{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:34:42Z","timestamp":1770471282323,"version":"3.49.0"},"reference-count":142,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: Curcumin (CUR) is well known for its therapeutic properties, particularly attributed to its antioxidant and anti-inflammatory effects in managing chronic diseases such as arthritis. While CUR application for biomedical purposes is well known, the phytochemical has several restrictions given its poor water solubility, physicochemical instability, and low bioavailability. These limitations have led to innovative formulations, with nanocarriers emerging as a promising alternative. For this reason, this study aimed to address the potential advantages of associating CUR with nanocarrier systems in managing arthritis through a scoping review. Methods: A systematic literature search of preclinical (in vivo) and clinical studies was performed in PubMed, Scopus, and Web of Science (December 2024). General inclusion criteria include using CUR or natural derivatives in nano-based formulations for arthritis treatment. These elements lead to the question: \u201cWhat is the impact of the association of CUR or derivatives in nanocarriers in treating arthritis?\u201d. Results: From an initial 536 articles, 34 were selected for further analysis (31 preclinical investigations and three randomized clinical trials). Most studies used pure CUR (25\/34), associated with organic (30\/34) nanocarrier systems. Remarkably, nanoparticles (16\/34) and nanoemulsions (5\/34) were emphasized. The formulations were primarily presented in liquid form (23\/34) and were generally administered to animal models through intra-articular injection (11\/31). Complete Freund\u2019s Adjuvant (CFA) was the most frequently utilized among the various models to induce arthritis-like joint damage. The findings indicate that associating CUR or its derivatives with nanocarrier systems enhances its pharmacological efficacy through controlled release and enhanced solubility, bioavailability, and stability. Moreover, the encapsulation of CUR showed better results in most cases than in its free form. Nonetheless, most studies were restricted to the preclinical model, not providing direct evidence in humans. Additionally, inadequate information and clarity presented considerable challenges for preclinical evidence, which was confirmed by SYRCLE\u2019s bias detection tools. Conclusions: Hence, this scoping review highlights the anti-arthritic effects of CUR nanocarriers as a promising alternative for improved treatment.<\/jats:p>","DOI":"10.3390\/pharmaceutics17081022","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T15:09:53Z","timestamp":1754492993000},"page":"1022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nanocarriers Containing Curcumin and Derivatives for Arthritis Treatment: Mapping the Evidence in a Scoping Review"],"prefix":"10.3390","volume":"17","author":[{"given":"Beatriz Yurie Sugisawa","family":"Sato","sequence":"first","affiliation":[{"name":"Curso de Biomedicina, Departamento de An\u00e1lises Cl\u00ednicas, Universidade Federal do Paran\u00e1, Curitiba 80210-170, Brazil"}]},{"given":"Susan Iida","family":"Chong","sequence":"additional","affiliation":[{"name":"Curso de Biomedicina, Departamento de An\u00e1lises Cl\u00ednicas, Universidade Federal do Paran\u00e1, Curitiba 80210-170, Brazil"}]},{"given":"Nathalia Mar\u00e7allo Peixoto","family":"Souza","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Paran\u00e1, Curitiba 80210-170, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-1239","authenticated-orcid":false,"given":"Raul Edison Luna","family":"Lazo","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Paran\u00e1, Curitiba 80210-170, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7049-4363","authenticated-orcid":false,"given":"Roberto","family":"Pontarolo","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Paran\u00e1, Curitiba 80210-170, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-8524","authenticated-orcid":false,"given":"Fabiane Gomes de Moraes","family":"Rego","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Paran\u00e1, Curitiba 80210-170, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-587X","authenticated-orcid":false,"given":"Luana Mota","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Paran\u00e1, Curitiba 80210-170, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-9306","authenticated-orcid":false,"given":"Marcel Henrique Marcondes","family":"Sari","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Federal do Paran\u00e1, Curitiba 80210-170, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.rcl.2017.04.005","article-title":"Ultrasound in Arthritis","volume":"55","author":"Plagou","year":"2017","journal-title":"Radiol. 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