{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T02:17:39Z","timestamp":1774318659428,"version":"3.50.1"},"reference-count":75,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministry of Science and Higher Education","doi-asserted-by":"publisher","award":["075-15-2021-588"],"award-info":[{"award-number":["075-15-2021-588"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012934","name":"Tomsk Polytechnic University","doi-asserted-by":"publisher","award":["Development program"],"award-info":[{"award-number":["Development program"]}],"id":[{"id":"10.13039\/100012934","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Novel hybrid magnetoactive composite scaffolds based on poly(3-hydroxybutyrate) (PHB), gelatin, and magnetite (Fe3O4) were fabricated by electrospinning. The morphology, structure, phase composition, and magnetic properties of composite scaffolds were studied. Fabrication procedures of PHB\/gelatin and PHB\/gelatin\/Fe3O4 scaffolds resulted in the formation of both core-shell and ribbon-shaped structure of the fibers. In case of hybrid PHB\/gelatin\/Fe3O4 scaffolds submicron-sized Fe3O4 particles were observed in the surface layers of the fibers. The X-ray photoelectron spectroscopy results allowed the presence of gelatin on the fiber surface (N\/C ratio\u20130.11) to be revealed. Incubation of the composite scaffolds in saline for 3 h decreased the amount of gelatin on the surface by more than ~75%. The differential scanning calorimetry results obtained for pure PHB scaffolds revealed a characteristic melting peak at 177.5 \u00b0C. The presence of gelatin in PHB\/gelatin and PHB\/gelatin\/Fe3O4 scaffolds resulted in the decrease in melting temperature to 168\u2013169 \u00b0C in comparison with pure PHB scaffolds due to the core-shell structure of the fibers. Hybrid scaffolds also demonstrated a decrease in crystallinity from 52.3% (PHB) to 16.9% (PHB\/gelatin) and 9.2% (PHB\/gelatin\/Fe3O4). All the prepared scaffolds were non-toxic and saturation magnetization of the composite scaffolds with magnetite was 3.27 \u00b1 0.22 emu\/g, which makes them prospective candidates for usage in biomedical applications.<\/jats:p>","DOI":"10.3390\/polym14030529","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:43:27Z","timestamp":1643420607000},"page":"529","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Core-Shell Magnetoactive PHB\/Gelatin\/Magnetite Composite Electrospun Scaffolds for Biomedical Applications"],"prefix":"10.3390","volume":"14","author":[{"given":"Artyom S.","family":"Pryadko","sequence":"first","affiliation":[{"name":"Physical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-8625","authenticated-orcid":false,"given":"Vladimir V.","family":"Botvin","sequence":"additional","affiliation":[{"name":"International Research and Development Center \u201cPiezo- and Magnetoelectric Materials\u201d, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}]},{"given":"Yulia R.","family":"Mukhortova","sequence":"additional","affiliation":[{"name":"Physical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"},{"name":"International Research and Development Center \u201cPiezo- and Magnetoelectric Materials\u201d, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}]},{"given":"Igor","family":"Pariy","sequence":"additional","affiliation":[{"name":"Physical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7391-0385","authenticated-orcid":false,"given":"Dmitriy V.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Faculty of Radiophysics, National Research Tomsk State University, 634050 Tomsk, Russia"}]},{"given":"Pavel P.","family":"Laktionov","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5647-5169","authenticated-orcid":false,"given":"Vera S.","family":"Chernonosova","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia"}]},{"given":"Boris P.","family":"Chelobanov","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, 630090 Novosibirsk, Russia"},{"name":"Laboratory of Molecular Medicine, Novosibirsk State University, 630090 Novosibirsk, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6652-7946","authenticated-orcid":false,"given":"Roman V.","family":"Chernozem","sequence":"additional","affiliation":[{"name":"Physical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"},{"name":"International Research and Development Center \u201cPiezo- and Magnetoelectric Materials\u201d, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}]},{"given":"Maria A.","family":"Surmeneva","sequence":"additional","affiliation":[{"name":"Physical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"},{"name":"International Research and Development Center \u201cPiezo- and Magnetoelectric Materials\u201d, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-7610","authenticated-orcid":false,"given":"Andrei L.","family":"Kholkin","sequence":"additional","affiliation":[{"name":"International Research and Development Center \u201cPiezo- and Magnetoelectric Materials\u201d, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"},{"name":"Department of Physics and CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8061-3047","authenticated-orcid":false,"given":"Roman A.","family":"Surmenev","sequence":"additional","affiliation":[{"name":"Physical Materials Science and Composite Materials Center, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"},{"name":"International Research and Development Center \u201cPiezo- and Magnetoelectric Materials\u201d, Research School of Chemistry and Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1039\/C6PY01455K","article-title":"Field responsive materials: Photo-, electro-, magnetic-and ultrasound-sensitive polymers","volume":"8","author":"Manouras","year":"2017","journal-title":"Polym. 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