{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:25:30Z","timestamp":1777645530896,"version":"3.51.4"},"reference-count":132,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["REQUIMTE 2019-57"],"award-info":[{"award-number":["REQUIMTE 2019-57"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["696295"],"award-info":[{"award-number":["696295"]}]},{"name":"Laborat\u00f3rio Associado para a Qu\u00edmica Verde\u2014Tecnologias e Processos Limpos","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"Laborat\u00f3rio Associado para a Qu\u00edmica Verde\u2014Tecnologias e Processos Limpos","award":["REQUIMTE 2019-57"],"award-info":[{"award-number":["REQUIMTE 2019-57"]}]},{"name":"Laborat\u00f3rio Associado para a Qu\u00edmica Verde\u2014Tecnologias e Processos Limpos","award":["696295"],"award-info":[{"award-number":["696295"]}]},{"name":"national research funding parties","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}]},{"name":"national research funding parties","award":["REQUIMTE 2019-57"],"award-info":[{"award-number":["REQUIMTE 2019-57"]}]},{"name":"national research funding parties","award":["696295"],"award-info":[{"award-number":["696295"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Olea europaea L. folium merits further exploration of the potential of its substrates for therapeutic supplements. Quantitative and qualitative analyses were conducted on samples of Madural, Verdeal, and Cobran\u00e7osa elementary leaves and leaf sprouts (mam\u00f5es) collected in the region of Valpa\u00e7os, Portugal. Organic analysis assessed the moisture content, total carbohydrates, ash, protein, and fat contents, total phenolic content (TPC), vitamin E, and fatty acid (FA) profiles. Moisture content was determined through infrared hygrometry and TPC was determined by a spectrophotometric method. Concerning organic analysis, all leaf samples showed similar moisture content, though Cobran\u00e7osa\u2019s leaf sprouts and Verdeal\u2019s elementary leaves had slightly lower contents. Meanwhile, these cultivars also showed a higher TPC, \u03b1-tocopherol isomer, and fatty acid composition (FAC). FAC in all samples exhibited higher contents of PUFA and SFA than MUFA, with a predominance of linolenic and palmitic acids. Organic analyses of Cobran\u00e7osa\u2019s leaf sprouts and Verdeal\u2019s elementary leaf extracts allow for the prediction of adequate physiological properties regarding neuroinflammatory, neurobehavioral, metabolic, cardiovascular, osteo-degenerative, anti-ageing, pulmonary, and immunological defense disorders. These physiological changes observed in our preliminary in silico studies suggest an excellent nutraceutical, which should be borne in mind during severe pandemic situations.<\/jats:p>","DOI":"10.3390\/plants12030688","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T04:59:10Z","timestamp":1675659550000},"page":"688","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Updated Organic Composition and Potential Therapeutic Properties of Different Varieties of Olive Leaves from Olea europaea"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0774-2168","authenticated-orcid":false,"given":"Diana Melo","family":"Ferreira","sequence":"first","affiliation":[{"name":"LAQV\/REQUIMTE\u2014Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-6338","authenticated-orcid":false,"given":"Nat\u00e1lia M.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Institute of Biomedical Sciences Abel Salazar\u2014ICBAS, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health\u2014CBSin, 4250-105 Porto, Portugal"}]},{"given":"Maria Helena","family":"Ch\u00e9u","sequence":"additional","affiliation":[{"name":"RECI\u2014Research Unit in Education and Community Intervention, Instituto Piaget\u2014ISEIT, 3515-776 Viseu, Portugal"}]},{"given":"Diana","family":"Meireles","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Institute of Biomedical Sciences Abel Salazar\u2014ICBAS, University of Porto, 4050-313 Porto, Portugal"}]},{"given":"Lara","family":"Lopes","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Institute of Biomedical Sciences Abel Salazar\u2014ICBAS, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health\u2014CBSin, 4250-105 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6767-6596","authenticated-orcid":false,"given":"Maria Beatriz","family":"Oliveira","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE\u2014Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4570-5445","authenticated-orcid":false,"given":"Jorge","family":"Machado","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Physiology, Institute of Biomedical Sciences Abel Salazar\u2014ICBAS, University of Porto, 4050-313 Porto, Portugal"},{"name":"Centre of Biosciences in Integrative Health\u2014CBSin, 4250-105 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"ref_1","unstructured":"Kiple, K.F., and Ornelas, K.C. 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