{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T02:41:51Z","timestamp":1774752111058,"version":"3.50.1"},"reference-count":133,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2019-106099RB-C43\/AEI\/ 10.13039\/501100011033"],"award-info":[{"award-number":["PID2019-106099RB-C43\/AEI\/ 10.13039\/501100011033"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["MAT2016-76039-C4-3-R (AEI\/FEDER, UE)"],"award-info":[{"award-number":["MAT2016-76039-C4-3-R (AEI\/FEDER, UE)"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["ELKARTEK (KK-2020\/00068, KK-2020\/00099, KK2019\/00039 and KK2019\/00101)"],"award-info":[{"award-number":["ELKARTEK (KK-2020\/00068, KK-2020\/00099, KK2019\/00039 and KK2019\/00101)"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["HAZITEK"],"award-info":[{"award-number":["HAZITEK"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Eusko Jaurlaritza","doi-asserted-by":"publisher","award":["PIBA (PIBA-2018-06)"],"award-info":[{"award-number":["PIBA (PIBA-2018-06)"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.<\/jats:p>","DOI":"10.3390\/polym12102261","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T09:04:12Z","timestamp":1601543052000},"page":"2261","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications"],"prefix":"10.3390","volume":"12","author":[{"given":"Sheila","family":"Maiz-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"},{"name":"Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV\/EHU, Barrio Sarriena, s\/n, 48940 Leioa, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0543-4134","authenticated-orcid":false,"given":"Leyre","family":"P\u00e9rez-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"},{"name":"Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV\/EHU, Barrio Sarriena, s\/n, 48940 Leioa, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-008X","authenticated-orcid":false,"given":"Leire","family":"Ruiz-Rubio","sequence":"additional","affiliation":[{"name":"BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"},{"name":"Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV\/EHU, Barrio Sarriena, s\/n, 48940 Leioa, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-4579","authenticated-orcid":false,"given":"Jose Luis","family":"Vilas-Vilela","sequence":"additional","affiliation":[{"name":"BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"},{"name":"Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV\/EHU, Barrio Sarriena, s\/n, 48940 Leioa, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6791-7620","authenticated-orcid":false,"given":"Senentxu","family":"Lanceros-Mendez","sequence":"additional","affiliation":[{"name":"BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV\/EHU Science Park, 48940 Leioa, Spain"},{"name":"IKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/acs.biomac.8b01242","article-title":"Degradable and Injectable Hydrogel for Drug Delivery in Soft Tissues","volume":"20","author":"Pertici","year":"2019","journal-title":"Biomacromolecules"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40824-018-0138-6","article-title":"Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering","volume":"22","author":"Lee","year":"2018","journal-title":"Biomater. 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