{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T20:22:27Z","timestamp":1774988547862,"version":"3.50.1"},"reference-count":241,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Recent advances in biomedical technologies are mostly related to the convergence of biology with microengineering. For instance, microfluidic devices are now commonly found in most research centers, clinics and hospitals, contributing to more accurate studies and therapies as powerful tools for drug delivery, monitoring of specific analytes, and medical diagnostics. Most remarkably, integration of cellularized constructs within microengineered platforms has enabled the recapitulation of the physiological and pathological conditions of complex tissues and organs. The so-called \u201corgan-on-a-chip\u201d technology, which represents a new avenue in the field of advanced in vitro models, with the potential to revolutionize current approaches to drug screening and toxicology studies. This review aims to highlight recent advances of microfluidic-based devices towards a body-on-a-chip concept, exploring their technology and broad applications in the biomedical field.<\/jats:p>","DOI":"10.3390\/s151229848","type":"journal-article","created":{"date-parts":[[2015,12,14]],"date-time":"2015-12-14T02:57:29Z","timestamp":1450061849000},"page":"31142-31170","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Microfluidic Organ\/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5249-5138","authenticated-orcid":false,"given":"Ana","family":"Perestrelo","sequence":"first","affiliation":[{"name":"International Clinical Research Center (ICRC), Integrated Center of Cellular Therapy and Regenerative Medicine (ICCT), St. Anne\u2019s University Hospital, Brno 656 91, Czech Republic"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1575-6367","authenticated-orcid":false,"given":"Ana","family":"\u00c1guas","sequence":"additional","affiliation":[{"name":"Center for Biomedical Research, University of Algarve, Faro 8005-139, Portugal"}]},{"given":"Alberto","family":"Rainer","sequence":"additional","affiliation":[{"name":"Tissue Engineering Unit, Universit\u00e0 Campus Bio-Medico di Roma, Rome 00128, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1341-1023","authenticated-orcid":false,"given":"Giancarlo","family":"Forte","sequence":"additional","affiliation":[{"name":"International Clinical Research Center (ICRC), Integrated Center of Cellular Therapy and Regenerative Medicine (ICCT), St. Anne\u2019s University Hospital, Brno 656 91, Czech Republic"},{"name":"Department of Biomaterials Science, University of Turku, Turku 20014, Finland"}]}],"member":"1968","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.8493529","article-title":"Tissue Engineering","volume":"260","author":"Langer","year":"1993","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/adhm.201500040","article-title":"Microfluidic organ-on-a-chip technology for advancement of drug development and toxicology","volume":"4","author":"Caplin","year":"2015","journal-title":"Adv. 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