{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T15:40:46Z","timestamp":1777218046406,"version":"3.51.4"},"reference-count":80,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Plants"],"abstract":"<jats:p>Topical application is an important administration route for drugs requiring local action on the skin, thereby avoiding their systemic absorption and adverse side effects. Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.), popularly known as rosemary, is an aromatic plant with needle-like leaves belonging to the Lamiaceae family. Rosemary has therapeutic properties and has been used in the folk medicine, pharmaceutical, and cosmetics industries, mainly for its antioxidant and anti-inflammatory properties, which are attributed to the presence of carnosol\/carnosic and ursolic acids. The therapeutic use of rosemary has been explored for the treatment of inflammatory diseases; however, other uses have been studied, such as wound healing and skin cancer and mycoses treatments, among others. Besides it therapeutic uses, rosemary has potential applications in cosmetic formulations and in the treatment of pathological and non-pathological conditions, such as cellulite, alopecia, ultraviolet damage, and aging. This review aims to critically discuss the topical applications of rosemary found in the literature while also offering relevant information for the development of topical formulations of its bioactive compounds.<\/jats:p>","DOI":"10.3390\/plants9050651","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T10:18:18Z","timestamp":1590142698000},"page":"651","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":182,"title":["Rosemary (Rosmarinus officinalis L., syn Salvia rosmarinus Spenn.) and Its Topical Applications: A Review"],"prefix":"10.3390","volume":"9","author":[{"given":"Lucas Malvezzi","family":"de Macedo","sequence":"first","affiliation":[{"name":"School of Medical Sciences, University of Campinas (Unicamp), Campinas 13083-894, Brazil"}]},{"given":"\u00c9rica Mendes dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Institute of Biology, University of Campinas (Unicamp), Campinas 13083-862, Brazil"}]},{"given":"Lucas","family":"Milit\u00e3o","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Campinas (Unicamp), Campinas 13083-871, Brazil"}]},{"given":"Louise Lacalendola","family":"Tundisi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Campinas (Unicamp), Campinas 13083-871, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-9474","authenticated-orcid":false,"given":"Jana\u00edna Artem","family":"Ataide","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Campinas (Unicamp), Campinas 13083-871, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana Barbosa","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), 3000-548 Coimbra, Portugal"},{"name":"CEB-Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-8189","authenticated-orcid":false,"given":"Priscila Gava","family":"Mazzola","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of Campinas (Unicamp), Campinas 13083-871, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.jep.2010.07.007","article-title":"Healing potential of Rosmarinus officinalis L. on full-thickness excision cutaneous wounds in alloxan-induced-diabetic BALB\/c mice","volume":"131","year":"2010","journal-title":"J. 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