{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:30:57Z","timestamp":1765888257147,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>A configuration of a refractometer sensor is described with the aim of optically detecting the crystallization process of paracetamol. The developed sensing head is based on a conventional cleaved multi-mode fiber. The fiber tip sensor structure was submitted to contact with the liquid of interest (paracetamol fully dissolved in 40% v\/v of ethanol\/water) and the crystallization process of paracetamol, induced with continued exposure to air, was monitored in real time.<\/jats:p>","DOI":"10.3390\/s20010087","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T03:15:01Z","timestamp":1577070901000},"page":"87","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Detection of the Crystallization Process of Paracetamol with a Multi-Mode Optical Fiber in a Reflective Configuration"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1828-4633","authenticated-orcid":false,"given":"Liliana","family":"Soares","sequence":"first","affiliation":[{"name":"INESC TEC\u2014Institute for Systems and Computer Engineering, Technology and Science, Rua do Campo Alegre 687, 4169-007 Porto, Portugal"},{"name":"Faculty of Biotechnology of Catholic University of Portugal, Rua de Diogo Botelho, 1327, 4169-005 Porto, Portugal"}]},{"given":"Susana","family":"Novais","sequence":"additional","affiliation":[{"name":"INESC TEC\u2014Institute for Systems and Computer Engineering, Technology and Science, Rua do Campo Alegre 687, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6381-981X","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"LEPABE\u2014Laboratory for Process Engineering, Environment, Biotechnology and Energy, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias s\/n, 4200-465 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-1056","authenticated-orcid":false,"given":"Orlando","family":"Fraz\u00e3o","sequence":"additional","affiliation":[{"name":"INESC TEC\u2014Institute for Systems and Computer Engineering, Technology and Science, Rua do Campo Alegre 687, 4169-007 Porto, Portugal"},{"name":"Department of Physics and Astronomy, Faculty of Sciences of University of Porto, Rua do Campo Alegre 687, 4169-007 Porto, Portugal"}]},{"given":"Susana","family":"Silva","sequence":"additional","affiliation":[{"name":"INESC TEC\u2014Institute for Systems and Computer Engineering, Technology and Science, Rua do Campo Alegre 687, 4169-007 Porto, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.cherd.2013.07.018","article-title":"Recent advances in the monitoring, modeling and control of crystallization systems","volume":"91","author":"Nagy","year":"2013","journal-title":"Chem. 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