{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T16:55:25Z","timestamp":1770137725530,"version":"3.49.0"},"reference-count":177,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia a Tecnologia (FCT)","award":["CEF UI0183\u2013UID\/BIA\/04004\/2020"],"award-info":[{"award-number":["CEF UI0183\u2013UID\/BIA\/04004\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia a Tecnologia (FCT)","award":["LAQV-REQUIMTE UIDB\/50006\/2020"],"award-info":[{"award-number":["LAQV-REQUIMTE UIDB\/50006\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia a Tecnologia (FCT)","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia a Tecnologia (FCT)","award":["SFRH\/BPD\/100865\/2014"],"award-info":[{"award-number":["SFRH\/BPD\/100865\/2014"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia a Tecnologia (FCT)","award":["SFRH\/BPD\/74299\/2010"],"award-info":[{"award-number":["SFRH\/BPD\/74299\/2010"]}]},{"name":"FCT","award":["CEF UI0183\u2013UID\/BIA\/04004\/2020"],"award-info":[{"award-number":["CEF UI0183\u2013UID\/BIA\/04004\/2020"]}]},{"name":"FCT","award":["LAQV-REQUIMTE UIDB\/50006\/2020"],"award-info":[{"award-number":["LAQV-REQUIMTE UIDB\/50006\/2020"]}]},{"name":"FCT","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]},{"name":"FCT","award":["SFRH\/BPD\/100865\/2014"],"award-info":[{"award-number":["SFRH\/BPD\/100865\/2014"]}]},{"name":"FCT","award":["SFRH\/BPD\/74299\/2010"],"award-info":[{"award-number":["SFRH\/BPD\/74299\/2010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Metabolomics is a powerful tool in diverse research areas, enabling an understanding of the response of organisms, such as plants, to external factors, their resistance and tolerance mechanisms against stressors, the biochemical changes and signals during plant development, and the role of specialized metabolites. Despite its advantages, metabolomics is still underused in areas such as nano-plant interactions. Nanoparticles (NPs) are all around us and have a great potential to improve and revolutionize the agri-food sector and modernize agriculture. They can drive precision and sustainability in agriculture as they can act as fertilizers, improve plant performance, protect or defend, mitigate environmental stresses, and\/or remediate soil contaminants. Given their high applicability, an in-depth understanding of NPs\u2019 impact on plants and their mechanistic action is crucial. Being aware that, in nano-plant interaction work, metabolomics is much less addressed than physiology, and that it is lacking a comprehensive review focusing on metabolomics, this review gathers the information available concerning the metabolomic tools used in studies focused on NP-plant interactions, highlighting the impact of metal-based NPs on plant metabolome, metabolite reconfiguration, and the reprogramming of metabolic pathways.<\/jats:p>","DOI":"10.3390\/plants12030491","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T03:48:08Z","timestamp":1674445688000},"page":"491","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Metabolomics as a Tool to Understand Nano-Plant Interactions: The Case Study of Metal-Based Nanoparticles"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1291-2667","authenticated-orcid":false,"given":"S\u00f3nia","family":"Silva","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3083-6218","authenticated-orcid":false,"given":"Maria Celeste","family":"Dias","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-7089","authenticated-orcid":false,"given":"Diana C. G. A.","family":"Pinto","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. S.","family":"Silva","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,21]]},"reference":[{"key":"ref_1","unstructured":"(2022, November 21). Nanotechnology Market by Type (Nanosensor and Nanodevice) and Application (Electronics, Energy, Chemical Manufacturing, Aerospace & Defense, Healthcare, and Others): Global Opportunity Analysis and Industry Forecast, 2021\u20132030. Available online: https:\/\/reports.valuates.com\/market-reports\/ALLI-Manu-1S71\/nanotechnology."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ghadimi, M., Zangenehtabar, S., and Homaeigohar, S. (2020). An overview of the water remediation potential of nanomaterials and their ecotoxicological impacts. Water, 12.","DOI":"10.3390\/w12041150"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1021\/acs.jafc.9b06615","article-title":"Nano-biotechnology in agriculture: Use of nanomaterials to promote plant growth and stress tolerance","volume":"68","author":"Zhao","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Silva, S., Dias, M.C., and Silva, A.M.S. (2022). Titanium and zinc based nanomaterials in agriculture: A promising approach to deal with (a)biotic stresses?. Toxics, 10.","DOI":"10.3390\/toxics10040172"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Dong, L., Chen, G., Liu, G., Huang, X., Xu, X., Li, L., Zhang, Y., Wang, J., Jin, M., and Xu, D. (2022). A review on recent advances in the applications of composite Fe3O4 magnetic nanoparticles in the food industry. Crit. Rev. Food Sci. Nutr.","DOI":"10.1080\/10408398.2022.2113363"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Shafiq, M., Anjum, S., Hano, C., Anjum, I., and Abbasi, B.H. (2020). An overview of the applications of nanomaterials and nanodevices in the food industry. Foods, 9.","DOI":"10.3390\/foods9020148"},{"key":"ref_7","unstructured":"Narain, R. (2020). Polymer Science and Nanotechnology, Elsevier."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/etc.706","article-title":"Ecotoxicity test methods for engineered nanomaterials: Practical experiences and recommendations from the bench","volume":"31","author":"Handy","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11057","DOI":"10.1007\/s11356-015-4355-4","article-title":"Cytotoxicity of aluminum oxide nanoparticles on Allium cepa root tip-effects of oxidative stress generation and biouptake","volume":"22","author":"Rajeshwari","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.plaphy.2017.10.013","article-title":"Wheat chronic exposure to TiO2-nanoparticles: Cyto- and genotoxic approach","volume":"121","author":"Silva","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.agee.2017.12.010","article-title":"Dose-dependent physiological responses of Triticum aestivum L. to soil applied TiO2 nanoparticles: Alterations in chlorophyll content, H2O2 production, and genotoxicity","volume":"255","author":"Rafique","year":"2018","journal-title":"Agric. Ecosyst. Environ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.plaphy.2016.07.030","article-title":"An overview on manufactured nanoparticles in plants: Uptake, translocation, accumulation and phytotoxicity","volume":"110","author":"Tripathi","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12951-022-01509-3","article-title":"Comparative physiological and metabolomic analyses reveal that Fe3O4 and ZnO nanoparticles alleviate Cd toxicity in tobacco","volume":"20","author":"Zou","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"59374","DOI":"10.1007\/s11356-022-19559-3","article-title":"Foliar-applied magnesium nanoparticles modulate drought stress through changes in physio-biochemical attributes and essential oil profile of yarrow (Achillea millefolium L.)","volume":"29","author":"Ojagh","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"131827","DOI":"10.1016\/j.chemosphere.2021.131827","article-title":"Explicating the cross-talks between nanoparticles, signaling pathways and nutrient homeostasis during environmental stresses and xenobiotic toxicity for sustainable cultivation of cereals","volume":"286 Pt. 3","author":"Banerjee","year":"2022","journal-title":"Chemosphere"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2174\/1573413716999200403152439","article-title":"Nanoparticles for Sustainable Agriculture and their Effect on Plants","volume":"17","author":"Srivastava","year":"2021","journal-title":"Curr. Nanosci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jbiotec.2021.06.022","article-title":"Role of nanoparticles in crop improvement and abiotic stress management","volume":"337","author":"Singh","year":"2021","journal-title":"J. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8016","DOI":"10.1021\/acs.est.8b02440","article-title":"Metabolomics reveals how cucumber (Cucumis sativus) reprograms metabolites to cope with silver ions and silver nanoparticle-induced oxidative stress","volume":"52","author":"Zhang","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1039\/C9EN00137A","article-title":"Metabolomics reveals that engineered nanomaterial exposure in soil alters both soil rhizosphere metabolite profiles and maize metabolic pathways","volume":"6","author":"Zhao","year":"2019","journal-title":"Environ. Sci.-Nano"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jhazmat.2019.02.084","article-title":"Applications of metabolomics in assessing ecological effects of emerging contaminants and pollutants on plants","volume":"373","author":"Matich","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Carrera, F.P., Noceda, C., Maridue\u00f1a-Zavala, M.G., and Cevallos-Cevallos, J.M. (2021). Metabolomics, a powerful tool for understanding plant abiotic stress. Agronomy, 11.","DOI":"10.3390\/agronomy11050824"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"\u0160ebesta, M., Kole\u0148c\u00edk, M., Sunil, B.R., Illa, R., Mosn\u00e1\u010dek, J., Ingle, A.P., and Ur\u00edk, M. (2021). Field application of ZnO and TiO2 nanoparticles on agricultural plants. Agronomy, 11.","DOI":"10.3390\/agronomy11112281"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Acharya, A., and Pal, P.K. (2020). Agriculture nanotechnology: Translating research outcome to field applications by influencing environmental sustainability. Nanoimpact, 19.","DOI":"10.1016\/j.impact.2020.100232"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Rajput, V.D., Minkina, T., Kumari, A., Singh, V.K., Verma, K.K., Mandzhieva, S., Sushkova, S., Srivastava, S., and Keswani, C. (2021). Coping with the challenges of abiotic stress in plants: New dimensions in the field application of nanoparticles. Plants, 10.","DOI":"10.3390\/plants10061221"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yan, A., and Chen, Z. (2019). Impacts of silver nanoparticles on plants: A focus on the phytotoxicity and underlying mechanism. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051003"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rivero-Montejo, S.D., Vargas-Hernandez, M., and Torres-Pacheco, I. (2021). nanoparticles as novel elicitors to improve bioactive compounds in plants. Agriculture, 11.","DOI":"10.3390\/agriculture11020134"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fchem.2017.00078","article-title":"Impact of metal and metal oxide nanoparticles on plant: A critical review","volume":"5","author":"Rastogi","year":"2017","journal-title":"Front. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/s41598-018-19275-4","article-title":"Risks, Release and concentrations of engineered nanomaterial in the environment","volume":"8","author":"Giese","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfda.2018.12.002","article-title":"The current application of nanotechnology in food and agriculture","volume":"27","author":"He","year":"2019","journal-title":"J. Food Drug Anal."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jconrel.2020.10.051","article-title":"Nanoparticles in sustainable agriculture: An emerging opportunity","volume":"329","author":"Singh","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1021\/acsnano.2c01131","article-title":"Nano and Plants","volume":"16","author":"Buriak","year":"2022","journal-title":"Acs Nano"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.coesh.2018.07.013","article-title":"Engineered NanoMaterials interactions with living plants: Benefits, hazards and regulatory policies","volume":"6","year":"2018","journal-title":"Curr. Opin. Environ. Sci. Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.coesh.2018.07.008","article-title":"Plant uptake and accumulation of engineered metallic nanoparticles from lab to field conditions","volume":"6","author":"Ma","year":"2018","journal-title":"Curr. Opin. Environ. Sci. Health"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.scitotenv.2019.01.234","article-title":"Nanomaterials and plants: Positive effects, toxicity and the remediation of metal and metalloid pollution in soil","volume":"662","author":"Zhu","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"100278","DOI":"10.1016\/j.impact.2020.100278","article-title":"Knowledge domain and emerging trends in nanoparticles and plants interaction research: A scientometric analysis","volume":"21","author":"Zeb","year":"2021","journal-title":"NanoImpact"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e2103414","DOI":"10.1002\/advs.202103414","article-title":"Recent advances in plant nanoscience","volume":"9","author":"Zhang","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.aoas.2020.08.001","article-title":"Accumulation of nanoparticles in the soil-plant systems and their effects on human health","volume":"65","author":"Rajput","year":"2020","journal-title":"Ann. Agric. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jes.2020.03.057","article-title":"Analytical methods and environmental processes of nanoplastics","volume":"94","author":"Li","year":"2020","journal-title":"J. Environ. Sci."},{"key":"ref_39","first-page":"100218","article-title":"Monitoring of engineered nanoparticles in soil-plant system: A review","volume":"11","author":"Shrivastava","year":"2019","journal-title":"Environ. Nanotechnol. Monit. Manag."},{"key":"ref_40","unstructured":"Yan, A., and Chen, Z. (2018). New Visions in Plant Science, IntechOpen."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.scitotenv.2013.02.059","article-title":"Evaluation of developmental responses of two crop plants exposed to silver and zinc oxide nanoparticles","volume":"452\u2013453","author":"Pokhrel","year":"2013","journal-title":"Sci. Total Environ."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1039\/C5MT00168D","article-title":"Mechanistic evaluation of translocation and physiological impact of titanium dioxide and zinc oxide nanoparticles on the tomato (Solanum lycopersicum L.) plant","volume":"7","author":"Raliya","year":"2015","journal-title":"Metallomics"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1039\/C7EN00015D","article-title":"Physiological effects of cerium oxide nanoparticles on the photosynthesis and water use efficiency of soybean (Glycine max (L.) Merr.)","volume":"4","author":"Cao","year":"2017","journal-title":"Environ. Sci.-Nano"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"40404","DOI":"10.1039\/C9RA08457F","article-title":"Advances in nanomaterials as novel elicitors of pharmacologically active plant specialized metabolites: Current status and future outlooks","volume":"9","author":"Anjum","year":"2019","journal-title":"RSC Adv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1146\/annurev-arplant-042110-103814","article-title":"Convergent evolution in plant specialized metabolism","volume":"62","author":"Pichersky","year":"2011","journal-title":"Annu. Rev. Plant Biol."},{"key":"ref_46","first-page":"494","article-title":"Bioactivity of secondary metabolites of various plants: A review","volume":"10","author":"Jain","year":"2019","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s11306-018-1446-5","article-title":"Crop metabolomics: From diagnostics to assisted breeding","volume":"14","author":"Alseekh","year":"2018","journal-title":"Metabolomics"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Tugizimana, F., Mhlongo, M.I., Piater, L.A., and Dubery, I.A. (2018). Metabolomics in plant priming research: The way forward?. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061759"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nalbantoglu, S., and Amri, H. (2019). Basic Principles and Strategies in Molecular Medicine, IntechOpen. Chapter 8.","DOI":"10.5772\/intechopen.88563"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.trac.2004.11.021","article-title":"Metabolomics: Current analytical platforms and methodologies","volume":"24","author":"Dunn","year":"2005","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.semnephrol.2010.07.007","article-title":"Analytical approaches to metabolomics and applications to systems biology","volume":"30","author":"Wang","year":"2010","journal-title":"Semin. Nephrol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1399-3054.2007.01001.x","article-title":"Metabolomic technologies and their application to the study of plants and plant-host interactions","volume":"132","author":"Allwood","year":"2008","journal-title":"Physiol. Plant"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1021\/ac504075g","article-title":"NMR spectroscopy for metabolomics and metabolic profiling","volume":"87","author":"Larive","year":"2015","journal-title":"Anal. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.copbio.2016.08.001","article-title":"The future of NMR-based metabolomics","volume":"43","author":"Markley","year":"2017","journal-title":"Curr. Opin. Biotechnol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/jxb\/eri010","article-title":"Metabolite fingerprinting and profiling in plants using NMR","volume":"56","author":"Krishnan","year":"2005","journal-title":"J. Exp. Bot."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s11306-013-0524-y","article-title":"NMR-based metabolomics in human disease diagnosis: Applications, limitations, and recommendations","volume":"9","author":"Emwas","year":"2013","journal-title":"Metabolomics"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00216-006-0687-8","article-title":"Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics","volume":"387","author":"Pan","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s11306-012-0412-x","article-title":"Mass spectrometry based environmental metabolomics: A primer and review","volume":"9","author":"Viant","year":"2012","journal-title":"Metabolomics"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Aretz, I., and Meierhofer, D. (2016). Advantages and pitfalls of mass spectrometry based metabolome profiling in systems biology. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17050632"},{"key":"ref_60","unstructured":"De Hoffmann, E., and Stroobant, V. (2007). Mass Spectrometry: Principles and Applications, John Wiley & Sons Ltd."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Gross, J.H. (2017). Mass Spectrometry, Springer.","DOI":"10.1007\/978-3-319-54398-7"},{"key":"ref_62","unstructured":"Kusch, P. (2018). Gas Chromatography, IntechOpen. Chapter 2."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1021\/cr300484s","article-title":"New advances in separation science for metabolomics: Resolving chemical diversity in a post-genomic era","volume":"113","author":"Kuehnbaum","year":"2013","journal-title":"Chem. Rev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.chroma.2018.07.017","article-title":"An untargeted lipidomic strategy combining comprehensive two-dimensional liquid chromatography and chemometric analysis","volume":"1568","author":"Jaumot","year":"2018","journal-title":"J. Chromatogr. A"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1002\/fes3.269","article-title":"Comparative physiological and metabolomic analyses revealed that foliar spraying with zinc oxide and silica nanoparticles modulates metabolite profiles in cucumber (Cucumis sativus L.)","volume":"10","author":"Li","year":"2021","journal-title":"Food Energy Secur."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14110","DOI":"10.1021\/es4033887","article-title":"Cerium Oxide nanoparticles modify the antioxidative stress enzyme activities and macromolecule composition in rice seedlings","volume":"47","author":"Rico","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"136487","DOI":"10.1016\/j.scitotenv.2019.136487","article-title":"Metabolomics of wheat grains generationally-exposed to cerium oxide nanoparticles","volume":"712","author":"Rico","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1021\/acs.jafc.7b01843","article-title":"Growth and metabolic responses of rice (Oryza sativa L.) cultivated in phosphorus-deficient soil amended with TiO2 nanoparticles","volume":"65","author":"Zahra","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.scitotenv.2018.07.061","article-title":"Phytotoxic effects of silver nanoparticles and silver ions to Arabidopsis thaliana as revealed by analysis of molecular responses and of metabolic pathways","volume":"644","author":"Ke","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jsps.2016.09.012","article-title":"Plant growth and diosgenin enhancement effect of silver nanoparticles in Fenugreek (Trigonella foenum-graecum L.)","volume":"25","author":"Jasim","year":"2017","journal-title":"Saudi Pharm J."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Lahuta, L.B., Szablinska-Piernik, J., Glowacka, K., Stalanowska, K., Railean-Plugaru, V., Horbowicz, M., Pomastowski, P., and Buszewski, B. (2022). The effect of bio-synthesized silver nanoparticles on germination, early seedling development, and metabolome of wheat (Triticum aestivum L.). Molecules, 27.","DOI":"10.3390\/molecules27072303"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s12010-019-03193-w","article-title":"Carnosic acid content increased by silver nanoparticle treatment in rosemary (Rosmarinus officinalis L.)","volume":"191","author":"Soltanabad","year":"2020","journal-title":"Appl. Biochem. Biotech."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Huang, X., and Keller, A.A. (2021). Metabolomic response of early-stage wheat (Triticum aestivum) to surfactant-aided foliar application of copper hydroxide and molybdenum trioxide nanoparticles. Nanomaterials, 11.","DOI":"10.3390\/nano11113073"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.impact.2016.08.005","article-title":"Application of metabolomics to assess the impact of Cu(OH)(2) nanopesticide on the nutritional value of lettuce (Lactuca sativa): Enhanced Cu intake and reduced antioxidants","volume":"3\u20134","author":"Zhao","year":"2016","journal-title":"Nanoimpact"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"8294","DOI":"10.1021\/acssuschemeng.7b01968","article-title":"Response at genetic, metabolic, and physiological levels of maize (Zea mays) exposed to a Cu(OH)2 nanopesticide","volume":"5","author":"Zhao","year":"2017","journal-title":"Acs. Sustain. Chem. Eng."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"146331","DOI":"10.1016\/j.scitotenv.2021.146331","article-title":"Exogenous application of ZnO nanoparticles and ZnSO4 distinctly influence the metabolic response in Phaseolus vulgaris L.","volume":"778","author":"Salehi","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.envpol.2017.06.062","article-title":"Metabolomics analysis of TiO2 nanoparticles induced toxicological effects on rice (Oryza sativa L.)","volume":"230","author":"Wu","year":"2017","journal-title":"Environ. Pollut"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"122982","DOI":"10.1016\/j.jhazmat.2020.122982","article-title":"TiO2 nanoparticles induced sugar impairments and metabolic pathway shift towards amino acid metabolism in wheat","volume":"399","author":"Silva","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1021\/acs.jafc.9b05107","article-title":"Relatively low dosages of CeO2 nanoparticles in the solid medium induce adjustments in the secondary metabolism and lonomic balance of bean (Phaseolus vulgaris L.) roots and leaves","volume":"68","author":"Salehi","year":"2020","journal-title":"J. Agr. Food Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"100271","DOI":"10.1016\/j.impact.2020.100271","article-title":"Metabolic profile and physiological response of cucumber foliar exposed to engineered MoS2 and TiO2 nanoparticles","volume":"20","author":"Song","year":"2020","journal-title":"NanoImpact"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Pociecha, E., Gorczyca, A., Dziurka, M., Matras, E., and Ocwieja, M. (2021). Silver nanoparticles and silver ions differentially affect the phytohormone balance and yield in wheat. Agriculture, 11.","DOI":"10.3390\/agriculture11080729"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Sun, L.Y., Song, F.B., Guo, J.H., Zhu, X.C., Liu, S.Q., Liu, F.L., and Li, X.N. (2020). Nano-ZnO-induced drought tolerance is associated with melatonin synthesis and metabolism in maize. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030782"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"137400","DOI":"10.1016\/j.scitotenv.2020.137400","article-title":"Physiological and metabolic responses of maize (Zea mays) plants to Fe3O4 nanoparticles","volume":"718","author":"Yan","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1039\/D0EN00582G","article-title":"Comparative physiological and metabolomics analysis reveals that single-walled carbon nanohorns and ZnO nanoparticles affect salt tolerance in Sophora alopecuroides","volume":"7","author":"Wan","year":"2020","journal-title":"Environ. Sci.-Nano"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"9669","DOI":"10.1021\/jf503526r","article-title":"Cerium oxide nanoparticles impact yield and modify nutritional parameters in wheat (Triticum aestivum L.)","volume":"62","author":"Rico","year":"2014","journal-title":"J. Agr. Food Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1021\/acs.est.5b05011","article-title":"1H NMR and GC-MS Based metabolomics reveal defense and detoxification mechanism of cucumber plant under nano-Cu stress","volume":"50","author":"Zhao","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1049\/nbt2.12005","article-title":"Nanoparticles as elicitors and harvesters of economically important secondary metabolites in higher plants: A review","volume":"15","author":"Lala","year":"2021","journal-title":"IET Nanobiotechnol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"120889","DOI":"10.1016\/j.jhazmat.2019.120889","article-title":"Antioxidant mechanisms to counteract TiO2-nanoparticles toxicity in wheat leaves and roots are organ dependent","volume":"380","author":"Silva","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Marslin, G., Sheeba, C.J., and Franklin, G. (2017). Nanoparticles alter secondary metabolism in plants via ROS burst. Front. Plant Sci., 8.","DOI":"10.3389\/fpls.2017.00832"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1021\/acs.iecr.5b01610","article-title":"Critical review on the toxicity of some widely used engineered nanoparticles","volume":"54","author":"Srivastava","year":"2015","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00709-018-1281-6","article-title":"Titanium dioxide nanoparticles impaired both photochemical and non-photochemical phases of photosynthesis in wheat","volume":"256","author":"Dias","year":"2018","journal-title":"Protoplasma"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Abasi, F., Raja, N.I., Mashwani, Z.U.R., Amjad, M.S., Ehsan, M., Mustafa, N., Haroon, M., and Prockow, J. (2022). Biogenic silver nanoparticles as a stress alleviator in plants: A mechanistic overview. Molecules, 27.","DOI":"10.3390\/molecules27113378"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.plaphy.2016.05.010","article-title":"Jointed toxicity of TiO2 NPs and Cd to rice seedlings: NPs alleviated Cd toxicity and Cd promoted NPs uptake","volume":"110","author":"Ji","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plaphy.2021.07.021","article-title":"Low levels of TiO2-nanoparticles interact antagonistically with Al and Pb alleviating their toxicity","volume":"167","author":"Dias","year":"2021","journal-title":"Plant Physiol. Biochem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1039\/D1NR08349J","article-title":"Synthesis, modification and application of titanium dioxide nanoparticles: A review","volume":"14","author":"Wang","year":"2022","journal-title":"Nanoscale"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10142-013-0341-4","article-title":"Titanium dioxide nanoparticles affect the growth and microRNA expression of tobacco (Nicotiana tabacum)","volume":"14","author":"Frazier","year":"2014","journal-title":"Funct. Integr. Genom."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.btre.2014.10.009","article-title":"TiO2 nanoparticle biosynthesis and its physiological effect on mung bean (Vigna radiata L.)","volume":"5","author":"Raliya","year":"2015","journal-title":"Biotechnol. Rep."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Li, J., Naeem, M.S., Wang, X.P., Liu, L.X., Chen, C., Ma, N., and Zhang, C.L. (2015). Nano-TiO2 is not phytotoxic as revealed by the oilseed rape growth and photosynthetic apparatus ultra-structural response. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0143885"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jes.2017.12.022","article-title":"Toxicity evaluation of ZnO and TiO2 nanomaterials in hydroponic red bean (Vigna angularis) plant: Physiology, biochemistry and kinetic transport","volume":"72","author":"Jahan","year":"2018","journal-title":"J. Environ. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.scitotenv.2018.04.263","article-title":"Effects of the exposure of TiO2 nanoparticles on basil (Ocimum basilicum) for two generations","volume":"636","author":"Tan","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.scitotenv.2018.02.264","article-title":"Influence of soil type on TiO2 nanoparticle fate in an agro-ecosystem","volume":"630","author":"Larue","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.chemosphere.2016.02.047","article-title":"Pure anatase and rutile + anatase nanoparticles differently affect wheat seedlings","volume":"151","author":"Silva","year":"2016","journal-title":"Chemosphere"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Sheikhalipour, M., Gohari, G., Esmaielpour, B., Panahirad, S., Milani, M.H., Kulak, M., and Janda, T. (2022). Melatonin and TiO2 NPs application-induced changes in growth, photosynthesis, antioxidant enzymes activities and secondary metabolites in stevia (Stevia rebaudiana Bertoni) under drought stress conditions. J. Plant Growth Regul.","DOI":"10.1007\/s00344-022-10679-1"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"124794","DOI":"10.1016\/j.chemosphere.2019.124794","article-title":"Foliar spray of TiO2 nanoparticles prevails over root application in reducing Cd accumulation and mitigating Cd-induced phytotoxicity in maize (Zea mays L.)","volume":"239","author":"Lian","year":"2020","journal-title":"Chemosphere"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s41598-020-57794-1","article-title":"Titanium dioxide nanoparticles (TiO2 NPs) promote growth and ameliorate salinity stress effects on essential oil profile and biochemical attributes of Dracocephalum moldavica","volume":"10","author":"Gohari","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"121364","DOI":"10.1016\/j.jhazmat.2019.121364","article-title":"Wheat exposure to cerium oxide nanoparticles over three generations reveals transmissible changes in nutrition, biochemical pools, and response to soil N","volume":"384","author":"Rico","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/etc.3374","article-title":"germination and early plant development of ten plant species exposed to titanium dioxide and cerium oxide nanoparticles","volume":"35","author":"Andersen","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.scitotenv.2015.11.143","article-title":"Effects of uncoated and citric acid coated cerium oxide nanoparticles, bulk cerium oxide, cerium acetate, and citric acid on tomato plants","volume":"563","author":"Barrios","year":"2016","journal-title":"Sci. Total Environ."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.plaphy.2014.09.018","article-title":"Cerium oxide nanoparticles alter the antioxidant capacity but do not impact tuber ionome in Raphanus sativus (L)","volume":"84","author":"Morales","year":"2014","journal-title":"Plant Physiol. Biochem."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1039\/C4EN00025K","article-title":"Effect of cerium oxide nanoparticles on asparagus lettuce cultured in an agar medium","volume":"1","author":"Cui","year":"2014","journal-title":"Environ. Sci.-Nano"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.plaphy.2016.09.013","article-title":"Physiological and biochemical responses of sunflower (Helianthus annuus L.) exposed to nano-CeO2 and excess boron: Modulation of boron phytotoxicity","volume":"110","author":"Tassi","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Skiba, E., Pietrzak, M., Glinska, S., and Wolf, W.M. (2021). The combined effect of ZnO and CeO2 nanoparticles on Pisum sativum L.: A photosynthesis and nutrients uptake study. Cells, 10.","DOI":"10.3390\/cells10113105"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Poscic, F., Mattiello, A., Fellet, G., Miceli, F., and Marchiol, L. (2016). Effects of cerium and titanium oxide nanoparticles in soil on the nutrient composition of barley (Hordeum vulgare L.) Kernels. Int. J. Environ. Res. Public Health, 13.","DOI":"10.3390\/ijerph13060577"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.plaphy.2016.04.008","article-title":"Zinc, copper, or cerium accumulation from metal oxide nanoparticles or ions in sweet potato: Yield effects and projected dietary intake from consumption","volume":"110","author":"Bradfield","year":"2017","journal-title":"Plant Physiol. Biochem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1021\/jf5052442","article-title":"Uptake and accumulation of bulk and nanosized cerium oxide particles and ionic cerium by radish (Raphanus sativus L.)","volume":"63","author":"Zhang","year":"2015","journal-title":"J. Agr. Food Chem."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1021\/jf405476u","article-title":"CeO2 and ZnO nanoparticles change the nutritional qualities of cucumber (Cucumis sativus)","volume":"62","author":"Zhao","year":"2014","journal-title":"J. Agr. Food Chem."},{"key":"ref_117","first-page":"1043","article-title":"Evidence of phytotoxicity and genotoxicity in Hordeum vulgare L. exposed to CeO2 and TiO2 nanoparticles","volume":"6","author":"Mattiello","year":"2015","journal-title":"Front. Plant Scie"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1366\/14-07495","article-title":"Differential effects of cerium oxide nanoparticles on rice, wheat, and barley roots: A fourier transform infrared (FT-IR) microspectroscopy study","volume":"69","author":"Rico","year":"2015","journal-title":"Appl. Spectrosc."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40659-018-0195-2","article-title":"The physiological and molecular mechanism of brassinosteroid in response to stress: A review","volume":"51","author":"Anwar","year":"2018","journal-title":"Biol. Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3762\/bjnano.6.181","article-title":"Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory","volume":"6","author":"Vance","year":"2015","journal-title":"Beilstein J. Nanotech."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kumar, S., Kumar, P., and Pathak, C.S. (2021). Silver Micro-Nanoparticles\u2014Properties, Synthesis, Characterization, and Applications, IntechOpen.","DOI":"10.5772\/intechopen.92480"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"15593258211044576","DOI":"10.1177\/15593258211044576","article-title":"Silver nanoparticles increase nitrogen, phosphorus, and potassium concentrations in leaves and stimulate root length and number of roots in tomato seedlings in a hormetic manner","volume":"19","year":"2021","journal-title":"Dose-Response"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Wahid, I., Kumari, S., Ahmad, R., Hussain, S.J., Alamri, S., Siddiqui, M.H., and Khan, M.I.R. (2020). Silver nanoparticle regulates salt tolerance in wheat through changes in aba concentration, ion homeostasis, and defense systems. Biomolecules, 10.","DOI":"10.3390\/biom10111506"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2015\/241614","article-title":"Silver Core-shell nanoclusters exhibiting strong growth inhibition of plant-pathogenic fungi","volume":"2015","author":"Ho","year":"2015","journal-title":"J. Nanomater."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Hasan, M., Mehmood, K., Mustafa, G., Zafar, A., Tariq, T., Hassan, S.G., Loomba, S., Zia, M., Mazher, A., and Mahmood, N. (2021). Phytotoxic evaluation of phytosynthesized silver nanoparticles on lettuce. Coatings, 11.","DOI":"10.3390\/coatings11020225"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1","DOI":"10.32615\/bp.2019.122","article-title":"Silver nanoparticles with different concentrations and particle sizes affect the functional traits of wheat","volume":"64","author":"Wang","year":"2020","journal-title":"Biol. Plant."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"898846","DOI":"10.3389\/fpls.2022.898846","article-title":"Impact of silver nanoparticles on lemon growth performance: Insecticidal and antifungal activities of essential oils from peels and leaves","volume":"13","author":"Mosa","year":"2022","journal-title":"Front. Plant Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1021\/acsbiomaterials.8b01092","article-title":"Synthesis and biomedical applications of copper oxide nanoparticles: An expanding horizon","volume":"5","author":"Verma","year":"2019","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"111858","DOI":"10.1016\/j.envres.2021.111858","article-title":"New frontiers in the plant extract mediated biosynthesis of copper oxide (CuO) nanoparticles and their potential applications: A review","volume":"203","author":"Cuong","year":"2022","journal-title":"Environ. Res."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Varympopi, A., Dimopoulou, A., Papafotis, D., Avramidis, P., Sarris, I., Karamanidou, T., Kerou, A.K., Vlachou, A., Vellis, E., and Giannopoulos, A. (2022). Antibacterial activity of copper nanoparticles against Xanthomonas campestris pv. vesicatoria in tomato plants. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23084080"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Sadek, M.E., Shabana, Y.M., Sayed-Ahmed, K., and Abou Tabl, A.H. (2022). Antifungal activities of sulfur and copper nanoparticles against cucumber postharvest diseases caused by Botrytis cinerea and Sclerotinia sclerotiorum. J. Fungi, 8.","DOI":"10.3390\/jof8040412"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"10805","DOI":"10.1021\/acs.est.1c02323","article-title":"Foliar application of copper oxide nanoparticles suppresses fusarium wilt development on chrysanthemum","volume":"55","author":"Elmer","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Wu, Q., Shi, J., Jiang, X., and Wu, H. (2021). Regulatory mechanism of copper oxide nanoparticles on uptake of different species of arsenic in rice. Nanomaterials, 11.","DOI":"10.3390\/nano11092228"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"110303","DOI":"10.1016\/j.ecoenv.2020.110303","article-title":"Green copper nanoparticles from a native Klebsiella pneumoniae strain alleviated oxidative stress impairment of wheat plants by reducing the chromium bioavailability and increasing the growth","volume":"192","author":"Noman","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"85271","DOI":"10.1007\/s11356-022-21799-2","article-title":"Clue of zinc oxide and copper oxide nanoparticles in the remediation of cadmium toxicity in Phaseolus vulgaris L. via the modulation of antioxidant and redox systems","volume":"29","author":"Hidouri","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1049\/nbt2.12002","article-title":"Applications of copper and silver nanoparticles on wheat plants to induce drought tolerance and increase yield","volume":"15","author":"Ahmed","year":"2021","journal-title":"IET Nanobiotechnol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s11671-017-1839-9","article-title":"Effect of zinc and copper nanoparticles on drought resistance of wheat seedlings","volume":"12","author":"Taran","year":"2017","journal-title":"Nanoscale Res. Lett."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Perez-Labrada, F., Lopez-Vargas, E.R., Ortega-Ortiz, H., Cadenas-Pliego, G., Benavides-Mendoza, A., and Juarez-Maldonado, A. (2019). Responses of tomato plants under saline stress to foliar application of copper nanoparticles. Plants, 8.","DOI":"10.3390\/plants8060151"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.envres.2015.02.019","article-title":"Nanoscale copper in the soil-plant system - toxicity and underlying potential mechanisms","volume":"138","author":"Anjum","year":"2015","journal-title":"Environ. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1007\/s11738-014-1667-9","article-title":"Copper oxide nanoparticle toxicity in mung bean (Vigna radiata L.) seedlings: Physiological and molecular level responses of in vitro grown plants","volume":"36","author":"Nair","year":"2014","journal-title":"Acta Physiol. Plant."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12011-014-0106-5","article-title":"A mechanistic study on the toxic effect of copper oxide nanoparticles in soybean (Glycine max L.) root development and lignification of root cells","volume":"162","author":"Nair","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3389\/fpls.2018.00872","article-title":"Copper nanoparticles induced genotoxicty, oxidative stress, and changes in superoxide dismutase (SOD) gene expression in cucumber (Cucumis sativus) plants","volume":"9","author":"Mosa","year":"2018","journal-title":"Front. Plant Sci."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.envpol.2018.04.066","article-title":"Impact of copper nanoparticles and ionic copper exposure on wheat (Triticum aestivum L.) root morphology and antioxidant response","volume":"239","author":"Zhang","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"AlQuraidi, A.O., Mosa, K.A., and Ramamoorthy, K. (2019). Phytotoxic and genotoxic effects of copper nanoparticles in coriander (Coriandrum sativum-Apiaceae). Plants, 8.","DOI":"10.3390\/plants8010019"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"122978","DOI":"10.1016\/j.jhazmat.2020.122978","article-title":"Bok choy (Brassica rapa) grown in copper oxide nanoparticles-amended soils exhibits toxicity in a phenotype-dependent manner: Translocation, biodistribution and nutritional disturbance","volume":"398","author":"Deng","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s10661-020-8188-3","article-title":"Effects of copper oxide nanoparticles on growth of lettuce (Lactuca sativa L.) seedlings and possible implications of nitric oxide in their antioxidative defense","volume":"192","author":"Pelegrino","year":"2020","journal-title":"Environ. Monit. Assess."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Yang, Z., Xiao, Y., Jiao, T., Zhang, Y., Chen, J., and Gao, Y. (2020). Effects of Copper Oxide Nanoparticles on the Growth of Rice (Oryza sativa L.) Seedlings and the Relevant Physiological Responses. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17041260"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11738-021-03307-0","article-title":"Zinc oxide nanoparticles (ZnO-NPs): A promising nanoparticle in renovating plant science","volume":"43","author":"Thounaojam","year":"2021","journal-title":"Acta Physiol. Plant"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"109510","DOI":"10.1016\/j.ijfoodmicro.2021.109510","article-title":"Reduction of Fusarium proliferatum growth and fumonisin accumulation by ZnO nanoparticles both on a maize based medium and irradiated maize grains","volume":"363","author":"Pena","year":"2022","journal-title":"Int. J. Food Microbiol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"112206","DOI":"10.1016\/j.jphotobiol.2021.112206","article-title":"Visible light-activated ZnO nanoparticles for microbial control of wheat crop","volume":"219","author":"Zudyte","year":"2021","journal-title":"J. Photoch. Photobio. B"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Tryfon, P., Kamou, N.N., Mourdikoudis, S., Karamanoli, K., Menkissoglu-Spiroudi, U., and Dendrinou-Samara, C. (2021). CuZn and ZnO nanoflowers as nano-fungicides against Botrytis cinerea and Sclerotinia sclerotiorum: Phytoprotection, translocation, and impact after foliar application. Materials, 14.","DOI":"10.3390\/ma14247600"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"155101","DOI":"10.1088\/1361-6528\/aa61f3","article-title":"Antifungal mechanisms of ZnO and Ag nanoparticles to Sclerotinia homoeocarpa","volume":"28","author":"Li","year":"2017","journal-title":"Nanotechnology"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ceramint.2020.08.139","article-title":"Superior antibacterial activity against seed-borne plant bacterial disease agents and enhanced physical properties of novel green synthesized nanostructured ZnO using Thymbra spicata plant extract","volume":"47","author":"Sahin","year":"2021","journal-title":"Ceram. Int."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1094\/PDIS-08-20-1763-RE","article-title":"Management of Ralstonia solanacearum in tomato using ZnO nanoparticles synthesized through matricaria chamomilla","volume":"105","author":"Khan","year":"2021","journal-title":"Plant Dis."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"23119","DOI":"10.1007\/s11356-019-05551-x","article-title":"Impact of ZnO nanoparticles on Cd toxicity and bioaccumulation in rice (Oryza sativa L.)","volume":"26","author":"Zhang","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"112738","DOI":"10.1016\/j.ecoenv.2021.112738","article-title":"Amelioration of AsV toxicity by concurrent application of ZnO-NPs and Se-NPs is associated with differential regulation of photosynthetic indexes, antioxidant pool and osmolytes content in soybean seedling","volume":"225","author":"Zeeshan","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.plaphy.2021.02.002","article-title":"Zinc oxide nanoparticles (ZnO-NPs) induce salt tolerance by improving the antioxidant system and photosynthetic machinery in tomato","volume":"161","author":"Faizan","year":"2021","journal-title":"Plant Physiol. Biochem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/03650340.2020.1723003","article-title":"Nano-ZnO alleviates drought stress via modulating the plant water use and carbohydrate metabolism in maize","volume":"67","author":"Sun","year":"2021","journal-title":"Arch. Agron. Soil Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"104561","DOI":"10.1016\/j.envexpbot.2021.104561","article-title":"H2O2 signaling regulates seed germination in ZnO nanoprimed wheat (Triticum aestivum L.) seeds for improving plant performance under drought stress","volume":"189","author":"Tomar","year":"2021","journal-title":"Environ. Exp. Bot."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Keerthana, P., Vijayakumar, S., Vidhya, E., Punitha, V.N., Nilavukkarasi, M., and Praseetha, P.K. (2021). Biogenesis of ZnO nanoparticles for revolutionizing agriculture: A step towards anti -infection and growth promotion in plants. Ind. Crops Prod., 170.","DOI":"10.1016\/j.indcrop.2021.113762"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"140240","DOI":"10.1016\/j.scitotenv.2020.140240","article-title":"Zinc oxide nanoparticles (ZnONPs) as a novel nanofertilizer: Influence on seed yield and antioxidant defense system in soil grown soybean (Glycine max cv. Kowsar)","volume":"738","author":"Fallah","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"102165","DOI":"10.1016\/j.cis.2020.102165","article-title":"Preparation, surface functionalization and application of Fe3O4 magnetic nanoparticles","volume":"281","author":"Liu","year":"2020","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Ganapathe, L.S., Mohamed, M.A., Mohamad Yunus, R., and Berhanuddin, D.D. (2020). Magnetite (Fe3O4) nanoparticles in biomedical application: From synthesis to surface functionalisation. Magnetochemistry, 6.","DOI":"10.3390\/magnetochemistry6040068"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"114254","DOI":"10.1016\/j.envres.2022.114254","article-title":"Foliar-applied nanoscale zero-valent iron (nZVI) and iron oxide (Fe3O4) induce differential responses in growth, physiology, antioxidative defense and biochemical indices in Leonurus cardiaca L.","volume":"215","author":"Jafari","year":"2022","journal-title":"Environ. Res."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"6644689","DOI":"10.1155\/2021\/6644689","article-title":"Effect of Fe3O4 and CuO nanoparticles on morphology, genotoxicity, and miRNA expression on different barley (Hordeum vulgare L.) Genotypes","volume":"2021","author":"Petrova","year":"2021","journal-title":"Sci. World J."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11738-020-03104-1","article-title":"Effects of iron oxide nanoparticles on the mineral composition and growth of soybean (Glycine max L.) plants","volume":"42","author":"Yang","year":"2020","journal-title":"Acta Physiol. Plant"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Alharby, H.F., and Ali, S. (2022). Combined role of Fe nanoparticles (Fe NPs) and Staphylococcus aureus L. in the alleviation of chromium stress in rice plants. Life, 12.","DOI":"10.3390\/life12030338"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.chemosphere.2019.03.075","article-title":"Uptake and translocation of magnetite (Fe3O4) nanoparticles and its impact on photosynthetic genes in barley (Hordeum vulgare L.)","volume":"226","author":"Tombuloglu","year":"2019","journal-title":"Chemosphere"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"122415","DOI":"10.1016\/j.jhazmat.2020.122415","article-title":"Foliar exposure of Fe3O4 nanoparticles on Nicotiana benthamiana: Evidence for nanoparticles uptake, plant growth promoter and defense response elicitor against plant virus","volume":"393","author":"Cai","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"21996","DOI":"10.1038\/s41598-021-01538-2","article-title":"Green synthesis and characterization of Fe3O4 nanoparticles using Chlorella-K01 extract for potential enhancement of plant growth stimulating and antifungal activity","volume":"11","author":"Win","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Konate, A., He, X., Zhang, Z.Y., Ma, Y.H., Zhang, P., Alugongo, G.M., and Rui, Y.K. (2017). Magnetic (Fe3O4) nanoparticles reduce heavy metals uptake and mitigate their toxicity in wheat seedling. Sustainabillity, 9.","DOI":"10.3390\/su9050790"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"119413","DOI":"10.1016\/j.envpol.2022.119413","article-title":"Iron oxide nanoparticles and selenium supplementation improve growth and photosynthesis by modulating antioxidant system and gene expression of chlorophyll synthase (CHLG) and protochlorophyllide oxidoreductase (POR) in arsenic-stressed Cucumis melo","volume":"307","author":"Shah","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"133201","DOI":"10.1016\/j.chemosphere.2021.133201","article-title":"Comparative analysis of iron oxide nanoparticles synthesized from ginger (Zingiber officinale) and cumin seeds (Cuminum cyminum) to induce resistance in wheat against drought stress","volume":"292","author":"Noor","year":"2022","journal-title":"Chemosphere"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"145221","DOI":"10.1016\/j.scitotenv.2021.145221","article-title":"Iron oxide nanoparticles ameliorated the cadmium and salinity stresses in wheat plants, facilitating photosynthetic pigments and restricting cadmium uptake","volume":"769","author":"Manzoor","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"116134","DOI":"10.1016\/j.envpol.2020.116134","article-title":"Physiological impacts of zero valent iron, Fe3O4 and Fe2O3 nanoparticles in rice plants and their potential as Fe fertilizers","volume":"269","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Kokina, I., Plaksenkova, I., Galek, R., Jermalonoka, M., Kirilova, E., Gerbreders, V., Krasovska, M., and Sledevskis, E. (2021). Genotoxic evaluation of Fe3O4 nanoparticles in different three barley (Hordeum vulgare L.) genotypes to explore the stress-resistant molecules. Molecules, 26.","DOI":"10.3390\/molecules26216710"},{"key":"ref_177","unstructured":"Cazimoglu, I. (2017). Detection of Volatile Organic Compounds in Plant Stress: A Study on Geraniol. [Doctoral Dissertation, University of Oxford]."}],"container-title":["Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2223-7747\/12\/3\/491\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:12:34Z","timestamp":1760119954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2223-7747\/12\/3\/491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,21]]},"references-count":177,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["plants12030491"],"URL":"https:\/\/doi.org\/10.3390\/plants12030491","relation":{},"ISSN":["2223-7747"],"issn-type":[{"value":"2223-7747","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,21]]}}}