{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:41:06Z","timestamp":1763037666226,"version":"build-2065373602"},"reference-count":79,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/115643\/2016","2020\/07826\/BD","UIDB\/05748\/2020","UIDP\/05748\/2020","UIDB\/50006\/2020","UIDP\/50006\/2020","PCIF\/GVB\/0150\/2018"],"award-info":[{"award-number":["SFRH\/BD\/115643\/2016","2020\/07826\/BD","UIDB\/05748\/2020","UIDP\/05748\/2020","UIDB\/50006\/2020","UIDP\/50006\/2020","PCIF\/GVB\/0150\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Strategies to minimize the effects of glyphosate (GLY), the most used herbicide worldwide, on non-target plants need to be developed. In this context, the current study was designed to evaluate the potential of nitric oxide (NO), provided as 200 \u00b5M sodium nitroprusside (SNP), to ameliorate GLY (10 mg kg\u22121 soil) phytotoxicity in tomato plants. Upon herbicide exposure, plant development was majorly inhibited in shoots and roots, followed by a decrease in flowering and fruit set; however, the co-application of NO partially prevented these symptoms, improving plant growth. Concerning redox homeostasis, lipid peroxidation (LP) and reactive oxygen species (ROS) levels rose in response to GLY in shoots of tomato plants, but not in roots. Additionally, GLY induced the overaccumulation of proline and glutathione, and altered ascorbate redox state, but resulted in the inhibition of the antioxidant enzymes. Upon co-treatment with NO, the non-enzymatic antioxidants were not particularly changed, but an upregulation of all antioxidant enzymes was found, which helped to keep ROS and LP under control. Overall, data point towards the benefits of NO against GLY in tomato plants by reducing the oxidative damage and stimulating detoxification pathways, while also preventing GLY-induced impairment of flowering and fruit fresh mass.<\/jats:p>","DOI":"10.3390\/plants10091862","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T21:36:58Z","timestamp":1631223418000},"page":"1862","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Foliar Application of Sodium Nitroprusside Boosts Solanum lycopersicum L. Tolerance to Glyphosate by Preventing Redox Disorders and Stimulating Herbicide Detoxification Pathways"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3330-2024","authenticated-orcid":false,"given":"Cristiano","family":"Soares","sequence":"first","affiliation":[{"name":"GreenUPorto\u2014Sustainable Agrifood Production Research Centre & INOV4AGRO, Biology Department, Faculty of Sciences of University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0757-929X","authenticated-orcid":false,"given":"Francisca","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"GreenUPorto\u2014Sustainable Agrifood Production Research Centre & INOV4AGRO, Biology Department, Faculty of Sciences of University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4450-3596","authenticated-orcid":false,"given":"Bruno","family":"Sousa","sequence":"additional","affiliation":[{"name":"GreenUPorto\u2014Sustainable Agrifood Production Research Centre & INOV4AGRO, Biology Department, Faculty of Sciences of University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8021-4783","authenticated-orcid":false,"given":"Edgar","family":"Pinto","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto (FFUP), Rua de Jorge Viterbo Ferreira n\u00ba 228, 4050-313 Porto, Portugal"},{"name":"Department of Environmental Health, School of Health, P.Porto (ESS-P.Porto), Rua Dr. Ant\u00f3nio Bernardino de Almeida, 400, 4200-072 Porto, Portugal"}]},{"given":"Isabel M. P. L. V. O.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laboratory of Bromatology and Hydrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto (FFUP), Rua de Jorge Viterbo Ferreira n\u00ba 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6857-5968","authenticated-orcid":false,"given":"Ruth","family":"Pereira","sequence":"additional","affiliation":[{"name":"GreenUPorto\u2014Sustainable Agrifood Production Research Centre & INOV4AGRO, Biology Department, Faculty of Sciences of University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-5243","authenticated-orcid":false,"given":"Fernanda","family":"Fidalgo","sequence":"additional","affiliation":[{"name":"GreenUPorto\u2014Sustainable Agrifood Production Research Centre & INOV4AGRO, Biology Department, Faculty of Sciences of University of Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/ps.1518","article-title":"Glyphosate: A once-in-a-century herbicide","volume":"64","author":"Duke","year":"2008","journal-title":"Pest Manag. 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