{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:02:29Z","timestamp":1770289349505,"version":"3.49.0"},"reference-count":54,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES), Brazil","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES), Brazil","award":["UIDB\/00674\/2020"],"award-info":[{"award-number":["UIDB\/00674\/2020"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES), Brazil","award":["UIDP\/00674\/2020"],"award-info":[{"award-number":["UIDP\/00674\/2020"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES), Brazil","award":["M1420-01-0145-FEDER-000005-CQM+"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005-CQM+"]}]},{"name":"Pr\u00f3-Reitoria de P\u00f3s-Gradua\u00e7\u00e3o e Pesquisa of the Federal University of Juiz de Fora (including fellowships)","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"Pr\u00f3-Reitoria de P\u00f3s-Gradua\u00e7\u00e3o e Pesquisa of the Federal University of Juiz de Fora (including fellowships)","award":["UIDB\/00674\/2020"],"award-info":[{"award-number":["UIDB\/00674\/2020"]}]},{"name":"Pr\u00f3-Reitoria de P\u00f3s-Gradua\u00e7\u00e3o e Pesquisa of the Federal University of Juiz de Fora (including fellowships)","award":["UIDP\/00674\/2020"],"award-info":[{"award-number":["UIDP\/00674\/2020"]}]},{"name":"Pr\u00f3-Reitoria de P\u00f3s-Gradua\u00e7\u00e3o e Pesquisa of the Federal University of Juiz de Fora (including fellowships)","award":["M1420-01-0145-FEDER-000005-CQM+"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005-CQM+"]}]},{"name":"FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/00674\/2020"],"award-info":[{"award-number":["UIDB\/00674\/2020"]}]},{"name":"FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDP\/00674\/2020"],"award-info":[{"award-number":["UIDP\/00674\/2020"]}]},{"name":"FCT-Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["M1420-01-0145-FEDER-000005-CQM+"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005-CQM+"]}]},{"name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","award":["001"],"award-info":[{"award-number":["001"]}]},{"name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","award":["UIDB\/00674\/2020"],"award-info":[{"award-number":["UIDB\/00674\/2020"]}]},{"name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","award":["UIDP\/00674\/2020"],"award-info":[{"award-number":["UIDP\/00674\/2020"]}]},{"name":"ARDITI-Ag\u00eancia Regional para o Desenvolvimento da Investiga\u00e7\u00e3o Tecnologia e Inova\u00e7\u00e3o","award":["M1420-01-0145-FEDER-000005-CQM+"],"award-info":[{"award-number":["M1420-01-0145-FEDER-000005-CQM+"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Polygonum hydropiperoides Michx. is an Asian native plant species that is also widely distributed in the Americas. Despite its traditional uses, P. hydropiperoides is scarcely scientifically exploited. This study aimed to chemically characterize and investigate the antioxidant and antibacterial activities of hexane (HE-Ph), ethyl acetate (EAE-Ph), and ethanolic (EE-Ph) extracts from aerial parts of P. hydropiperoides. The chemical characterization was performed through HPLC-DAD-ESI\/MSn. The antioxidant activity was assessed by the phosphomolybdenum reducing power, nitric oxide inhibition, and the \u03b2-carotene bleaching assays. The antibacterial activity was determined by the minimal inhibitory concentration (MIC) and the minimal bactericidal concentration followed by the classification of the antibacterial effect. Chemical characterization revealed the expressive presence of phenolic acids and flavonoids in EAE-Ph. An increased antioxidant capacity was revealed in EAE-Ph. Regarding antibacterial activity, EAE-Ph showed weak to moderate property against 13 strains tested with MIC values ranging from 625 to 5000 \u00b5g\/mL, with bactericidal or bacteriostatic effects. Glucogallin and gallic acid stand out as the most relevant bioactive compounds. These results suggest that P. hydropiperoides is a natural source of active substances, supporting this species\u2019 traditional use.<\/jats:p>","DOI":"10.3390\/plants12081606","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T07:11:43Z","timestamp":1681110703000},"page":"1606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phenolics Profiling by HPLC-DAD-ESI\/MSn of the Scientific Unknown Polygonum hydropiperoides Michx. and Its Antioxidant and Anti-Methicillin-Resistant Staphylococcus aureus Activities"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2648-2285","authenticated-orcid":false,"given":"Ygor Ferreira Garcia","family":"da Costa","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0180-5172","authenticated-orcid":false,"given":"Eulogio Jos\u00e9","family":"Llorent-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Physical and Analytical Chemistry, Faculty of Experimental Sciences, University of Ja\u00e9n, Campus Las Lagunillas s\/n, E-23071 Ja\u00e9n, Spain"}]},{"given":"Laura Silva","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"}]},{"given":"Pedro Henrique Santos","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"}]},{"given":"Elita","family":"Scio","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8512-4464","authenticated-orcid":false,"given":"Orlando Vieira","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-4286","authenticated-orcid":false,"given":"Paula Cristina","family":"Castilho","sequence":"additional","affiliation":[{"name":"Madeira Chemical Center, Faculty of Exact and Engineering, University of Madeira, Campus da Penteada, 9020-105 Funchal, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9153-2402","authenticated-orcid":false,"given":"Maria Silvana","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2017). 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