{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T13:13:05Z","timestamp":1766754785287,"version":"build-2065373602"},"reference-count":128,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT) through national funds\/MCTES (Portugal)","award":["UIDB\/50006\/2020","REQUIMTE 2019-57","n\u00b0 696295"],"award-info":[{"award-number":["UIDB\/50006\/2020","REQUIMTE 2019-57","n\u00b0 696295"]}]},{"name":"Laborat\u00f3rio Associado para a Qu\u00edmica Verde\u2014Tecnologias e Processos Limpos\u2014UIDB\/50006\/2020","award":["UIDB\/50006\/2020","REQUIMTE 2019-57","n\u00b0 696295"],"award-info":[{"award-number":["UIDB\/50006\/2020","REQUIMTE 2019-57","n\u00b0 696295"]}]},{"name":"national research funding parties in Belgium (FWO), France (INRA), Germany (BLE), Italy (MIPAAF), Latvia (IZM), Norway (RCN), Portugal (FCT), and Spain (AEI) in a joint action of JPI HDHL, JPI-OCEANS, and FACCE-JPI launched in 2019 under the ERA-NET ERA-HDHL","award":["UIDB\/50006\/2020","REQUIMTE 2019-57","n\u00b0 696295"],"award-info":[{"award-number":["UIDB\/50006\/2020","REQUIMTE 2019-57","n\u00b0 696295"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Leaf extract of Cydonia Oblonga Mill. is interesting for further exploration of the potential of its substrates for therapeutic supplements. Quantitative and qualitative analyses were conducted on samples of green (October), yellow (November), and brown (December) quince leaves collected in the region of Pinhel, Portugal. Mineral analysis determined the measurements of the levels of several macro- and micro-elements. Organic analysis assessed the moisture content, total phenolic content (TPC), vitamin E, and fatty acid (FA) profiles. Mineral analysis was based on ICP-MS techniques, while the profiles of vitamin E and FA relied on HPLC-DAD-FLD and GC-FID techniques, respectively. Moisture content was determined through infrared hygrometry and TPC was determined by spectrophotometric methods. Regarding the mineral content, calcium, magnesium, and iron were the most abundant minerals. Concerning organic analysis, all leaf samples showed similar moisture content, while the TPC of gallic acid equivalents (GAE) and total vitamin E content, the most predominant of which was the \u03b1-tocopherol isomer, showed significant variations between green-brown and yellow leaves. FA composition in all leaf samples exhibited higher contents of SFA and PUFA than MUFA, with a predominance of palmitic and linolenic acids. Organic and inorganic analysis of quince leaves allow for the prediction of adequate physiological properties, mainly cardiovascular, pulmonary, and immunological defenses, which with our preliminary in silico studies suggest an excellent supplement to complementary therapy, including drastic pandemic situations.<\/jats:p>","DOI":"10.3390\/plants11192638","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T01:21:07Z","timestamp":1665364867000},"page":"2638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Potential Therapeutic Properties of the Leaf of Cydonia Oblonga Mill. Based on Mineral and Organic Profiles"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-2168","authenticated-orcid":false,"given":"Diana Melo","family":"Ferreira","sequence":"first","affiliation":[{"name":"LAQV\/REQUIMTE\u2014Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-6338","authenticated-orcid":false,"given":"Nat\u00e1lia M.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health, 4250-105 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-0715","authenticated-orcid":false,"given":"Lara","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health, 4250-105 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4570-5445","authenticated-orcid":false,"given":"Jorge","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health, 4250-105 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-6596","authenticated-orcid":false,"given":"Maria Beatriz","family":"Oliveira","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE\u2014Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1021\/jf903836k","article-title":"First report on Cydonia oblonga Miller anticancer potential: Differential antiproliferative effect against human kidney and colon cancer cells","volume":"58","author":"Carvalho","year":"2010","journal-title":"J. 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