{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:38:17Z","timestamp":1773351497133,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["(2010\/17.721-4)"],"award-info":[{"award-number":["(2010\/17.721-4)"]}]},{"name":"Portuguese Science and Technology Foundation (FCT) for the funded projects M-ERA-NET\/0004\/2015 (PAIRED) and UIDB\/04469\/2020 (strategic fund) financed from national funds, and co-financed Education (FCT\/MEC) from national funds and FEDER, under the Partner","award":["M-ERA-NET\/0004\/2015 (PAIRED) and UIDB\/04469\/2020 (strategic fund)"],"award-info":[{"award-number":["M-ERA-NET\/0004\/2015 (PAIRED) and UIDB\/04469\/2020 (strategic fund)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Chitosan films have been extensively studied as dressings in formulations for the treatment of chronic wounds. The incorporation of aloe vera (Aloe barbadensis Miller) into chitosan dressings could potentialize the healing process since aloe vera shows several pharmacological activities. This work aimed to evaluate the effect of aloe vera and chitosan concentrations on the physicochemical properties of the developed films. The films were obtained by casting technique and characterized with respect to their color parameters, morphology, barrier and mechanical properties, and thermal analysis. Results showed that the presence of aloe vera modified the films\u2032 color parameters, changed barrier properties, increased fluid handling capacity (FHC), and decreased water-vapor permeability (WVP). The reduced elongation at break resulted in more rigid films. Aloe vera concentration did not significantly change film properties, but the presence of this gel increased the films\u2019 stability at temperatures below 200 \u00b0C, showing similar behavior as chitosan films above 400 \u00b0C. The results suggest a crosslinking\/complexation between chitosan and aloe vera, which combine appropriate physicochemical properties for application as wound dressing materials.<\/jats:p>","DOI":"10.3390\/polym13081187","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T11:31:59Z","timestamp":1617795119000},"page":"1187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effect of Chitosan and Aloe Vera Extract Concentrations on the Physicochemical Properties of Chitosan Biofilms"],"prefix":"10.3390","volume":"13","author":[{"given":"Cristiana M. P.","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF), Federal University of S\u00e3o Paulo (UNIFESP), Diadema, S\u00e3o Paulo 09913-030, Brazil"}]},{"given":"Murilo S.","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF), Federal University of S\u00e3o Paulo (UNIFESP), Diadema, S\u00e3o Paulo 09913-030, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2586-6834","authenticated-orcid":false,"given":"Mariana A.","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF), Federal University of S\u00e3o Paulo (UNIFESP), Diadema, S\u00e3o Paulo 09913-030, Brazil"}]},{"given":"Patr\u00edcia S.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF), Federal University of S\u00e3o Paulo (UNIFESP), Diadema, S\u00e3o Paulo 09913-030, Brazil"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-6612","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Severino","sequence":"additional","affiliation":[{"name":"University of Tiradentes (Unit), Biotechnological Postgraduate Program, Aracaju 49010-390, Brazil"},{"name":"Institute of Technology and Research (ITP), Nanomedicine and Nanotechnology Laboratory (LNMed), Aracaju 49010-390, Brazil"},{"name":"Tiradentes Institute, 150 Mt Vernon St, Dorchester, MA 02125, USA"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9737-6017","authenticated-orcid":false,"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[{"name":"CEB-Centre of Biological Engineering, Campus de Gualtar, University of Minho, 4710-057 Braga, Portugal"},{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Classius F.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Institute of Environmental, Chemical and Pharmaceutical Sciences (ICAQF), Federal University of S\u00e3o Paulo (UNIFESP), Diadema, S\u00e3o Paulo 09913-030, Brazil"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ijpharm.2016.11.006","article-title":"Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications","volume":"523","author":"Gainza","year":"2017","journal-title":"Int. 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