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ARNET","award":["LA\/P\/0069\/2020"],"award-info":[{"award-number":["LA\/P\/0069\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Polycaprolactone (PCL) is widely used in tissue engineering due to its interesting properties, namely biocompatibility, biodegradability, elastic nature, availability, cost efficacy, and the approval of health authorities such as the American Food and Drug Administration (FDA). The PCL degradation rate is not the most adequate for specific applications such as skin regeneration due to the hydrophobic nature of bulk PCL. However, PCL electrospun fiber meshes, due to their low diameters resulting in high surface area, are expected to exhibit a fast degradation rate. In this work, in vitro and in vivo degradation studies were performed over 90 days to evaluate the potential of electrospun PCL as a wound dressing. Enzymatic and hydrolytic degradation studies in vitro, performed in a static medium, demonstrated the influence of lipase, which promoted a rate of degradation of 97% for PCL meshes. In an in vivo scenario, the degradation was slower, although the samples were not rejected, and were well-integrated in the surrounding tissues inside the subcutaneous pockets specifically created.<\/jats:p>","DOI":"10.3390\/polym14163397","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T01:56:40Z","timestamp":1661133400000},"page":"3397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":251,"title":["Electrospun Polycaprolactone (PCL) Degradation: An In Vitro and In Vivo Study"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-1069","authenticated-orcid":false,"given":"Juliana R.","family":"Dias","sequence":"first","affiliation":[{"name":"Center for Rapid and Sustainable Product Development (CDRsp), Polytechnic Institute of Leiria, 2030-028 Marinha Grande, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2191-8892","authenticated-orcid":false,"given":"Aureliana","family":"Sousa","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), Universidade do Porto, 4200-135 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-6848","authenticated-orcid":false,"given":"Ana","family":"Augusto","sequence":"additional","affiliation":[{"name":"MARE-Marine and Environmental Sciences Center, ARNET, ESTM, Instituto Polit\u00e9cnico de Leiria, 2520-630 Peniche, Portugal"}]},{"given":"Paulo J.","family":"B\u00e1rtolo","sequence":"additional","affiliation":[{"name":"Singapore Center for 3D Printing, Nanyang Technological University, 22 Jurong West, Singapore 639798, Singapore"}]},{"given":"Pedro L.","family":"Granja","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto, 4200-135 Porto, Portugal"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), Universidade do Porto, 4200-135 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.msec.2018.08.050","article-title":"Biomechanical performance of hybrid electrospun structures for skin regeneration","volume":"93","author":"Dias","year":"2018","journal-title":"Mater. 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