{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:29:15Z","timestamp":1768703355850,"version":"3.49.0"},"reference-count":148,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/NAN-MAT\/1431\/2021"],"award-info":[{"award-number":["PTDC\/NAN-MAT\/1431\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["DOI 10.54499\/PTDC\/NAN-MAT\/1431\/2021"],"award-info":[{"award-number":["DOI 10.54499\/PTDC\/NAN-MAT\/1431\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["2021.08095.BD"],"award-info":[{"award-number":["2021.08095.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background:\u00a0Ganoderma lucidum (GL), commonly known as the \u201cLingzhi\u201d or \u201cReishi\u201d mushroom, has long been recognized for its potential health benefits and medicinal properties in traditional Chinese medicine. The unique potential combination of bioactive compounds present in GL, such as triterpenoids, polysaccharides, and peptides, has inspired interest in leveraging their therapeutic potential In recent years, the emerging field of nanotechnology has opened up new possibilities for using the remarkable properties of GL at the nanoscale. Objetive: The main objective of this review is to explore the unique potential of GL in traditional and innovative therapies, particularly in cancer treatment, and to assess how nanotechnology-based strategies can enhance its therapeutic applications.is to explore. Results: Nanotechnology-based strategies have been investigated for the efficient extraction and purification of bioactive compounds from GL. Additionally, nanocarriers and nanoformulations have been developed to protect these sensitive bioactive compounds from degradation, ensuring their stability during storage and transportation. The use of GL-based nanomaterials has shown promising results in several biomedical applications, namely due to their anticancer activity by targeting cancer cells, inducing apoptosis, and inhibiting tumor growth. Conclusions: The combination of GL and nanotechnology presents an exciting frontier in the development of novel therapeutic and biomedical applications. Nevertheless, further research and development in this interdisciplinary field are warranted to fully exploit the synergistic benefits offered by GL and nanotechnology. Future prospects include the development of robust clinical trials focused on GL nanotechnology-based cancer therapies to clarify mechanisms of actions and optimize formulations, ultimately leading to innovative solutions for human health and well-being.<\/jats:p>","DOI":"10.3390\/pharmaceutics17040422","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T06:58:43Z","timestamp":1742972323000},"page":"422","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Unlocking the Potential of Ganoderma lucidum (Curtis): Botanical Overview, Therapeutic Applications, and Nanotechnological Advances"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5002-7485","authenticated-orcid":false,"given":"Ana","family":"Eira","sequence":"first","affiliation":[{"name":"Laboratory of Drug Development and Technologies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Maria Beatriz S.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Development and Technologies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-9945","authenticated-orcid":false,"given":"Yannick St\u00e9phane Fotsing","family":"Fongang","sequence":"additional","affiliation":[{"name":"Higher Teachers\u2019 Training College, The University of Maroua, Maroua P.O. Box 55, Cameroon"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-9839","authenticated-orcid":false,"given":"C\u00e1tia","family":"Domingues","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Development and Technologies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Group of Pharmaceutical Technology, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Institute for Clinical and Biomedical Research (iCBR) Area of Environment Genetics and Oncobiology (CI MAGO), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Ivana","family":"Jarak","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Development and Technologies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0786-6280","authenticated-orcid":false,"given":"Filipa","family":"Mascarenhas-Melo","sequence":"additional","affiliation":[{"name":"Higher School of Health, Polytechnic Institute of Guarda, 6300-307 Guarda, Portugal"},{"name":"BRIDGES\u2014Biotechnology Research, Innovation and Design of Health Products, Polytechnic University of Guarda, 6300-559 Guarda, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8170-1113","authenticated-orcid":false,"given":"Ana","family":"Figueiras","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Development and Technologies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"},{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), Group of Pharmaceutical Technology, University of Coimbra, 3000-548 Coimbra, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"ref_1","unstructured":"(2024, November 20). 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