{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:34:48Z","timestamp":1777635288104,"version":"3.51.4"},"reference-count":62,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Biomaterials have long been explored in regenerative medicine strategies for the repair or replacement of damaged organs and tissues, due to their biocompatibility, versatile physicochemical properties and tuneable mechanical cues capable of matching those of native tissues. However, poor adhesion under wet conditions (such as those found in tissues) has thus far limited their wider application. Indeed, despite its favourable physicochemical properties, facile gelation and biocompatibility, gellan gum (GG)-based hydrogels lack the tissue adhesiveness required for effective clinical use. Aiming at assessing whether substitution of GG by dopamine (DA) could be a suitable approach to overcome this problem, database searches were conducted on PubMed\u00ae and Embase\u00ae up to 2 March 2021, for studies using biomaterials covalently modified with a catechol-containing substituent conferring improved adhesion properties. In this regard, a total of 47 reports (out of 700 manuscripts, ~6.7%) were found to comply with the search\/selection criteria, the majority of which (34\/47, ~72%) were describing the modification of natural polymers, such as chitosan (11\/47, ~23%) and hyaluronic acid (6\/47, ~13%); conjugation of dopamine (as catechol \u201cdonor\u201d) via carbodiimide coupling chemistry was also predominant. Importantly, modification with DA did not impact the biocompatibility and mechanical properties of the biomaterials and resulting hydrogels. Overall, there is ample evidence in the literature that the bioinspired substitution of polymers of natural and synthetic origin by DA or other catechol moieties greatly improves adhesion to biological tissues (and other inorganic surfaces).<\/jats:p>","DOI":"10.3390\/polym13193317","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T21:38:09Z","timestamp":1632865089000},"page":"3317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0196-8649","authenticated-orcid":false,"given":"Pedro M.","family":"Costa","sequence":"first","affiliation":[{"name":"Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ci\u00eancia e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Portugal"}]},{"given":"David A.","family":"Learmonth","sequence":"additional","affiliation":[{"name":"Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ci\u00eancia e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Portugal"}]},{"given":"David B.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ci\u00eancia e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Portugal"}]},{"given":"Mafalda P.","family":"Cautela","sequence":"additional","affiliation":[{"name":"Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ci\u00eancia e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Portugal"}]},{"given":"Ana C. N.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ci\u00eancia e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7636-7816","authenticated-orcid":false,"given":"Renato","family":"Andrade","sequence":"additional","affiliation":[{"name":"Cl\u00ednica do Drag\u00e3o, Espregueira-Mendes Sports Centre-FIFA Medical Centre of Excellence, 4350-415 Porto, Portugal"},{"name":"Dom Henrique Research Centre, 4350-415 Porto, Portugal"},{"name":"Faculty of Sports, University of Porto, 4200-450 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-4900","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Espregueira-Mendes","sequence":"additional","affiliation":[{"name":"Cl\u00ednica do Drag\u00e3o, Espregueira-Mendes Sports Centre-FIFA Medical Centre of Excellence, 4350-415 Porto, Portugal"},{"name":"Dom Henrique Research Centre, 4350-415 Porto, Portugal"},{"name":"ICVS\/3B\u2019s-PT Government Associate Laboratory, Braga, Portugal"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal"}]},{"given":"Tiago R.","family":"Veloso","sequence":"additional","affiliation":[{"name":"Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ci\u00eancia e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Portugal"}]},{"given":"Cristiana B.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ci\u00eancia e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-7418","authenticated-orcid":false,"given":"Rui A.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Stemmatters, Biotecnologia e Medicina Regenerativa SA, Parque de Ci\u00eancia e Tecnologia Avepark, Zona Industrial da Gandra, 4805-017 Barco, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1139\/o87-095","article-title":"Limb regeneration in vertebrates: Regulatory factors","volume":"65","author":"Liversage","year":"1987","journal-title":"Biochem. 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