{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:17:01Z","timestamp":1777663021977,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>This prospective, double-blind, six-arm parallel randomised controlled trial aimed to compare the performance of two universal adhesives (UAs) in non-carious cervical lesions (NCCLs), using the FDI criteria, and analysed if participants\/NCCLs\u2019 characteristics influenced the outcome. Thirty-eight 18- to 65-year-old participants were seeking routine dental care at a university clinic. At baseline, 210 NCCLs were randomly allocated to six groups (35 restorations\u2019 each). The UAs tested were FuturabondU (FBU) and AdheseUniversal (ADU) applied in either etch-and-rinse (ER) and self-etch (SE) modes. FuturabondDC (FBDC) in SE and in SE with selective enamel etching (SE-EE) modes were controls. NCCLs were restored with AdmiraFusion. The analysis included nonparametric tests, Kaplan-Meier and log-rank tests (\u03b1 = 0.05). At 2-years, of 191 restorations, ten were missed due to retention loss (all groups, p &gt; 0.05). FBDC (p = 0.037) and FBU (p = 0.041) performed worse than ADU in SE mode. FBDC and FBU also showed worse functional success rate (p = 0.012, p = 0.007, respectively) and cumulative retention rates (p = 0.022, p = 0.012, respectively) than ADU. Some participants\/NCCLs\u2019 characteristics influenced (p &lt; 0.05) the outcomes. FBU did not perform as well as ADU, especially in SE mode and due to functional properties. Participants\u2019 age and NCCLs\u2019 degree of dentin sclerosis and internal shape angle influenced FBU performance.<\/jats:p>","DOI":"10.3390\/polym14010033","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T02:02:57Z","timestamp":1640224977000},"page":"33","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Universal Adhesives and Adhesion Modes in Non-Carious Cervical Restorations: 2-Year Randomised Clinical Trial"],"prefix":"10.3390","volume":"14","author":[{"given":"Patricia","family":"Manarte-Monteiro","sequence":"first","affiliation":[{"name":"FP-I3ID, Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"}]},{"given":"Joana","family":"Domingues","sequence":"additional","affiliation":[{"name":"FP-I3ID, Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8028-8619","authenticated-orcid":false,"given":"Liliana","family":"Teixeira","sequence":"additional","affiliation":[{"name":"FP-I3ID, Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-1241","authenticated-orcid":false,"given":"Sandra","family":"Gavinha","sequence":"additional","affiliation":[{"name":"FP-I3ID, Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1774-1337","authenticated-orcid":false,"given":"Maria Concei\u00e7\u00e3o","family":"Manso","sequence":"additional","affiliation":[{"name":"FP-I3ID, Faculty of Health Sciences, University Fernando Pessoa, 4200-150 Porto, Portugal"},{"name":"Fernando Pessoa Energy, Environmental and Health Research Unit (FP-ENAS), 4249-004 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.dental.2015.11.005","article-title":"Influence of different etching modes on bond strength and fatigue strength to dentin using universal adhesive systems","volume":"32","author":"Takamizawa","year":"2016","journal-title":"Dent. 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