{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T09:01:56Z","timestamp":1765357316432,"version":"build-2065373602"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["PTDC\/SAU-PAR\/28459\/2017","CVAgrobiodiversity\/333111699"],"award-info":[{"award-number":["PTDC\/SAU-PAR\/28459\/2017","CVAgrobiodiversity\/333111699"]}]},{"DOI":"10.13039\/501100001871","name":"FCT\/AgaKhan Development Network (AKDN)","doi-asserted-by":"publisher","award":["PTDC\/SAU-PAR\/28459\/2017","CVAgrobiodiversity\/333111699"],"award-info":[{"award-number":["PTDC\/SAU-PAR\/28459\/2017","CVAgrobiodiversity\/333111699"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Medicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Sideroxylon marginatum, and Tamarix senegalensis). Traditional preparations of these medicinal plants, namely aqueous extracts (infusions) and ethanolic extracts, were tested against both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum strains using the SYBR Green detection method. The in vitro cytotoxicity was evaluated in Caco-2 and PLP2 cells using a sulforhodamine B colorimetric assay. An ethanolic extract of A. gorgonum and infusions of T. senegalensis exhibited high antiplasmodial activities (EC50 &lt; 5 \u03bcg\/mL) without cytotoxicity (GI50 &gt; 400 \u03bcg\/mL). Extracts of L. rotundifolia and S. marginatum exhibited moderate activities, with EC50 values ranging from 10\u201330 \u03bcg\/mL. The A. gorgonum ethanolic extract showed activity toward early ring stages, and parasites treated with the T. senegalensis infusions progressed to the early trophozoite stage, although did not develop further to the late trophozoite or schizont stages. Antimalarial activities and the lack of cytotoxicity of the extracts are reported in the present study and support previous claims by traditional practitioners for the use of these plants against malaria while suggesting their ethnopharmacological usefulness as future antimalarials.<\/jats:p>","DOI":"10.3390\/plants12040963","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T06:37:59Z","timestamp":1676875079000},"page":"963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antimalarial and Cytotoxic Activity of Native Plants Used in Cabo Verde Traditional Medicine"],"prefix":"10.3390","volume":"12","author":[{"given":"Anyse P.","family":"Essoh","sequence":"first","affiliation":[{"name":"Linking Landscape, Environment, Agriculture and Food (LEAF) & Associated Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal"},{"name":"UNDP\/UNFPA\/UNICEF Joint Office of Cabo Verde-Energy, Environment and Climate Change Portfolio, Ed. Na\u00e7\u00f5es Unidas, Achada Santo Ant\u00f3nio, Praia P.O. Box 62, Cape Verde"}]},{"given":"Gustavo Capatti","family":"Cassiano","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-2326","authenticated-orcid":false,"given":"Filipa","family":"Mandim","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5189","authenticated-orcid":false,"given":"Lillian","family":"Barros","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"},{"name":"Laborat\u00f3rio Associado para a Sustentabilidade e Tecnologia em Regi\u00f5es de Montanha (SusTEC), Instituto Polit\u00e9cnico de Bragan\u00e7a, Campus de Santa Apol\u00f3nia, 5300-253 Bragan\u00e7a, Portugal"}]},{"given":"Isildo","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investiga\u00e7\u00e3o e Desenvolvimento Agr\u00e1rio (INIDA), S\u00e3o Jorge dos \u00d3rg\u00e3os, Santiago CP 84, Cape Verde"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5364-9087","authenticated-orcid":false,"given":"M\u00e1rcia Melo","family":"Medeiros","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5555-2388","authenticated-orcid":false,"given":"M\u00f3nica","family":"Moura","sequence":"additional","affiliation":[{"name":"Research Centre in Biodiversity and Genetic Resources (CIBIO), InBIO Associate Laboratory, Pole of Azores, Faculdade de Ci\u00eancias e Tecnologia, Universidade dos A\u00e7ores, 9500-321 Ponta Delgada, Portugal"}]},{"given":"Pedro Vitor Lemos","family":"Cravo","sequence":"additional","affiliation":[{"name":"Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, 1349-008 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-6302","authenticated-orcid":false,"given":"Maria M.","family":"Romeiras","sequence":"additional","affiliation":[{"name":"Linking Landscape, Environment, Agriculture and Food (LEAF) & Associated Laboratory TERRA, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal"},{"name":"Centre for Ecology, Evolution and Environmental Changes (cE3c), & CHANGE-Global Change and Sustainability Institute, Faculdade de Ci\u00eancias, Universidade de Lisboa, 1749-016 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s41182-021-00379-z","article-title":"What sub-Saharan African countries can learn from malaria elimination in China","volume":"49","author":"Badmos","year":"2021","journal-title":"Trop. 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