{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:32:04Z","timestamp":1770330724732,"version":"3.49.0"},"reference-count":104,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PTDC\/AGR-CFL\/100217\/2008","award":["SFRH\/BD\/66016\/2009"],"award-info":[{"award-number":["SFRH\/BD\/66016\/2009"]}]},{"name":"PTDC\/AGR-CFL\/100217\/2008","award":["2022.07433.CEECIND"],"award-info":[{"award-number":["2022.07433.CEECIND"]}]},{"name":"PTDC\/AGR-CFL\/100217\/2008","award":["122180"],"award-info":[{"award-number":["122180"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["SFRH\/BD\/66016\/2009"],"award-info":[{"award-number":["SFRH\/BD\/66016\/2009"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["2022.07433.CEECIND"],"award-info":[{"award-number":["2022.07433.CEECIND"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia (FCT)","award":["122180"],"award-info":[{"award-number":["122180"]}]},{"name":"Funda\u00e7\u00e3o Calouste Gulbenkian","award":["SFRH\/BD\/66016\/2009"],"award-info":[{"award-number":["SFRH\/BD\/66016\/2009"]}]},{"name":"Funda\u00e7\u00e3o Calouste Gulbenkian","award":["2022.07433.CEECIND"],"award-info":[{"award-number":["2022.07433.CEECIND"]}]},{"name":"Funda\u00e7\u00e3o Calouste Gulbenkian","award":["122180"],"award-info":[{"award-number":["122180"]}]},{"name":"FCT\u2019s UIDB\/05183\/2020 MED project","award":["SFRH\/BD\/66016\/2009"],"award-info":[{"award-number":["SFRH\/BD\/66016\/2009"]}]},{"name":"FCT\u2019s UIDB\/05183\/2020 MED project","award":["2022.07433.CEECIND"],"award-info":[{"award-number":["2022.07433.CEECIND"]}]},{"name":"FCT\u2019s UIDB\/05183\/2020 MED project","award":["122180"],"award-info":[{"award-number":["122180"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Phlomis purpurea grows spontaneously in the southern Iberian Peninsula, namely in cork oak (Quercus suber) forests. In a previous transcriptome analysis, we reported on its immunity against Phytophthora cinnamomi. However, little is known about the involvement of secondary metabolites in the P. purpurea defense response. It is known, though, that root exudates are toxic to this pathogen. To understand the involvement of secondary metabolites in the defense of P. purpurea, a metabolome analysis was performed using the leaves and roots of plants challenged with the pathogen for over 72 h. The putatively identified compounds were constitutively produced. Alkaloids, fatty acids, flavonoids, glucosinolates, polyketides, prenol lipids, phenylpropanoids, sterols, and terpenoids were differentially produced in these leaves and roots along the experiment timescale. It must be emphasized that the constitutive production of taurine in leaves and its increase soon after challenging suggests its role in P. purpurea immunity against the stress imposed by the oomycete. The rapid increase in secondary metabolite production by this plant species accounts for a concerted action of multiple compounds and genes on the innate protection of Phlomis purpurea against Phytophthora cinnamomi. The combination of the metabolome with the transcriptome data previously disclosed confirms the mentioned innate immunity of this plant against a devastating pathogen. It suggests its potential as an antagonist in phytopathogens\u2019 biological control. Its application in green forestry\/agriculture is therefore possible.<\/jats:p>","DOI":"10.3390\/plants12101929","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T01:40:02Z","timestamp":1683682802000},"page":"1929","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Metabolome Analysis and the Immunity of Phlomis purpurea against Phytophthora cinnamomi"],"prefix":"10.3390","volume":"12","author":[{"given":"Dina","family":"Neves","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias e Tecnologia, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-7700","authenticated-orcid":false,"given":"Andreia","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Grapevine Pathogen Systems Lab (GPS Lab), Biosystems & Integrative Sciences Institute (BioISI), Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"},{"name":"Departamento de Biologia Vegetal, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande 016, 1749-016 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-0797","authenticated-orcid":false,"given":"Marisa","family":"Maia","sequence":"additional","affiliation":[{"name":"Grapevine Pathogen Systems Lab (GPS Lab), Biosystems & Integrative Sciences Institute (BioISI), Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal"},{"name":"Departamento de Biologia Vegetal, Faculdade de Ci\u00eancias da Universidade de Lisboa, Campo Grande 016, 1749-016 Lisboa, Portugal"}]},{"given":"Endre","family":"Laczko","sequence":"additional","affiliation":[{"name":"Functional Genomics Center, UZH\/ETHZ, Winterthurerstr. 190, CH-8057 Z\u00fcrich, Switzerland"}]},{"given":"Maria Salom\u00e9","family":"Pais","sequence":"additional","affiliation":[{"name":"Academia das Ci\u00eancias de Lisboa, R. da Academia das Ci\u00eancias de Lisboa, 19, 1200-168 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-9815","authenticated-orcid":false,"given":"Alfredo","family":"Cravador","sequence":"additional","affiliation":[{"name":"MED\u2014Mediterranean Institute for Agriculture, Environment and Development & CHANGE\u2014Global Change and Sustainability Institute, Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pbi.2012.03.002","article-title":"Chemical warfare or modulators of defence responses\u2014The function of secondary metabolites in plant immunity","volume":"15","author":"Bednarek","year":"2012","journal-title":"Curr. 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