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and collagen (Coll) scaffolds have been prepared and their physico-chemical properties have been evaluated. Their structural properties were studied by Fourier Transform Infrared Spectroscopy with Attenuated Internal Reflection (FTIR\u2013ATR) accompanied by evaluation of thermal stability, porosity, density, moisture content and microstructure by Scanning Electron Microscopy\u2014SEM. Additionally, cutaneous assessment using human epidermal keratinocytes (NHEK), dermal fibroblasts (NHDF) and melanoma cells (A375 and G-361) was performed. Based on thermal studies, two regions in DTG curves could be distinguished in each type of scaffold, what can be assigned to the elimination of water and the polymeric structure degradation of the materials components. The type of scaffold had no major effect on the porosity of the materials, but the water content of the materials decreased with increasing dialdehyde chitosan content in subjected matrices. Briefly, a drop in proliferation was noticed for scaffolds containing 20DAC\/80Coll compared to matrices with collagen alone. Furthermore, increased content of DAC (50DAC\/50Coll) either significantly induced the proliferation rate or maintains its ratio compared to the control matrix. This delivery is a promising technique for additional explorations targeting therapies in regenerative dermatology. The using of dialdehyde chitosan as one of the main scaffolds components is the novelty in terms of bioengineering.<\/jats:p>","DOI":"10.3390\/polym14091818","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T07:08:58Z","timestamp":1651475338000},"page":"1818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Scaffolds Loaded with Dialdehyde Chitosan and Collagen\u2014Their Physico-Chemical Properties and Biological Assessment"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3957-9542","authenticated-orcid":false,"given":"Sylwia","family":"Grabska-Zieli\u0144ska","sequence":"first","affiliation":[{"name":"Department of Physical Chemistry and Physicochemistry of Polymers, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toru\u0144, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-609X","authenticated-orcid":false,"given":"Judith M.","family":"Pin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of M\u00fcnster, Von-Esmarch-Str. 58, 48149 M\u00fcnster, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2563-2376","authenticated-orcid":false,"given":"Beata","family":"Kaczmarek-Szczepa\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toru\u0144, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8407-0078","authenticated-orcid":false,"given":"Ewa","family":"Olewnik-Kruszkowska","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry and Physicochemistry of Polymers, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toru\u0144, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-2725","authenticated-orcid":false,"given":"Alina","family":"Sionkowska","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Toru\u0144, Poland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-4605","authenticated-orcid":false,"given":"Fernando J.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4200-180 Porto, Portugal"},{"name":"INEB\u2014Instituto de Engenharia Biom\u00e9dica, Universidade do Porto, 4200-180 Porto, Portugal"},{"name":"FEUP\u2014Faculdade de Engenharia, Universidade do Porto, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-2158","authenticated-orcid":false,"given":"Kerstin","family":"Steinbrink","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of M\u00fcnster, Von-Esmarch-Str. 58, 48149 M\u00fcnster, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-263X","authenticated-orcid":false,"given":"Konrad","family":"Kleszczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of M\u00fcnster, Von-Esmarch-Str. 58, 48149 M\u00fcnster, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","first-page":"a004978","article-title":"The collagen family","volume":"3","year":"2011","journal-title":"Cold Spring Harb. 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