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(ALiCE)"],"award-info":[{"award-number":["LA\/P\/0045\/2020 (ALiCE)"]}]},{"name":"FCT","award":["CEECINST\/00156\/2018\/CP1642\/CT0001"],"award-info":[{"award-number":["CEECINST\/00156\/2018\/CP1642\/CT0001"]}]},{"name":"FCT","award":["2021.00027.CEECIND\/CP1664\/CT0007"],"award-info":[{"award-number":["2021.00027.CEECIND\/CP1664\/CT0007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Polymers"],"abstract":"<jats:p>Over the last decade, researchers have developed a variety of new analytical and clinical diagnostic devices. These devices are predominantly based on microfluidic technologies, where biological samples can be processed and manipulated for the collection and detection of important biomolecules. Polydimethylsiloxane (PDMS) is the most commonly used material in the fabrication of these microfluidic devices. However, it has a hydrophobic nature (contact angle with water of 110\u00b0), leading to poor wetting behavior and issues related to the mixing of fluids, difficulties in obtaining uniform coatings, and reduced efficiency in processes such as plasma separation and molecule detection (protein adsorption). This work aimed to consider the fabrication aspects of PDMS microfluidic devices for biological applications, such as surface modification methods. Therefore, we studied and characterized two methods for obtaining hydrophilic PDMS surfaces: surface modification by bulk mixture and the surface immersion method. To modify the PDMS surface properties, three different surfactants were used in both methods (Pluronic\u00ae F127, polyethylene glycol (PEG), and polyethylene oxide (PEO)) at different percentages. Water contact angle (WCA) measurements were performed to evaluate the surface wettability. Additionally, capillary flow studies were performed with microchannel molds, which were produced using stereolithography combined with PDMS double casting and replica molding procedures. A PDMS microfluidic device for blood plasma separation was also fabricated by soft lithography with PDMS modified by PEO surfactant at 2.5% (v\/v), which proved to be the best method for making the PDMS hydrophilic, as the WCA was lower than 50\u00b0 for several days without compromising the PDMS\u2019s optical properties. Thus, this study indicates that PDMS surface modification shows great potential for enhancing blood plasma separation efficiency in microfluidic devices, as it facilitates fluid flow, reduces cell aggregations and the trapping of air bubbles, and achieves higher levels of sample purity.<\/jats:p>","DOI":"10.3390\/polym16101416","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T09:30:03Z","timestamp":1715851803000},"page":"1416","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Polydimethylsiloxane Surface Modification of Microfluidic Devices for Blood Plasma Separation"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7625-167X","authenticated-orcid":false,"given":"Margarida","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Microelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LABBELS\u2014Associate Laboratory, 4800-122 Braga, Portugal, and 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-8934","authenticated-orcid":false,"given":"In\u00eas Maia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"MEtRICs, Mechanical Engineering Department, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"IN+, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1649-001 Lisboa, Portugal"},{"name":"Department of Diagnostic and Therapeutic Systems Engineering, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7421-6902","authenticated-orcid":false,"given":"Joel","family":"Borges","sequence":"additional","affiliation":[{"name":"Physics Center of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LaPMET, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9041-2188","authenticated-orcid":false,"given":"Vera","family":"Faustino","sequence":"additional","affiliation":[{"name":"Microelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LABBELS\u2014Associate Laboratory, 4800-122 Braga, Portugal, and 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1884-2380","authenticated-orcid":false,"given":"Delfim","family":"Soares","sequence":"additional","affiliation":[{"name":"Microelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LABBELS\u2014Associate Laboratory, 4800-122 Braga, Portugal, and 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5506-996X","authenticated-orcid":false,"given":"Filipe","family":"Vaz","sequence":"additional","affiliation":[{"name":"Physics Center of Minho and Porto Universities (CF-UM-UP), University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LaPMET, University of Minho, 4710-057 Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2460-0556","authenticated-orcid":false,"given":"Gra\u00e7a","family":"Minas","sequence":"additional","affiliation":[{"name":"Microelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LABBELS\u2014Associate Laboratory, 4800-122 Braga, Portugal, and 4800-058 Guimar\u00e3es, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3428-637X","authenticated-orcid":false,"given":"Rui","family":"Lima","sequence":"additional","affiliation":[{"name":"MEtRICs, Mechanical Engineering Department, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"CEFT, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"},{"name":"ALiCE, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3884-6496","authenticated-orcid":false,"given":"Diana","family":"Pinho","sequence":"additional","affiliation":[{"name":"Microelectromechanical Systems Research Unit, CMEMS-UMinho, University of Minho, Campus de Azur\u00e9m, 4800-058 Guimar\u00e3es, Portugal"},{"name":"LABBELS\u2014Associate Laboratory, 4800-122 Braga, Portugal, and 4800-058 Guimar\u00e3es, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"ref_1","unstructured":"Saxena, S., and Joshi, R. 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