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Also, blends of these two polymers were used in different weight ratios (25:75, 50:50 and 75:25) to obtain physical barriers with different properties. All membranes had a suitable pore size to prevent fibroblast infiltration, and their porosity and permeability values were in a range that allowed the passage of nutrients. The membrane made from a blend of 25%wt of PEA_ala and 75% wt of PEA_phe showed the highest value of swelling capacity, suggesting a higher lubricant feature. The same membrane suffered a more pronounced degradation, as evidenced by the in vitro enzymatic degradation tests. All membranes showed suitable toughness values, a crucial property with regard to application. In vitro cytotoxicity tests performed with a NIH3T3 fibroblast cell line revealed decreased cell viability after 7 days, suggesting that these membranes are not ideal substrates to promote fibroblast adhesion and proliferation. These membranes as physical barriers represent a significant advance in the field given the limited literature on electrospun AAA-PEAs and their use to prevent tendon adhesion.<\/jats:p>","DOI":"10.3390\/polym17030395","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T08:47:57Z","timestamp":1738572477000},"page":"395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tackling the Problem of Tendon Adhesions: Physical Barriers Prepared from \u03b1-Amino Acid-Based Poly(ester amide)s"],"prefix":"10.3390","volume":"17","author":[{"given":"Sofia","family":"Saraiva","sequence":"first","affiliation":[{"name":"Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), ARISE, Department of Chemical Engineering, University of Coimbra, P\u00f3lo II, Rua S\u00edlvio Lima, 3030-790 Coimbra, Portugal"}]},{"given":"Francisca","family":"R\u00e9nio","sequence":"additional","affiliation":[{"name":"Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), ARISE, Department of Chemical Engineering, University of Coimbra, P\u00f3lo II, Rua S\u00edlvio Lima, 3030-790 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-5271","authenticated-orcid":false,"given":"Patr\u00edcia","family":"Pereira","sequence":"additional","affiliation":[{"name":"Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), ARISE, Department of Chemical Engineering, University of Coimbra, P\u00f3lo II, Rua S\u00edlvio Lima, 3030-790 Coimbra, Portugal"},{"name":"IPN, Instituto Pedro Nunes, Associa\u00e7\u00e3o para a Inova\u00e7\u00e3o e Desenvolvimento em Ci\u00eancia e Tecnologia, Rua Pedro Nunes, 3030-199 Coimbra, Portugal"}]},{"given":"Patr\u00edcia","family":"Santos","sequence":"additional","affiliation":[{"name":"Centre for Mechanical Engineering, Materials and Processes (CEMMPRE), ARISE, Department of Chemical Engineering, University of Coimbra, P\u00f3lo II, Rua S\u00edlvio Lima, 3030-790 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-160X","authenticated-orcid":false,"given":"Carlos T. 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