{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:24:34Z","timestamp":1778509474471,"version":"3.51.4"},"reference-count":47,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Portuguese National Science Foundation (FCT)","doi-asserted-by":"publisher","award":["DL 57\/2016\/CP1377\/CT0094"],"award-info":[{"award-number":["DL 57\/2016\/CP1377\/CT0094"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese National Science Foundation (FCT)","doi-asserted-by":"publisher","award":["CEECINST\/00018\/2021"],"award-info":[{"award-number":["CEECINST\/00018\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese National Science Foundation (FCT)","doi-asserted-by":"publisher","award":["PTDC\/CTM-CTM\/29813\/2017"],"award-info":[{"award-number":["PTDC\/CTM-CTM\/29813\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Portuguese National Science Foundation (FCT)","doi-asserted-by":"publisher","award":["PTDC\/BII-BIO\/31570\/2017"],"award-info":[{"award-number":["PTDC\/BII-BIO\/31570\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"research projects","doi-asserted-by":"publisher","award":["DL 57\/2016\/CP1377\/CT0094"],"award-info":[{"award-number":["DL 57\/2016\/CP1377\/CT0094"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"research projects","doi-asserted-by":"publisher","award":["CEECINST\/00018\/2021"],"award-info":[{"award-number":["CEECINST\/00018\/2021"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"research projects","doi-asserted-by":"publisher","award":["PTDC\/CTM-CTM\/29813\/2017"],"award-info":[{"award-number":["PTDC\/CTM-CTM\/29813\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"research projects","doi-asserted-by":"publisher","award":["PTDC\/BII-BIO\/31570\/2017"],"award-info":[{"award-number":["PTDC\/BII-BIO\/31570\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>In recent years, there has been a growing interest in developing smart drug delivery systems based on natural resources combined with stimulus-sensitive elements. This trend aims to formulate innovative and sustainable delivery platforms tailored for topical applications. This work proposed the use of layer-by-layer (LbL) methodology to fabricate biocompatible photo-responsive multilayer systems. These systems are composed of a polyoxometalate inorganic salt (POM) ([NaP5W30O110]14\u2212) and a natural origin polymer, chitosan (CHT). Curcumin (CUR), a natural bioactive compound, was incorporated to enhance the functionality of these systems during the formation of hollow capsules. The capsules produced, with sizes between 2\u20135\u00b5m (SEM), were further dispersed into CHT\/VCO (virgin coconut oil) emulsion solutions that were casted into molds and dried at 37 \u00b0C for 48 h. The system presented a higher water uptake in PBS than in acidic conditions, still significantly lower than that earlier reported to other CHT\/VCO-based systems. The drug release profile is not significantly influenced by the medium pH reaching a maximum of 37% \u00b1 1% after 48 h. The antioxidant performance of the designed structures was further studied, suggesting a synergistic beneficial effect resulting from CUR, POM, and VCO individual bioactivities. The increased amount of those excipients released to the media over time promoted an increase in the antioxidant activity of the system, reaching a maximum of 38.1% \u00b1 0.1% after 48 h. This work represents a promising step towards developing advanced, sustainable drug delivery systems for topical applications.<\/jats:p>","DOI":"10.3390\/polym16050641","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T05:20:32Z","timestamp":1709011232000},"page":"641","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chitosan\/Virgin Coconut Oil-Based Emulsions Doped with Photosensitive Curcumin Loaded Capsules: A Functional Carrier to Topical Treatment"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8582-2465","authenticated-orcid":false,"given":"Lu\u00edsa C.","family":"Rodrigues","sequence":"first","affiliation":[{"name":"3B\u2019s Research Group, I3Bs\u2014Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal"}]},{"given":"Adriana P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs\u2014Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-9419","authenticated-orcid":false,"given":"Simone S.","family":"Silva","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs\u2014Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4295-6129","authenticated-orcid":false,"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[{"name":"3B\u2019s Research Group, I3Bs\u2014Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ci\u00eancia e Tecnologia, Zona Industrial da Gandra, Barco, 4805-017 Guimar\u00e3es, Portugal"},{"name":"ICVS\/3B\u2019s\u2014PT Government Associate Laboratory, 4710-057 Braga\/Guimar\u00e3es, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kulchar, R.J., Singh, R., Ding, S., Alexander, E., Leong, K.W., and Daniell, H. (2023). Delivery of biologics: Topical administration. Biomaterials, 302.","DOI":"10.1016\/j.biomaterials.2023.122312"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19145","DOI":"10.1021\/acsomega.2c08016","article-title":"New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective","volume":"8","author":"Raina","year":"2023","journal-title":"ACS Omega"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"113929","DOI":"10.1016\/j.addr.2021.113929","article-title":"Topical drug delivery: History, percutaneous absorption, and product development","volume":"177","author":"Roberts","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"957732","DOI":"10.3389\/fddev.2022.957732","article-title":"Recent advances and future prospective of topical and transdermal delivery systems","volume":"2","author":"Tapfumaneyi","year":"2022","journal-title":"Front. Drug Deliv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1021\/bm400527y","article-title":"Multifunctional Compartmentalized Capsules with a Hierarchical Organization from the Nano to the Macro Scales","volume":"14","author":"Costa","year":"2013","journal-title":"Biomacromolecules"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/adhm.201600219","article-title":"Design Advances in Particulate Systems for Biomedical Applications","volume":"5","author":"Lima","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Ribeiro, C., Borges, J., Costa, A.M.S., Gaspar, V.M., Bermudez, V.D.Z., and Mano, J.F. (2018). Preparation of Well-Dispersed Chitosan\/Alginate Hollow Multilayered Microcapsules for Enhanced Cellular Internalization. Molecules, 23.","DOI":"10.3390\/molecules23030625"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113884","DOI":"10.1016\/j.addr.2021.113884","article-title":"Drug delivery carriers with therapeutic functions","volume":"176","author":"Cai","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/jsde.12698","article-title":"Design and characterization of dual-pronged liposome-embedded gel for enhanced dermal delivery","volume":"26","author":"Saxena","year":"2023","journal-title":"J. Surfactants Deterg."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wells, C.M., Harris, M., Choi, L., Murali, V.P., Guerra, F.D., and Jennings, J.A. (2019). Stimuli-Responsive Drug Release from Smart Polymers. J. Funct. Biomater., 10.","DOI":"10.3390\/jfb10030034"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1039\/D2BM00497F","article-title":"Layer-by-layer assembly methods and their biomedical applications","volume":"10","author":"Zhang","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.reactfunctpolym.2019.02.013","article-title":"Development of bioactive compounds-loaded chitosan films by using a QbD approach\u2014A novel and potential wound dressing material","volume":"138","author":"Colobatiu","year":"2019","journal-title":"React. Funct. Polym."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Aranaz, I., Alc\u00e1ntara, A.R., Civera, M.C., Arias, C., Elorza, B., Caballero, A.H., and Acosta, N. (2021). Chitosan: An Overview of Its Properties and Applications. Polymers, 13.","DOI":"10.3390\/polym13193256"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.2174\/0929867326666190827153532","article-title":"Polyoxometalates in Biomedicine: Update and Overview","volume":"27","author":"Mougharbel","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"ref_15","unstructured":"Farzana, R., Iqra, P., and Hunaiza, T. (2018). Antioxidant and antimicrobial effects of polyoxometalates. Microbiol. Curr. Res., 2."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1039\/C5TB02606G","article-title":"Light responsive multilayer surfaces with controlled spatial extinction capability","volume":"4","author":"Rodrigues","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hamilton, A.E., and Gilbert, R.J. (2023). Curcumin Release from Biomaterials for Enhanced Tissue Regeneration Following Injury or Disease. Bioengineering, 10.","DOI":"10.3390\/bioengineering10020262"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Szcz\u0119sna, W., Tsirigotis-Maniecka, M., Lamch, \u0141., Szyk-Warszy\u0144ska, L., Zboi\u0144ska, E., Warszy\u0144ski, P., and Wilk, K.A. (2022). Multilayered Curcumin-Loaded Hydrogel Microcarriers with Antimicrobial Function. Molecules, 27.","DOI":"10.20944\/preprints202201.0410.v1"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sideek, S.A., El-Nassan, H.B., Fares, A.R., ElMeshad, A.N., and Elkasabgy, N.A. (2023). Different Curcumin-Loaded Delivery Systems for Wound Healing Applications: A Comprehensive Review. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15010038"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"104200","DOI":"10.1016\/j.jddst.2023.104200","article-title":"Recent advances in curcumin-loaded biomimetic nanomedicines for targeted therapies","volume":"80","author":"Lei","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1007\/s11837-022-05180-9","article-title":"A Review on Curcumin-Loaded Electrospun Nanofibers and their Application in Modern Medicine","volume":"74","author":"Mitra","year":"2022","journal-title":"JOM"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00210-022-02310-7","article-title":"Local administration of curcumin-loaded nanoparticles enhances periodontal repair in vivo","volume":"396","author":"Fernandes","year":"2023","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Sood, A., Dev, A., Das, S.S., Kim, H.J., Kumar, A., Thakur, V.K., and Han, S.S. (2023). Curcumin-loaded alginate hydrogels for cancer therapy and wound healing applications: A review. Int. J. Biol. Macromol., 232.","DOI":"10.1016\/j.ijbiomac.2023.123283"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"215233","DOI":"10.1016\/j.ccr.2023.215233","article-title":"Curcumin-Incorporated Biomaterials: In silico and in vitro evaluation of biological potentials","volume":"492","author":"Torbat","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1080\/10717544.2020.1853280","article-title":"Curcumin nanoparticles incorporated in PVA\/collagen composite films promote wound healing","volume":"27","author":"Leng","year":"2020","journal-title":"Drug Deliv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/jbm.b.33032","article-title":"Acceleration of dermal wound healing by using electrospun curcumin-loaded poly(\u03b5-caprolactone)-poly(ethylene glycol)-poly(\u03b5-caprolactone) fibrous mats","volume":"102","author":"Fu","year":"2014","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"116839","DOI":"10.1016\/j.carbpol.2020.116839","article-title":"Approach on chitosan\/virgin coconut oil-based emulsion matrices as a platform to design superabsorbent materials","volume":"249","author":"Silva","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Silva, S.S., Rodrigues, L.C., Fernandes, E.M., da Costa, D.S., Villalva, D.G., Loh, W., and Reis, R.L. (2023). Chitosan\/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach. Mar. Drugs, 21.","DOI":"10.3390\/md21070394"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Arifin, H.R., Utaminingsih, F., Djali, M., Nurhadi, B., Lembong, E., and Marta, H. (2023). The Role of Virgin Coconut Oil in Corn Starch\/NCC-Based Nanocomposite Film Matrix: Physical, Mechanical, and Water Vapor Transmission Characteristics. Polymers, 15.","DOI":"10.20944\/preprints202306.1024.v1"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ismail, N.A., Mohamad, S.F., Ibrahim, M.A., and Amin, K.A.M. (2014). Evaluation of Gellan Gum Film Containing Virgin Coconut Oil for Transparent Dressing Materials. Adv. Biomater., 2014.","DOI":"10.1155\/2014\/351248"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1590\/S0104-14282001000200007","article-title":"Caracter\u00edsticas e propriedades de quitosanas purificadas nas formas neutra, acetato e cloridrato","volume":"11","author":"Signini","year":"2001","journal-title":"Pol\u00edmeros"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1021\/ic00061a010","article-title":"Rigid nonlabile polyoxometalate cryptates [ZP5W30O110](15-n)\u2014That exhibit unprecedented selectivity for certain lanthanide and other multivalent cations","volume":"32","author":"Creaser","year":"1993","journal-title":"Inorg. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s13197-011-0251-1","article-title":"Genesis and development of DPPH method of antioxidant assay","volume":"48","author":"Kedare","year":"2011","journal-title":"J. Food Sci. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ruiz, A.L., Ramirez, A., and McEnnis, K. (2022). Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14020421"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e17488","DOI":"10.1016\/j.heliyon.2023.e17488","article-title":"Advances in drug delivery systems, challenges and future directions","volume":"9","author":"Ezike","year":"2023","journal-title":"Heliyon"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Trucillo, P. (2021). Drug Carriers: Classification, Administration, Release Profiles, and Industrial Approach. Processes, 9.","DOI":"10.3390\/pr9030470"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"118427","DOI":"10.1016\/j.carbpol.2021.118427","article-title":"Recent advances in chitosan-based layer-by-layer biomaterials and their biomedical applications","volume":"271","author":"Hu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_38","first-page":"52","article-title":"Preparation, Characterization and Performance Evaluation of Chitosan as an Adsorbent for Remazol Red","volume":"2","author":"Dey","year":"2016","journal-title":"Int. J. Latest Res. Eng. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1039\/B402617A","article-title":"Porous calcium carbonate microparticles as templates for encapsulation of bioactive compounds","volume":"14","author":"Sukhorukov","year":"2004","journal-title":"J. Mater. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2174\/2211738509666210204121258","article-title":"The Influence of Surface Charge on the Antiviral Effect of Curcumin Loaded in Nanocarrier System","volume":"9","author":"Nabila","year":"2021","journal-title":"Pharm. Nanotechnol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kocak, F.Z., Yar, M., and Rehman, I.U. (2022). Hydroxyapatite-Integrated, Heparin- and Glycerol-Functionalized Chitosan-Based Injectable Hydrogels with Improved Mechanical and Proangiogenic Performance. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105370"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"25227","DOI":"10.1021\/acsomega.1c03016","article-title":"Understanding the Molecular-Level Interactions of Glucosamine-Glycerol Assemblies: A Model System for Chitosan Plasticization","volume":"6","author":"Smith","year":"2021","journal-title":"ACS Omega"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"302","DOI":"10.12968\/jowc.2023.32.5.302","article-title":"Wound pH and temperature as predictors of healing: An observational study","volume":"32","author":"Derwin","year":"2023","journal-title":"J. Wound Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/ijd.15733","article-title":"Therapeutic benefits of natural oils along with permeation enhancing activity","volume":"61","author":"Amra","year":"2022","journal-title":"Int. J. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.3109\/03639045.2015.1047847","article-title":"Penetration enhancing effects of selected natural oils utilized in topical dosage forms","volume":"41","author":"Viljoen","year":"2015","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ijbiomac.2019.08.085","article-title":"Antioxidant and antibacterial activities of omega-3 rich oils\/curcumin nanoemulsions loaded in chitosan and alginate-based microbeads","volume":"140","author":"Hashim","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/fsn3.671","article-title":"Physicochemical properties, antioxidant capacities, and metal contents of virgin coconut oil produced by wet and dry processes","volume":"6","author":"Ghani","year":"2018","journal-title":"Food Sci. Nutr."}],"container-title":["Polymers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4360\/16\/5\/641\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:05:35Z","timestamp":1760105135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4360\/16\/5\/641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,27]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["polym16050641"],"URL":"https:\/\/doi.org\/10.3390\/polym16050641","relation":{},"ISSN":["2073-4360"],"issn-type":[{"value":"2073-4360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,27]]}}}