{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T09:12:11Z","timestamp":1775207531131,"version":"3.50.1"},"reference-count":227,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"iMed.ULisboa","award":["UID\/DTP\/04138\/2013"],"award-info":[{"award-number":["UID\/DTP\/04138\/2013"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (FCT), Portugal","award":["UID\/DTP\/04138\/2013"],"award-info":[{"award-number":["UID\/DTP\/04138\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Hypericum L. genus plants are distributed worldwide, with numerous species identified throughout all continents, except Antarctica. These plant species are currently used in various systems of traditional medicine to treat mild depression, wounds and burns, diarrhea, pain, fevers, and their secondary metabolites previously shown, and the in vitro and\/or in vivo cytotoxic, antimicrobial, anti-inflammatory, antioxidant, antihyperglycemic, and hepatoprotective activities, as well as the acetylcholinesterase and monoamine oxidase inhibitory activities. We conducted a systematic bibliographic search according to the Cochrane Collaboration guidelines to answer the question: \u201cWhat is known about plants of Hypericum genus as a source of natural products with potential clinical biological activity?\u201d We documented 414 different natural products with confirmed in vitro\/in vivo biological activities, and 58 different Hypericum plant species as sources for these natural products. Phloroglucinols, acylphloroglucinols, xanthones, and benzophenones were the main chemical classes identified. The selective cytotoxicity against tumor cells, cell protection, anti-inflammatory, antimicrobial, antidepressant, anti-Alzheimer\u2019s, and adipogenesis-inhibition biological activities are described. Acylphloroglucinols were the most frequent compounds with anticancer and cell-protection mechanisms. To date, no work has been published with a full descriptive list directly relating secondary metabolites to their species of origin, plant parts used, extraction methodologies, mechanisms of action, and biological activities.<\/jats:p>","DOI":"10.3390\/plants11192509","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T05:20:58Z","timestamp":1664169658000},"page":"2509","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Hypericum Genus as a Natural Source for Biologically Active Compounds"],"prefix":"10.3390","volume":"11","author":[{"given":"Gon\u00e7alo Infante","family":"Caldeira","sequence":"first","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5611-0047","authenticated-orcid":false,"given":"Lu\u00eds Pleno","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6549-8047","authenticated-orcid":false,"given":"Rita","family":"Serrano","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-7883","authenticated-orcid":false,"given":"Olga Duarte","family":"Silva","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisbon, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,26]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Taxonomy and Chemotaxonomy of the Genus Hypericum","volume":"5","author":"Crockett","year":"2011","journal-title":"Med. Aromat. Plant Sci. Biotechnol."},{"key":"ref_2","unstructured":"Beck, L. (2005). Pedanius Dioscorides of Anazarbus-De Materia Medica, Olms."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"112686","DOI":"10.1016\/j.jep.2020.112686","article-title":"Ethnopharmacology of Hypericum species in China: A comprehensive review on ethnobotany, phytochemistry and pharmacology","volume":"254","author":"Zhang","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2174\/1389557519666190926120211","article-title":"Hypericum spp.: An Update on the Biological Activities and Metabolic Profiles","volume":"20","author":"Marrelli","year":"2020","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_5","unstructured":"(2021, December 11). Available online: http:\/\/www.efloras.org\/florataxon.aspx?flora_id=2&taxon_id=116180."},{"key":"ref_6","unstructured":"Menezes de Sequeira, M., Esp\u00edrito-Santo, D., Aguiar, C., Capelo, J., and Honrado, J. (2012). Checklist da Flora de Portugal (Continental, A\u00e7ores e Madeira), Associa\u00e7\u00e3o Lusitana de Fitossociologia."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1080\/1057563021000060149","article-title":"Variability in phenolic composition of Hypericum androsaemum","volume":"17","author":"Valentao","year":"2003","journal-title":"Nat. Prod. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jep.2006.04.010","article-title":"The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal","volume":"108","author":"Ferreira","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_9","first-page":"1930","article-title":"Antioxidant properties, total phenolic, total carotenoid and chlorophyll content of anatomical parts of Hypericum foliosum","volume":"5","author":"Rainha","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jep.2017.02.016","article-title":"Hypericum perforatum (St John\u2019s wort) beyond depression: A therapeutic perspective for pain conditions","volume":"200","author":"Galeotti","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/JCP.0b013e31829cc3af","article-title":"Conditional probability of response or nonresponse of placebo compared with antidepressants or St John\u2019s Wort in major depressive disorder","volume":"33","author":"Sarris","year":"2013","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2174\/1389557515666150709105844","article-title":"New potential pharmaceutical applications of Hypericum species","volume":"16","author":"Marrelli","year":"2016","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_13","unstructured":"Agency, E.M. (2009). Community Herbal Monograph on Hypericum perforatum L., Herba (Well-Established Medicinal Use), Committee on Herbal Medicinal Products."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1572-5995(05)80043-2","article-title":"A Survey on the Hypericum genus: Secondary metabolites and bioactivity","volume":"30","author":"Avato","year":"2005","journal-title":"Stud. Nat. Prod. Chem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1055\/a-0581-5286","article-title":"Hyperforin and Miquelianin from St. John\u2019s Wort Attenuate Gene Expression in Neuronal Cells After Dexamethasone-Induced Stress","volume":"84","author":"Verjee","year":"2018","journal-title":"Planta Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jep.2015.04.053","article-title":"LC-MS\/MS based studies on the anti-depressant effect of hypericin in the chronic unpredictable mild stress rat model","volume":"169","author":"Zhai","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.euroneuro.2004.07.004","article-title":"Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin","volume":"15","author":"Cervo","year":"2005","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/S0140-6736(99)00214-7","article-title":"Antibacterial activity of hyperforin from St John\u2019s wort, against multiresistant Staphylococcus aureus and gram-positive bacteria","volume":"353","author":"Schempp","year":"1999","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Imreova, P., Feruszova, J., Kyzek, S., Bodnarova, K., Zduriencikova, M., Kozics, K., Mucaji, P., Galova, E., Sevcovicova, A., and Miadokova, E. (2017). Hyperforin Exhibits Antigenotoxic Activity on Human and Bacterial Cells. Molecules, 22.","DOI":"10.3390\/molecules22010167"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12935-016-0279-4","article-title":"Cytotoxic and apoptogenic effect of hypericin, the bioactive component of Hypericum perforatum on the MCF-7 human breast cancer cell line","volume":"16","author":"Mirmalek","year":"2015","journal-title":"Cancer Cell Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e00195","DOI":"10.1042\/BSR20150028","article-title":"Photoactivation of hypericin decreases the viability of RINm5F insulinoma cells through reduction in JNK\/ERK phosphorylation and elevation of caspase-9\/caspase-3 cleavage and Bax-to-Bcl-2 ratio","volume":"35","author":"Yi","year":"2015","journal-title":"Biosci. Rep."},{"key":"ref_22","first-page":"269","article-title":"Hyperforin induces apoptosis of chronic lymphocytic leukemia cells through upregulation of the BH3-only protein Noxa","volume":"40","author":"Zaher","year":"2012","journal-title":"Int J. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1042\/CBI20120108","article-title":"Hypericin-PDT-induced rapid necrotic death in human squamous cell carcinoma cultures after multiple treatment","volume":"36","author":"Sharma","year":"2012","journal-title":"Cell Biol. Int."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cbi.2011.02.026","article-title":"Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway","volume":"190","author":"Liu","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jphotobiol.2010.06.004","article-title":"Comparative in vitro study on the characteristics of different photosensitizers employed in PDT","volume":"100","author":"Berlanda","year":"2010","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1055\/s-2007-979533","article-title":"Biologically active and other chemical constituents of the herb of Hypericum perforatum L.","volume":"30","author":"Nahrstedt","year":"1997","journal-title":"Pharmacopsychiatry"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1021\/ed081p1450","article-title":"Chemistry of St. John\u2019s Wort Hypericin and Hyperforin","volume":"81","author":"Vollmer","year":"2004","journal-title":"J. Chem. Educ."},{"key":"ref_28","first-page":"193","article-title":"Various dereplication strategies using LC-MS for rapid natural product lead identification and drug discovery","volume":"2","author":"Sashidhara","year":"2006","journal-title":"Nat. Prod. Commun."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Es-Safi, N., Essassi, E.M., and Banoub, J. (2010). Mass Spectrometry as a Powerful Analytical Technique for the Structural Characterization of Synthesized and Natural Products. Detection of Biological Agents for the Prevention of Bioterrorism, NATO. Chemistry and Biology.","DOI":"10.1007\/978-90-481-9815-3_20"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11418-021-01489-y","article-title":"Characteristic metabolites of Hypericum plants: Their chemical structures and biological activities","volume":"75","author":"Tanaka","year":"2021","journal-title":"J. Nat. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cbdv.201300304","article-title":"Recent advances regarding constituents and bioactivities of plants from the genus Hypericum","volume":"12","author":"Zhao","year":"2015","journal-title":"Chem. Biodivers."},{"key":"ref_32","unstructured":"(2022, April 30). Available online: www.theplantlist.org."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wang, J., Shi, M.J., Wang, J.J., Li, J., and Ji, T.F. (2019). Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum acmosepalum. Molecules, 24.","DOI":"10.3390\/molecules24010050"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"104535","DOI":"10.1016\/j.fitote.2020.104535","article-title":"Hyperacmosins E\u2013G, three new homoadamantane-type polyprenylated acylphloroglucinols from Hypericum acmosepalum","volume":"142","author":"Wang","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/10286020.2020.1739662","article-title":"Hyperacmosins H\u2013J, three new polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum acmosepalum","volume":"22","author":"Wang","year":"2020","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1080\/10286020.2021.1880395","article-title":"Two new polycyclic polyprenylated acylphloroglucinols derivatives from Hypericum acmosepalum","volume":"23","author":"Suo","year":"2021","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.fitote.2018.03.011","article-title":"Cytotoxic prenylated acylphloroglucinols from Hypericum annulatum","volume":"127","author":"Nedialkov","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/np500426m","article-title":"Acylphloroglucinol derivatives from Hypericum andinum: Antidepressant-like activity of andinin A","volume":"77","author":"Stolz","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/10286020.2019.1581175","article-title":"Hyperascyrins L\u2013N, rare methylated polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum ascyron","volume":"21","author":"Zhen","year":"2019","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/acs.jnatprod.9b00354","article-title":"Hypascyrins A\u2013E, Prenylated Acylphloroglucinols from Hypericum ascyron","volume":"82","author":"Niwa","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1021\/acs.orglett.8b04022","article-title":"Norascyronones A and B, 2,3,4- nor-Polycyclic Polyprenylated Acylphloroglucinols from Hypericum ascyron","volume":"21","author":"Hu","year":"2019","journal-title":"Org. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1021\/acs.jnatprod.8b00176","article-title":"Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron","volume":"81","author":"Hu","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1039\/C4RA11675E","article-title":"Hyperattenins A\u2013I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy","volume":"5","author":"Li","year":"2015","journal-title":"Rsc. Adv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"8558","DOI":"10.1021\/acs.orglett.9b03098","article-title":"Hyperberins A and B, Type B Polycyclic Polyprenylated Acylphloroglucinols with Bicyclo[5.3.1]hendecane Core from Hypericum beanii","volume":"21","author":"Xu","year":"2019","journal-title":"Org. Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1248\/cpb.59.1250","article-title":"Spirocyclic acylphloroglucinol derivatives from Hypericum beanii","volume":"59","author":"Chen","year":"2011","journal-title":"Chem. Pharm. Bull."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1021\/acs.jafc.0c05417","article-title":"Anti-Inflammatory, Antioxidant, and Anti-Nonalcoholic Steatohepatitis Acylphloroglucinol Meroterpenoids from Hypericum bellum Flowers","volume":"69","author":"Zhou","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1590\/S0102-695X2013000500018","article-title":"Antiproliferative activity of the hexanic extract and phloroglucinols from Hypericum brasiliense","volume":"23","author":"Franca","year":"2013","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/14786419.2019.1619723","article-title":"Polycyclic polyprenylated acylphloroglucinols from Hypericum choisianum","volume":"35","author":"Zhang","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1021\/np400287r","article-title":"Bioactive polyprenylated acylphloroglucinol derivatives from Hypericum cohaerens","volume":"76","author":"Liu","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"112216","DOI":"10.1016\/j.phytochem.2019.112216","article-title":"Hyperelodiones A\u2013C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRalpha","volume":"170","author":"Qiu","year":"2020","journal-title":"Phytochemistry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.fitote.2016.08.014","article-title":"Erecricins A\u2013E, prenylated acylphloroglucinols from the roots of Hypericum erectum","volume":"114","author":"Lu","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s13659-019-0206-1","article-title":"Diverse Polyphenols from Hypericum faberi","volume":"9","author":"Zhang","year":"2019","journal-title":"Nat. Prod. Bioprospect."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1021\/acs.jnatprod.0c01202","article-title":"Diverse Polycyclic Polyprenylated Acylphloroglucinol Congeners with Anti-Nonalcoholic Steatohepatitis Activity from Hypericum forrestii","volume":"84","author":"Lu","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"104529","DOI":"10.1016\/j.bioorg.2020.104529","article-title":"Nine prenylated acylphloroglucinols with potential anti-depressive and hepatoprotective activities from Hypericum scabrum","volume":"107","author":"Ma","year":"2021","journal-title":"Bioorg. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"104959","DOI":"10.1016\/j.fitote.2021.104959","article-title":"Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii","volume":"153","author":"Zong","year":"2021","journal-title":"Fitoterapia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1021\/acs.jnatprod.5b00057","article-title":"Polycyclic Polyprenylated Acylphloroglucinol Congeners Possessing Diverse Structures from Hypericum henryi","volume":"78","author":"Yang","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13659-019-00229-w","article-title":"Dearomatized Isoprenylated Acylphloroglucinol Derivatives with Potential Antitumor Activities from Hypericum henryi","volume":"10","author":"Ye","year":"2020","journal-title":"Nat. Prod. Bioprospect."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/cbdv.200900009","article-title":"Polycyclic polyprenylated acylphloroglucinols and chromone O-glucosides from Hypericum henryi subsp. uraloides","volume":"7","author":"Chen","year":"2010","journal-title":"Chem. Biodivers."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.fitote.2018.12.014","article-title":"homo-Adamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum hookerianum","volume":"133","author":"Ye","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"104678","DOI":"10.1016\/j.fitote.2020.104678","article-title":"Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum","volume":"146","author":"Wang","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1021\/acs.jnatprod.8b00017","article-title":"Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum","volume":"81","author":"Li","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"104984","DOI":"10.1016\/j.fitote.2021.104984","article-title":"Discovery of phloroglucinols from Hypericum japonicum as ferroptosis inhibitors","volume":"153","author":"Peng","year":"2021","journal-title":"Fitoterapia"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1007\/s00894-014-2337-y","article-title":"Evaluation of the antiradical activity of hyperjovinol-A utilizing donor-acceptor maps","volume":"20","author":"Alfaro","year":"2014","journal-title":"J. Mol. Model."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1016\/j.bmcl.2010.06.047","article-title":"Petiolins J\u2013M, prenylated acylphloroglucinols from Hypericum pseudopetiolatum var. kiusianum","volume":"20","author":"Tanaka","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"7926","DOI":"10.1021\/acs.orglett.0c02853","article-title":"Longisglucinols A\u2013C, Structurally Intriguing Polycyclic Polyprenylated Acylphloroglucinols with Anti-inflammatory Activity from Hypericum longistylum","volume":"22","author":"Zhang","year":"2020","journal-title":"Org. Lett."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Tocci, N., Weil, T., Perenzoni, D., Moretto, M., Nurk, N., Madrinan, S., Ferrazza, R., Guella, G., and Mattivi, F. (2020). Potent Antifungal Properties of Dimeric Acylphloroglucinols from Hypericum mexicanum and Mechanism of Action of a Highly Active 3\u2019Prenyl Uliginosin B. Metabolites, 10.","DOI":"10.3390\/metabo10110459"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1039\/C8OB00650D","article-title":"Hypermonins A and B, two 6-norpolyprenylated acylphloroglucinols with unprecedented skeletons from Hypericum monogynum","volume":"16","author":"Zeng","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"7021","DOI":"10.1021\/acs.joc.0c02880","article-title":"Hypermoins A\u2013D: Rearranged Nor-Polyprenylated Acylphloroglucinols from the Flowers of Hypericum monogynum","volume":"86","author":"Zeng","year":"2021","journal-title":"J. Org. Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/10286020.2019.1698551","article-title":"Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum","volume":"23","author":"Zeng","year":"2021","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1097\/CAD.0b013e3283626626","article-title":"Antiproliferative activity of the dimeric phloroglucinol and benzophenone derivatives of Hypericum spp. native to southern Brazil","volume":"24","author":"Pinhatti","year":"2013","journal-title":"Anticancer. Drugs"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1111\/jphp.12307","article-title":"Uliginosin B, a natural phloroglucinol derivative, presents a multimediated antinociceptive effect in mice","volume":"66","author":"Stolz","year":"2014","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ejmech.2018.05.038","article-title":"Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus","volume":"155","author":"Rahman","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1021\/np2003319","article-title":"Antibacterial acylphloroglucinols from Hypericum olympicum","volume":"75","author":"Shiu","year":"2012","journal-title":"J. Nat. Prod."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.bioorg.2019.03.025","article-title":"Hyperpatulols A\u2013I, spirocyclic acylphloroglucinol derivatives with anti-migration activities from the flowers of Hypericum patulum","volume":"87","author":"Liu","year":"2019","journal-title":"Bioorg. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"104902","DOI":"10.1016\/j.bioorg.2021.104902","article-title":"Discovery of nor-bicyclic polyprenylated acylphloroglucinols possessing diverse architectures with anti-hepatoma activities from Hypericum patulum","volume":"111","author":"Duan","year":"2021","journal-title":"Bioorg. Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6478","DOI":"10.1021\/acs.joc.1c00319","article-title":"Hypaluton A, an Immunosuppressive 3,4-nor-Polycyclic Polyprenylated Acylphloroglucinol from Hypericum patulum","volume":"86","author":"Duan","year":"2021","journal-title":"J. Org. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.phytochem.2019.04.011","article-title":"Hyperforatins L\u2013U: Prenylated acylphloroglucinols with a terminal double bond from Hypericum perforatum L. (St John\u2019s Wort)","volume":"164","author":"Guo","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8130","DOI":"10.1039\/C8OB02067A","article-title":"Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum","volume":"16","author":"Guo","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1021\/acs.jnatprod.6b01178","article-title":"Tricyclic Polyprenylated Acylphloroglucinols from St John\u2019s Wort, Hypericum perforatum","volume":"80","author":"Guo","year":"2017","journal-title":"J. Nat. Prod."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"104550","DOI":"10.1016\/j.fitote.2020.104550","article-title":"Polycyclic polyprenylated acylphloroglucinols with acetylcholinesterase inhibitory activities from Hypericum perforatum","volume":"143","author":"Lou","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"6903","DOI":"10.1021\/acs.orglett.0c02434","article-title":"Hyperfols A and B: Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum perforatum","volume":"22","author":"Lou","year":"2020","journal-title":"Org. Lett."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"113525","DOI":"10.1016\/j.jep.2020.113525","article-title":"Hypericum perforatum extract and hyperforin inhibit the growth of neurotropic parasite Toxoplasma gondii and infection-induced inflammatory responses of glial cells in vitro","volume":"267","author":"Shinjyo","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"105144","DOI":"10.1016\/j.bioorg.2021.105144","article-title":"Polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum perforatum and absolute configurations assignment of previously reported analogues","volume":"114","author":"Guo","year":"2021","journal-title":"Bioorg. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"11438","DOI":"10.1039\/D1SC03356E","article-title":"Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer\u2019s activity from St. John\u2019s wort","volume":"12","author":"Guo","year":"2021","journal-title":"Chem. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.parint.2012.10.006","article-title":"Anti-Trichomonas vaginalis activity of Hypericum polyanthemum extract obtained by supercritical fluid extraction and isolated compounds","volume":"62","author":"Cargnin","year":"2013","journal-title":"Parasitol. Int."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1021\/acs.orglett.0c00786","article-title":"Hyperprins A and B, Two Complex Meroterpenoids from Hypericum przewalskii","volume":"22","author":"Zong","year":"2020","journal-title":"Org. Lett."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"112761","DOI":"10.1016\/j.phytochem.2021.112761","article-title":"Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum pseudohenryi","volume":"187","author":"Sun","year":"2021","journal-title":"Phytochemistry"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.1021\/ol5030579","article-title":"Bioactive Acylphloroglucinols with Adamantyl Skeleton from Hypericum sampsonii","volume":"16","author":"Zhu","year":"2014","journal-title":"Org. Lett."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1039\/D0OB02072A","article-title":"Two new seco-polycyclic polyprenylated acylphloroglucinol from Hypericum sampsonii","volume":"19","author":"Zhang","year":"2021","journal-title":"Org. Biomol. Chem."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Moghadam, S.E., Farimani, M.M., Soroury, S., Ebrahimi, S.N., and Jabbarzadeh, E. (2019). Hypermongone C Accelerates Wound Healing through the Modulation of Inflammatory Factors and Promotion of Fibroblast Migration. Molecules, 24.","DOI":"10.3390\/molecules24102022"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.phytochem.2017.06.011","article-title":"Polyprenylated acylphloroglucinols from Hypericum scabrum","volume":"142","author":"Liu","year":"2017","journal-title":"Phytochemistry"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1016\/j.bmcl.2017.09.001","article-title":"Polycyclic polyprenylated acylphloroglucinol derivatives from Hypericum scabrum","volume":"27","author":"Hu","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.tetlet.2016.04.026","article-title":"Four new prenylated phloroglucinol derivatives from Hypericum scabrum","volume":"57","author":"Gao","year":"2016","journal-title":"Tetrahedron. Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1021\/acs.jnatprod.5b01063","article-title":"Polycyclic Polyprenylated Acylphloroglucinol Congeners from Hypericum scabrum","volume":"79","author":"Gao","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"22181","DOI":"10.1038\/s41598-020-79305-y","article-title":"Unusual derivatives from Hypericum scabrum","volume":"10","author":"Soroury","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cbi.2018.11.016","article-title":"Neuroprotective role of hyperforin on aluminum maltolate-induced oxidative damage and apoptosis in PC12 cells and SH-SY5Y cells","volume":"299","author":"Wang","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1080\/14786419.2019.1698576","article-title":"Phloroglucinol derivatives from Hypericum species induce in vitro proliferation of cells involved in the wound healing process","volume":"35","author":"Bridi","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.brainres.2017.08.023","article-title":"Hyperforin protects against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation","volume":"1678","author":"Ma","year":"2018","journal-title":"Brain Res."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Dellafiora, L., Galaverna, G., Cruciani, G., Dall\u2019Asta, C., and Bruni, R. (2018). On the Mechanism of Action of Anti-Inflammatory Activity of Hypericin: An In Silico Study Pointing to the Relevance of Janus Kinases Inhibition. Molecules, 23.","DOI":"10.3390\/molecules23123058"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/jphp.12823","article-title":"Persistence of STAT-1 inhibition and induction of cytokine resistance in pancreatic beta cells treated with St John\u2019s wort and its component hyperforin","volume":"71","author":"Novelli","year":"2019","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopha.2017.09.114","article-title":"Hyperforin attenuates aluminum-induced Abeta production and Tau phosphorylation via regulating Akt\/GSK-3beta signaling pathway in PC12 cells","volume":"96","author":"Huang","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.lfs.2015.11.004","article-title":"Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells","volume":"144","author":"Silva","year":"2016","journal-title":"Life Sci."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biocel.2016.10.017","article-title":"St. John\u2019s wort extract and hyperforin inhibit multiple phosphorylation steps of cytokine signaling and prevent inflammatory and apoptotic gene induction in pancreatic beta cells","volume":"81","author":"Novelli","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3109\/1547691X.2015.1101512","article-title":"St. John\u2019s wort and its componenthyperforin alleviate experimental autoimmune encephalomyelitis through expansion of regulatory T-cells","volume":"13","author":"Nosratabadi","year":"2016","journal-title":"J. Immunotoxicol."},{"key":"ref_105","first-page":"4159","article-title":"Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes","volume":"127","author":"Takada","year":"2014","journal-title":"J. Cell Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00592-013-0518-2","article-title":"St. John\u2019s wort extract and hyperforin protect rat and human pancreatic islets against cytokine toxicity","volume":"51","author":"Novelli","year":"2014","journal-title":"Acta Diabetol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1017\/S146114571100188X","article-title":"The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner","volume":"16","author":"Gibon","year":"2013","journal-title":"Int. J. Neuropsychoph."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1471-4159.2011.07433.x","article-title":"Hyperforin promotes nnitochondrial function and development of oligodendrocytes","volume":"119","author":"Wang","year":"2011","journal-title":"J. Neurochem."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1038\/tp.2011.19","article-title":"Tetrahydrohyperforin prevents cognitive deficit, A beta deposition, tau phosphorylation and synaptotoxicity in the APPswe\/PSEN1 Delta E9 model of Alzheimer\u2019s disease: A possible effect on APP processing","volume":"1","author":"Inestrosa","year":"2011","journal-title":"Transl. Psychiat."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1021\/acs.orglett.5b00100","article-title":"Hypersubones A and B, New Polycyclic Acylphloroglucinols with Intriguing Adamantane Type Cores from Hypericum subsessile","volume":"17","author":"Liao","year":"2015","journal-title":"Org. Lett."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"104755","DOI":"10.1016\/j.fitote.2020.104755","article-title":"Anti-adipogenicadamantane type polycyclic polyprenylated acylphloroglucinols from Hypericum subsessile","volume":"147","author":"Cao","year":"2020","journal-title":"Fitoterapia"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s13659-020-00245-1","article-title":"Adipogenesis Inhibitory Activity of Hypersampsone P from Hypericum subsessile","volume":"10","author":"Zhou","year":"2020","journal-title":"Nat. Prod. Bioprospect."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1021\/acs.jnatprod.5b00667","article-title":"Polycyclic Polyprenylated Derivatives from Hypericum uralum: Neuroprotective Effects and Antidepressant-like Activity of Uralodin A","volume":"79","author":"Zhou","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1021\/acs.jnatprod.5b00830","article-title":"1,9-seco-Bicyclic Polyprenylated Acylphloroglucinols from Hypericum uralum","volume":"78","author":"Zhang","year":"2015","journal-title":"J. Nat. Prod."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"112771","DOI":"10.1016\/j.phytochem.2021.112771","article-title":"Structurally diverse polyprenylated acylphloroglucinols from Hypericum uralum Buch.-Ham. ex D. Don","volume":"187","author":"Fang","year":"2021","journal-title":"Phytochemistry"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1021\/acs.jnatprod.9b01187","article-title":"Hypersonins A\u2013D, Polycyclic Polyprenylated Acylphloroglucinols with a 1,2-seco-Homoadamantane Architecture from Hypericum wilsonii","volume":"83","author":"Xie","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"105246","DOI":"10.1016\/j.bioorg.2021.105246","article-title":"Discovery of bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum wilsonii","volume":"115","author":"Duan","year":"2021","journal-title":"Bioorg. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1248\/cpb.c16-00243","article-title":"Yezo\u2019otogirins D\u2013H, Acylphloroglucinols and Meroterpenes from Hypericum yezoense","volume":"64","author":"Tanaka","year":"2016","journal-title":"Chem. Pharm. Bull."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1016\/j.bmcl.2011.07.004","article-title":"Yojironins E\u2013I, prenylated acylphloroglucinols from Hypericum yojiroanum","volume":"21","author":"Tanaka","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1016\/j.tetlet.2011.04.106","article-title":"Yojironins A\u2013D, meroterpenoids and prenylated acylphloroglucinols from Hypericum yojiroanum","volume":"52","author":"Mamemura","year":"2011","journal-title":"Tetrahedron. Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1021\/acs.jmedchem.9b02056","article-title":"Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Cav3.1 Low Voltage-Gated Ca(2+) Channel","volume":"63","author":"Ye","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.cclet.2019.10.014","article-title":"Hyperinoids A and B, two polycyclic meroterpenoids from Hypericum patulum","volume":"31","author":"Jia","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"717904","DOI":"10.3389\/fchem.2021.717904","article-title":"New Polyprenylated Acylphloroglucinol Derivatives and Xanthones From Hypericum wilsonii","volume":"9","author":"Hao","year":"2021","journal-title":"Front. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.cclet.2020.07.037","article-title":"Three new decarbonyl prenylphloroglucinols bearing unusual spirost subunits from Hypericum scabrum and their neuronal activities","volume":"32","author":"Ma","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1039\/D1QO00271F","article-title":"Norwilsonnol A, an immunosuppressive polycyclic polyprenylated acylphloroglucinol with a spiro[5-oxatricyclo[6.4.0.0(3,7)]dodecane-6\u2019,1-1\u2019,2\u2019-dioxane] system from Hypericum wilsonii","volume":"8","author":"Xie","year":"2021","journal-title":"Org. Chem. Front."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1002\/cjoc.202100210","article-title":"Hypermonones A\u2013I, New Polyprenylated Acylphloroglucinols from Hypericum monogynum with Multidrug Resistance Reversal Activity","volume":"39","author":"Zeng","year":"2021","journal-title":"Chin. J. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"635076","DOI":"10.3389\/fimmu.2021.635076","article-title":"Hyperforin Ameliorates Imiquimod-Induced Psoriasis-Like Murine Skin Inflammation by Modulating IL-17A-Producing gamma delta T Cells","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"105063","DOI":"10.1016\/j.fitote.2021.105063","article-title":"Hyperpatulones C\u2013G, new spirocyclic polycyclic polyprenylated acylphloroglucinols from the leaves of Hypericum patulum","volume":"155","author":"Zhang","year":"2021","journal-title":"Fitoterapia"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/j.cclet.2020.10.027","article-title":"Hyperterpenoids A and B: Two pairs of unprecedented 6\/6\/4\/6\/6 polycyclic cyclobutane meroterpenoids with potent neuroprotective and anti-inflammatory activities from Hypericum beanii","volume":"32","author":"Zhen","year":"2021","journal-title":"Chin. Chem. Lett."},{"key":"ref_130","first-page":"1","article-title":"Antimicrobial activity of dimeric acylphloroglucinols isolated from southern Brazilian Hypericum species against to resistant bacterial","volume":"10","author":"Bridi","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1039\/D1OB02107A","article-title":"Discovery of 13,15-nor-polycyclic polyprenylated acylphloroglucinols from Hypericum longistylum with anti-inflammatory activity","volume":"20","author":"Shi","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/cjoc.202100468","article-title":"Hybeanones A and B, Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii","volume":"40","author":"Yang","year":"2022","journal-title":"Chin. J. Chem."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"104275","DOI":"10.1016\/j.bioorg.2020.104275","article-title":"Dimethylated acylphloroglucinol meroterpenoids with anti-oral-bacterial and anti-inflammatory activities from Hypericum elodeoides","volume":"104","author":"Li","year":"2020","journal-title":"Bioorg. Chem."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4103\/pm.pm_485_17","article-title":"Hypericin, an Anthraquinone Derivative of Hypericum hookerianum Wight and Arn. (Hypericaceae) of Palni Hills, South India, Exhibits Anti-Inflammatory Property in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages","volume":"14","author":"Mahendrakumar","year":"2018","journal-title":"Pharmacogn. Mag."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"FSO371","DOI":"10.4155\/fsoa-2018-0096","article-title":"The synergistic effect of hydroalcoholic extracts of Origanum vulgare, Hypericum perforatum and their active components carvacrol and hypericin against Staphylococcus aureus","volume":"5","author":"Bahmani","year":"2019","journal-title":"Future Sci. OA"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"112948","DOI":"10.1016\/j.jep.2020.112948","article-title":"Chemical constituents with cytotoxic and anti-inflammatory activity in Hypericum sampsonii and the antitumor potential under the view of cancer-related inflammation","volume":"259","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pdpdt.2018.08.008","article-title":"Hypericin-assisted photodynamic therapy against anaplastic thyroid cancer","volume":"24","author":"Kim","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Yonar, D., Kilic Suloglu, A., Selmanoglu, G., and Sunnetcioglu, M.M. (2019). An Electron paramagnetic resonance (EPR) spin labeling study in HT-29 Colon adenocarcinoma cells after Hypericin-mediated photodynamic therapy. BMC Mol. Cell Biol., 20.","DOI":"10.1186\/s12860-019-0205-4"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4062\/biomolther.2016.034","article-title":"Hypericin, a Naphthodianthrone Derivative, Prevents Methylglyoxal-Induced Human Endothelial Cell Dysfunction","volume":"25","author":"Do","year":"2017","journal-title":"Biomol. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1128\/AAC.00545-15","article-title":"Development of a novel formulation with hypericin to treat cutaneous leishmaniasis based on photodynamic therapy in in vitro and in vivo studies","volume":"59","author":"Montoya","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.tiv.2014.06.011","article-title":"Single pre-treatment with hypericin, a St. John\u2019s wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells","volume":"28","author":"Jendzelovska","year":"2014","journal-title":"Toxicol. Vitr."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1055\/s-0033-1360174","article-title":"Photodynamic Effect of Hypericin after Topical Application in the Ex Ovo Quail Chorioallantoic Membrane Model","volume":"80","author":"Cavarga","year":"2014","journal-title":"Planta Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00213-012-2950-3","article-title":"Reversal of NO-induced nociceptive hypersensitivity by St. John\u2019s wort and hypericin: NF-kappaB, CREB and STAT1 as molecular targets","volume":"227","author":"Galeotti","year":"2013","journal-title":"Psychopharmacology"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s10930-012-9433-6","article-title":"Evaluation of the in vitro inhibitory impact of hypericin on placental glutathione S-transferase pi","volume":"31","author":"Dalmizrak","year":"2012","journal-title":"Protein J."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1111\/j.1476-5381.2009.00513.x","article-title":"Hypericin prolongs action potential duration in hippocampal neurons by acting on K+ channels","volume":"159","author":"Wang","year":"2010","journal-title":"Brit. J. Pharmacol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejphar.2010.02.035","article-title":"Hypericin, the active component of St. John\u2019s wort, inhibits glutamate release in the rat cerebrocortical synaptosomes via a mitogen-activated protein kinase-dependent pathway","volume":"634","author":"Chang","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"ref_147","first-page":"1302","article-title":"Hypericin, a medicinal compound from St. John\u2019s Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells","volume":"45","author":"Cruz","year":"2020","journal-title":"Drug Chem. Toxicol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ijbiomac.2019.12.231","article-title":"Inhibition of pancreatic lipase by the constituents in St. John\u2019s Wort: In vitro and in silico investigations","volume":"145","author":"Hou","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"828984","DOI":"10.3389\/fmicb.2022.828984","article-title":"Identification of Hypericin as a Candidate Repurposed Therapeutic Agent for COVID-19 and Its Potential Anti-SARS-CoV-2 Activity","volume":"13","author":"Matos","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"114767","DOI":"10.1016\/j.jep.2021.114767","article-title":"Anti-fatigue effect of hypericin in a chronic forced exercise mouse model","volume":"284","author":"Sun","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"108560","DOI":"10.1016\/j.intimp.2022.108560","article-title":"The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism","volume":"105","author":"Zhai","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1080\/14786419.2010.524647","article-title":"Elegaphenone and 7-epi-clusianone, the major cytotoxic constituents of Hypericum elegans","volume":"25","author":"Nedialkov","year":"2011","journal-title":"Nat. Prod. Res."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1475-2875-10-167","article-title":"Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: A bioassay-guided fractionation of the stem bark","volume":"10","author":"Zofou","year":"2011","journal-title":"Malar. J."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1080\/14786419.2020.1865955","article-title":"Two new benzophenone glycosides from the aerial parts of Hypericum przewalskii","volume":"36","author":"Xie","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1080\/14786419.2020.1756800","article-title":"Hyperprzeone A, a new benzophenone with cytotoxicity from Hypericum przewalskii Maxim","volume":"35","author":"Zhang","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.fitote.2016.10.014","article-title":"Chiral separation and absolute configurations of two pairs of racemic polyprenylated benzophenones from Hypericum sampsonii","volume":"116","author":"Tian","year":"2017","journal-title":"Fitoterapia"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Huang, C.Y., Chang, T.C., Wu, Y.J., Chen, Y., and Chen, J.J. (2020). Benzophenone and Benzoylphloroglucinol Derivatives from Hypericum sampsonii with Anti-Inflammatory Mechanism of Otogirinin A. Molecules, 25.","DOI":"10.3390\/molecules25194463"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1080\/14786419.2019.1586690","article-title":"Bioactive compounds from the aerial parts of Hypericum sampsonii","volume":"35","author":"Kim","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1055\/s-0029-1240942","article-title":"The antinociceptive effect of a benzopyran (HP1) isolated from Hypericum polyanthemum in mice hot-plate test is blocked by naloxone","volume":"76","author":"Haas","year":"2010","journal-title":"Planta Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.fitote.2016.10.003","article-title":"Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum","volume":"115","author":"Gao","year":"2016","journal-title":"Fitoterapia"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijbiomac.2017.10.103","article-title":"Development, characterization, antioxidant and hepatoprotective properties of poly(epsilon-caprolactone) nanoparticles loaded with a neuroprotective fraction of Hypericum perforatum","volume":"110","author":"Oliveira","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"104421","DOI":"10.1016\/j.fitote.2019.104421","article-title":"Three new prenyloxy chromanones from aerial parts of Hypericum aucheri","volume":"139","author":"Nedialkov","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"104578","DOI":"10.1016\/j.bioorg.2020.104578","article-title":"Cytotoxic polyprenylated phloroglucinol derivatives from Hypericum elodeoides Choisy modulating the transactivation of RXRalpha","volume":"107","author":"Qiu","year":"2021","journal-title":"Bioorg. Chem."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phytochem.2018.12.011","article-title":"Polycyclic polyprenylated acylphloroglucinol and phenolic metabolites from the aerial parts of Hypericum elatoides and their neuroprotective and anti-neuroinflammatory activities","volume":"159","author":"Yan","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/cbdv.201100310","article-title":"Lavandulyl flavanones from the stems of Hypericum calycinum L.","volume":"9","author":"Win","year":"2012","journal-title":"Chem. Biodivers."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/2049-632X.12051","article-title":"Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities","volume":"68","author":"Esposito","year":"2013","journal-title":"Pathog. Dis."},{"key":"ref_167","first-page":"249","article-title":"Bioassay Directed Isolation Studies on Hypericum oblongifolium","volume":"40","author":"Sajid","year":"2018","journal-title":"J. Chem. Soc. Pak."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10600-021-03441-8","article-title":"A New Benzophenone and Bioactive Constituents of Hypericum nokoense","volume":"57","author":"Wu","year":"2021","journal-title":"Chem. Nat. Compd."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.phymed.2011.02.013","article-title":"Antibacterial and synergy of a flavanonol rhamnoside with antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)","volume":"18","author":"An","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Larit, F., Elokely, K.M., Nael, M.A., Benyahia, S., Leon, F., Cutler, S.J., and Ghoneim, M.M. (2021). Proposed Mechanism for the Antitrypanosomal Activity of Quercetin and Myricetin Isolated from Hypericum afrum Lam.: Phytochemistry, In Vitro Testing and Modeling Studies. Molecules, 26.","DOI":"10.3390\/molecules26041009"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"e2100244","DOI":"10.1002\/cbdv.202100244","article-title":"alpha-Glucosidase Inhibition Action of Major Flavonoids Identified from Hypericum Attenuatum Choisy and Their Synergistic Effects","volume":"18","author":"Jin","year":"2021","journal-title":"Chem. Biodivers."},{"key":"ref_172","first-page":"e928402","article-title":"A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model","volume":"27","author":"Feng","year":"2021","journal-title":"Med. Sci. Monit."},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Farooq, U., Khan, T., Shah, S.A., Hossain, M.S., Ali, Y., Ullah, R., Raziq, N., Shahid, M., and Capasso, R. (2021). Isolation, Characterization and Neuroprotective Activity of Folecitin: An In Vivo Study. Life, 11.","DOI":"10.3390\/life11080825"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e13898","DOI":"10.1111\/jfbc.13898","article-title":"Flavonoids from Hypericum patulum enhance glucose consumption and attenuate lipid accumulation in HepG2 cells","volume":"45","author":"Duan","year":"2021","journal-title":"J. Food Biochem."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"13104","DOI":"10.1111\/jcmm.15915","article-title":"Astilbin prevents osteoarthritis development through the TLR4\/MD-2 pathway","volume":"24","author":"Sun","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3389\/fphar.2020.01065","article-title":"Hyperoside Protected Against Oxidative Stress-Induced Liver Injury via the PHLPP2-AKT-GSK-3beta Signaling Pathway In Vivo and In Vitro","volume":"11","author":"Xing","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_177","first-page":"617","article-title":"Hyperoside exhibits anticancer activity in non-small cell lung cancer cells with T790M mutations by upregulating FoxO1 via CCAT1","volume":"43","author":"Hu","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.31925\/farmacia.2021.6.9","article-title":"Hypericum Sp. Extracts Improve Anxiety-Like Behaviour and Influence Cerebral Hmox1 Expression in a Rat Model of Fg-7142-Induced Anxiety","volume":"69","author":"Toma","year":"2021","journal-title":"Farmacia"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"112970","DOI":"10.1016\/j.phytochem.2021.112970","article-title":"Chemical constituents from the flowers of Hypericum monogynum L. with COX-2 inhibitory activity","volume":"193","author":"Li","year":"2022","journal-title":"Phytochemistry"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"8706400","DOI":"10.1155\/2021\/8706400","article-title":"Hyperoside Attenuate Inflammation in HT22 Cells via Upregulating SIRT1 to Activities Wnt\/beta-Catenin and Sonic Hedgehog Pathways","volume":"2021","author":"Huang","year":"2021","journal-title":"Neural Plast."},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Lin, C., Wu, M.H., and Dong, J.Y. (2012). Quercetin-4 \u2018-O-beta-D-glucopyranoside (QODG) Inhibits Angiogenesis by Suppressing VEGFR2-Mediated Signaling in Zebrafish and Endothelial Cells. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0031708"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1055\/s-0030-1250386","article-title":"The anti-immobility effect of hyperoside on the forced swimming test in rats is mediated by the D2-like receptors activation","volume":"77","author":"Haas","year":"2011","journal-title":"Planta Med."},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Huang, Z.-Q., Chen, P., Su, W.-W., Wang, Y.-G., Wu, H., Peng, W., and Li, P.-B. (2018). Antioxidant Activity and Hepatoprotective Potential of Quercetin 7-Rhamnoside In Vitro and In Vivo. Molecules, 23.","DOI":"10.3390\/molecules23051188"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3892\/ijmm.2013.1414","article-title":"Effect of quercetin 7-rhamnoside on glycochenodeoxycholic acid-induced L-02 human normal liver cell apoptosis","volume":"32","author":"Liang","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Quispe, Y.N.G., Hwang, S.H., Wang, Z.Q., and Lim, S.S. (2017). Screening of Peruvian Medicinal Plants for Tyrosinase Inhibitory Properties: Identification of Tyrosinase Inhibitors in Hypericum laricifolium Juss. Molecules, 22.","DOI":"10.3390\/molecules22030402"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/aps.2015.148","article-title":"Hyperoside induces both autophagy and apoptosis in non-small cell lung cancer cells in vitro","volume":"37","author":"Fu","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2741\/4814","article-title":"Hyperoside exerts potent anticancer activity in skin cancer","volume":"25","author":"Kong","year":"2020","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"112884","DOI":"10.1016\/j.jep.2020.112884","article-title":"Hyperoside alleviates epilepsy-induced neuronal damage by enhancing antioxidant levels and reducing autophagy","volume":"257","author":"Cao","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e1900069","DOI":"10.1002\/cbdv.201900069","article-title":"Rutin as Deoxyribonuclease I Inhibitor","volume":"16","author":"Kolarevic","year":"2019","journal-title":"Chem. Biodivers."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.3892\/mmr.2017.7453","article-title":"Effect of hyperoside on the apoptosis of A549 human non-small cell lung cancer cells and the underlying mechanism","volume":"16","author":"Yang","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/jphp.12717","article-title":"Permeation characteristics of hypericin across Caco-2 monolayers in the presence of single flavonoids, defined flavonoid mixtures or Hypericum extract matrix","volume":"71","author":"Verjee","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.biopha.2017.05.019","article-title":"Hyperoside protects against chronic mild stress-induced learning and memory deficits","volume":"91","author":"Gong","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.biopha.2016.06.035","article-title":"The preventive effects of hyperoside on lung cancer in vitro by inducing apoptosis and inhibiting proliferation through Caspase-3 and P53 signaling pathway","volume":"83","author":"Liu","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/aps.2016.7","article-title":"Hyperoside exerts anti-inflammatory and anti-arthritic effects in LPS-stimulated human fibroblast-like synoviocytes in vitro and in mice with collagen-induced arthritis","volume":"37","author":"Jin","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s10753-014-9863-8","article-title":"Hyperoside inhibits high-glucose-induced vascular inflammation in vitro and in vivo","volume":"37","author":"Ku","year":"2014","journal-title":"Inflammation"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroscience.2013.01.032","article-title":"Quercetin up-Regulates Mitochondrial Complex-I Activity to Protect against Programmed Cell Death in Rotenone Model of Parkinson\u2019s Disease in Rats","volume":"236","author":"Karuppagounder","year":"2013","journal-title":"Neuroscience"},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejphar.2011.09.177","article-title":"Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid beta-protein via the PI3K\/Akt\/Bad\/Bcl(XL)-regulated mitochondrial apoptotic pathway","volume":"672","author":"Zeng","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.antiviral.2010.08.016","article-title":"Inhibition of influenza virus replication by plant-derived isoquercetin","volume":"88","author":"Kim","year":"2010","journal-title":"Antivir. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"114257","DOI":"10.1016\/j.jep.2021.114257","article-title":"Botanicals and phytochemicals from the bark of Hypericum roeperianum (Hypericaceae) had strong antibacterial activity and showed synergistic effects with antibiotics against multidrug-resistant bacteria expressing active efflux pumps","volume":"277","author":"Demgne","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"8701801","DOI":"10.1155\/2017\/8701801","article-title":"Hyperforin\/HP-beta-Cyclodextrin Enhances Mechanosensitive Ca2+ Signaling in HaCaT Keratinocytes and in Atopic Skin Ex Vivo Which Accelerates Wound Healing","volume":"2017","author":"Takada","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.fitote.2017.12.020","article-title":"Hyperattenins L and M, two new polyprenylated acylphloroglucinols with adamantyl and homoadamantyl core structures from Hypericum attenuatum","volume":"125","author":"Li","year":"2018","journal-title":"Fitoterapia"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bioorg.2017.09.001","article-title":"Polycyclic phloroglucinols as PTP1B inhibitors from Hypericum longistylum: Structures, PTP1B inhibitory activities, and interactions with PTP1B","volume":"75","author":"Cao","year":"2017","journal-title":"Bioorg. Chem."},{"key":"ref_203","first-page":"1231","article-title":"Polyprenylated Phloroglucinols from Hypericum maculatum","volume":"10","author":"Nedialkov","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/14786419.2012.695365","article-title":"Hyperinakin, a new anti-inflammatory phloroglucinol derivative from Hypericum nakamurai","volume":"27","author":"Cheng","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Abdallah, H.M., Timraz, N.Z., Ibrahim, S.R.M., El-Halawany, A.M., Malebari, A.M., Shehata, I.A., and El-Bassossy, H.M. (2021). Nitric-Oxide-Mediated Vasodilation of Bioactive Compounds Isolated from Hypericum revolutum in Rat Aorta. Biology, 10.","DOI":"10.3390\/biology10060541"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1111\/cbdd.13002","article-title":"The anti-Trichomonas vaginalis phloroglucinol derivative isoaustrobrasilol B modulates extracellular nucleotide hydrolysis","volume":"90","author":"Menezes","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"105097","DOI":"10.1016\/j.fitote.2021.105097","article-title":"Chemical structures and induction of cell death via heat shock protein inhibition of the prenylated phloroglucinol derivatives isolated from Hypericum erectum","volume":"156","author":"Muatsumoto","year":"2022","journal-title":"Fitoterapia"},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Zhang, S., Yin, J., Li, X., Zhang, J., Yue, R., Diao, Y., Li, H., Wang, H., Shan, L., and Zhang, W. (2014). Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-689"},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"5360","DOI":"10.1021\/acs.orglett.6b02725","article-title":"Hypatulins A and B, Meroterpenes from Hypericum patulum","volume":"18","author":"Tanaka","year":"2016","journal-title":"Org Lett"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s11418-021-01540-y","article-title":"Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron","volume":"75","author":"Niwa","year":"2021","journal-title":"J. Nat. Med."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1002\/cbdv.201100154","article-title":"Polycyclic polyprenylated acylphloroglucinols and cytotoxic constituents of Hypericum androsaemum","volume":"9","author":"Wang","year":"2012","journal-title":"Chem. Biodivers."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"4314807","DOI":"10.1155\/2020\/4314807","article-title":"Cytotoxic Constituents of the Bark of Hypericum roeperianum towards Multidrug-Resistant Cancer Cells","volume":"2020","author":"Guefack","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"4394","DOI":"10.1080\/14786419.2021.1998896","article-title":"Discovery of immunosuppressive Lupane-type Triterpenoids from Hypericum longistylum","volume":"36","author":"Yan","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/jcp.24392","article-title":"Neuroprotective activity of pDING in response to HIV-1 Tat","volume":"229","author":"Darbinian","year":"2014","journal-title":"J. Cell Physiol."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/ptr.3453","article-title":"Phenol glycosides with in vitro anti-Helicobacter pylori activity from Hypericum erectum Thunb","volume":"25","author":"Moon","year":"2011","journal-title":"Phytother. Res."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"27588","DOI":"10.1038\/srep27588","article-title":"(\u00b1)-Japonones A and B, two pairs of new enantiomers with anti-KSHV activities from Hypericum japonicum","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ijantimicag.2013.08.007","article-title":"A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus","volume":"42","author":"Shiu","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"104923","DOI":"10.1016\/j.fitote.2021.104923","article-title":"Acmoxanthones A-E, New Lavandulated Xanthones from Hypericum acmosepalum N. Robson","volume":"154","author":"Wang","year":"2021","journal-title":"Fitoterapia"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.5504\/BBEQ.2011.0099","article-title":"Acute Toxicity, Antidepressive and Mao Inhibitory Activity of Mangiferin Isolated from Hypericum Aucheri","volume":"25","author":"Dimitrov","year":"2011","journal-title":"Biotechnol. Biotech. Equip."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.3390\/ijms13078210","article-title":"Isojacareubin from the Chinese herb Hypericum japonicum: Potent antibacterial and synergistic effects on clinical methicillin-resistant Staphylococcus aureus (MRSA)","volume":"13","author":"Zuo","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phytochem.2017.11.009","article-title":"Phenolic metabolites from Hypericum kelleri Bald., an endemic species of Crete (Greece)","volume":"146","author":"Mathioudaki","year":"2018","journal-title":"Phytochemistry"},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1021\/acs.jnatprod.8b00325","article-title":"Additional Insights into Hypericum perforatum Content: Isolation, Total Synthesis, and Absolute Configuration of Hyperbiphenyls A and B from Immunomodulatory Root Extracts","volume":"81","author":"Breard","year":"2018","journal-title":"J. Nat. Prod."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.plaphy.2013.05.046","article-title":"Bioassay-guided fractionation of extracts from Hypericum perforatum in vitro roots treated with carboxymethylchitosans and determination of antifungal activity against human fungal pathogens","volume":"70","author":"Tocci","year":"2013","journal-title":"Plant Physiol. Bioch."},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1080\/14786419.2019.1677655","article-title":"A new polyketide from the bark of Hypericum roeperianum Schimp. (Hypericaceae)","volume":"35","author":"Damen","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_225","doi-asserted-by":"crossref","unstructured":"Ji, Y., Zhang, R., Zhang, C., Li, X., Negrin, A., Yuan, C., Kennelly, E.J., and Long, C. (2019). Cytotoxic Xanthones from Hypericum stellatum, an Ethnomedicine in Southwest China. Molecules, 24.","DOI":"10.3390\/molecules24193568"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.curtheres.2014.04.003","article-title":"Effect of xanthone derivatives on animal models of depression","volume":"76","author":"Zhao","year":"2014","journal-title":"Curr. Ther. Res. Clin. Exp."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.fct.2018.05.009","article-title":"Prenylated beta-diketones, two new additions to the family of biologically active Hypericum perforatum L. (Hypericaceae) secondary metabolites","volume":"118","author":"Radulovic","year":"2018","journal-title":"Food Chem. Toxicol."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/19\/2509\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:39:27Z","timestamp":1760143167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/11\/19\/2509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,26]]},"references-count":227,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["plants11192509"],"URL":"https:\/\/doi.org\/10.3390\/plants11192509","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,26]]}}}