{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T01:29:45Z","timestamp":1774661385094,"version":"3.50.1"},"reference-count":100,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/00100\/2020"],"award-info":[{"award-number":["UIDB\/00100\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDB\/04565\/2020"],"award-info":[{"award-number":["UIDB\/04565\/2020"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["LA\/P\/0056\/2020"],"award-info":[{"award-number":["LA\/P\/0056\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"<jats:p>Due to their structural features, macrocyclic compounds such as calixarenes, conjugated with a variety of fluorophores have led to the development of fluorescent probes for numerous applications. This review covers the recent advances (from 2009 to date) made in calixarene-based fluorescent sensors and their biological applications. In addition to the fluorescence mechanisms used to signal the analyte binding, this article focuses mainly on the detection of biological relevant ions, on the selective sensing of biomolecules, such as amino acids, enzymes, drugs and other organic compounds, and on intracellular imaging. Calixarene-containing fluorescent nanoparticles and nanoaggregates for imaging and drug delivery are also described. Finally, this review presents some conclusions and future perspectives in this field.<\/jats:p>","DOI":"10.3390\/s24227181","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T03:53:14Z","timestamp":1731383594000},"page":"7181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Recent Advances in Calixarene-Based Fluorescent Sensors for Biological Applications"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7297-5139","authenticated-orcid":false,"given":"Paula M.","family":"Marcos","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Institute of Molecular Sciences, Faculdade de Ci\u00eancias, Universidade de Lisboa, Edif\u00edcio C8, 1749-016 Lisboa, Portugal"},{"name":"Faculdade de Farm\u00e1cia, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-1498","authenticated-orcid":false,"given":"M\u00e1rio N.","family":"Berberan-Santos","sequence":"additional","affiliation":[{"name":"IBB-Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1021\/ar500009g","article-title":"Supramolecular chemistry of p-sulfonatocalix[n]arenes and its biological applications","volume":"47","author":"Guo","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"112121","DOI":"10.1016\/j.ejmech.2020.112121","article-title":"Para-sulfonatocalix[n]arene-based biomaterials: Recent progress in pharmaceutical and biological applications","volume":"190","author":"Noruzi","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/acs.accounts.2c00026","article-title":"Combining excellent selectivity with broad target scope: Biosensing with arrayed deep cavitand hosts","volume":"55","author":"Zhong","year":"2022","journal-title":"Acc. Chem. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108220","DOI":"10.1016\/j.cclet.2023.108220","article-title":"Macrocyclic supramolecular biomaterials in anti-cancer therapeutics","volume":"34","author":"Hazarika","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"115994","DOI":"10.1016\/j.ejmech.2023.115994","article-title":"Promises of anionic calix[n]arenes in life science: State of the art in 2023","volume":"264","author":"Lazar","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"ref_6","unstructured":"Gutsche, C.D. (2008). Calixarenes. Monographs in Supramolecular Chemistry, The Royal Society of Chemistry."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Neri, P., Sesseler, J.L., and Wang, M.-X. (2016). Calixarenes and Beyond, Springer International Publishing.","DOI":"10.1007\/978-3-319-31867-7"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"9657","DOI":"10.1021\/acs.chemrev.8b00605","article-title":"Revisiting fluorescent calixarenes: From molecular sensors to smart materials","volume":"119","author":"Kumar","year":"2019","journal-title":"Chem. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"116086","DOI":"10.1016\/j.trac.2020.116086","article-title":"Fluorescent probes based on macrocyclic hosts: Construction, mechanism and analytical applications","volume":"133","author":"Jiang","year":"2020","journal-title":"Trends Anal. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"213560","DOI":"10.1016\/j.ccr.2020.213560","article-title":"Supramolecular fluorescent sensors: An historical overview and update","volume":"427","author":"Guo","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"13790","DOI":"10.1039\/D3CC04179D","article-title":"A summary of calixarene-based fluorescent sensors developed during the past five years","volume":"59","author":"Ren","year":"2023","journal-title":"Chem. Commun."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Valeur, B., and Berberan-Santos, M.N. (2012). Molecular Fluorescence. Principles and Applications, Wiley-VCH. [2nd ed.].","DOI":"10.1002\/9783527650002"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1039\/C7NJ00652G","article-title":"Fluorescence properties of p-tert-butyldihomooxacalix[4]arene derivatives and the effect of anion complexation","volume":"41","author":"Miranda","year":"2017","journal-title":"New J. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1021\/ar500116d","article-title":"Dynamically analyte-responsive macrocyclic host-fluorophore systems","volume":"47","author":"Ghale","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3762\/bjoc.15.139","article-title":"Complexation of a guanidinium-modified calixarene with diverse dyes and investigation of the corresponding photophysical response","volume":"15","author":"Wang","year":"2019","journal-title":"Beilstein J. Org. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lou, X.-Y., Song, N., and Yang, Y.-W. (2017). Fluorescence resonance energy transfer Systems in Supramolecular Macrocyclic Chemistry. Molecules, 22.","DOI":"10.3390\/molecules22101640"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"215256","DOI":"10.1016\/j.ccr.2023.215256","article-title":"Suprareceptors emerging from click chemistry: Comparing the triazole based scaffolds of calixarenes, cyclodextrins, cucurbiturils and pillararenes","volume":"493","author":"Mummidivarapu","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1039\/c0cc00219d","article-title":"A lower rim triazole linked calix[4]arene conjugate as a fluorescence switch on sensor for Zn2+ in blood serum milieu","volume":"46","author":"Pathak","year":"2010","journal-title":"Chem. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1021\/jo201865x","article-title":"Triazole-linked thiophene conjugate of calix[4]arene: Its selective recognition of Zn2+ and as biomimetic model in supporting the events of the metal detoxification and oxidative stress involving metallothionein","volume":"76","author":"Pathak","year":"2011","journal-title":"J. Org. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"13999","DOI":"10.1002\/chem.201102791","article-title":"Selective recognition of cysteine in its free and protein-bound states by the Zn2+ complex of a triazole-based calix[4]arene conjugate","volume":"17","author":"Pathak","year":"2011","journal-title":"Chem. Eur. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"8294","DOI":"10.1021\/ac301821c","article-title":"Multiple sensor array of Mn2+, Fe2+, Co2+, Ni2+, Cu2+ and Zn2+ complexes of a triazole linked imino-phenol based calix[4]arene conjugate for the selective recognition of Asp, Glu, Cys and His","volume":"84","author":"Pathak","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/10610278.2013.868897","article-title":"A fluorescent di-zinc (II) complex f bis-calix[4]arene conjugate as chemosensing-ensemble for the selective recognition of ATP","volume":"26","author":"Mummidivarapu","year":"2014","journal-title":"Supramol. Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1080\/10610278.2015.1129406","article-title":"Structure of a di-zinc complex of a bis-calix[4]arene conjugate and its sensing of cysteine among the amino acids","volume":"28","author":"Mummidivarapu","year":"2016","journal-title":"Supramol. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"5763","DOI":"10.1021\/jo500892r","article-title":"Phenylene-diimine-capped conjugate of lower rim 1,3-calix[4]arene as molecular receptor for Mg2+ via arm conformational changes followed by aggregation and mimicking the species by molecular mechanics","volume":"79","author":"Nehra","year":"2014","journal-title":"J. Org. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"8181","DOI":"10.1021\/jo901676s","article-title":"Lower rim 1,3-di{bis(2-picolyl)} amide derivative of calix[4]arene (L) as ratiometric primary sensor toward Ag+ and the complex of Ag+ as secondary sensor toward Cys: Experimental, computational, and microscopy studies and INHIBIT logic gate properties of L","volume":"74","author":"Joseph","year":"2009","journal-title":"J. Org. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10847-018-0872-3","article-title":"New fluorescent sensor based on a calix[4]arene bearing two triazole-coumarin units for copper ions: Application for Cu2+ detection in human blood serum","volume":"93","author":"Hosseinzadeh","year":"2019","journal-title":"J. Inc. Phenom. Macrocycl. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1039\/c3an00209h","article-title":"Fluorescence switch on\u2013off\u2013on receptor constructed of quinoline allied calix[4]arene for selective recognition of Cu2+ from blood serum and F\u2212 from industrial waste water","volume":"138","author":"Sutariya","year":"2013","journal-title":"Analyst"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jlumin.2018.12.009","article-title":"Novel luminescent paper based calix[4]arene chelation enhanced fluorescence-photoinduced electron transfer probe for Mn2+, Cr3+ and F\u2212","volume":"208","author":"Sutariya","year":"2019","journal-title":"J. Luminesc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jlumin.2019.04.029","article-title":"Novel tritopic calix[4]arene CHEF-PET fluorescence paper based probe for La3+, Cu2+ and Br\u2212: Its computational investigation and application to real samples","volume":"212","author":"Sutariya","year":"2019","journal-title":"J. Luminesc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9855","DOI":"10.1039\/C9NJ01388A","article-title":"Luminescent behaviour of pyrene-allied calix[4]arene for the highly pH-selective recognition and determination of Zn2+, Hg2+ and I\u2212 via the CHEF-PET mechanism: Computational experiment and paper-based device","volume":"43","author":"Sutariya","year":"2019","journal-title":"New J. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6255","DOI":"10.1039\/D2CC00847E","article-title":"Calix[6]arenes with halogen bond donor groups as selective and efficient anion transporters","volume":"58","author":"Singh","year":"2022","journal-title":"Chem. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1039\/c0nj00323a","article-title":"Magnesium dependent complexation of tri-anionic calix[4]arene detergents by the nucleotide binding domain 1 (NBD1) of multidrug resistance protein MRP1","volume":"34","author":"Nault","year":"2010","journal-title":"New J. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1021\/jo101759f","article-title":"1,3-Diamido-calix[4]arene conjugates of amino acids: Recognition of \u2013COOH side chain present in amino acids, peptides, and proteins by experimental and computational studies","volume":"76","author":"Acharya","year":"2011","journal-title":"J. Org. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"11674","DOI":"10.1021\/ja303465x","article-title":"Antibody-free reading of the histone code using a simple chemical sensor array","volume":"134","author":"Minaker","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"10725","DOI":"10.1039\/D1RA08617K","article-title":"Enzyme assays with supramolecular chemosensors\u2013the label-free approach","volume":"12","author":"Nilam","year":"2022","journal-title":"RSC Adv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"11558","DOI":"10.1021\/ja904165c","article-title":"Substrate-selective supramolecular tandem assays: Monitoring enzyme inhibition of arginase and diamine oxidase by fluorescent dye displacement from calixarene and cucurbituril macrocycles","volume":"131","author":"Nau","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1039\/c1sc00231g","article-title":"Operational calixarene-based fluorescent sensing systems for choline and acetylcholine and their application to enzymatic reactions","volume":"2","author":"Guo","year":"2011","journal-title":"Chem. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1002\/chem.201103397","article-title":"A fluorescence-based supramolecular tandem assay for monitoring lysine methyltransferase activity in homogenous solution","volume":"18","author":"Florea","year":"2012","journal-title":"Chem. Eur. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/anie.201309583","article-title":"Chemosensing ensembles for monitoring biomembrane transport in real time","volume":"53","author":"Ghale","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8755","DOI":"10.1002\/chem.201300980","article-title":"Specifically monitoring butyrylcholinesterase by supramolecular tandem assay","volume":"19","author":"Guo","year":"2013","journal-title":"Chem. Eur. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/slct.201600226","article-title":"pH-Responsive indicator displacement assay of acetylcholine based on acridine-p-sulfonatocalix[4]arene supramolecular system: Fluorescence off\/on switching and reversible pKa shift","volume":"5","author":"Sayed","year":"2016","journal-title":"ChemistrySelect"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1002\/open.201900299","article-title":"Label-free fluorescent kinase and phosphatase enzyme assays with supramolecular host-dye pairs","volume":"8","author":"Liu","year":"2019","journal-title":"CemistryOpen"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/10610278.2020.1857762","article-title":"Sensitive fluorescence detection of saliva pepsin by a supramolecular tandem assay enables the diagnosis of gastroesophageal reflux disease","volume":"33","author":"Zheng","year":"2021","journal-title":"Supramol. Chem."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Yu, H., Chai, X., Geng, W.C., Zhang, L., Ding, F., and Guo, D.S. (2021). Facile and label-free fluorescence strategy for evaluating the influence of bioactive ingredients on FMO3 activity via supramolecular host-guest reporter pair. Biosens. Bioelectron., 192.","DOI":"10.1016\/j.bios.2021.113488"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Duan, Q., Wang, L., Wang, F., Zhang, H., and Lu, K. (2020). Calix[n]arene\/pillar[n]arene-functionalized graphene nanocomposites and their applications. Front. Chem., 8.","DOI":"10.3389\/fchem.2020.00504"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"26557","DOI":"10.1021\/acsami.5b07833","article-title":"Florescent detection of tadalafil based on competitive host-guest interaction using p-sulfonated calix[6]arene functionalized graphene","volume":"48","author":"Yang","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"79350","DOI":"10.1039\/C6RA14835B","article-title":"A FRET-based fluorescent approach for labetalol sensing using calix[6]arene functionalized MnO2@graphene as a receptor","volume":"6","author":"Ye","year":"2016","journal-title":"RSC Adv."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bios.2016.04.005","article-title":"p-Sulfonated calix[8]arene functionalized graphene as a \u201cturn on\u201d fluorescent sensing platform for aconitine determination","volume":"82","author":"Yang","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.aca.2017.11.039","article-title":"Design of a calix[4]arene-functionalized metal-organic framework probe for highly sensitive and selective monitor of hippuric acid for indexing toluene exposure","volume":"1001","author":"Du","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1039\/C7SC04989G","article-title":"Ultrasensitive and specific fluorescence detection of a cancer biomarker via nanomolar binding to a guanidinium-modified calixarene","volume":"9","author":"Zheng","year":"2018","journal-title":"Chem. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"4945","DOI":"10.1021\/jacs.8b02331","article-title":"Biomarker displacement activation: A general host\u2212guest strategy for targeted phototheranostics in vivo","volume":"140","author":"Gao","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jconrel.2020.05.008","article-title":"A host-guest drug delivery nanosystem for supramolecular chemotherapy","volume":"324","author":"Hu","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15966","DOI":"10.1021\/jacs.0c06872","article-title":"Substitution Activated Precise Phototheranostics through Supramolecular Assembly of AIEgen and Calixarene","volume":"142","author":"Feng","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.7150\/thno.33459","article-title":"Facile fluorescence monitoring of gut microbial metabolite trimethylamine N-oxide via molecular recognition of guanidinium-modified calixarene","volume":"9","author":"Yu","year":"2019","journal-title":"Theranostics"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1002\/open.201900316","article-title":"Supramolecular tandem assay for pyridoxal-5\u2032-phosphate by the reporter pair of guanidinocalix[5]arene and fluorescein","volume":"8","author":"Yue","year":"2019","journal-title":"ChemistryOpen"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"338494","DOI":"10.1016\/j.aca.2021.338494","article-title":"Nano-scale selective and sensitive optical sensor for metronidazole based on fluorescence quenching: 1H-Phenanthro [9,10-d] imidazolylcalix[4]arene fluorescent probe","volume":"1162","author":"Simsir","year":"2021","journal-title":"Anal. Chim. Acta"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1908435","DOI":"10.1002\/adma.201908435","article-title":"A general hypoxia-responsive molecular container for tumor-targeted therapy","volume":"13","author":"Zhang","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"20137","DOI":"10.1021\/jacs.9b09563","article-title":"Fluorescence monitoring of peptide transport pathways into large and giant vesicles by supramolecular host\u2212dye reporter pairs","volume":"141","author":"Pan","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1002\/anie.202011185","article-title":"An amphiphilic sulfonatocalix[5]arene as an activator for membrane transport of lysine-rich peptides and proteins","volume":"60","author":"Pan","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"133757","DOI":"10.1016\/j.snb.2023.133757","article-title":"A host-dye complex for sensitive fluorescence detection and clearing of spermine in cells","volume":"386","author":"Duan","year":"2023","journal-title":"Sens. Actuators B Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12039-021-01965-8","article-title":"Supramolecular conjugates of calixarenes in biological cells by microscopy","volume":"133","author":"Nag","year":"2021","journal-title":"J. Chem. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1021\/ac301009h","article-title":"Pyrophosphate sensing by a fluorescent Zn2+ bound triazole linked imino-thiophenyl conjugate of calix[4]arene in HEPES buffer medium: Spectroscopy, microscopy, and cellular studies","volume":"84","author":"Pathak","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1039\/c2an35740b","article-title":"A Zn2+ specific triazole based calix[4]arene conjugate (L) as a fluorescence sensor for histidine and cysteine in HEPES buffer milieu","volume":"137","author":"Pathak","year":"2012","journal-title":"Analyst"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1021\/ic202426v","article-title":"Imino-phenolic-pyridyl conjugates of calix[4]arene (L1 and L2) as primary fluorescence switch-on sensors for Zn2+ in solution and in HeLa cells and the recognition of pyrophosphate and ATP by [ZnL2]","volume":"51","author":"Pathak","year":"2012","journal-title":"Inorg. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/bio.3585","article-title":"A reversible calix[4]arene armed phenolphthalein based fluorescent probe for the detection of Zn2+ and an application in living cells","volume":"34","author":"Erdemir","year":"2019","journal-title":"Luminescence"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"127574","DOI":"10.1016\/j.snb.2019.127574","article-title":"Calix[4]arene based a NIR-fluorescent sensor with an enhanced stokes shift for the real-time visualization of Zn (II) in living cells","volume":"306","author":"Erdemir","year":"2020","journal-title":"Sens. Actuators B Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"120133","DOI":"10.1016\/j.ica.2020.120133","article-title":"Upper rim modified calix[4]arene towards selective turn-on fluorescence sensor for spectroscopically silent metal ions","volume":"516","author":"Anandababu","year":"2021","journal-title":"Inorg. Chim. Acta"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1109\/JSEN.2023.3244323","article-title":"A ratiometric and switchable fluorescent sensor based on calixarene-HBT with a large stokes shift for the real-time detecting of Zn2+ and Cu2+ in living cells","volume":"23","author":"Erdemir","year":"2023","journal-title":"IEEE Sens. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.snb.2016.04.155","article-title":"Synthesis and evaluation of fluorescence properties of Cu2+ selective azocalix[4]arenes and their application in living cell imaging","volume":"234","author":"Bhatti","year":"2016","journal-title":"Sens. Actuators B Chem."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"13231","DOI":"10.1021\/acsomega.9b01402","article-title":"Ratiometric Cu2+ binding, cell imaging, mitochondrial targeting, and anticancer activity with nanomolar IC50 by spiro-indoline-conjugated calix[4]arene","volume":"4","author":"Nag","year":"2019","journal-title":"ACS Omega"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"9832","DOI":"10.1039\/C9NJ01632E","article-title":"A luminescent on-off probe based calix[4]arene linked through triazole with ruthenium (II) polypyridine complexes to sense copper (II) and sulfide ions","volume":"43","author":"Ramachandran","year":"2019","journal-title":"New J. Chem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"108741","DOI":"10.1016\/j.dyepig.2020.108741","article-title":"Ion sensing of sister sensors based-on calix[4]arene in aqueous medium and their bioimaging applications","volume":"184","author":"Alizada","year":"2021","journal-title":"Dyes Pigments"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1021\/ac400059w","article-title":"Quinoline driven fluorescence turn on 1,3-bis-calix[4]arene conjugate-based receptor to discriminate Fe3+ from Fe2+","volume":"85","author":"Pathak","year":"2013","journal-title":"Anal. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"6907","DOI":"10.1021\/ac301492h","article-title":"Cd2+ complex of a triazole-based calix[4]arene conjugate as a selective fluorescent chemosensor for Cys","volume":"84","author":"Pathak","year":"2012","journal-title":"Anal. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1039\/C4DT01726A","article-title":"Interaction of a dinuclear fluorescent Cd (II) complex of calix[4]arene conjugate withphosphates and its applicability in cell imaging","volume":"44","author":"Mummidivarapu","year":"2015","journal-title":"Dalton Trans."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.snb.2015.05.103","article-title":"A new perylene bisimide-armed calix[4]-aza-crown as \u201cturn on\u201d fluorescent sensor for Hg2+ ion and its application to living cells","volume":"220","author":"Erdemir","year":"2015","journal-title":"Sens. Actuators B Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.saa.2016.08.042","article-title":"New water soluble Hg2+ selective fluorescent calix[4]arenes: Synthesis and application in living cells imaging","volume":"171","author":"Oguz","year":"2017","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectroscoy"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jhazmat.2018.01.022","article-title":"Synthesis and characterisation of calix[4]arene based bis (triazole)-bis(hexahydroquinoline): Probing highly selective fluorescence quenching towards mercury (Hg2+) analyte","volume":"347","author":"Khan","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Yilmaz, B., Keskinates, M., and Bayrakci, M. (2021). Novel integrated sensing system of calixarene and rhodamine molecules for selective colorimetric and fluorometric detection of Hg2+ ions in living cells. Spectrochim. Acta Part A Mol. Biomol. Spectroscoy, 245.","DOI":"10.1016\/j.saa.2020.118904"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"7723","DOI":"10.1021\/acsomega.9b00582","article-title":"Development of nitrobenzoxadiazole-appended calix[4]arene conjugate (L) for selective sensing of trivalent Cr3+, Fe3+ and Al3+ ions in solution and in the solid state and imaging MCF7 cells by {L + Al3+}","volume":"4","author":"Dinda","year":"2019","journal-title":"ACS Omega"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"11850","DOI":"10.1021\/acs.joc.8b01761","article-title":"Fluorescent lower rim 1,3-dibenzooxadiazole conjugate of calix[4]arene in selective sensing of fluoride in solution and in biological cells using confocal microscopy","volume":"83","author":"Uttam","year":"2018","journal-title":"J. Org. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1039\/C4OB02333A","article-title":"Design and synthesis of a multivalent fluorescent folate\u2013calix[4]arene conjugate: Cancer cell penetration and intracellular localization","volume":"13","author":"Consoli","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"7593","DOI":"10.1016\/j.tet.2015.07.077","article-title":"Cell proliferation effects of calix[4]arene derivatives","volume":"71","author":"Santos","year":"2015","journal-title":"Tetrahedron"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1021\/acsami.6b14656","article-title":"A bimodal, cationic, and water-soluble calix[4]arene conjugate: Design, synthesis, characterization and transfection of red fluorescent protein encoded plasmid in cancer cells","volume":"9","author":"Samanta","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1080\/07391102.2019.1668301","article-title":"Formation of the inclusion complex of water soluble fluorescent calix[4]arene and naringenin: Solubility, cytotoxic effect and molecular modelling studies","volume":"38","author":"Oguz","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1039\/C5MD00580A","article-title":"Enhancement of aqueous stability and fluorescence brightness of indocyanine green using small calix[4]arene micelles for near-infrared fluorescence imaging","volume":"7","author":"Jin","year":"2016","journal-title":"Med. Chem. Commun."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"15884","DOI":"10.1002\/anie.201609138","article-title":"Protein-sized bright fluorogenic nanoparticles based on cross-linked calixarene micelles with cyanine corona","volume":"55","author":"Shulov","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zairov, R., Mustafina, A., Shamsutdinova, N., Nizameev, I., Moreira, B., Sudakova, S., Podyachev, S., Fattakhova, A., Safina, G., and Lundstrom, I. (2017). High performance magneto-fluorescent nanoparticles assembled from terbium and gadolinium 1,3-diketones. Sci. Rep., 7.","DOI":"10.1038\/srep40486"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"12519","DOI":"10.1002\/anie.201807373","article-title":"Supramolecular assemblies with near-infrared emission mediated in two stages by cucurbituril and amphiphilic calixarene for lysosome-targeted cell imaging","volume":"57","author":"Chen","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1002\/anie.202003427","article-title":"An efficient near-infrared emissive artificial supramolecular light-harvesting system for imaging in the Golgi apparatus","volume":"59","author":"Chen","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"10008","DOI":"10.1002\/anie.201916430","article-title":"Calixarene-based supramolecular AIE dots with highly inhibited nonradiative decay and intersystem crossing for ultrasensitive fluorescence image-guided cancer surgery","volume":"59","author":"Chen","year":"2020","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"22443","DOI":"10.1021\/acsami.2c02851","article-title":"Synchronous imaging in Golgi apparatus and lysosome enabled by amphiphilic calixarene-based artificial light-harvesting systems","volume":"14","author":"Hou","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/nn1034873","article-title":"Multistimuli responsive supramolecular vesicles based on the recognition of p-sulfonatocalixarene and its controllable release of doxorubicin","volume":"5","author":"Wang","year":"2011","journal-title":"ACS Nano"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1021\/cm504653k","article-title":"Multifunctional vehicle of amphiphilic calix[4]arene mediated by liposome","volume":"27","author":"Wang","year":"2015","journal-title":"Chem. Mater."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"17470","DOI":"10.1039\/C5RA24941D","article-title":"Synthesis of calixarene\u2013polyglycerol conjugates and their self-assembly toward nano and microtubes","volume":"6","author":"Rafiee","year":"2016","journal-title":"RSC Adv."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"13010","DOI":"10.1039\/C8NJ01790E","article-title":"Highly branched amine-functionalized p-sulfonatocalix[4]arene decorated with human plasma proteins as a smart, targeted, and stealthy nano-vehicle for the combination chemotherapy of MCF7 cells","volume":"42","author":"Rahimi","year":"2018","journal-title":"New J. Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1039\/D2OB00656A","article-title":"Monoglycocalix[4]arene-based nanoparticles for tumor selective drug delivery via GLUT1 recognition of hyperglycolytic cancers","volume":"20","author":"Zhang","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2006223","DOI":"10.1002\/smll.202006223","article-title":"Calixarene-embedded nanoparticles for interference-free gene\u2013drug combination cancer therapy","volume":"17","author":"Liu","year":"2021","journal-title":"Small"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1007\/s12274-022-4332-4","article-title":"Calixarene-integrated nano-drug delivert system for tumor-targeted delivery and tracking of anti-cancer drugs in vivo","volume":"15","author":"Xu","year":"2022","journal-title":"Nano Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.7150\/thno.72559","article-title":"Calixarene-modified albumin for stoichiometric delivery of multiple drugs in combination-chemotherapy","volume":"12","author":"Wang","year":"2022","journal-title":"Theranostics"}],"container-title":["Sensors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/22\/7181\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:29:07Z","timestamp":1760113747000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1424-8220\/24\/22\/7181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,8]]},"references-count":100,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2024,11]]}},"alternative-id":["s24227181"],"URL":"https:\/\/doi.org\/10.3390\/s24227181","relation":{},"ISSN":["1424-8220"],"issn-type":[{"value":"1424-8220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,8]]}}}