{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:12:10Z","timestamp":1760267530202,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T00:00:00Z","timestamp":1519689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Portuguese Foundation for Science and Technology","award":["PhD research grant PD\/BD\/135023\/2017"],"award-info":[{"award-number":["PhD research grant PD\/BD\/135023\/2017"]}]},{"name":"North Portugal Regional Operational Program (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, and through the European Regional Development Fund (ERDF)","award":["Project NanoSTIMA"],"award-info":[{"award-number":["Project NanoSTIMA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Recent trends on microbiology point out the urge to develop optical micro-tools with multifunctionalities such as simultaneous manipulation and sensing. Considering that miniaturization has been recognized as one of the most important paradigms of emerging sensing biotechnologies, optical fiber tools, including Optical Fiber Tweezers (OFTs), are suitable candidates for developing multifunctional small sensors for Medicine and Biology. OFTs are flexible and versatile optotools based on fibers with one extremity patterned to form a micro-lens. These are able to focus laser beams and exert forces onto microparticles strong enough (piconewtons) to trap and manipulate them. In this paper, through an exploratory analysis of a 45 features set, including time and frequency-domain parameters of the back-scattered signal of particles trapped by a polymeric lens, we created a novel single feature able to differentiate synthetic particles (PMMA and Polystyrene) from living yeasts cells. This single statistical feature can be useful for the development of label-free hybrid optical fiber sensors with applications in infectious diseases detection or cells sorting. It can also contribute, by revealing the most significant information that can be extracted from the scattered signal, to the development of a simpler method for particles characterization (in terms of composition, heterogeneity degree) than existent technologies.<\/jats:p>","DOI":"10.3390\/s18030710","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T14:18:08Z","timestamp":1519741088000},"page":"710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Single Particle Differentiation through 2D Optical Fiber Trapping and Back-Scattered Signal Statistical Analysis: An Exploratory Approach"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-587X","authenticated-orcid":false,"given":"Joana S.","family":"Paiva","sequence":"first","affiliation":[{"name":"INESC TEC-INESC Technology and Science, 4200 Porto, Portugal"},{"name":"Physics and Astronomy Department, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"given":"Rita S. R.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"INESC TEC-INESC Technology and Science, 4200 Porto, Portugal"}]},{"given":"Jo\u00e3o P. S.","family":"Cunha","sequence":"additional","affiliation":[{"name":"INESC TEC-INESC Technology and Science, 4200 Porto, Portugal"},{"name":"Faculty of Engineering, University of Porto, 4200 Porto, Portugal"}]},{"given":"Carla C.","family":"Rosa","sequence":"additional","affiliation":[{"name":"INESC TEC-INESC Technology and Science, 4200 Porto, Portugal"},{"name":"Physics and Astronomy Department, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-2068","authenticated-orcid":false,"given":"Pedro A. S.","family":"Jorge","sequence":"additional","affiliation":[{"name":"INESC TEC-INESC Technology and Science, 4200 Porto, Portugal"},{"name":"Physics and Astronomy Department, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2018,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ribeiro, R., Dahal, P., Guerreiro, A., Jorge, P., and Viegas, J. (2017). Fabrication of Fresnel plates on optical fibres by FIB milling for optical trapping, manipulation and detection of single cells. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-04490-2"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Genuer, V., Gal, O., M\u00e9teau, J., Marcoux, P., Schultz, E., Lacot, \u00c9., Maurin, M., and Dinten, J. (arXiv, 2016). 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