{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:14:59Z","timestamp":1771884899259,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science, Research and Innovation Fund (NSRF) via the Program Management Unit for Human Resources & Institutional Development, Research and Innovation","award":["B13F660136"],"award-info":[{"award-number":["B13F660136"]}]},{"name":"Research and Innovation Fund","award":["67A103000207"],"award-info":[{"award-number":["67A103000207"]}]},{"name":"Doctoral Dissertation Scholarship, Faculty of Pharmaceutical Sciences, Khon Kaen University","award":["67-1(1)\/2567"],"award-info":[{"award-number":["67-1(1)\/2567"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>The resin extract of Garcinia nigrolineata (GNR-E), a tropical plant used in Southeast Asian traditional medicine, was evaluated for its antidepressant-like effects in a chronic mild stress (CMS) mouse model, with imipramine as a reference drug. GNR-E dose-dependently alleviated CMS-induced anhedonia (sucrose preference test) and behavioral despair (forced swimming and tail suspension tests). Neurochemical analyses revealed that GNR-E increased serotonin (5-HT) and norepinephrine (NE) levels, reduced expression of their transporters (SERT, NET) and receptors (5-HT1A, 1B, 2A, 2C, 7; \u03b12A, 2C) in the frontal cortex and hippocampus, and normalized HPA-axis hyperactivity by lowering serum corticosterone and modulating glucocorticoid receptor (GR) and SGK-1 mRNA expression. In vitro, GNR-E inhibited monoamine oxidase (MAO)-A and -B (Ki = 2.33 and 1.55 \u00b5g\/mL, respectively). Phytochemical analysis identified xanthones, particularly cowanin, as key constituents. These findings highlight GNR-E\u2019s potential as a novel plant-based antidepressant, warranting further investigation into its active compounds and clinical applications.<\/jats:p>","DOI":"10.3390\/plants14233651","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T08:44:28Z","timestamp":1764751468000},"page":"3651","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antidepressant-like Effects of Garcinia nigrolineata Resin Extract in a Chronic Mild Stress Mouse Model: Modulation of Monoaminergic and HPA-Axis Pathways"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6313-4984","authenticated-orcid":false,"given":"Yutthana","family":"Chotritthirong","sequence":"first","affiliation":[{"name":"Graduate School of Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-8721","authenticated-orcid":false,"given":"Yaowared","family":"Sumanont","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-9953","authenticated-orcid":false,"given":"Supawadee","family":"Daodee","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-5441","authenticated-orcid":false,"given":"Abdulwaris","family":"Mading","sequence":"additional","affiliation":[{"name":"Graduate School of Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"},{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4065-6090","authenticated-orcid":false,"given":"Chantana","family":"Boonyarat","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9927-0670","authenticated-orcid":false,"given":"Charinya","family":"Khamphukdee","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1434-3958","authenticated-orcid":false,"given":"Decha","family":"Kumla","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Burapha University, 169 Long Had Bangsaen Road, Chonburi 20131, Thailand"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9926-7092","authenticated-orcid":false,"given":"Juthamart","family":"Maneenet","sequence":"additional","affiliation":[{"name":"Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0145, Japan"}]},{"given":"Kinzo","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Daiichi University of Pharmacy, Fukuoka 815-8511, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3321-1061","authenticated-orcid":false,"given":"Anake","family":"Kijjoa","sequence":"additional","affiliation":[{"name":"ICBAS-Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-193X","authenticated-orcid":false,"given":"Suresh","family":"Awale","sequence":"additional","affiliation":[{"name":"Natural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0145, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7331-8373","authenticated-orcid":false,"given":"Orawan","family":"Monthakantirat","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cai, H., Xie, X.M., Zhang, Q., Cui, X., Lin, J.X., Sim, K., Ungvari, G.S., Zhang, L., and Xiang, Y.T. 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