{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:10:43Z","timestamp":1772709043842,"version":"3.50.1"},"reference-count":46,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/BTM-MAT\/31470\/2017"],"award-info":[{"award-number":["PTDC\/BTM-MAT\/31470\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50025\/2020-2023"],"award-info":[{"award-number":["UIDB\/50025\/2020-2023"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Hybrid scaffolds obtained by combining two or more biopolymers are studied in the context of tissue regeneration due to the possibility of achieving new functional properties or structural features. The aim of this work was to produce a new type of hybrid polycaprolactone (PCL)\/chitosan (CS) electrospun mat through the controlled deposition of CS flakes interspaced between the PCL fibers. A poly(ethylene oxide) (PEO) solution was used to transport CS flakes with controlled size. This, and the PCL solution, were simultaneously electrospun onto a rotatory mandrel in a perpendicular setup. Different PCL\/CS mass ratios were also studied. The morphology of the resulting fibers, evaluated by SEM, confirmed the presence of the CS flakes between the PCL fibers. The addition of PEO\/CS fibers resulted in hydrophilic mats with lower Young\u2019s modulus relatively to PCL mats. In vitro cell culture results indicated that the addition of CS lowers both the adhesion and the proliferation of human dermal fibroblasts. The present work demonstrates the feasibility of achieving a controlled deposition of a polymeric component in granular form onto a collector where electrospun nanofibers are being deposited, thereby producing a hybrid scaffold.<\/jats:p>","DOI":"10.3390\/polym14081496","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T21:08:22Z","timestamp":1649365702000},"page":"1496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Study on the Incorporation of Chitosan Flakes in Electrospun Polycaprolactone Scaffolds"],"prefix":"10.3390","volume":"14","author":[{"given":"Diana","family":"Querido","sequence":"first","affiliation":[{"name":"Cenimat\/I3N, Physics Department, School of Science and Technology, Universidade Nova de Lisboa, Caparica, 2819-516 Almada, Portugal"}]},{"given":"T\u00e2nia","family":"Vieira","sequence":"additional","affiliation":[{"name":"Cenimat\/I3N, Physics Department, School of Science and Technology, Universidade Nova de Lisboa, Caparica, 2819-516 Almada, Portugal"}]},{"given":"Jos\u00e9 Lu\u00eds","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cenimat\/I3N, Physics Department, School of Science and Technology, Universidade Nova de Lisboa, Caparica, 2819-516 Almada, Portugal"}]},{"given":"C\u00e9lia","family":"Henriques","sequence":"additional","affiliation":[{"name":"Cenimat\/I3N, Physics Department, School of Science and Technology, Universidade Nova de Lisboa, Caparica, 2819-516 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-6545","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"Borges","sequence":"additional","affiliation":[{"name":"Cenimat\/I3N, Materials Science Department, School of Science and Technology, Universidade Nova de Lisboa, Caparica, 2819-516 Almada, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-4272","authenticated-orcid":false,"given":"Jorge Carvalho","family":"Silva","sequence":"additional","affiliation":[{"name":"Cenimat\/I3N, Physics Department, School of Science and Technology, Universidade Nova de Lisboa, Caparica, 2819-516 Almada, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Valdoz, J.C., Johnson, B.C., Jacobs, D.J., Franks, N.A., Dodson, E.L., Sanders, C., Cribbs, C.G., and van Ry, P.M. 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