{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:59:05Z","timestamp":1762253945632,"version":"build-2065373602"},"reference-count":77,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIBD\/EMS\/00285\/2020"],"award-info":[{"award-number":["UIBD\/EMS\/00285\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>To compare the adhesive interface of eroded dentin formed by a functional dental adhesive and a gold standard strategy, by testing microtensile bond strength (\u03bcTBS), hardness\/elastic modulus. Permanent sound human molars were randomly allocated to four experimental groups, all subject to artificial erosion (0.05 M citric acid; 3\u00d7 daily, 5 days). Groups included control Clearfil SE Bond 2 (CFSE), and experimental group Clearfil SE Protect (CFP), at two different time points-immediate (24 h) and long term (3 months\u20133 M). Samples were sectioned into microspecimens for \u03bcTBS (n = 8) and into 2-mm thick slabs for nanoindentation assays (n = 3). Groups CFSE_3M and CFP_3M were stored in artificial saliva. Statistical analysis included two-way ANOVA for \u03bcTBS data, while hardness\/modulus results were analyzed using Kruskal\u2013Wallis H Test (significance level of 5%; SPSS v.27.0). Although no significant differences were found between mean \u03bcTBS values, for different adhesives and time points (p &gt; 0.05), a positive trend, with \u03bcTBS rising in the CFP_3M group, was observed. Regarding hardness, no significant differences were seen in the hybrid layer, considering the two variables (p &gt; 0.05), while the reduced elastic modulus rose in CFP_3M when compared to 24 h. Thus, CFP shows similar mechanical and adhesive performance to CFSE in eroded dentin, although it may comprise promising long-term results. This is advantageous in eroded substrates due to their increased enzymatic activity and need for remineralization.<\/jats:p>","DOI":"10.3390\/polym13203562","type":"journal-article","created":{"date-parts":[[2021,10,17]],"date-time":"2021-10-17T23:25:15Z","timestamp":1634513115000},"page":"3562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Investigating a Commercial Functional Adhesive with 12-MDPB and Reactive Filler to Strengthen the Adhesive Interface in Eroded Dentin"],"prefix":"10.3390","volume":"13","author":[{"given":"Madalena","family":"Belmar da Costa","sequence":"first","affiliation":[{"name":"Unit of Conservative Dentistry, Instituto Universit\u00e1rio Egas Moniz (IUEM), Monte de Caparica, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7902-6104","authenticated-orcid":false,"given":"Ant\u00f3nio HS","family":"Delgado","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Monte de Caparica, 2829-511 Almada, Portugal"},{"name":"Division of Biomaterials & Tissue Engineering, UCL Eastman Dental Institute, Royal Free Hospital, Hampstead, London NW3 2PF, UK"}]},{"given":"Tom\u00e1s","family":"Amorim Afonso","sequence":"additional","affiliation":[{"name":"Unit of Conservative Dentistry, Instituto Universit\u00e1rio Egas Moniz (IUEM), Monte de Caparica, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-5936","authenticated-orcid":false,"given":"Lu\u00eds","family":"Proen\u00e7a","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Monte de Caparica, 2829-511 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8486-5436","authenticated-orcid":false,"given":"Ana Sofia","family":"Ramos","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, University of Coimbra, CEMMPRE, 3030-788 Coimbra, Portugal"}]},{"given":"Ana","family":"Mano Azul","sequence":"additional","affiliation":[{"name":"Unit of Conservative Dentistry, Instituto Universit\u00e1rio Egas Moniz (IUEM), Monte de Caparica, 2829-511 Almada, Portugal"},{"name":"Centro de Investiga\u00e7\u00e3o Interdisciplinar Egas Moniz (CiiEM), Monte de Caparica, 2829-511 Almada, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1111\/adj.12681","article-title":"Tooth wear and aging","volume":"64","author":"Bartlett","year":"2019","journal-title":"Aust. Dent. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00784-015-1511-7","article-title":"Consensus report of the European Federation of Conservative Dentistry: Erosive tooth wear\u2014diagnosis and management","volume":"19","author":"Carvalho","year":"2015","journal-title":"Clin. Oral Investig."},{"key":"ref_3","first-page":"111","article-title":"Severe tooth wear: European consensus statement on management guidelines","volume":"19","author":"Loomans","year":"2017","journal-title":"J. Adhes. Dent."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/01694243.2020.1835266","article-title":"How to improve bond stability to eroded dentin: A comprehensive review","volume":"35","author":"Ozcan","year":"2021","journal-title":"J. Adhes. Sci. Technol."},{"key":"ref_5","first-page":"7","article-title":"From buonocore\u2019s pioneering acid-etch technique to self-adhering restoratlves. A status perspective of rapidly advancing dentai adheslve technology","volume":"22","author":"Yoshihara","year":"2020","journal-title":"J. Adhes. Dent."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.dental.2007.02.009","article-title":"Dental adhesion review: Aging and stability of the bonded interface","volume":"24","author":"Breschi","year":"2008","journal-title":"Dent. Mater."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s10439-010-9969-6","article-title":"Adhesive\/Dentin interface: The weak link in the composite restoration","volume":"38","author":"Spencer","year":"2010","journal-title":"Ann. Biomed. Eng."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/jbm.820160307","article-title":"The promotion of adhesion by the infiltration of monomers into tooth substrates","volume":"16","author":"Nakabayashi","year":"1982","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_9","first-page":"121","article-title":"Bonding performance of universal adhesives to eroded dentin","volume":"20","author":"Siqueira","year":"2018","journal-title":"J. Adhes. Dent."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jdent.2003.10.009","article-title":"Resin bonding to cervical sclerotic dentin: A review","volume":"32","author":"Tay","year":"2004","journal-title":"J. Dent."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00784-019-02918-9","article-title":"Improving bonding to eroded dentin by using collagen cross-linking agents: 2 years of water storage","volume":"24","author":"Hilgemberg","year":"2020","journal-title":"Clin. Oral Investig."},{"key":"ref_12","first-page":"69","article-title":"Role of etching mode on bonding longevity of a universal adhesive to eroded dentin","volume":"19","author":"Forgerini","year":"2017","journal-title":"J. Adhes. Dent."},{"key":"ref_13","first-page":"121","article-title":"Bond strength to eroded enamel and dentin using a universal adhesive system","volume":"19","author":"Frattes","year":"2017","journal-title":"J. Adhes. Dent."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1016\/j.dental.2015.11.007","article-title":"Mechanisms of degradation of the hybrid layer in adhesive dentistry and therapeutic agents to improve bond durability-A literature review","volume":"32","author":"Frassetto","year":"2016","journal-title":"Dent. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s40496-015-0070-y","article-title":"Long-Term Durability of Dental Adhesives","volume":"2","author":"Pashley","year":"2015","journal-title":"Curr. Oral Heal. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00784-012-0697-1","article-title":"The effect of a tin-containing fluoride mouth rinse on the bond between resin composite and erosively demineralised dentin","volume":"17","author":"Flury","year":"2013","journal-title":"Clin. Oral Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1177\/0022034515623741","article-title":"Paucity of nanolayering in resin-dentin interfaces of MDP-based adhesives","volume":"95","author":"Tian","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4012\/dmj.2014-205","article-title":"The role of MDP in a bonding resin of a two-step self-etching adhesive system","volume":"34","author":"Matsui","year":"2015","journal-title":"Dent. Mater. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/eos.12346","article-title":"Comparison between universal adhesives and two-step self-etch adhesives in terms of dentin bond fatigue durability in self-etch mode","volume":"125","author":"Tsujimoto","year":"2017","journal-title":"Eur. J. Oral Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jdsr.2010.04.002","article-title":"New strategy to create \u201cSuper Dentin\u201d using adhesive technology: Reinforcement of adhesive-dentin interface and protection of tooth structures","volume":"47","author":"Nikaido","year":"2011","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2341\/05-62","article-title":"Morphological and Mechanical Characterization of the Acid-base Resistant Zone at the Adhesive-dentin Interface of Intact and Caries-affected Dentin","volume":"31","author":"Inoue","year":"2006","journal-title":"Oper. Dent."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4012\/dmj.28.717","article-title":"The acid-base resistant zone in three dentin bonding systems","volume":"28","author":"Inoue","year":"2009","journal-title":"Dent. Mater. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.dental.2014.10.006","article-title":"Can quaternary ammonium methacrylates inhibit matrix MMPs and cathepsins?","volume":"31","author":"Agee","year":"2015","journal-title":"Dent. Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0109-5641(02)00060-X","article-title":"Antibacterial activity and bonding characteristics of an adhesive resin containing antibacterial monomer MDPB","volume":"19","author":"Imazato","year":"2003","journal-title":"Dent. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/0103-644020160635","article-title":"Effect of fluoride-releasing adhesive systems on the mechanical properties of eroded dentin","volume":"27","author":"Guedes","year":"2016","journal-title":"Braz. Dent. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.4012\/dmj.2020-165","article-title":"The concept of super enamel formation \u2014Relationship between chemical interaction and enamel acid-base resistant zone at the self-etch adhesive\/enamel interface","volume":"39","author":"Nikaido","year":"2020","journal-title":"Dent. Mater. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"9731280","DOI":"10.1155\/2021\/9731280","article-title":"Fluoride-Releasing Self-Etch Adhesives Create Thick ABRZ at the Interface","volume":"2021","author":"Nikaido","year":"2021","journal-title":"BioMed Res. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.dental.2016.11.015","article-title":"Academy of Dental Materials guidance on in vitro testing of dental composite bonding effectiveness to dentin\/enamel using micro-tensile bond strength (\u03bcTBS) approach","volume":"33","author":"Armstrong","year":"2017","journal-title":"Dent. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1557\/JMR.1992.1564","article-title":"An improved technique for determining hardness and elastic modulus using load and displacement sensing indentation experiments","volume":"7","author":"Oliver","year":"1992","journal-title":"J. Mater. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0300-5712(96)00065-6","article-title":"The dentin substrate: Structure properties related to bonding","volume":"25","author":"Marshall","year":"1997","journal-title":"J. Dent."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1708-8240.1991.tb00985.x","article-title":"Hybrid Layer as a Dentin-Bonding Mechanism","volume":"3","author":"Nakabayashi","year":"1991","journal-title":"J. Esthet. Restor. Dent."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1177\/0022034510391799","article-title":"Limitations in bonding to dentin and experimental strategies to prevent bond degradation","volume":"90","author":"Liu","year":"2011","journal-title":"J. Dent. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jbm.b.31253","article-title":"Recent advances in the theory and mechanism of adhesive resin bonding to dentin: A critical review","volume":"88","author":"Vaidyanathan","year":"2009","journal-title":"J. Biomed. Mater. Res.-Part B Appl. Biomater."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10103-013-1321-6","article-title":"Effects of Er:YAG and Er,Cr:YSGG laser irradiation on the adhesion to eroded dentin","volume":"30","author":"Ramos","year":"2013","journal-title":"Lasers Med. Sci."},{"key":"ref_35","first-page":"24","article-title":"Analysis of laboratory adhesion studies in eroded enamel and dentin: A scoping review","volume":"8","author":"Delgado","year":"2021","journal-title":"Biomater. Investig. Dent."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Kharouf, N., Eid, A., Hardan, L., Bourgi, R., Arntz, Y., Jmal, H., Foschi, F., Sauro, S., Ball, V., and Haikel, Y. (2021). Antibacterial and Bonding Properties of Universal Adhesive Dental Polymers Doped with Pyrogallol. Polymers, 13.","DOI":"10.3390\/polym13101538"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Vasconcelos e Cruz, J., Polido, M., Brito, J., and Gon\u00e7alves, L.L. (2020). Dentin Bonding and SEM Analysis of a New Experimental Universal Adhesive System Containing a Dendrimer. Polymers, 12.","DOI":"10.3390\/polym12020461"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.sdentj.2019.09.004","article-title":"Tooth surface loss: A review of literature","volume":"32","author":"Warreth","year":"2020","journal-title":"Saudi Dent. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.archoralbio.2016.11.017","article-title":"Wettability and surface morphology of eroded dentin treated with chitosan","volume":"75","author":"Ururahy","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00784-011-0650-8","article-title":"Long-term bonding to eroded dentin requires superficial bur preparation","volume":"16","author":"Zimmerli","year":"2012","journal-title":"Clin. Oral Investig."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Flury, S., Lussi, A., and Peutzfeldt, A. (2017). Long-Term Bond Strength of Two Benzalkonium Chloride-Modified Adhesive Systems to Eroded Dentin. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/1207208"},{"key":"ref_42","first-page":"337","article-title":"Effect of Metalloproteinase Inhibitors on Bond Strength of a Self-etching Adhesive on Erosively Demineralized Dentin","volume":"21","author":"Passos","year":"2019","journal-title":"J. Adhes. Dent."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2341\/15-130-C","article-title":"Two-year Randomized Clinical Trial of Self-etching Adhesives and Selective Enamel Etching","volume":"41","author":"Pena","year":"2016","journal-title":"Oper. Dent."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.dental.2010.08.190","article-title":"Eight-year clinical evaluation of a 2-step self-etch adhesive with and without selective enamel etching","volume":"26","author":"Peumans","year":"2010","journal-title":"Dent. Mater."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.5395\/rde.2019.44.e45","article-title":"Influence of 10-MDP concentration on the adhesion and physical properties of self-adhesive resin cements","volume":"44","author":"Shibuya","year":"2019","journal-title":"Restor. Dent. Endod."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1016\/j.actbio.2011.04.026","article-title":"Nanolayering of phosphoric acid ester monomer on enamel and dentin","volume":"7","author":"Yoshihara","year":"2011","journal-title":"Acta Biomater."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1016\/j.dental.2009.11.148","article-title":"Relationship between bond-strength tests and clinical outcomes","volume":"26","author":"Peumans","year":"2010","journal-title":"Dent. Mater."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.dental.2010.10.023","article-title":"State of the art of self-etch adhesives","volume":"27","author":"Yoshihara","year":"2011","journal-title":"Dent. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/13102818.2015.1090296","article-title":"In vitro antibacterial activity of various adhesive materials against oral streptococci","volume":"30","author":"Ozel","year":"2016","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1177\/0022034510389472","article-title":"The Inhibitory Effects of Quaternary Ammonium Methacrylates on Soluble and Matrix-bound MMPs","volume":"90","author":"Agee","year":"2011","journal-title":"J. Dent. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.dental.2005.05.009","article-title":"In vitro antibacterial effects of the dentin primer of Clearfil Protect Bond","volume":"22","author":"Imazato","year":"2006","journal-title":"Dent. Mater."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1177\/00220345970760030901","article-title":"Incorporation of Antibacterial Monomer MDPB into Dentin Primer","volume":"76","author":"Imazato","year":"1997","journal-title":"J. Dent. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0300-5712(97)00013-4","article-title":"Antibacterial activity of dentine primer containing MDPB after curing","volume":"26","author":"Imazato","year":"1998","journal-title":"J. Dent."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"460","DOI":"10.4012\/dmj.2017-294","article-title":"Antibacterial activity and dentin bonding ability of combined use of Clearfil SE Protect and sodium hypochlorite","volume":"37","author":"Muratovska","year":"2018","journal-title":"Dent. Mater. J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"620","DOI":"10.4012\/dmj.2017-209","article-title":"Improving the durability of resin-dentin bonds with an antibacterial monomer MDPB","volume":"37","author":"Hashimoto","year":"2018","journal-title":"Dent. Mater. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"E114","DOI":"10.2341\/19-102-L","article-title":"Bioactive Materials Subjected to Erosion\/Abrasion and Their Influence on Dental Tissues","volume":"350","author":"Viana","year":"2020","journal-title":"Oper. Dent."},{"key":"ref_57","first-page":"337","article-title":"Effect of Fluoride-containing Restorative Materials on Dentin Adhesion and Demineralization of Hard Tissues Adjacent to Restorations","volume":"17","author":"Ayres","year":"2015","journal-title":"J. Adhes. Dent."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4012\/dmj.2010-214","article-title":"Effect of functional monomers in all-in-one adhesive systems on formation of enamel\/dentin acid-base resistant zone","volume":"30","author":"Nikaido","year":"2011","journal-title":"Dent. Mater. J."},{"key":"ref_59","first-page":"163","article-title":"Assessment of the nanostructure of acid\u2013base resistant zone by the application of all-in-one adhesive systems: Super dentin formation","volume":"19","author":"Nikaido","year":"2009","journal-title":"Biomed. Mater. Eng."},{"key":"ref_60","first-page":"183","article-title":"Ultrastructure of the Dentin-Adhesive Interface after acid-base challenge","volume":"6","author":"Tsuchiya","year":"2004","journal-title":"J. Adhes. Dent."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"545","DOI":"10.4012\/dmj.25.545","article-title":"Evaluation of Antibacterial and Fluoride-releasing Adhesive System on Dentin-Microtensile Bond Strength and Acid-base Challenge","volume":"25","author":"Shinohara","year":"2006","journal-title":"Dent. Mater. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.dental.2012.06.013","article-title":"Resin-based composite performance: Are there some things we can\u2019t predict?","volume":"29","author":"Ferracane","year":"2013","journal-title":"Dent. Mater."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.dental.2017.04.013","article-title":"Academy of Dental Materials guidance\u2014Resin composites: Part I\u2014Mechanical properties","volume":"33","author":"Ilie","year":"2017","journal-title":"Dent. Mater."},{"key":"ref_64","first-page":"147","article-title":"Influence of Different Pretreatments on the Microtensile Bond Strength to Eroded Dentin","volume":"19","author":"Deari","year":"2017","journal-title":"J. Adhes. Dent."},{"key":"ref_65","first-page":"133","article-title":"Role of chlorhexidine in bond strength to artificially eroded dentin over time","volume":"17","author":"Calabria","year":"2015","journal-title":"J. Adhes. Dent."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Moda, M.D., Fagundes, T.C., Briso, A.L.F., and Dos Santos, P.H. (2018). Analysis of the bond interface between self-adhesive resin cement to eroded dentin in vitro. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0208024"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1016\/j.biomaterials.2006.01.040","article-title":"Reactivation of inactivated endogenous proteolytic activities in phosphoric acid-etched dentine by etch-and-rinse adhesives","volume":"27","author":"Mazzoni","year":"2006","journal-title":"Biomaterials"},{"key":"ref_68","first-page":"186","article-title":"The durability of a fluoride-releasing resin adhesive system to dentin","volume":"28","author":"Nakajima","year":"2003","journal-title":"Oper. Dent."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1177\/0022034512446339","article-title":"Effects of MMP Inhibitors Incorporated within Dental Adhesives","volume":"91","author":"Almahdy","year":"2012","journal-title":"J. Dent. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"ref_71","unstructured":"Buzalaf, M.A.R., Magalh\u00e3es, A.C., and Wiegand, A. (2012). Alternatives to Fluoride in the prevention and treatment of dental erosion. Erosive Tooth Wear: From Diagnosis to Therapy, S. Karger AG."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1177\/0022034514538046","article-title":"MMP Inhibitors on Dentin Stability","volume":"93","author":"Montagner","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.dental.2017.11.005","article-title":"Dentin bonding systems: From dentin collagen structure to bond preservation and clinical applications","volume":"34","author":"Breschi","year":"2018","journal-title":"Dent. Mater."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.dental.2020.03.009","article-title":"Chlorhexidine preserves the hybrid layer in vitro after 10-years aging","volume":"36","author":"Breschi","year":"2020","journal-title":"Dent. Mater."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Francois, P., Fouquet, V., Attal, J., and Dursun, E. (2020). Commercially Available Fluoride-Releasing Restorative Materials: A Review and a Proposal for Classification. Materials, 13.","DOI":"10.3390\/ma13102313"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Hara, A.T., Queiroz, C.S., Freitas, P.M., Giannini, M., Serra, M.C., and Cury, J.A. (2005). Fluoride release and secondary caries inhibition by adhesive systems on root dentine. Eur. J. Oral Sci., 245\u2013250.","DOI":"10.1111\/j.1600-0722.2005.00214.x"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00784-016-1847-7","article-title":"Correlation between bond strength and nanomechanical properties of adhesive interface","volume":"21","author":"Freitas","year":"2017","journal-title":"Clin. Oral Investig."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/13\/20\/3562\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:15:28Z","timestamp":1760166928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/13\/20\/3562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":77,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["polym13203562"],"URL":"https:\/\/doi.org\/10.3390\/polym13203562","relation":{},"ISSN":["2073-4360"],"issn-type":[{"type":"electronic","value":"2073-4360"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}