{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:01:32Z","timestamp":1760148092411,"version":"build-2065373602"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["956720"],"award-info":[{"award-number":["956720"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photonics"],"abstract":"<jats:p>Pharmacological dilation of the eye to have a larger pupil diameter may allow a better understanding of the wavefront error changes with accommodation. This work aimed to investigate whether dilation of the pupil with Phenylephrine Hydrochloride (PHCl) application changes the accommodative response and the Zernike coefficient magnitude with accommodative demand when computed to a common pupil size. Sixteen right eyes of healthy young subjects were measured with the commercial Hartmann\u2013Shack aberrometer IRX3 (Imagine Eyes, Orsay, France) 30 min after two drops of 1.0% PHCl were applied. The eye wavefronts for accommodative demands from 0 to 5 D were measured in natural conditions and after pupil dilatation. Statistically significant differences between both conditions were found for the Zernike coefficients C3\u22121, C31,\u00a0C40 and C60. Without the effect of PHCl, higher values were found for all higher-order Zernike coefficients (HOA). With increased accommodative response, an increase of C3\u22121 and a decrease of C31 was observed and the C40 becomes more negative; the change from positive to negative is shown in the accommodative demand of 1.5 D. Conversely, C60 increases with increasing accommodative demand. To conclude, the results demonstrated that the mydriatic effect of PHCl causes changes in the magnitude of HOA when accommodation is stimulated. The trends observed in the different Zernike coefficients were the same reported in previous studies.<\/jats:p>","DOI":"10.3390\/photonics10040381","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T03:17:35Z","timestamp":1680146255000},"page":"381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Changes in Wavefront Error of the Eye for Different Accommodation Targets under the Application of Phenylephrine Hydrochloride"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-7595","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mech\u00f3-Garc\u00eda","sequence":"first","affiliation":[{"name":"Clinical & Experimental Optometry Research Laboratory, Centre of Physics (Optometry), School of Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"Physics Center of Minho and Porto Universities (CF-UM-UP), 4710-057 Braga, Portugal"}]},{"given":"I\u00f1aki","family":"Blanco-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Clinical & Experimental Optometry Research Laboratory, Centre of Physics (Optometry), School of Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"Physics Center of Minho and Porto Universities (CF-UM-UP), 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3921-6357","authenticated-orcid":false,"given":"Paulo","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Clinical & Experimental Optometry Research Laboratory, Centre of Physics (Optometry), School of Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"Physics Center of Minho and Porto Universities (CF-UM-UP), 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3664-4273","authenticated-orcid":false,"given":"Rute J.","family":"Macedo-de-Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Clinical & Experimental Optometry Research Laboratory, Centre of Physics (Optometry), School of Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"Physics Center of Minho and Porto Universities (CF-UM-UP), 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-9680","authenticated-orcid":false,"given":"Miguel","family":"Faria-Ribeiro","sequence":"additional","affiliation":[{"name":"Clinical & Experimental Optometry Research Laboratory, Centre of Physics (Optometry), School of Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"Physics Center of Minho and Porto Universities (CF-UM-UP), 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9050-4170","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Gonz\u00e1lez-M\u00e9ijome","sequence":"additional","affiliation":[{"name":"Clinical & Experimental Optometry Research Laboratory, Centre of Physics (Optometry), School of Sciences, University of Minho, 4710-057 Braga, Portugal"},{"name":"Physics Center of Minho and Porto Universities (CF-UM-UP), 4710-057 Braga, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1097\/j.jcrs.0000000000000713","article-title":"Spherical aberration for expanding depth of focus","volume":"47","author":"Burguera","year":"2021","journal-title":"J. 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