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RES was incorporated into the materials with a high loading efficiency (&gt;75%) using the rotary evaporator technique. This incorporation induced the amorphization of RES, resulting in enhanced solubility and in vitro release when compared to the free polyphenolic compound. The release profiles displayed pH dependence, exhibiting notably faster release at pH 5.2 compared to pH 7.4. The gradual release of RES over time demonstrated an initial time lag of approximately 4 h, being well described by the Weibull model. In vitro cytotoxicity studies were conducted on human osteosarcoma cells (MG-63), revealing a concentration-dependent decrease in cell viability for RES-loaded samples (for concentrations &gt;50 \u00b5g mL\u22121).<\/jats:p>","DOI":"10.3390\/polym16070879","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T10:58:02Z","timestamp":1711105082000},"page":"879","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Resveratrol-Loaded Polydimethylsiloxane\u2013Silica Hybrid Materials: Synthesis, Characterization, and Antitumoral Activity"],"prefix":"10.3390","volume":"16","author":[{"given":"Sofia","family":"Viegas","sequence":"first","affiliation":[{"name":"Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1265-5744","authenticated-orcid":false,"given":"Diogo","family":"Marinheiro","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9882-4766","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Biology, CESAM-Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-8880","authenticated-orcid":false,"given":"Ana L.","family":"Daniel-da-Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2500-9389","authenticated-orcid":false,"given":"Ricardo","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-0696","authenticated-orcid":false,"given":"Helena","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biology, CESAM-Centre for Environmental and Marine Studies, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-9532","authenticated-orcid":false,"given":"Jos\u00e9 Carlos","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Materials and Ceramic Engineering, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-3160","authenticated-orcid":false,"given":"B\u00e1rbara J. 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Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3389\/fphys.2019.00814","article-title":"New Advances in the Study of Bone Tumors: A Lesson from the 3D Environment","volume":"10","author":"Cortini","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_5","first-page":"224","article-title":"Bone grafts and biomaterials substitutes for bone defect repair: A review","volume":"2","author":"Wang","year":"2017","journal-title":"Bioact. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1097\/BOT.0000000000000978","article-title":"Size Matters: Defining Critical in Bone Defect Size!","volume":"31","author":"Schemitsch","year":"2017","journal-title":"J. Orthop. Trauma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/BOT.0000000000001420","article-title":"Autograft, Allograft, and Bone Graft Substitutes: Clinical Evidence and Indications for Use in the Setting of Orthopaedic Trauma Surgery","volume":"33","author":"Baldwin","year":"2019","journal-title":"J. Orthop. Trauma"},{"key":"ref_8","unstructured":"Ates, B., Koytepe, S., Balcioglu, S., Ulu, A., and Gurses, C. (2017). Hybrid Polymer Composite Materials, Elsevier."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Tang, G., Liu, Z., Liu, Y., Yu, J., Wang, X., Tan, Z., and Ye, X. (2021). Recent Trends in the Development of Bone Regenerative Biomaterials. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.665813"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.1016\/j.matpr.2021.03.009","article-title":"Advancement in hybrid materials, its applications and future challenges: A review","volume":"47","author":"Das","year":"2021","journal-title":"Mater. Today Proc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5083","DOI":"10.1039\/c0sm01348j","article-title":"Softening bioactive glass for bone regeneration: Sol\u2013gel hybrid materials","volume":"7","author":"Valliant","year":"2011","journal-title":"Soft Matter"},{"key":"ref_12","first-page":"39","article-title":"Hybrid Materials\u2014Past, Present and Future","volume":"1","author":"Kickelbick","year":"2014","journal-title":"Hybrid Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1023\/A:1008600723220","article-title":"Structures, Properties and Potential Applications of Ormosils","volume":"13","author":"Mackenzie","year":"1998","journal-title":"J. Sol Gel Sci. Technol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"117624","DOI":"10.1016\/j.memsci.2019.117624","article-title":"High-performance electrospinning-phase inversion composite PDMS membrane for extractive membrane bioreactor: Fabrication, characterization, optimization and application","volume":"597","author":"Ren","year":"2020","journal-title":"J. Membr. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.radphyschem.2012.08.004","article-title":"Effect of electron beam irradiation on dynamic mechanical, thermal and morphological properties of LLDPE and PDMS rubber blends","volume":"81","author":"Giri","year":"2012","journal-title":"Radiat. Phys. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.actbio.2019.06.040","article-title":"Permeability and mechanical properties of gradient porous PDMS scaffolds fabricated by 3D-printed sacrificial templates designed with minimal surfaces","volume":"96","author":"Montazerian","year":"2019","journal-title":"Acta Biomater."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jmbbm.2013.01.010","article-title":"Enhanced mechanical properties and blood compatibility of PDMS\/liquid crystal cross-linked membrane materials","volume":"20","author":"Rao","year":"2013","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.progpolymsci.2018.06.001","article-title":"PDMS with designer functionalities\u2014Properties, modifications strategies, and applications","volume":"83","author":"Wolf","year":"2018","journal-title":"Prog. Polym. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ariati, R., Sales, F., Souza, A., Lima, R.A., and Ribeiro, J. (2021). Polydimethylsiloxane Composites Characterization and Its Applications: A Review. Polymers, 13.","DOI":"10.3390\/polym13234258"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1016\/j.actbio.2010.02.012","article-title":"Sol\u2013gel silica-based biomaterials and bone tissue regeneration","volume":"6","author":"Arcos","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.colsurfb.2012.01.020","article-title":"Bioactive silica-based drug delivery systems containing doxorubicin hydrochloride: In vitro studies","volume":"93","author":"Prokopowicz","year":"2012","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.actbio.2008.07.027","article-title":"Correlation between physicochemical properties of doxorubicin-loaded silica\/polydimethylsiloxane xerogel and in vitro release of drug","volume":"5","author":"Prokopowicz","year":"2009","journal-title":"Acta Biomater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1021\/acsbiomaterials.0c01546","article-title":"Cellular Response to Sol\u2013Gel Hybrid Materials Releasing Boron and Calcium Ions","volume":"7","author":"Coelho","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.msec.2016.01.083","article-title":"A biocompatible hybrid material with simultaneous calcium and strontium release capability for bone tissue repair","volume":"62","author":"Almeida","year":"2016","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.porgcoat.2015.09.011","article-title":"A novel organic-inorganic PMMA\/polysilazane hybrid polymer for corrosion protection","volume":"89","author":"Coan","year":"2015","journal-title":"Prog. Org. Coat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1080\/01932691.2018.1489276","article-title":"Polyacrylate\/silica hybrid materials: A step towards multifunctional properties","volume":"40","author":"Tiwari","year":"2019","journal-title":"J. Dispers. Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Akinwumi, B.C., Bordun, K.-A.M., and Anderson, H.D. (2018). Biological Activities of Stilbenoids. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030792"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Salehi, B., Mishra, A.P., Nigam, M., Sener, B., Kilic, M., Sharifi-Rad, M., Fokou, P.V.T., Martins, N., and Sharifi-Rad, J. (2018). Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines, 6.","DOI":"10.3390\/biomedicines6030091"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1752-153X-5-88","article-title":"Trans-, cis-, and dihydro-resveratrol: A comparative study","volume":"5","author":"Anisimova","year":"2011","journal-title":"Chem. Central J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5344\/ajev.1992.43.1.49","article-title":"Concentration of the Phytoalexin Resveratrol in Wine","volume":"43","author":"Siemann","year":"1992","journal-title":"Am. J. Enol. Vitic."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/0140-6736(92)91277-F","article-title":"Wine, alcohol, platelets, and the French paradox for coronary heart disease","volume":"339","author":"Renaud","year":"1992","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/fsn3.855","article-title":"Resveratrol: A miraculous natural compound for diseases treatment","volume":"6","author":"Koushki","year":"2018","journal-title":"Food Sci. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/10408347.2019.1637242","article-title":"Characteristics, Biological Properties and Analytical Methods of Trans -Resveratrol: A Review","volume":"50","author":"Chorilli","year":"2020","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.3390\/nu6125871","article-title":"Effects of Resveratrol Supplementation on Bone Growth in Young Rats and Microarchitecture and Remodeling in Ageing Rats","volume":"6","author":"Lee","year":"2014","journal-title":"Nutrients"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.msec.2017.04.038","article-title":"Bone regeneration: Biomaterials as local delivery systems with improved osteoinductive properties","volume":"82","author":"Martin","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_36","first-page":"5032","article-title":"Protective effects of resveratrol on osteoporosis via activation of the SIRT1-NF-\u03baB signaling pathway in rats","volume":"14","author":"Wang","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1002\/jbmr.4115","article-title":"Regular Supplementation with Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial","volume":"35","author":"Wong","year":"2020","journal-title":"J. Bone Miner. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Peng, L., and Jiang, D. (2018). Resveratrol eliminates cancer stem cells of osteosarcoma by STAT3 pathway inhibition. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0205918"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.5114\/aoms.2020.100777","article-title":"Resveratrol is cytotoxic and acts synergistically with NF-\u03baB inhibition in osteosarcoma MG-63 cells","volume":"17","author":"Xu","year":"2021","journal-title":"Arch. Med. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.3892\/mmr.2015.4338","article-title":"Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells","volume":"12","author":"Zou","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0006-2952(96)00820-9","article-title":"Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins","volume":"53","author":"Belguendouz","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.chroma.2006.09.013","article-title":"Determination of stoichiometric coefficients and apparent formation constants for \u03b2-cyclodextrin complexes of trans-resveratrol using reversed-phase liquid chromatography","volume":"1135","author":"Barrachina","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1124\/jpet.102.033340","article-title":"Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model","volume":"302","author":"Marier","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3892\/etm.2015.2895","article-title":"Bioavailability and safety study of resveratrol 500 mg tablets in healthy male and female volunteers","volume":"11","author":"Sergides","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2174\/092986712799945085","article-title":"Resveratrol in Medicinal Chemistry: A Critical Review of its Pharmacokinetics, Drug-Delivery, and Membrane Interactions","volume":"19","author":"Neves","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.2217\/nnm-2020-0289","article-title":"Resveratrol: Nanocarrier-based delivery systems to enhance its therapeutic potential","volume":"15","author":"Singh","year":"2020","journal-title":"Nanomedicine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.colsurfb.2013.11.025","article-title":"A characterization study of resveratrol\/sulfobutyl ether-\u03b2-cyclodextrin inclusion complex and in vitro anticancer activity","volume":"115","author":"Venuti","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jcis.2015.10.022","article-title":"Enhancing delivery and cytotoxicity of resveratrol through a dual nanoencapsulation approach","volume":"462","author":"Soo","year":"2016","journal-title":"J. Colloid Interface Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6447","DOI":"10.1039\/C9FO01338E","article-title":"Liposome co-encapsulation as a strategy for the delivery of curcumin and resveratrol","volume":"10","author":"Huang","year":"2019","journal-title":"Food Funct."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.colsurfb.2017.12.044","article-title":"Resveratrol liposomes and lipid nanocarriers: Comparison of characteristics and inducing browning of white adipocytes","volume":"164","author":"Zu","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.ijpharm.2009.03.021","article-title":"Resveratrol-loaded polymeric micelles protect cells from A\u03b2-induced oxidative stress","volume":"375","author":"Lu","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Pe\u00f1alva, R., Morales, J., Gonz\u00e1lez-Navarro, C.J., Larra\u00f1eta, E., Quincoces, G., Pe\u00f1uelas, I., and Irache, J.M. (2018). Increased Oral Bioavailability of Resveratrol by Its Encapsulation in Casein Nanoparticles. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092816"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.2217\/nnm-2019-0244","article-title":"Oat protein-shellac nanoparticles as a delivery vehicle for resveratrol to improve bioavailability in vitro and in vivo","volume":"14","author":"Yang","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.tifs.2019.07.048","article-title":"Nanocarriers for resveratrol delivery: Impact on stability and solubility concerns","volume":"91","author":"Santos","year":"2019","journal-title":"Trends Food Sci. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chaudhary, Z., Subramaniam, S., Khan, G.M., Abeer, M.M., Qu, Z., Janjua, T., Kumeria, T., Batra, J., and Popat, A. (2019). Encapsulation and Controlled Release of Resveratrol Within Functionalized Mesoporous Silica Nanoparticles for Prostate Cancer Therapy. Front. Bioeng. Biotechnol., 7.","DOI":"10.3389\/fbioe.2019.00225"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Qin, L., He, Y., Zhao, X., Zhang, T., Qin, Y., and Du, A. (2020). Preparation, Characterization, and In Vitro Sustained Release Profile of Resveratrol-Loaded Silica Aerogel. Molecules, 25.","DOI":"10.3390\/molecules25122752"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Marinheiro, D., Ferreira, B.J.M.L., Oskoei, P., Oliveira, H., and Daniel-Da-Silva, A.L. (2021). Encapsulation and Enhanced Release of Resveratrol from Mesoporous Silica Nanoparticles for Melanoma Therapy. Materials, 14.","DOI":"10.3390\/ma14061382"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejpb.2015.04.002","article-title":"Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature","volume":"93","author":"Kristl","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Cunha, C., Marinheiro, D., Ferreira, B.J.M.L., Oliveira, H., and Daniel-Da-Silva, A.L. (2023). Morin Hydrate Encapsulation and Release from Mesoporous Silica Nanoparticles for Melanoma Therapy. Molecules, 28.","DOI":"10.3390\/molecules28124776"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jconrel.2014.06.041","article-title":"Mathematical models in drug delivery: How modeling has shaped the way we design new drug delivery systems","volume":"190","author":"Peppas","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","article-title":"Mechanisms of solute release from porous hydrophilic polymers","volume":"15","author":"Korsmeyer","year":"1983","journal-title":"Int. J. Pharm."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0168-3659(87)90034-4","article-title":"A simple equation for description of solute release I. Fickian and non-fickian release from non-swellable devices in the form of slabs, spheres, cylinders or discs","volume":"5","author":"Ritger","year":"1987","journal-title":"J. Control. Release"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0928-0987(01)00095-1","article-title":"Modeling and comparison of dissolution profiles","volume":"13","author":"Costa","year":"2001","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1115\/1.4010337","article-title":"A Statistical Distribution Function of Wide Applicability","volume":"18","author":"Weibull","year":"1951","journal-title":"J. Appl. Mech."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.2042-7158.1972.tb08930.x","article-title":"Letters to the Editor: Linearization of dissolution rate curves by the Weibull distribution","volume":"24","author":"Langenbucher","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/bjc.1987.190","article-title":"A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity","volume":"56","author":"Twentyman","year":"1987","journal-title":"Br. J. Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.jnoncrysol.2009.01.010","article-title":"Structural study of sol\u2013gel silicate glasses by IR and Raman spectroscopies","volume":"355","author":"Aguiar","year":"2009","journal-title":"J. Non Cryst. Solids"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"14624","DOI":"10.1021\/jp203524p","article-title":"Surfactant-Synthesized PDMS\/Silica Nanomaterials Improve Robustness and Stain Resistance of Carbonate Stone","volume":"115","author":"Illescas","year":"2011","journal-title":"J. Phys. Chem. C"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.msec.2014.12.025","article-title":"Evaluating structural and microstructural changes of PDMS\u2013SiO2 hybrid materials after sterilization by gamma irradiation","volume":"48","author":"Almeida","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1021\/cm00005a017","article-title":"Dimethyldiethoxysilane\/tetraethoxysilane copolymers: Precursors for the silicon-carbon-oxygen system","volume":"1","author":"Babonneau","year":"1989","journal-title":"Chem. Mater."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/00387019808006772","article-title":"A FT-IR Study of the Hydrolysis of Tetraethylorthosilicate (TEOS)","volume":"31","author":"Rubio","year":"1998","journal-title":"Spectrosc. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1002\/cctc.201902038","article-title":"Spectroscopic Signatures of Pressurized Carbon Dioxide in Diffuse Reflectance Infrared Spectroscopy of Heterogeneous Catalysts","volume":"12","author":"Fehr","year":"2020","journal-title":"ChemCatChem"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1016\/S0032-3861(99)00741-7","article-title":"Solid-state NMR study of structure, size and dynamics of domains in hybrid siloxane networks","volume":"41","author":"Brus","year":"2000","journal-title":"Polymer"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1351\/pac198557040603","article-title":"Reporting physisorption data for gas\/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984)","volume":"57","author":"Sing","year":"1985","journal-title":"Pure Appl. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1800173","DOI":"10.1002\/smtd.201800173","article-title":"Evaluation of the BET Theory for the Characterization of Meso and Microporous MOFs","volume":"2","author":"Ambroz","year":"2018","journal-title":"Small Methods"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.polymer.2015.06.053","article-title":"PDMS-SiO2 hybrid materials\u2014A new insight into the role of Ti and Zr as additives","volume":"72","author":"Almeida","year":"2015","journal-title":"Polymer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6549","DOI":"10.1007\/BF00356392","article-title":"Gelation kinetics of an organically modified silicate","volume":"28","author":"Hu","year":"1993","journal-title":"J. Mater. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1021\/acs.molpharmaceut.7b00529","article-title":"In Vitro Dissolution, Cellular Membrane Permeability, and Anti-Inflammatory Response of Resveratrol-Encapsulated Mesoporous Silica Nanoparticles","volume":"14","author":"Florek","year":"2017","journal-title":"Mol. Pharm."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Catenacci, L., Sorrenti, M., Bonferoni, M.C., Hunt, L., and Caira, M.R. (2020). Inclusion of the Phytoalexin trans-Resveratrol in Native Cyclodextrins: A Thermal, Spectroscopic, and X-Ray Structural Study. Molecules, 25.","DOI":"10.3390\/molecules25040998"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1208\/s12249-011-9584-3","article-title":"Cyclodextrin-Based Nanosponges for Delivery of Resveratrol: In Vitro Characterisation, Stability, Cytotoxicity and Permeation Study","volume":"12","author":"Ansari","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1208\/s12249-019-1349-4","article-title":"Preparation, Characterization, and In vitro Evaluation of Curcumin- and Resveratrol-Loaded Solid Lipid Nanoparticles","volume":"20","author":"Gumireddy","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/S0032-3861(00)00652-2","article-title":"Polydimethylsiloxane thermal degradation Part 1. Kinetic aspects","volume":"42","author":"Camino","year":"2001","journal-title":"Polymer"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.foodchem.2017.05.146","article-title":"Resveratrol: A thermoanalytical study","volume":"237","author":"Silva","year":"2017","journal-title":"Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1049\/iet-nbt.2016.0063","article-title":"Biocompatibility assessment of SiO2\u2013TiO2 composite powder on MG63 osteoblast cell lines for orthopaedic applications","volume":"11","author":"Chellappa","year":"2017","journal-title":"IET Nanobiotechnol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.colcom.2018.11.002","article-title":"Embedding CuO Nanoparticles in PDMS-SiO2 Coating to Improve Antibacterial Characteristic and Corrosion Resistance","volume":"28","author":"Tavakoli","year":"2019","journal-title":"Colloid Interface Sci. 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