Deschaintre","year":"2009","journal-title":"Neurology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer\u2019s disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/YCO.0000000000000239","article-title":"Interaction between cerebrovascular disease and Alzheimer pathology","volume":"29","author":"Saito","year":"2016","journal-title":"Curr. Opin. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1038\/ncomms11934","article-title":"Early role of vascular dysregulation on late-onset Alzheimer\u2019s disease based on multifactorial data-driven analysis","volume":"7","author":"Sotero","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrneurol.2017.188","article-title":"Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders","volume":"14","author":"Sweeney","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1110\/ps.041266605","article-title":"The aggregation kinetics of Alzheimer\u2019s beta-amyloid peptide is controlled by stochastic nucleation","volume":"14","author":"Hortschansky","year":"2005","journal-title":"Protein Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","article-title":"LRP\/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms","volume":"43","author":"Deane","year":"2004","journal-title":"Neuron"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1111\/j.1471-4159.2007.04938.x","article-title":"Cerebral clearance of human amyloid-beta peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes","volume":"103","author":"Ito","year":"2007","journal-title":"J. Neurochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1172\/JCI25247","article-title":"P-glycoprotein deficiency at the blood-brain barrier increases amyloid-\u03b2 in an Alzheimer disease mouse model","volume":"115","author":"Cirrito","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_33","unstructured":"Gauthier, S., Webster, C., Servaes, S., Morais, J.A., and Rosa-Neto, P. (2022). World Alzheimer Report 2022: Life after Diagnosis: Navigating Treatment, Care and Support, Alzheimer\u2019s Disease International."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1532-5415.2007.01600.x","article-title":"Reaction to a dementia diagnosis in individuals with Alzheimer\u2019s disease and mild cognitive impairment","volume":"56","author":"Carpenter","year":"2008","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"725","DOI":"10.2217\/nnm-2019-0316","article-title":"Nanoparticles as contrast agents for the diagnosis of Alzheimer\u2019s disease: A systematic review","volume":"15","author":"Ulanova","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jalz.2014.03.003","article-title":"The clinical use of cerebrospinal fluid biomarker testing for Alzheimer\u2019s disease diagnosis: A consensus paper from the Alzheimer\u2019s Biomarkers Standardization Initiative","volume":"10","author":"Molinuevo","year":"2014","journal-title":"Alzheimers Dement."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3233\/JAD-171093","article-title":"A Systematic Review and Aggregated Analysis on the Impact of Amyloid PET Brain Imaging on the Diagnosis, Diagnostic Confidence, and Management of Patients being Evaluated for Alzheimer\u2019s Disease","volume":"63","author":"Fantoni","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nrneurol.2009.215","article-title":"The clinical use of structural MRI in Alzheimer disease","volume":"6","author":"Frisoni","year":"2010","journal-title":"Nat. Rev. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/alz.12756","article-title":"The Alzheimer\u2019s Association appropriate use recommendations for blood biomarkers in Alzheimer\u2019s disease","volume":"18","author":"Hansson","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/joim.12816","article-title":"Biomarkers for Alzheimer\u2019s disease: Current status and prospects for the future","volume":"284","author":"Blennow","year":"2018","journal-title":"J. Intern Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1056\/NEJMp1208061","article-title":"Brain amyloid imaging-FDA approval of florbetapir F18 injection","volume":"367","author":"Yang","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40336-015-0102-6","article-title":"Beta-amyloid imaging with florbetaben","volume":"3","author":"Sabri","year":"2015","journal-title":"Clin. Transl. Imaging"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.jalz.2015.02.004","article-title":"Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer\u2019s disease: Phase 3 study","volume":"11","author":"Sabri","year":"2015","journal-title":"Alzheimers Dement."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00259-015-3208-1","article-title":"Imaging beta-amyloid using [(18)F]flutemetamol positron emission tomography: From dosimetry to clinical diagnosis","volume":"43","author":"Heurling","year":"2016","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13024-017-0162-3","article-title":"Tau PET imaging: Present and future directions","volume":"12","author":"Lemoine","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e-1","DOI":"10.1016\/j.jalz.2013.01.002","article-title":"Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer\u2019s Association","volume":"9","author":"Johnson","year":"2013","journal-title":"Alzheimers Dement."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Sharma, B., and Pervushin, K. (2020). Magnetic Nanoparticles as In Vivo Tracers for Alzheimer\u2019s Disease. Magnetochemistry, 6.","DOI":"10.3390\/magnetochemistry6010013"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14079","DOI":"10.1073\/pnas.96.24.14079","article-title":"Detection of neuritic plaques in Alzheimer\u2019s disease by magnetic resonance microscopy","volume":"96","author":"Benveniste","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/mrm.20266","article-title":"In vivo visualization of Alzheimer\u2019s amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent","volume":"52","author":"Jack","year":"2004","journal-title":"Magn. Reson. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1552-6569.2007.00179.x","article-title":"In vivo visualization of senile-plaque-like pathology in Alzheimer\u2019s disease patients by MR microscopy on a 7T system","volume":"18","author":"Nakada","year":"2008","journal-title":"J. Neuroimaging"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e1580","DOI":"10.1002\/wnan.1580","article-title":"Integration of gadolinium in nanostructure for contrast enhanced-magnetic resonance imaging","volume":"12","author":"Marasini","year":"2020","journal-title":"Wiley Interdiscip Rev. Nanomed. Nanobiotechnol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1186\/1556-276X-9-538","article-title":"Potential applications of magnetic particles to detect and treat Alzheimer\u2019s disease","volume":"9","author":"Busquets","year":"2014","journal-title":"Nanoscale Res. Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/smll.201202111","article-title":"Chemical design of biocompatible iron oxide nanoparticles for medical applications","volume":"9","author":"Ling","year":"2013","journal-title":"Small"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Chaparro, C.I.P., Loureiro, L.R., Valente, M.A., Videira, P.A., Borges, J.P., and Soares, P.I.P. (2019, January 22\u201323). Application of Hyperthermia for Cancer Treatment: Synthesis and Characterization of Magnetic Nanoparticles and their internalization on Tumor Cell Lines. Proceedings of the 2019 IEEE 6th Portuguese Meeting on Bioengineering (ENBENG), Lisbon, Portugal.","DOI":"10.1109\/ENBENG.2019.8692485"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.apsusc.2016.04.181","article-title":"Iron oxide nanoparticles stabilized with a bilayer of oleic acid for magnetic hyperthermia and MRI applications","volume":"383","author":"Soares","year":"2016","journal-title":"Appl. Surf. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"100742","DOI":"10.1016\/j.pmatsci.2020.100742","article-title":"Design and engineering of magneto-responsive devices for cancer theranostics: Nano to macro perspective","volume":"116","author":"Soares","year":"2021","journal-title":"Prog. Mater. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature15649","article-title":"Brain cancer: Tumour cells on neighbourhood watch","volume":"528","author":"Sontheimer","year":"2015","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1039\/C8BM01528G","article-title":"Bifunctional magnetopolymersomes of iron oxide nanoparticles and carboxymethylcellulose conjugated with doxorubicin for hyperthermo-chemotherapy of brain cancer cells","volume":"7","author":"Carvalho","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11060-018-03005-x","article-title":"Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients","volume":"141","author":"Grauer","year":"2019","journal-title":"J. Neurooncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"8511","DOI":"10.1016\/j.biomaterials.2013.07.075","article-title":"Transferrin-conjugated magnetic silica PLGA nanoparticles loaded with doxorubicin and paclitaxel for brain glioma treatment","volume":"34","author":"Cui","year":"2013","journal-title":"Biomaterials"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"32159","DOI":"10.1021\/acsami.6b10175","article-title":"Dual-Targeting Magnetic PLGA Nanoparticles for Codelivery of Paclitaxel and Curcumin for Brain Tumor Therapy","volume":"8","author":"Cui","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Dulinska-Litewka, J., Lazarczyk, A., Halubiec, P., Szafranski, O., Karnas, K., and Karewicz, A. (2019). Superparamagnetic Iron Oxide Nanoparticles-Current and Prospective Medical Applications. Materials, 12.","DOI":"10.3390\/ma12040617"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1148\/radiol.2017162759","article-title":"Ten Things You Might Not Know about Iron Oxide Nanoparticles","volume":"284","year":"2017","journal-title":"Radiology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"77558","DOI":"10.1039\/C6RA14265F","article-title":"Enhanced magnetic properties and MRI performance of bi-magnetic core-shell nanoparticles","volume":"6","author":"Cardona","year":"2016","journal-title":"RSC Adv."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/mrm.10529","article-title":"Detection of Alzheimer\u2019s amyloid in transgenic mice using magnetic resonance microimaging","volume":"50","author":"Wadghiri","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Wadghiri, Y.Z., Li, J., Wang, J., Hoang, D.M., Sun, Y., Xu, H., Tsui, W., Li, Y., Boutajangout, A., and Wang, A. (2013). Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer\u2019s disease transgenic mice using magnetic resonance microimaging. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057097"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1016\/j.neurobiolaging.2008.09.021","article-title":"Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer\u2019s disease","volume":"31","author":"Larbanoix","year":"2010","journal-title":"Neurobiol. Aging"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/cmmi.1626","article-title":"In vitro and in vivo characterization of several functionalized ultrasmall particles of iron oxide, vectorized against amyloid plaques and potentially able to cross the blood-brain barrier: Toward earlier diagnosis of Alzheimer\u2019s disease by molecular imaging","volume":"10","author":"Ansciaux","year":"2015","journal-title":"Contrast. Media Mol. Imaging"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.biomaterials.2014.12.005","article-title":"Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer\u2019s disease mice using magnetic resonance imaging (MRI)","volume":"44","author":"Cheng","year":"2015","journal-title":"Biomaterials"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.2147\/IJN.S240953","article-title":"Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with Abeta Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer\u2019s Disease","volume":"15","author":"Liu","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.jconrel.2020.02.035","article-title":"Magnetic targeted delivery of the SPIONs-labeled mesenchymal stem cells derived from human Wharton\u2019s jelly in Alzheimer\u2019s rat models","volume":"321","author":"Hour","year":"2020","journal-title":"J. Control Release"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1021\/cn300196n","article-title":"Influence of the physiochemical properties of superparamagnetic iron oxide nanoparticles on amyloid beta protein fibrillation in solution","volume":"4","author":"Mahmoudi","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.msec.2015.10.026","article-title":"Effect of PEGylated superparamagnetic iron oxide nanoparticles (SPIONs) under magnetic field on amyloid beta fibrillation process","volume":"59","author":"Mirsadeghi","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8656","DOI":"10.1039\/c3nr00345k","article-title":"Protein corona affects the relaxivity and MRI contrast efficiency of magnetic nanoparticles","volume":"5","author":"Amiri","year":"2013","journal-title":"Nanoscale"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Garello, F., Svenskaya, Y., Parakhonskiy, B., and Filippi, M. (2022). Micro\/Nanosystems for Magnetic Targeted Delivery of Bioagents. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061132"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"19421","DOI":"10.1039\/C6NR07542H","article-title":"Designed synthesis and surface engineering strategies of magnetic iron oxide nanoparticles for biomedical applications","volume":"8","author":"Wu","year":"2016","journal-title":"Nanoscale"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jcis.2013.12.045","article-title":"Effects of surfactants on the magnetic properties of iron oxide colloids","volume":"419","author":"Soares","year":"2014","journal-title":"J. Colloid. Interface Sci."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Wu, Y.Y., Lu, Z.G., Li, Y., Yang, J., and Zhang, X. (2020). Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection. Nanomaterials, 10.","DOI":"10.3390\/nano10081441"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1021\/cm200399t","article-title":"Hybrid, silica-coated, Janus-like plasmonic-magnetic nanoparticles","volume":"23","author":"Sotiriou","year":"2011","journal-title":"Chem. Mater."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0927-7757(02)00305-9","article-title":"Preparation and characterization of magnetite nanoparticles coated by amino silane","volume":"212","author":"Ma","year":"2003","journal-title":"Colloid. Surface A"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s11060-005-9059-z","article-title":"The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma","volume":"78","author":"Jordan","year":"2006","journal-title":"J. Neurooncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3233\/JAD-121171","article-title":"SPION-enhanced magnetic resonance imaging of Alzheimer\u2019s disease plaques in AbetaPP\/PS-1 transgenic mouse brain","volume":"34","author":"Sillerud","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhu, N., Ji, H., Yu, P., Niu, J., Farooq, M.U., Akram, M.W., Udego, I.O., Li, H., and Niu, X. (2018). Surface Modification of Magnetic Iron Oxide Nanoparticles. Nanomaterials, 8.","DOI":"10.3390\/nano8100810"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.biomaterials.2008.10.003","article-title":"A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells","volume":"30","author":"Veiseh","year":"2009","journal-title":"Biomaterials"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2217\/nnm.15.193","article-title":"Orlistat and antisense-miRNA-loaded PLGA-PEG nanoparticles for enhanced triple negative breast cancer therapy","volume":"11","author":"Foygel","year":"2016","journal-title":"Nanomedicine"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.nano.2009.07.008","article-title":"Development of multiple-layer polymeric particles for targeted and controlled drug delivery","volume":"6","author":"Koppolu","year":"2010","journal-title":"Nanomedicine"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0022-1759(82)90007-2","article-title":"Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells","volume":"52","author":"Molday","year":"1982","journal-title":"J. Immunol. Methods"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1016\/j.biomaterials.2007.01.043","article-title":"Nanotoxicity of iron oxide nanoparticle internalization in growing neurons","volume":"28","author":"Pisanic","year":"2007","journal-title":"Biomaterials"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2147\/IJN.S191878","article-title":"Superparamagnetic iron oxide nanoparticles combined with NGF and quercetin promote neuronal branching morphogenesis of PC12 cells","volume":"14","author":"Katebi","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1021\/cn3002015","article-title":"Glyconanoparticle aided detection of beta-amyloid by magnetic resonance imaging and attenuation of beta-amyloid induced cytotoxicity","volume":"4","author":"Kouyoumdjian","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Manek, E., Darvas, F., and Petroianu, G.A. (2020). Use of Biodegradable, Chitosan-Based Nanoparticles in the Treatment of Alzheimer\u2019s Disease. Molecules, 25.","DOI":"10.3390\/molecules25204866"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Poudel, P., and Park, S. (2022). Recent Advances in the Treatment of Alzheimer\u2019s Disease Using Nanoparticle-Based Drug Delivery Systems. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14040835"},{"key":"ref_93","first-page":"25","article-title":"Effect of Magnetic Tacrine-Loaded Chitosan Nanoparticles on Spatial Learning, Memory, Amyloid Precursor Protein and Seladin-1 Expression in the Hippocampus Of Streptozotocin-Exposed Rats","volume":"3","author":"Hassanzadeh","year":"2016","journal-title":"Int. Clin. Neurosci. J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"7345","DOI":"10.1523\/JNEUROSCI.20-19-07345.2000","article-title":"The human DIMINUTO\/DWARF1 homolog seladin-1 confers resistance to Alzheimer\u2019s disease-associated neurodegeneration and oxidative stress","volume":"20","author":"Greeve","year":"2000","journal-title":"J. Neurosci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"105661","DOI":"10.1039\/C6RA20903C","article-title":"Transferrin-conjugated drug\/dye-co-encapsulated magnetic nanocarriers for active-targeting fluorescent\/magnetic resonance imaging and anti-tumor effects in human brain tumor cells","volume":"6","author":"Wang","year":"2016","journal-title":"RSC Adv."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.saa.2014.07.059","article-title":"Synthesis and characterization of polyethylene glycol (PEG) coated Fe3O4 nanoparticles by chemical co-precipitation method for biomedical applications","volume":"135","author":"Anbarasu","year":"2015","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s11671-017-2084-y","article-title":"Enhanced MRI T2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles","volume":"12","author":"Thapa","year":"2017","journal-title":"Nanoscale Res. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Jana, S., and Jana, S. (2022). Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, Wiley Online Library. [1st ed.].","DOI":"10.1007\/978-981-16-4787-1"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1080\/10717544.2020.1775724","article-title":"Multifunctional magnetite nanoparticles to enable delivery of siRNA for the potential treatment of Alzheimer\u2019s","volume":"27","author":"Garcia","year":"2020","journal-title":"Drug Deliv."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1021\/acsbiomaterials.9b00086","article-title":"Improving Sensitivity and Specificity of Amyloid-beta Peptides and Tau Protein Detection with Antibiofouling Magnetic Nanoparticles for Liquid Biopsy of Alzheimer\u2019s Disease","volume":"5","author":"Li","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_101","first-page":"1","article-title":"Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications","volume":"7","author":"Martins","year":"2018","journal-title":"Adv. Healthc. Mater."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.2147\/IJN.S165184","article-title":"Magnetic targeting of paclitaxel-loaded poly(lactic-co-glycolic acid)-based nanoparticles for the treatment of glioblastoma","volume":"13","author":"Ganipineni","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"107211","DOI":"10.1016\/j.microc.2022.107211","article-title":"Novel magnetic beads with improved performance for Alzheimer\u2019s disease biomarker detection","volume":"175","author":"Pando","year":"2022","journal-title":"Microchem. J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/d41586-021-02483-w","article-title":"The tangled history of mRNA vaccines","volume":"597","author":"Dolgin","year":"2021","journal-title":"Nature"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"100299","DOI":"10.1016\/j.mtadv.2022.100299","article-title":"Fabrication of active targeting lipid nanoparticles: Challenges and perspectives","volume":"16","author":"Menon","year":"2022","journal-title":"Mater. Today Adv."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/wnan.122","article-title":"Magnetoliposomes as magnetic resonance imaging contrast agents","volume":"3","author":"Soenen","year":"2011","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.1002\/adma.201502227","article-title":"Nanotheranostics: Congo Red\/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer\u2019s Disease in APPswe\/PS1dE9 Transgenic Mice","volume":"27","author":"Hu","year":"2015","journal-title":"Adv. Mater."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s12951-022-01524-4","article-title":"Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer\u2019s disease via NLRP3-inhibition","volume":"20","author":"Ruan","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1602\/neurorx.2.1.3","article-title":"The blood-brain barrier: Bottleneck in brain drug development","volume":"2","author":"Pardridge","year":"2005","journal-title":"NeuroRx"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"703545","DOI":"10.1155\/2013\/703545","article-title":"Receptor-mediated endocytosis and brain delivery of therapeutic biologics","volume":"2013","author":"Xiao","year":"2013","journal-title":"Int. J. Cell Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/1479-7364-3-3-281","article-title":"Human ATP-binding cassette (ABC) transporter family","volume":"3","author":"Vasiliou","year":"2009","journal-title":"Hum. Genom."},{"key":"ref_112","unstructured":"Zhu, X., Jin, K., Huang, Y., and Pang, Z. (2019). Brain Targeted Drug Delivery System, Elsevier Ltd."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Cavaco, M., Gaspar, D., Arb Castanho, M., and Neves, V. (2020). Antibodies for the Treatment of Brain Metastases, a Dream or a Reality?. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12010062"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0169-409X(95)00005-R","article-title":"Antibody Delivery through the Blood-Brain-Barrier","volume":"15","author":"Bickel","year":"1995","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_115","first-page":"227","article-title":"Targeted Treatment Strategies for Neurological Diseases","volume":"22","author":"Zhang","year":"2017","journal-title":"Oncologist"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1208\/s12248-008-9055-2","article-title":"CNS delivery via adsorptive transcytosis","volume":"10","author":"Herve","year":"2008","journal-title":"AAPS J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.addr.2004.10.010","article-title":"Cell-penetrating peptides: Mechanism and kinetics of cargo delivery","volume":"57","author":"Zorko","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/0092-8674(88)90263-2","article-title":"Cellular uptake of the tat protein from human immunodeficiency virus","volume":"55","author":"Frankel","year":"1988","journal-title":"Cell"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3700","DOI":"10.1021\/acs.molpharmaceut.2c00523","article-title":"Peptides as Pharmacological Carriers to the Brain: Promises, Shortcomings and Challenges","volume":"19","author":"Parrasia","year":"2022","journal-title":"Mol. Pharm."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Sanchez-Navarro, M., and Giralt, E. (2022). Peptide Shuttles for Blood-Brain Barrier Drug Delivery. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14091874"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2010.01.036","article-title":"Endocytosis of nanomedicines","volume":"145","author":"Sahay","year":"2010","journal-title":"J. Control Release"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2016.05.044","article-title":"Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases","volume":"235","author":"Saraiva","year":"2016","journal-title":"J. Control Release"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/17425247.2019.1583205","article-title":"Blood-brain barrier receptors and transporters: An insight on their function and how to exploit them through nanotechnology","volume":"16","author":"Moura","year":"2019","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"104952","DOI":"10.1016\/j.neuint.2020.104952","article-title":"Central nervous system delivery of molecules across the blood-brain barrier","volume":"144","author":"Gosselet","year":"2021","journal-title":"Neurochem. Int."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jconrel.2022.03.007","article-title":"Blood-brain barrier crossing using magnetic stimulated nanoparticles","volume":"345","author":"Chen","year":"2022","journal-title":"J. Control Release"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jconrel.2012.09.021","article-title":"Magnetic targeting of nanoparticles across the intact blood-brain barrier","volume":"164","author":"Kong","year":"2012","journal-title":"J. Control Release"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1021\/cn400093z","article-title":"Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells","volume":"4","author":"Thomsen","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jconrel.2015.02.027","article-title":"Remote control of the permeability of the blood-brain barrier by magnetic heating of nanoparticles: A proof of concept for brain drug delivery","volume":"206","author":"Tabatabaei","year":"2015","journal-title":"J. Control Release"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ejpb.2008.03.009","article-title":"Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles","volume":"70","author":"Wilson","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.brainres.2008.01.039","article-title":"Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted delivery of rivastigmine into the brain to treat Alzheimer\u2019s disease","volume":"1200","author":"Wilson","year":"2008","journal-title":"Brain Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejps.2014.06.024","article-title":"Surface modified PLGA nanoparticles for brain targeting of Bacoside-A","volume":"63","author":"Jose","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1023\/A:1018947208597","article-title":"Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity","volume":"16","author":"Olivier","year":"1999","journal-title":"Pharm. Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jconrel.2011.08.017","article-title":"Transport of drugs across the blood-brain barrier by nanoparticles","volume":"161","author":"Wohlfart","year":"2012","journal-title":"J. Control Release"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2006.10.015","article-title":"Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: Revisiting the role of surfactants","volume":"117","author":"Petri","year":"2007","journal-title":"J. Control Release"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/10611860903105986","article-title":"Uptake of apolipoprotein E fragment coupled liposomes by cultured brain microvessel endothelial cells and intact brain capillaries","volume":"17","author":"Hulsermann","year":"2009","journal-title":"J. Drug Target"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1021\/nn4058215","article-title":"Lipoprotein-based nanoparticles rescue the memory loss of mice with Alzheimer\u2019s disease by accelerating the clearance of amyloid-beta","volume":"8","author":"Song","year":"2014","journal-title":"ACS Nano"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1021\/mp900306x","article-title":"ApoE3 mediated poly(butyl) cyanoacrylate nanoparticles containing curcumin: Study of enhanced activity of curcumin against beta amyloid induced cytotoxicity using in vitro cell culture model","volume":"7","author":"Mulik","year":"2010","journal-title":"Mol. Pharm."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1023\/A:1006948027674","article-title":"Transferrin and transferrin receptor function in brain barrier systems","volume":"20","author":"Moos","year":"2000","journal-title":"Cell Mol. Neurobiol."},{"key":"ref_139","unstructured":"Chang, J., and Betbeder, D. (2012). Nanomedicine and the Nervous System, CRC. [1st ed.]."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ejps.2005.03.008","article-title":"Targeting liposomes with protein drugs to the blood-brain barrier in vitro","volume":"25","author":"Visser","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jconrel.2008.03.007","article-title":"Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26","volume":"128","author":"Pang","year":"2008","journal-title":"J. Control Release"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.colsurfb.2015.06.067","article-title":"Dual ligand immunoliposomes for drug delivery to the brain","volume":"134","author":"Loureiro","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1021\/bc400055h","article-title":"B6 peptide-modified PEG-PLA nanoparticles for enhanced brain delivery of neuroprotective peptide","volume":"24","author":"Liu","year":"2013","journal-title":"Bioconjug. Chem."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1007\/s00018-005-5371-1","article-title":"Mammalian lactoferrin receptors: Structure and function","volume":"62","author":"Suzuki","year":"2005","journal-title":"Cell Mol. Life Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S151474","article-title":"Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer\u2019s disease","volume":"13","author":"Meng","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"6646","DOI":"10.7150\/thno.76574","article-title":"Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-beta burden via depolymerization and intestinal metabolism","volume":"12","author":"Liu","year":"2022","journal-title":"Theranostics"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Wen, X., Wang, K., Zhao, Z., Zhang, Y., Sun, T., Zhang, F., Wu, J., Fu, Y., Du, Y., and Zhang, L. (2014). Brain-targeted delivery of trans-activating transcriptor-conjugated magnetic PLGA\/lipid nanoparticles. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106652"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1186\/s11671-016-1676-2","article-title":"Passage of Magnetic Tat-Conjugated Fe(3)O(4)@SiO(2) Nanoparticles Across In Vitro Blood-Brain Barrier","volume":"11","author":"Zhao","year":"2016","journal-title":"Nanoscale Res. Lett."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1358\/dof.2001.026.06.668342","article-title":"Glycopeptide analgesics","volume":"26","author":"Polt","year":"2001","journal-title":"Drugs Future"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2217\/nnm.11.11","article-title":"Investigation on mechanisms of glycopeptide nanoparticles for drug delivery across the blood-brain barrier","volume":"6","author":"Tosi","year":"2011","journal-title":"Nanomedicine"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1166\/jns.2012.1013","article-title":"The Bridge Between Nanotechnology and Neuroscience: Neuro-Nanomedicine","volume":"2","author":"Tosi","year":"2012","journal-title":"J. Nanoneuroscience"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jtemb.2017.12.006","article-title":"Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer\u2019s disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery","volume":"49","author":"Vilella","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"101658","DOI":"10.1016\/j.arr.2022.101658","article-title":"Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform","volume":"79","author":"Pinto","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.biomaterials.2009.09.104","article-title":"Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain","volume":"31","author":"Wang","year":"2010","journal-title":"Biomaterials"},{"key":"ref_155","first-page":"1","article-title":"A Conditionally Releasable \u201cDo not Eat Me\u201d CD47 Signal Facilitates Microglia-Targeted Drug Delivery for the Treatment of Alzheimer\u2019s Disease","volume":"30","author":"Zhang","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12951-018-0356-z","article-title":"Memantine loaded PLGA PEGylated nanoparticles for Alzheimer\u2019s disease: In vitro and in vivo characterization","volume":"16","author":"Ettcheto","year":"2018","journal-title":"J Nanobiotechnology"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/03639045.2012.758130","article-title":"Preparation, characterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting","volume":"40","author":"Md","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12951-020-00626-1","article-title":"Neuron tau-targeting biomimetic nanoparticles for curcumin delivery to delay progression of Alzheimer\u2019s disease","volume":"18","author":"Gao","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"81001","DOI":"10.18632\/oncotarget.20944","article-title":"PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Abeta generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer\u2019s disease mice","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.nano.2018.09.010","article-title":"Cationic carrier peptide enhances cerebrovascular targeting of nanoparticles in Alzheimer\u2019s disease brain","volume":"16","author":"Ahlschwede","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ejmech.2014.04.050","article-title":"Multifunctional nanoliposomes with curcumin-lipid derivative and brain targeting functionality with potential applications for Alzheimer disease","volume":"80","author":"Mourtas","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.nano.2013.12.001","article-title":"Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Abeta aggregation features and cross the blood-brain-barrier: Implications for therapy of Alzheimer disease","volume":"10","author":"Bana","year":"2014","journal-title":"Nanomedicine"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/acs.molpharmaceut.0c00461","article-title":"Design and Validation of Liposomal ApoE2 Gene Delivery System to Evade Blood-Brain Barrier for Effective Treatment of Alzheimer\u2019s Disease","volume":"18","author":"Arora","year":"2021","journal-title":"Mol. Pharm."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2157-7439.1000171","article-title":"Functionalization with TAT-Peptide Enhances Blood-Brain Barrier Crossing In vitro of Nanoliposomes Carrying a Curcumin-Derivative to Bind Amyloid-\u0392 Peptide","volume":"04","author":"Sancini","year":"2013","journal-title":"J. Nanomed. Nanotechnol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1016\/j.biomaterials.2013.10.075","article-title":"Multimodal nanoprobes to target cerebrovascular amyloid in Alzheimer\u2019s disease brain","volume":"35","author":"Jaruszewski","year":"2014","journal-title":"Biomaterials"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.carres.2014.07.020","article-title":"Heparin nanoparticles for beta amyloid binding and mitigation of beta amyloid associated cytotoxicity","volume":"405","author":"Wang","year":"2015","journal-title":"Carbohydr. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nnano.2014.254","article-title":"Towards non-invasive diagnostic imaging of early-stage Alzheimer\u2019s disease","volume":"10","author":"Viola","year":"2015","journal-title":"Nat. Nanotechnol."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/9\/2316\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:50:27Z","timestamp":1760129427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/15\/9\/2316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,13]]},"references-count":167,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["pharmaceutics15092316"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics15092316","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,13]]}}}